Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism.

Bruzelius M, Strawbridge RJ, Trégouët D, Wiggins KL, Gertow K, Sabater-Lleal M, Öhrvik J, Bergendal A, Silveira A, Sundström A, Kieler H, Syvänen A, Smith NL, Morange P, Odeberg J, Hamsten A

Thromb. Res. 134 (2) 426-432 [2014-08-00; online 2014-04-22]

We investigated whether genetic variations robustly associated with coronary artery disease are also associated with risk of venous thromboembolism in a well-defined, female case-control study (n=2753) from Sweden. 39 single nucleotide polymorphisms in 32 loci associated with coronary artery disease in genome-wide association studies were identified in a literature search and genotyped in the ThromboEmbolism Hormone Study (TEHS). Association with venous thromboembolism was assessed by logistic regression. Only rs579459 in the ABO locus demonstrated a significant association with VTE. A tentative association between ANRIL and VTE in the discovery analysis failed to replicate in a meta-analysis of 4 independent cohorts (total n=7181). It appears that only the ABO locus is a shared risk factor for coronary artery disease and VTE.

NGI Uppsala (SNP&SEQ Technology Platform)

National Genomics Infrastructure

PubMed 24745723

DOI 10.1016/j.thromres.2014.03.054

Crossref 10.1016/j.thromres.2014.03.054

pii: S0049-3848(14)00184-4