CRISPR Functional Genomics

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SciLifeLab Infrastructure Unit Since 2017. Previously called "High-throughput Genome Engineering (HTGE)"

Primary: Shown in the list of current labels, if end date is not specified.

Started: 2017

Ended: Current

Year 2024

PubMed DOI Crossref
Radiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based LRP2 knockout human kidney cell model.
Durinova A, Smutna L, Barta P, ..., Pavek P, Trejtnar F
EJNMMI Radiopharm Chem 9 (1) 32 [2024-04-18; online 2024-04-18]
CRISPR Functional Genomics [Collaborative]
PubMed DOI Crossref
Deletion of the TMEM30A gene enables leukemic cell evasion of NK cell cytotoxicity.
Kristenson L, Badami C, Ljungberg A, ..., Tang KW, Thorén FB
Proc. Natl. Acad. Sci. U.S.A. 121 (15) e2316447121 [2024-04-09; online 2024-04-01]
CRISPR Functional Genomics [Service]

Year 2023

PubMed DOI Crossref
An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver.
Fernández Moro C, Geyer N, Harrizi S, ..., Bozóky B, Gerling M
Nat Commun 14 (1) 5024 [2023-08-18; online 2023-08-18]
CRISPR Functional Genomics [Service] NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]
DOI Crossref
A large-scale sORF screen identifies putative microproteins and provides insights into their interaction partners, localisation and function
Schlesinger D, Dirks C, Luzon CN, ..., Eirich J, Elsässer SJ
- - (-) - [2023-06-13; online 2023-06-13]
Bioinformatics Support for Computational Resources [Service] CRISPR Functional Genomics [Service]
PubMed DOI Crossref
Investigation of enzalutamide, docetaxel, and cabazitaxel resistance in the castration resistant prostate cancer cell line C4 using genome-wide CRISPR/Cas9 screening.
Haldrup J, Weiss S, Schmidt L, Sørensen KD
Sci Rep 13 (1) 9043 [2023-06-03; online 2023-06-03]
CRISPR Functional Genomics [Service]
PubMed DOI Crossref
CRISPR-Cas9 knockout screen identifies novel treatment targets in childhood high-grade glioma.
Wenger A, Karlsson I, Kling T, Carén H
Clin Epigenetics 15 (1) 80 [2023-05-09; online 2023-05-09]
CRISPR Functional Genomics [Service] Integrated Microscopy Technologies Gothenburg [Service]

Year 2022

PubMed DOI Crossref
New regulators of the tetracycline‐inducible gene expression system identified by chemical and genetic screens
Colicchia V, Häggblad M, Sirozh O, ..., Hühn D, Fernandez‐Capetillo O
FEBS Open Bio 12 (10) 1896-1908 [2022-10-00; online 2022-09-11]
CRISPR Functional Genomics [Service] Chemical Biology Consortium Sweden (CBCS) [Service]
PubMed DOI Crossref
MYC assembles and stimulates topoisomerases 1 and 2 in a "topoisome".
Das SK, Kuzin V, Cameron DP, ..., Levens D, Baranello L
Mol. Cell 82 (1) 140-158.e12 [2022-01-06; online 2021-12-09]
CRISPR Functional Genomics [Service]
PubMed DOI Crossref
Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR-Cas9 screen.
Mennuni M, Filograna R, Felser A, ..., Lytovchenko O, Larsson N
EMBO Rep. 23 (1) e53054 [2022-01-05; online 2021-11-15]
CRISPR Functional Genomics [Service] NGI Short read [Service] National Genomics Infrastructure [Service]

Year 2021

PubMed DOI Crossref
Rapid genome editing by CRISPR-Cas9-POLD3 fusion
Reint G, Li Z, Labun K, ..., Taipale J, Haapaniemi E
Elife 10 (-) - [2021-12-13; online 2021-12-13]
CRISPR Functional Genomics [Collaborative]
PubMed DOI Crossref
Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound.
Giovannucci TA, Salomons FA, Haraldsson M, ..., Johnsen JI, Dantuma NP
Cell Death Dis 12 (10) 914 [2021-10-06; online 2021-10-06]
CRISPR Functional Genomics [Service] Chemical Biology Consortium Sweden (CBCS) [Collaborative] Global Proteomics and Proteogenomics [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

Year 2020

DOI Crossref
Developmental and MAPK-responsive transcription factors drive distinct malignant subtypes and genetic dependencies in pancreatic cancer
Laise P, Turunen M, Garcia AC, ..., Olive KP, Califano A
- - (-) - [2020-10-27; online 2020-10-27]
CRISPR Functional Genomics [Service]
PubMed DOI Crossref
Designing custom CRISPR libraries for hypothesis-driven drug target discovery.
Iyer VS, Jiang L, Shen Y, ..., Schmierer B, Wermeling F
Computational and Structural Biotechnology Journal 18 (-) 2237-2246 [2020-08-18; online 2020-08-18]
Bioinformatics Support for Computational Resources [Service] CRISPR Functional Genomics [Collaborative]
PubMed DOI Crossref
A regulatory role for CHD2 in myelopoiesis.
Shahin Varnoosfaderani F, Palau A, Dong W, ..., Svensson JP, Lennartsson A
Epigenetics 15 (6-7) 702-714 [2020-01-10; online 2020-01-10]
Bioinformatics Support for Computational Resources [Service] CRISPR Functional Genomics [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

Year 2019

PubMed DOI Crossref
Reply to "CRISPR screens are feasible in TP53 wild-type cells".
Haapaniemi E, Botla S, Persson J, Schmierer B, Taipale J
Mol. Syst. Biol. 15 (8) e9059 [2019-08-00; online 2019-08-30]
CRISPR Functional Genomics [Collaborative]
PubMed DOI Crossref
TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation.
Miller DSJ, Schmierer B, Hill CS
J. Cell. Sci. 132 (14) - [2019-07-15; online 2019-07-15]
CRISPR Functional Genomics [Collaborative]

Year 2018

PubMed DOI Crossref
Contribution of allelic imbalance to colorectal cancer.
Palin K, Pitkänen E, Turunen M, ..., Taipale J, Aaltonen LA
Nat Commun 9 (1) 3664 [2018-09-10; online 2018-09-10]
Bioinformatics Support for Computational Resources [Service] CRISPR Functional Genomics [Collaborative] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]
PubMed DOI Crossref
CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response.
Haapaniemi E, Botla S, Persson J, Schmierer B, Taipale J
Nat. Med. 24 (7) 927-930 [2018-07-00; online 2018-06-11]
CRISPR Functional Genomics [Collaborative] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service] Protein Science Facility (PSF) [Service]

Year 2017

PubMed DOI Crossref
CRISPR/Cas9 screening using unique molecular identifiers.
Schmierer B, Botla SK, Zhang J, ..., Kivioja T, Taipale J
Mol. Syst. Biol. 13 (10) 945 [2017-10-09; online 2017-10-09]
CRISPR Functional Genomics [Technology development]
SciLifeLab Data Centre
Publications 9.5.0