Ohlin M

Protective Non-neutralizing anti-N-terminal Domain mAb Maintains Fc-mediated Function against SARS-COV-2 Variants up to BA.2.86-JN.1 with Superfluous In Vivo Protection against JN.1 Due to Attenuated Virulence.

Izadi A, Godzwon M, Söderlund Strand A, ..., Ohlin M, Nordenfelt P

J. Immunol. 213 (5) 678-689 [2024-09-01; online 2024-07-17]

Drug Discovery and Development (DDD) [Service]

Mammalian cell display with automated oligo design and library assembly allows for rapid residue level conformational epitope mapping.

Thalén NB, Karlander M, Lundqvist M, ..., Ohlin M, Rockberg J

Commun Biol 7 (1) 805 [2024-07-03; online 2024-07-03]

Drug Discovery and Development (DDD) [Service]

The hinge-engineered IgG1-IgG3 hybrid subclass IgGh47 potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodies.

Izadi A, Karami Y, Bratanis E, ..., Malmström L, Nordenfelt P

Nat Commun 15 (1) 3600 [2024-04-27; online 2024-04-27]

Drug Discovery and Development (DDD) [Service]

Design, structure and plasma binding of ancestral β-CoV scaffold antigens.

Hueting D, Schriever K, Sun R, ..., Andréll J, Syrén PO

Nat Commun 14 (1) 6527 [2023-10-16; online 2023-10-16]

Cryo-EM [Service] Drug Discovery and Development (DDD) [Service]

Reply to Pandey: IgG3 allotypes, modulation of antigen binding by constant domain changes, and therapeutic applications of Fc engineering.

Izadi A, Bahnan W, Ohlin M, Nordenfelt P

Proc. Natl. Acad. Sci. U.S.A. 120 (22) e2306562120 [2023-05-30; online 2023-05-22]

Drug Discovery and Development (DDD) [Service]

Subclass-switched anti-spike IgG3 oligoclonal cocktails strongly enhance Fc-mediated opsonization.

Izadi A, Hailu A, Godzwon M, ..., Bahnan W, Nordenfelt P

Proc. Natl. Acad. Sci. U.S.A. 120 (15) e2217590120 [2023-04-11; online 2023-04-03]

Drug Discovery and Development (DDD) [Service]

Allergome-wide peptide microarrays enable epitope deconvolution in allergen-specific immunotherapy

Mikus M, Zandian A, Sjöberg R, ..., van Hage M, Ohlin M

Journal of Allergy and Clinical Immunology 147 (3) 1077-1086 [2021-03-00; online 2021-03-00]

Autoimmunity and Serology Profiling [Collaborative]

Antibody-encoding repertoires of bone marrow and peripheral blood—a focus on IgE

Levin M, Levander F, Palmason R, Greiff L, Ohlin M

Journal of Allergy and Clinical Immunology 139 (3) 1026-1030 [2017-03-00; online 2017-03-00]

Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support for Computational Resources [Service] Bioinformatics Support, Infrastructure and Training [Collaborative] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]