Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling.

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Lund H, Pieber M, Parsa R, Grommisch D, Ewing E, Kular L, Han J, Zhu K, Nijssen J, Hedlund E, Needhamsen M, Ruhrmann S, Guerreiro-Cacais AO, Berglund R, Forteza MJ, Ketelhuth DFJ, Butovsky O, Jagodic M, Zhang XM, Harris RA

Nat. Immunol. 19 (5) 1-7 [2018-05-00; online 2018-04-16]

The cytokine transforming growth factor-β (TGF-β) regulates the development and homeostasis of several tissue-resident macrophage populations, including microglia. TGF-β is not critical for microglia survival but is required for the maintenance of the microglia-specific homeostatic gene signature

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PubMed 29662171

DOI 10.1038/s41590-018-0091-5

Crossref 10.1038/s41590-018-0091-5

pii 10.1038/s41590-018-0091-5