Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction.

Llona-Minguez S, Throup A, Steiner E, Lightowler M, Van der Haegen S, Homan E, Eriksson L, Stenmark P, Jenmalm-Jensen A, Helleday T

Org. Biomol. Chem. 15 (37) 7758-7764 [2017-09-26; online 2017-09-12]

Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels-Alder reaction. Using previously unexplored cyclic ketones, heterocyclic amines and cyclopentadiene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between "drug-like" molecules and natural products.

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed 28891572

DOI 10.1039/c7ob02069d

Crossref 10.1039/c7ob02069d