Affinity Proteomics Stockholm

Proteome profiling of home-sampled dried blood spots reveals proteins of SARS-CoV-2 infections.

Fredolini C, Dodig-Crnković T, Bendes A, ..., Roxhed N, Schwenk JM

Commun Med (Lond) 4 (1) 55 [2024-04-02; online 2024-04-02]

Affinity Proteomics Stockholm [Technology development]

The impact of circulating protein levels identified by affinity proteomics on short-term, overall breast cancer risk.

Grassmann F, Mälarstig A, Dahl L, ..., Schwenk JM, Czene K

Br. J. Cancer 130 (4) 620-627 [2024-03-00; online 2023-12-22]

CPAP may promote an endothelial inflammatory milieu in sleep apnoea after coronary revascularization

Peker Y, Celik Y, Behboudi A, ..., Gottlieb DJ, Jelic S

EBioMedicine - (-) 105015 [2024-02-00; online 2024-02-00]

Profiling of Surface Protein Epitopes on Viral Particles by Multiplex Dual-Reporter Strategy

Sahi M, Andersson S, Mattson C, ..., Chiodi F, Fredolini C

J Vis Exp - (203) - [2024-01-12; online 2024-01-12]

Affinity Proteomics Stockholm [Technology development]

Year 2023

Screening for Circulating Inflammatory Proteins Does Not Reveal Plasma Biomarkers of Constant Tinnitus.

Cederroth CR, Hong MG, Freydin MB, ..., Bulla J, Williams FMK

J Assoc Res Otolaryngol - (-) - [2023-12-11; online 2023-12-11]

Affinity Proteomics Stockholm [Service] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative]

Protein profiling in plasma for biomarkers of seizure.

Akel S, Banote RK, Asztely F, Zelano J

Epilepsy Res 197 (-) 107241 [2023-11-00; online 2023-10-11]

Preanalytic handling of clinical blood samples in assessing immunological proteins - Role of storage duration.

Eren F, Schwieler L, Orhan F, ..., Engberg G, Erhardt S

Brain, Behavior, and Immunity 114 (-) 163-164 [2023-11-00; online 2023-08-16]

Large-scale proximity extension assay reveals CSF midkine and DOPA decarboxylase as supportive diagnostic biomarkers for Parkinson's disease.

Paslawski W, Khosousi S, Hertz E, ..., Boxer A, Svenningsson P

Transl Neurodegener 12 (1) 42 [2023-09-04; online 2023-09-04]

The development of blood protein profiles in extremely preterm infants follows a stereotypic evolution pattern.

Zhong W, Danielsson H, Brusselaers N, ..., Uhlén M, Hellström A

Commun Med (Lond) 3 (1) 107 [2023-08-02; online 2023-08-02]

Immunological protein profiling of first-episode psychosis patients identifies CSF and blood biomarkers correlating with disease severity.

Eren F, Schwieler L, Orhan F, ..., Engberg G, Erhardt S

Brain, Behavior, and Immunity 111 (-) 376-385 [2023-07-00; online 2023-05-04]

Persistent immunosuppressive effects of dibutyl phthalate exposure in adult male mice

Pierozan P, Källsten L, Theodoropoulou E, Almamoun R, Karlsson O

Science of The Total Environment 878 (-) 162741 [2023-06-00; online 2023-06-00]

Soluble CD14 and osteoprotegerin associate with ankle-brachial index as a measure of arterial stiffness in patients with mild to moderate chronic kidney disease in a five-year prospective study.

Sendic S, Mansouri L, Hong M, ..., Lundahl J, Jacobson SH

Cardiorenal Med - (-) 1 [2023-05-15; online 2023-05-15]

A Longitudinal Study of Individual Radiation Responses in Pediatric Patients Treated with Proton and Photon Radiotherapy, and Interventional Cardiology: Rationale and Research Protocol of the HARMONIC Project.

Andreassi MG, Haddy N, Harms-Ringdahl M, ..., Fuentes M, Haghdoost S

Int J Mol Sci 24 (9) - [2023-05-08; online 2023-05-08]

Achieving symptom relief in patients with myalgic encephalomyelitis by targeting the neuro-immune interface and optimizing disease tolerance.

Rodriguez L, Pou C, Lakshmikanth T, ..., Julin P, Brodin P

Oxf Open Immunol 4 (1) iqad003 [2023-04-17; online 2023-04-17]

Affinity Proteomics Stockholm [Service] Cellular Immunomonitoring [Technology development]

A glycan epitope correlates with tau in serum and predicts progression to Alzheimer's disease in combination with APOE4 allele status.

Zhou RZ, Vetrano DL, Grande G, ..., Tjernberg L, Schedin-Weiss S

Alzheimers Dement - (-) - [2023-04-12; online 2023-04-12]

A wide scan of plasma proteins demonstrates thioredoxin reductase 1 as a potential new diagnostic biomarker for hepatocellular carcinoma.

Zenlander R, Fredolini C, Schwenk JM, ..., Eggertsen G, Stål P

Scand. J. Gastroenterol. - (-) 1-11 [2023-04-05; online 2023-04-05]

Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia.

Palma Medina LM, Babačić H, Dzidic M, ..., Strålin K, Norrby-Teglund A

Respir. Res. 24 (1) 62 [2023-02-24; online 2023-02-24]

Multi-organ single-cell analysis reveals an on/off switch system with potential for personalized treatment of immunological diseases.

Lilja S, Li X, Smelik M, ..., Wang H, Benson M

Cell Reports Medicine - (-) 100956 [2023-02-17; online 2023-02-17]

Microneedle Patch for Painless Intradermal Collection of Interstitial Fluid Enabling Multi-analyte Measurement of Small Molecules, SARS-CoV-2 Antibodies, and Protein Profiling.

Ribet F, Bendes A, Fredolini C, ..., Stemme G, Roxhed N

Adv Healthc Mater - (-) e2202564 [2023-02-07; online 2023-02-07]

Proteomic Analysis of Mucosal and Systemic Responses to SARS-CoV-2 Antigen.

Martinson N, Gordhan B, Petkov S, ..., Kana B, Herrera C

Vaccines (Basel) 11 (2) - [2023-02-02; online 2023-02-02]

Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models.

Allesøe RL, Lundgaard AT, Hernández Medina R, ..., Brunak S, IMI DIRECT Consortium

Nat. Biotechnol. - (-) - [2023-01-02; online 2023-01-02]

Year 2022

Microfluidic Device for Patient-Centric Multiplexed Assays with Readout in Centralized Laboratories.

Hauser J, Dale M, Beck O, ..., Fredolini C, Roxhed N

Anal. Chem. - (-) - [2022-12-22; online 2022-12-22]

Affinity Proteomics Stockholm [Technology development]

A protein signature associated with active tuberculosis identified by plasma profiling and network-based analysis.

Mousavian Z, Folkesson E, Fröberg G, ..., Källenius G, Sundling C

iScience 25 (12) 105652 [2022-12-22; online 2022-11-22]

A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses.

Lenart K, Hellgren F, Ols S, ..., Petsch B, Loré K

Mol Ther Methods Clin Dev 27 (-) 309-323 [2022-12-08; online 2022-10-06]

Affinity Proteomics Stockholm [Service] Affinity Proteomics Uppsala [Service]

Proteomic Analysis of Pleural Effusions from COVID-19 Deceased Patients: Enhanced Inflammatory Markers.

Razaghi A, Szakos A, Alouda M, ..., Björnstedt M, Szekely L

Diagnostics 12 (11) 2789 [2022-11-14; online 2022-11-14]

Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults.

Dong Y, Li Y, Liu K, ..., Du Y, Qiu C

Alzheimers Dement - (-) - [2022-09-15; online 2022-09-15]

Immunomodulation by intravenous omega-3 fatty acid treatment in older subjects hospitalized for COVID-19: A single-blind randomized controlled trial.

Arnardottir H, Pawelzik SC, Sarajlic P, ..., Wheelock CE, Bäck M

Clin Transl Med 12 (9) e895 [2022-09-00; online 2022-09-20]

Mobilization of systemic CCL4 following HIV pre-exposure prophylaxis in young men in Africa.

Petkov S, Herrera C, Else L, ..., Fox J, Chiodi F

Front Immunol 13 (-) 965214 [2022-07-27; online 2022-07-27]

Longitudinal assessment of inflammatory markers in the peripartum period by depressive symptom trajectory groups.

Bränn E, Skalkidou A, Schwarz J, ..., Sundström Poromaa I, Fransson E

Brain Behav Immun Health 22 (-) 100468 [2022-07-00; online 2022-05-02]

The Karolinska KI/K COVID-19 Immune Atlas: An open resource for immunological research and educational purposes.

Ljunggren HG, Ask EH, Cornillet M, ..., Strålin K, Björkström NK

Scand. J. Immunol. - (-) e13195 [2022-06-02; online 2022-06-02]

Genetic Landscape of the ACE2 Coronavirus Receptor.

Yang Z, Macdonald-Dunlop E, Chen J, ..., Wilson JF, Shen X

Circulation 145 (18) 1398-1411 [2022-05-03; online 2022-04-07]

Affinity Proteomics Stockholm [Service] NGI SNP genotyping [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Systems analysis shows a role of cytophilic antibodies in shaping innate tolerance to malaria.

Lautenbach MJ, Yman V, Silva CS, ..., Färnert A, Sundling C

Cell Rep 39 (3) 110709 [2022-04-19; online 2022-04-21]

Multiomics Analysis Reveals the Impact of Microbiota on Host Metabolism in Hepatic Steatosis.

Zeybel M, Arif M, Li X, ..., Borén J, Mardinoglu A

Adv Sci (Weinh) 9 (11) e2104373 [2022-04-00; online 2022-02-07]

Blood protein profiles related to preterm birth and retinopathy of prematurity.

Danielsson H, Tebani A, Zhong W, ..., Uhlén M, Hellström A

Pediatr. Res. 91 (4) 937-946 [2022-03-00; online 2021-04-24]

Salivary biomarkers in children with juvenile idiopathic arthritis and healthy age-matched controls: a prospective observational study.

Collin M, Ernberg M, Christidis N, Hedenberg-Magnusson B

Sci Rep 12 (1) 3240 [2022-02-25; online 2022-02-25]

Circulating proteins reveal prior use of menopausal hormonal therapy and increased risk of breast cancer.

Thomas CE, Dahl L, Byström S, ..., Schwenk JM, Gabrielson M

Transl Oncol 17 (-) 101339 [2022-01-13; online 2022-01-13]

Year 2021

Endogenous Levels of Gamma Amino-Butyric Acid Are Correlated to Glutamic-Acid Decarboxylase Antibody Levels in Type 1 Diabetes.

Hill H, Elksnis A, Lundkvist P, ..., Carlsson PO, Espes D

Biomedicines 10 (1) - [2021-12-31; online 2021-12-31]

Immunoprofiling of active and inactive systemic juvenile idiopathic arthritis reveals distinct biomarkers: a single-center study.

Qu H, Sundberg E, Aulin C, ..., Olsson M, Harris HE

Pediatr Rheumatol Online J 19 (1) 173 [2021-12-28; online 2021-12-28]

Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection

Bauer W, Weber M, Diehl-Wiesenecker E, ..., Micke P, Kappert K

Viruses 13 (12) 2456 [2021-12-07; online 2021-12-07] Open Access

Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors.

Iglesias MJ, Kruse LD, Sanchez-Rivera L, ..., Odeberg J, Butler LM

Arterioscler. Thromb. Vasc. Biol. 41 (12) 2990-3004 [2021-12-00; online 2021-10-28]

High Dimensional Immune Profiling Reveals Different Response Patterns in Active and Latent Tuberculosis Following Stimulation With Mycobacterial Glycolipids.

Silva CS, Sundling C, Folkesson E, ..., Correia-Neves M, Källenius G

Front Immunol 12 (-) 727300 [2021-11-23; online 2021-11-23]

Affinity Proteomics Stockholm [Service] Cellular Immunomonitoring [Collaborative]

Elevated circulating follistatin associates with an increased risk of type 2 diabetes.

Wu C, Borné Y, Gao R, ..., Groop L, De Marinis Y

Nat Commun 12 (1) 6486 [2021-11-10; online 2021-11-10]

Affinity Proteomics Stockholm [Collaborative] Affinity Proteomics Uppsala [Service]

Virological and immunological features of SARS-COV-2 infected children with distinct symptomatology.

Cotugno N, Ruggiero A, Pascucci GR, ..., De Rossi A, Palma P

Pediatr Allergy Immunol 32 (8) 1833-1842 [2021-11-00; online 2021-07-16]

Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease patients.

Zeybel M, Altay O, Arif M, ..., Borén J, Mardinoglu A

Mol. Syst. Biol. 17 (10) e10459 [2021-10-00; online 2021-10-26]

Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate COVID-19.

Altay O, Arif M, Li X, ..., Uhlén M, Mardinoglu A

Adv Sci (Weinh) 8 (17) e2101222 [2021-09-00; online 2021-06-28]

Bifidobacteria-mediated immune system imprinting early in life

Henrick BM, Rodriguez L, Lakshmikanth T, ..., Frese SA, Brodin P

Cell 184 (15) 3884-3898.e11 [2021-07-00; online 2021-07-00]

Affinity Proteomics Stockholm [Service] Bioinformatics Support and Infrastructure [Service] Bioinformatics Support for Computational Resources [Service] Bioinformatics Support, Infrastructure and Training [Service] Cellular Immunomonitoring [Technology development] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2.

Roxhed N, Bendes A, Dale M, ..., Fredolini C, Schwenk JM

Nat Commun 12 (1) 3695 [2021-06-17; online 2021-06-17]

Affinity Proteomics Stockholm [Technology development]

Bead-Based Assays for Validating Proteomic Profiles in Body Fluids.

Bendes A, Dale M, Mattsson C, ..., Schwenk JM, Fredolini C

Methods Mol. Biol. 2344 (-) 65-78 [2021-06-12; online 2021-06-12]

Affinity Proteomics Stockholm [Technology development]

Circulating proteins associated with allergy development in infants-an exploratory analysis.

Stockfelt M, Hong M, Hesselmar B, ..., Lundell A, Rudin A

Clin Proteomics 18 (1) 11 [2021-03-15; online 2021-03-15]

Changes in Circulating Cytokines and Adipokines After RYGB in Patients with and without Type 2 Diabetes.

Katsogiannos P, Kamble PG, Pereira MJ, ..., Eriksson JW, Espes D

Obesity (Silver Spring) 29 (3) 535-542 [2021-03-00; online 2021-02-25]

Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity.

Kvedaraite E, Hertwig L, Sinha I, ..., Svensson M, Karolinska KI/K COVID-19 Study Group

Proc. Natl. Acad. Sci. U.S.A. 118 (6) e2018587118 [2021-02-09; online 2021-01-23]

Longitudinal plasma protein profiling of newly diagnosed type 2 diabetes.

Gummesson A, Björnson E, Fagerberg L, ..., Uhlén M, Bergström G

EBioMedicine 63 (-) 103147 [2021-01-00; online 2020-12-03]

Genetics meets proteomics: perspectives for large population-based studies.

Suhre K, McCarthy MI, Schwenk JM

Nat. Rev. Genet. 22 (1) 19-37 [2021-01-00; online 2020-08-28]

Year 2020

Innate lymphoid cell composition associates with COVID-19 disease severity.

García M, Kokkinou E, Carrasco García A, ..., Mjösberg J, Karolinska KI/K COVID‐19 Study Group

Clin Transl Immunology 9 (12) e1224 [2020-12-14; online 2020-12-14]

Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study.

Gudmundsdottir V, Pedersen HK, Mazzoni G, ..., Pedersen O, Brunak S

Genome Med 12 (1) 109 [2020-12-01; online 2020-12-01]

The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19.

Consiglio CR, Cotugno N, Sardh F, ..., Palma P, Brodin P

Cell 183 (4) 968-981.e7 [2020-11-12; online 2020-09-06]

Affinity Proteomics Stockholm [Service] Autoimmunity and Serology Profiling [Service] Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Technology development]

A high-stringency blueprint of the human proteome.

Adhikari S, Nice EC, Deutsch EW, ..., Aebersold R, Baker MS

Nat Commun 11 (1) 5301 [2020-10-16; online 2020-10-16]

Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortality.

Hong MG, Dodig-Crnković T, Chen X, ..., Magnusson PK, Schwenk JM

Life Sci. Alliance 3 (10) e202000817 [2020-10-00; online 2020-07-31]

Affinity Proteomics Stockholm [Collaborative] Autoimmunity and Serology Profiling [Service] Bioinformatics Support for Computational Resources [Service]

MAIT cell activation and dynamics associated with COVID-19 disease severity.

Parrot T, Gorin JB, Ponzetta A, ..., Strålin K, Sandberg JK

Sci Immunol 5 (51) - [2020-09-28; online 2020-09-30]

Integration of molecular profiles in a longitudinal wellness profiling cohort.

Tebani A, Gummesson A, Zhong W, ..., Uhlen M, Fagerberg L

Nat Commun 11 (1) 4487 [2020-09-08; online 2020-09-08]

Affinity Proteomics Stockholm [Collaborative] Autoimmunity and Serology Profiling [Collaborative] Bioinformatics Long-term Support WABI [Collaborative] Bioinformatics Support for Computational Resources [Service] Bioinformatics Support, Infrastructure and Training [Collaborative] Cellular Immunomonitoring [Collaborative] Swedish Metabolomics Centre (SMC) [Collaborative]

Profiling of Inflammatory Proteins in Plasma of HIV-1-Infected Children Receiving Antiretroviral Therapy.

Lemma M, Petkov S, Bekele Y, ..., Howe R, Chiodi F

Proteomes 8 (3) 24 [2020-09-07; online 2020-09-07]

Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19.

Rodriguez L, Pekkarinen PT, Lakshmikanth T, ..., Kekäläinen E, Brodin P

Cell Reports Medicine 1 (5) 100078 [2020-08-25; online 2020-08-05]

Affinity Proteomics Stockholm [Service] Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Technology development]

Natural killer cell immunotypes related to COVID-19 disease severity.

Maucourant C, Filipovic I, Ponzetta A, ..., Björkström NK, Karolinska COVID-19 Study Group

Sci Immunol 5 (50) eabd6832 [2020-08-21; online 2020-08-23]

Affinity Proteomics Stockholm [Service] Bioinformatics Support for Computational Resources [Service]

Human Immune System Variation during 1 Year.

Lakshmikanth T, Muhammad SA, Olin A, ..., Uhlen M, Brodin P

Cell Rep 32 (3) 107923 [2020-07-21; online 2020-07-23]

Affinity Proteomics Stockholm [Service] Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Technology development]

Facets of individual-specific health signatures determined from longitudinal plasma proteome profiling.

Dodig-Crnković T, Hong MG, Thomas CE, ..., Uhlén M, Schwenk JM

EBioMedicine 57 (-) 102854 [2020-07-00; online 2020-07-03]

Whole-genome sequence association analysis of blood proteins in a longitudinal wellness cohort.

Zhong W, Gummesson A, Tebani A, ..., Fagerberg L, Uhlén M

Genome Med 12 (1) 53 [2020-06-23; online 2020-06-23]

Affinity Proteomics Stockholm [Collaborative] Bioinformatics Support for Computational Resources [Service]

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts.

Atabaki-Pasdar N, Ohlsson M, Viñuela A, ..., Pavo I, Franks PW

PLoS Med. 17 (6) e1003149 [2020-06-00; online 2020-06-19]

The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver disease.

Zhang C, Bjornson E, Arif M, ..., Borén J, Mardinoglu A

Mol. Syst. Biol. 16 (4) e9495 [2020-04-00; online 2020-04-28]

Affinity Proteomics Stockholm [Service] Bioinformatics Support for Computational Resources [Service]

Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer.

Drobin K, Marczyk M, Halle M, ..., Schwenk JM, Haghdoost S

Cancers (Basel) 12 (3) 753 [2020-03-22; online 2020-03-22]

Newborn Screening for Presymptomatic Diagnosis of Complement and Phagocyte Deficiencies.

Dezfouli M, Bergström S, Skattum L, ..., Nilsson P, Hammarström L

Front Immunol 11 (-) 455 [2020-03-17; online 2020-03-17]

Year 2019

Protein profiling and network enrichment analysis in individuals before and after the onset of rheumatoid arthritis.

Brink M, Lundquist A, Alexeyenko A, Lejon K, Rantapää-Dahlqvist S

Arthritis Res. Ther. 21 (1) 288 [2019-12-16; online 2019-12-16]

Affinity Proteomics Stockholm [Service] Bioinformatics Support and Infrastructure [Service] Bioinformatics Support, Infrastructure and Training [Service]

Mass Spectrometry-Based Plasma Proteomics: Considerations from Sample Collection to Achieving Translational Data.

Ignjatovic V, Geyer PE, Palaniappan KK, ..., Deutsch EW, Schwenk JM

J. Proteome Res. 18 (12) 4085-4097 [2019-12-06; online 2019-10-11]

Affinity Proteomics Stockholm [Collaborative] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service] Spatial Proteomics [Collaborative]

The human secretome

Uhlén M, Karlsson MJ, Hober A, ..., Fagerberg L, Sivertsson Å

Sci. Signal. 12 (609) eaaz0274 [2019-11-26; online 2019-11-26]

CSF levels of apolipoprotein C1 and autotaxin found to associate with neuropathic pain and fibromyalgia.

Lind AL, Just D, Mikus M, ..., Gordh T, Månberg A

J Pain Res 12 (-) 2875-2889 [2019-10-15; online 2019-10-15]

Multiplexed analysis of the secretin-like GPCR-RAMP interactome.

Lorenzen E, Dodig-Crnković T, Kotliar IB, ..., Schwenk JM, Sakmar TP

Sci Adv 5 (9) eaaw2778 [2019-09-00; online 2019-09-18]

sTRAIL-R2 (Soluble TNF [Tumor Necrosis Factor]-Related Apoptosis-Inducing Ligand Receptor 2) a Marker of Plaque Cell Apoptosis and Cardiovascular Events.

Gonçalves I, Singh P, Tengryd C, ..., Nilsson J, Edsfeldt A

Stroke 50 (8) 1989-1996 [2019-08-00; online 2019-07-05]

Affinity Proteomics Stockholm [Service] Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service]

Systematic Development of Sandwich Immunoassays for the Plasma Secretome.

Häussler RS, Bendes A, Iglesias M, ..., Qundos U, Schwenk JM

Proteomics 19 (15) e1900008 [2019-08-00; online 2019-07-22]

Affinity Proteomics Stockholm [Technology development]

Screening a Resource of Recombinant Protein Fragments for Targeted Proteomics.

Edfors F, Forsström B, Vunk H, ..., Schwenk JM, Uhlen M

J. Proteome Res. 18 (7) 2706-2718 [2019-07-05; online 2019-06-07]

Affinity Proteomics Stockholm [Technology development]

Development of parallel reaction monitoring assays for cerebrospinal fluid proteins associated with Alzheimer's disease.

Andersson A, Remnestål J, Nellgård B, ..., Nilsson P, Fredolini C

Clin. Chim. Acta 494 (-) 79-93 [2019-07-00; online 2019-03-09]

Affinity Proteomics Stockholm [Technology development]

Systematic assessment of antibody selectivity in plasma based on a resource of enrichment profiles.

Fredolini C, Byström S, Sanchez-Rivera L, ..., Lehtiö J, Schwenk JM

Sci Rep 9 (1) 8324 [2019-06-06; online 2019-06-06]

Affinity Proteomics Stockholm [Technology development] Autoimmunity and Serology Profiling [Technology development] Bioinformatics Support for Computational Resources [Service] Global Proteomics and Proteogenomics [Technology development]

Plasma protein profiling reveals candidate biomarkers for multiple sclerosis treatment.

Bedri SK, Nilsson OB, Fink K, ..., Grönlund H, Glaser A

PLoS ONE 14 (5) e0217208 [2019-05-29; online 2019-05-29]

Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients.

Idborg H, Zandian A, Ossipova E, ..., Svenungsson E, Jakobsson PJ

Front Immunol 10 (-) 1029 [2019-05-17; online 2019-05-17]

Affinity Proteomics Stockholm [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF) [Service]

A High-throughput Bead-based Affinity Assay Enables Analysis of Genital Protein Signatures in Women At Risk of HIV Infection.

Månberg A, Bradley F, Qundos U, ..., Nilsson P, Broliden K

Mol. Cell Proteomics 18 (3) 461-476 [2019-03-00; online 2018-11-30]

Circulating proteins as predictors of cardiovascular mortality in end-stage renal disease.

Feldreich T, Nowak C, Fall T, ..., Green D, Ärnlöv J

J Nephrol 32 (1) 111-119 [2019-02-00; online 2018-11-29]

Affinity Proteomics Stockholm [Service] Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service]

Targeted Analysis of Serum Proteins Encoded at Known Inflammatory Bowel Disease Risk Loci.

Drobin K, Assadi G, Hong MG, ..., D'Amato M, Halfvarson J

Inflamm Bowel Dis 25 (2) 306-316 [2019-01-10; online 2018-10-26]

Affinity Proteomics Stockholm [Collaborative] Bioinformatics Support for Computational Resources [Service] Drug Discovery and Development (DDD) [Collaborative]

Growth differentiation factor 15 is positively associated with incidence of diabetes mellitus: the Malmö Diet and Cancer-Cardiovascular Cohort.

Bao X, Borné Y, Muhammad IF, ..., Orho-Melander M, Engström G

Diabetologia 62 (1) 78-86 [2019-01-00; online 2018-10-22]

Affinity Proteomics Stockholm [Service] Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service]

Year 2018

Progress on Identifying and Characterizing the Human Proteome: 2018 Metrics from the HUPO Human Proteome Project.

Omenn GS, Lane L, Overall CM, ..., Baker MS, Deutsch EW

J. Proteome Res. 17 (12) 4031-4041 [2018-12-07; online 2018-08-23]

Markers of Basement Membrane Remodeling Are Associated With Higher Mortality in Patients With Known Atherosclerosis.

Holm Nielsen S, Tengryd C, Edsfeldt A, ..., Nilsson J, Goncalves I

J Am Heart Assoc 7 (21) e009193 [2018-11-06; online 2019-01-05]

Affinity Proteomics Stockholm [Service] Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service]

Stereotypic Immune System Development in Newborn Children

Olin A, Henckel E, Chen Y, ..., Bohlin K, Brodin P

Cell 174 (5) 1277-1292.e14 [2018-08-00; online 2018-08-00]

Affinity Proteomics Stockholm [Service] Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Technology development] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage.

Matic LP, Jesus Iglesias M, Vesterlund M, ..., Odeberg J, Hedin U

JACC Basic Transl Sci 3 (4) 464-480 [2018-08-00; online 2018-08-01]

Affinity Proteomics Stockholm [Collaborative] Bioinformatics Support for Computational Resources [Service] Global Proteomics and Proteogenomics [Collaborative]

Multiplexed Antigen Bead Arrays for the Assessment of Antibody Selectivity and Epitope Mapping.

Ayoglu B, Nilsson P, Schwenk JM

Methods Mol. Biol. 1785 (-) 239-248 [2018-05-02; online 2018-05-02]

Affinity Proteomics Stockholm [Technology development] Autoimmunity and Serology Profiling [Technology development]

High-Density Antigen Microarrays for the Assessment of Antibody Selectivity and Off-Target Binding.

Sjöberg R, Andersson E, Hellström C, ..., Nilsson P, Ayoglu B

Methods Mol. Biol. 1785 (-) 231-238 [2018-05-02; online 2018-05-02]

Affinity Proteomics Stockholm [Technology development] Autoimmunity and Serology Profiling [Technology development] Bioinformatics Support for Computational Resources [Service]

Protein profiling in serum after traumatic brain injury in rats reveals potential injury markers.

Thelin EP, Just D, Frostell A, ..., Nilsson P, Bellander BM

Behav. Brain Res. 340 (-) 71-80 [2018-03-15; online 2016-08-31]

Current applications of antibody microarrays.

Chen Z, Dodig-Crnković T, Schwenk JM, Tao SC

Clin Proteomics 15 (-) 7 [2018-02-28; online 2018-02-28]

Affinity proteomic profiling of plasma for proteins associated to area-based mammographic breast density.

Byström S, Eklund M, Hong MG, ..., Schwenk JM, Gabrielson M

Breast Cancer Res. 20 (1) 14 [2018-02-14; online 2018-02-14]

Affinity Proteomics Stockholm [Collaborative] Bioinformatics Support for Computational Resources [Service]

Year 2017

The Human Plasma Proteome Draft of 2017: Building on the Human Plasma PeptideAtlas from Mass Spectrometry and Complementary Assays.

Schwenk JM, Omenn GS, Sun Z, ..., Moritz RL, Deutsch EW

J. Proteome Res. 16 (12) 4299-4310 [2017-12-01; online 2017-10-10]

High levels of cerebrospinal fluid chemokines point to the presence of neuroinflammation in peripheral neuropathic pain: a cross-sectional study of 2 cohorts of patients compared with healthy controls.

Bäckryd E, Lind AL, Thulin M, ..., Gerdle B, Gordh T

Pain 158 (12) 2487-2495 [2017-12-00; online 2017-09-21]

Affinity Proteomics Stockholm [Service] Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service]

Elevated Markers of Death Receptor-Activated Apoptosis are Associated with Increased Risk for Development of Diabetes and Cardiovascular Disease.

Mattisson IY, Björkbacka H, Wigren M, ..., Almgren P, Nilsson J

EBioMedicine 26 (-) 187-197 [2017-12-00; online 2017-11-24]

Affinity Proteomics Stockholm [Service] Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service]

Thiol-ene-epoxy thermoset for low-temperature bonding to biofunctionalized microarray surfaces.

Zhou XC, Sjöberg R, Druet A, ..., Haraldsson T, Carlborg CF

Lab Chip 17 (21) 3672-3681 [2017-10-25; online 2017-10-05]

Affinity Proteomics Stockholm [Technology development] Autoimmunity and Serology Profiling [Technology development]

High-Density Serum/Plasma Reverse Phase Protein Arrays.

Hellström C, Dodig-Crnković T, Hong MG, ..., Nilsson P, Sjöberg R

Methods Mol. Biol. 1619 (-) 229-238 [2017-07-05; online 2017-07-05]

Affinity Proteomics Stockholm [Technology development] Autoimmunity and Serology Profiling [Technology development]

Bead-Based and Multiplexed Immunoassays for Protein Profiling via Sequential Affinity Capture.

Birgersson E, Schwenk JM, Ayoglu B

Methods Mol. Biol. 1619 (-) 45-54 [2017-07-05; online 2017-07-05]

Affinity Proteomics Stockholm [Technology development]

Affinity Proteomics Exploration of Melanoma Identifies Proteins in Serum with Associations to T-Stage and Recurrence.

Byström S, Fredolini C, Edqvist PH, ..., Pontén F, Schwenk JM

Transl Oncol 10 (3) 385-395 [2017-06-00; online 2017-04-20]

Affinity Proteomics Stockholm [Collaborative] Tissue Profiling [Collaborative]

Neuroproteomic Profiling of Cerebrospinal Fluid (CSF) by Multiplexed Affinity Arrays.

Häggmark-Månberg A, Nilsson P, Schwenk JM

Methods Mol. Biol. 1598 (-) 247-254 [2017-05-17; online 2017-05-17]

Affinity Proteomics Stockholm [Technology development] Autoimmunity and Serology Profiling [Technology development]

A Preliminary Report: Radical Surgery and Stem Cell Transplantation for the Treatment of Patients With Pancreatic Cancer.

Omazic B, Ayoglu B, Löhr M, ..., Maeurer MJ, Ringden O

J. Immunother. 40 (4) 132-139 [2017-05-00; online 2017-03-25]

Affinity Proteomics Stockholm [Collaborative] Autoimmunity and Serology Profiling [Collaborative]

Discovery of circulating proteins associated to knee radiographic osteoarthritis.

Lourido L, Ayoglu B, Fernández-Tajes J, ..., Nilsson P, Blanco FJ

Sci Rep 7 (1) 137 [2017-03-09; online 2017-03-09]

IL-8 predicts early mortality in patients with acute hypercapnic respiratory failure treated with noninvasive positive pressure ventilation.

Jónsdóttir B, Jaworowski Å, San Miguel C, Melander O

BMC Pulm Med 17 (1) 35 [2017-02-08; online 2017-02-08]

Affinity Proteomics Stockholm [Service] Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service]

Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury.

Mikus M, Drobin K, Gry M, ..., Nilsson P, Schuppe-Koistinen I

Liver Int. 37 (1) 132-140 [2017-01-00; online 2016-05-26]

Year 2016

PDGFB, a new candidate plasma biomarker for venous thromboembolism: results from the VEREMA affinity proteomics study.

Bruzelius M, Iglesias MJ, Hong MG, ..., Trégouët DA, Odeberg J

Blood 128 (23) e59-e66 [2016-12-08; online 2016-10-14]

CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease.

Remnestål J, Just D, Mitsios N, ..., Nilsson P, Häggmark-Månberg A

Proteomics Clin Appl 10 (12) 1242-1253 [2016-12-00; online 2016-10-10]

Affinity Proteomics Stockholm [Collaborative] Fluorescence Tissue Profiling [Collaborative]

Multidimensional Normalization to Minimize Plate Effects of Suspension Bead Array Data.

Hong MG, Lee W, Nilsson P, Pawitan Y, Schwenk JM

J. Proteome Res. 15 (10) 3473-3480 [2016-10-07; online 2016-08-30]

Affinity Proteomics Stockholm [Technology development]

Protein profiles of CCL5, HPGDS, and NPSR1 in plasma reveal association with childhood asthma.

Hamsten C, Häggmark A, Grundström J, ..., Nilsson P, van Hage M

Allergy 71 (9) 1357-1361 [2016-09-00; online 2016-05-25]

Affinity Proteomics Stockholm [Collaborative] Tissue Profiling [Collaborative]

Elevated levels of FN1 and CCL2 in bronchoalveolar lavage fluid from sarcoidosis patients.

Hamsten C, Wiklundh E, Grönlund H, ..., Grunewald J, Häggmark-Månberg A

Respir. Res. 17 (1) 69 [2016-06-04; online 2016-06-04]

Multiplexed protein profiling by sequential affinity capture.

Ayoglu B, Birgersson E, Mezger A, ..., Nilsson P, Schwenk JM

Proteomics 16 (8) 1251-1256 [2016-04-00; online 2016-03-31]

Affinity Proteomics Stockholm [Technology development]

Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease.

Khoonsari PE, Häggmark A, Lönnberg M, ..., Kultima K, Shevchenko G

PLoS ONE 11 (3) e0150672 [2016-03-07; online 2016-03-07]

Year 2015

Immunocapture strategies in translational proteomics.

Fredolini C, Byström S, Pin E, ..., Nilsson P, Schwenk JM

Expert Rev Proteomics 13 (1) 83-98 [2015-11-11; online 2015-11-11]

Affinity Proteomics Stockholm [Technology development]

Heat differentiated complement factor profiling.

Hamsten C, Skattum L, Truedsson L, ..., Nilsson P, Neiman M

J Proteomics 126 (-) 155-162 [2015-08-03; online 2015-06-07]

Affinity Proteomics Stockholm [Technology development]

Analysis of the Human Prostate-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling Identifies TMEM79 and ACOXL as Two Putative, Diagnostic Markers in Prostate Cancer.

O'Hurley G, Busch C, Fagerberg L, ..., Uhlén M, Pontén F

PLoS ONE 10 (8) e0133449 [2015-08-03; online 2015-08-03]

Affinity Proteomics Stockholm NGI Stockholm (Genomics Applications) NGI Stockholm (Genomics Production) National Genomics Infrastructure Spatial Proteomics Tissue Profiling [Technology development]

Circulating carnosine dipeptidase 1 associates with weight loss and poor prognosis in gastrointestinal cancer.

Arner P, Henjes F, Schwenk JM, ..., Nilsson P, Rydén M

PLoS ONE 10 (4) e0123566 [2015-04-21; online 2015-04-21]

Affinity Proteomics Stockholm

Year 2014

Affinity proteomic profiling of plasma, cerebrospinal fluid, and brain tissue within multiple sclerosis.

Byström S, Ayoglu B, Häggmark A, ..., Nilsson P, Schwenk JM

J. Proteome Res. 13 (11) 4607-4619 [2014-11-07; online 2014-09-19]

Affinity Proteomics Stockholm [Collaborative] Fluorescence Tissue Profiling

Parallel barcoding of antibodies for DNA-assisted proteomics.

Dezfouli M, Vickovic S, Iglesias MJ, Schwenk JM, Ahmadian A

Proteomics 14 (21-22) 2432-2436 [2014-11-00; online 2014-09-30]

Affinity Proteomics Stockholm [Technology development] NGI Stockholm (Genomics Applications) NGI Stockholm (Genomics Production) National Genomics Infrastructure

Plasma profiling reveals three proteins associated to amyotrophic lateral sclerosis.

Häggmark A, Mikus M, Mohsenchian A, ..., Kuźma-Kozakiewicz M, Nilsson P

Ann Clin Transl Neurol 1 (8) 544-553 [2014-08-00; online 2014-07-14]

Affinity proteomics within rare diseases: a BIO-NMD study for blood biomarkers of muscular dystrophies.

Ayoglu B, Chaouch A, Lochmüller H, ..., Nilsson P, Al-Khalili Szigyarto C

EMBO Mol Med 6 (7) 918-936 [2014-07-00; online 2014-06-13]

Bead arrays for antibody and complement profiling reveal joint contribution of antibody isotypes to C3 deposition.

Ayoglu B, Szarka E, Huber K, ..., Nilsson P, Papp K

PLoS ONE 9 (5) e96403 [2014-05-05; online 2014-05-05]

Affinity Proteomics Stockholm [Collaborative] Autoimmunity and Serology Profiling [Technology development]

Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria.

Bachmann J, Burté F, Pramana S, ..., Fernandez-Reyes D, Nilsson P

PLoS Pathog. 10 (4) e1004038 [2014-04-00; online 2014-04-17]

Analysis of plasma from prostate cancer patients links decreased carnosine dipeptidase 1 levels to lymph node metastasis

Qundos U, Johannesson H, Fredolini C, ..., Nilsson P, Schwenk JM

Translational Proteomics 2 (-) 14-24 [2014-03-00; online 2014-03-00]

Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics.

Fagerberg L, Hallström BM, Oksvold P, ..., Ponten F, Uhlén M

Mol. Cell Proteomics 13 (2) 397-406 [2014-02-00; online 2013-12-07]

Affinity Proteomics Stockholm [Technology development] Autoimmunity and Serology Profiling [Technology development] NGI Stockholm (Genomics Applications) NGI Stockholm (Genomics Production) National Genomics Infrastructure Spatial Proteomics Tissue Profiling

Magnetic bead assisted labeling of antibodies at nanogram scale.

Dezfouli M, Vickovic S, Iglesias MJ, ..., Schwenk JM, Ahmadian A

Proteomics 14 (1) 14-18 [2014-01-00; online 2013-12-07]

Affinity Proteomics Stockholm [Technology development] NGI Stockholm (Genomics Applications) NGI Stockholm (Genomics Production) National Genomics Infrastructure

Year 2013

Profiling post-centrifugation delay of serum and plasma with antibody bead arrays.

Qundos U, Hong M, Tybring G, ..., Nilsson P, Schwenk JM

J Proteomics 95 (-) 46-54 [2013-12-16; online 2013-05-02]

Selectivity analysis of single binder assays used in plasma protein profiling.

Neiman M, Fredolini C, Johansson H, ..., Nilsson P, Schwenk JM

Proteomics 13 (23-24) 3406-3410 [2013-12-00; online 2013-10-24]

Affinity Proteomics Stockholm [Technology development]

Identification of candidate serum proteins for classifying well-differentiated small intestinal neuroendocrine tumors.

Darmanis S, Cui T, Drobin K, ..., Schwenk JM, Giandomenico V

PLoS ONE 8 (11) e81712 [2013-11-25; online 2013-11-25]

Antibody-based profiling of cerebrospinal fluid within multiple sclerosis.

Häggmark A, Byström S, Ayoglu B, ..., Schwenk JM, Nilsson P

Proteomics 13 (15) 2256-2267 [2013-08-00; online 2013-05-23]

Highly multiplexed antibody suspension bead arrays for plasma protein profiling.

Drobin K, Nilsson P, Schwenk JM

Methods Mol. Biol. 1023 (-) 137-145 [2013-06-15; online 2013-06-15]

Affinity Proteomics Stockholm [Technology development]

Year 2012

Antibodies for profiling the human proteome-The Human Protein Atlas as a resource for cancer research.

Asplund A, Edqvist PH, Schwenk JM, Pontén F

Proteomics 12 (13) 2067-2077 [2012-07-00; online 2012-05-25]

Affinity Proteomics Stockholm [Technology development] Tissue Profiling

Classification of protein profiles from antibody microarrays using heat and detergent treatment.

Häggmark A, Neiman M, Drobin K, ..., Nilsson P, Schwenk JM

N Biotechnol 29 (5) 564-570 [2012-06-15; online 2011-10-26]

Affinity Proteomics Stockholm [Technology development]

Year 2011

Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model.

Kato BS, Nicholson G, Neiman M, ..., Spector TD, Schwenk JM

Proteome Sci 9 (-) 73 [2011-11-17; online 2011-11-17]

Plasma profiling reveals human fibulin-1 as candidate marker for renal impairment.

Neiman M, Hedberg JJ, Dönnes PR, ..., Schwenk JM, Nilsson P

J. Proteome Res. 10 (11) 4925-4934 [2011-11-04; online 2011-09-29]

The Human Protein Atlas as a proteomic resource for biomarker discovery.

Pontén F, Schwenk JM, Asplund A, Edqvist PH

J. Intern. Med. 270 (5) 428-446 [2011-11-00; online 2011-08-03]

Affinity Proteomics Stockholm [Technology development] Tissue Profiling

Generation of monospecific antibodies based on affinity capture of polyclonal antibodies.

Hjelm B, Forsström B, Igel U, ..., Johansson C, Uhlén M

Protein Sci. 20 (11) 1824-1835 [2011-11-00; online 2011-09-08]

Affinity Proteomics Stockholm [Technology development] Autoimmunity and Serology Profiling [Technology development] Spatial Proteomics

A roadmap to generate renewable protein binders to the human proteome.

Colwill K, Renewable Protein Binder Working Group , Gräslund S

Nat. Methods 8 (7) 551-558 [2011-05-15; online 2011-05-15]

Affinity Proteomics Stockholm [Technology development] Autoimmunity and Serology Profiling [Technology development]

Antibody suspension bead arrays.

Schwenk JM, Nilsson P

Methods Mol. Biol. 723 (-) 29-36 [2011-03-04; online 2011-03-04]

Affinity Proteomics Stockholm [Technology development]

Systematic antibody and antigen-based proteomic profiling with microarrays.

Ayoglu B, Häggmark A, Neiman M, ..., Schwenk JM, Nilsson P

Expert Rev. Mol. Diagn. 11 (2) 219-234 [2011-03-00; online 2011-03-17]

Affinity Proteomics Stockholm [Technology development] Autoimmunity and Serology Profiling [Technology development]

Year 2010

Toward next generation plasma profiling via heat-induced epitope retrieval and array-based assays.

Schwenk JM, Igel U, Neiman M, ..., Nilsson P, Uhlen M

Mol. Cell Proteomics 9 (11) 2497-2507 [2010-11-00; online 2010-08-05]

Affinity Proteomics Stockholm [Technology development]