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Bioinformatics 39 (4) - [2023-04-03; online 2023-04-12]
DNA methylation analysis using arrays is a widely used method in research and clinical studies to study Epigenetics. Although several packages have been published to incur the results, most of them require a deep computational knowledge to perform the analysis. To resolve the limitation and to offer an easily accessible solution for researchers, we developed methylR a graphical tool that can analyze not only the raw data but also performs different downstream analyses with a few mouse clicks. We used standard and established open-source published packages or pipelines in methylR. We evaluated a publicly available dataset and compared the published results with those obtained with our tool. We implemented eight downstream analysis modules that can perform multidimensional analyses to pathway enrichment. Although the main application is designed for Illumina DNA methylation array data analysis, we made the accessory modules suitable for other kinds of data analysis as well. Freely available at Github: https://github.com/JD2112/methylr; Webserver: https://methylr.research.liu.se.
Clinical Genomics Linköping [Technology development]
PubMed 37039839
DOI 10.1093/bioinformatics/btad184
Crossref 10.1093/bioinformatics/btad184
pmc: PMC10125902
pii: 7114023