Valerie NCK

Duplexed CeTEAM drug biosensors reveal determinants of PARP inhibitor selectivity in cells.

Pires MJ, Alam S, Lovric A, ..., Altun M, Valerie NCK

J. Biol. Chem. - (-) 108361 [2025-02-26; online 2025-02-26]

Chemical Biology Consortium Sweden [Service]

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.

Valerie NCK, Sanjiv K, Mortusewicz O, ..., Page BDG, Altun M

Nat Commun 15 (1) 10347 [2024-12-06; online 2024-12-06]

Chemical Biology Consortium Sweden [Service]

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.

Page BDG, Valerie NCK, Wright RHG, ..., Beato M, Helleday T

Nat Commun 9 (1) 250 [2018-01-17; online 2018-01-17]

Bioinformatics Support for Computational Resources [Service] Chemical Biology Consortium Sweden [Collaborative] Drug Discovery and Development [Service] Protein Science Facility (PSF) [Service]

Correction to Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.

Llona-Minguez S, Höglund A, Ghassemian A, ..., Scobie M, Helleday T

J. Med. Chem. 60 (17) 7614 [2017-09-14; online 2017-09-01]

Protein Science Facility (PSF) [Service]

Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.

Llona-Minguez S, Höglund A, Ghassemian A, ..., Scobie M, Helleday T

J. Med. Chem. 60 (10) 4279-4292 [2017-05-25; online 2017-05-16]

Chemical Biology Consortium Sweden [Collaborative] Drug Discovery and Development [Collaborative] Protein Science Facility (PSF) [Service]

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.

Herold N, Rudd SG, Ljungblad L, ..., Helleday T, Schaller T

Nat. Med. 23 (2) 256-263 [2017-02-00; online 2017-01-09]

Chemical Biology Consortium Sweden [Collaborative] Protein Science Facility (PSF) [Service]