Visible-Light Mediated Oxidative Fragmentation of Ethers and Acetals by Means of Fe(III) Catalysis.

Lindroth R, Ondrejkov√° A, Wallentin CJ

Org. Lett. 24 (8) 1662-1667 [2022-03-04; online 2022-02-22]

A new method employing iron(III) acetylacetonate along with visible light is described to effect oxidative ring opening of cyclic ethers and acetals with unparalleled efficiency. The method allows for a photocatalytic radical chemistry approach to functionalize relatively inert cyclic ethers into useful synthetic intermediates. The methodology sheds further light on the use of underexplored iron complexes in visible-light photochemical contexts and illustrates that simple Fe(III) complexes can initiate redox processes from 4LMCT excited states.

Swedish NMR Centre (SNC) [Service]

PubMed 35192351

DOI 10.1021/acs.orglett.2c00231

Crossref 10.1021/acs.orglett.2c00231

pmc: PMC8902804

Publications 9.5.0