Aneuploidy in neuroblastoma tumors is not associated with inactivating point mutations in the STAG2 gene.

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Djos A, Fransson S, Kogner P, Martinsson T

BMC Med. Genet. 14 (-) 102 [2013-10-02; online 2013-10-02]

Chromosomal instability is a hallmark of human cancer caused by errors in mitotic control and chromosome segregation. STAG2 encodes a subunit of the cohesion complex that participates in mitotic chromatid separation and was recently found to show low expression and inactivating mutations in Ewing's sarcoma, melanoma and glioblastoma.In the childhood tumor neuroblastoma (NB) segmental chromosomal alterations are associated with poor prognosis whereas tumors displaying whole chromosome gains and losses have a much better prognosis. As the genetic contribution to aneuploidy is unknown in NB, we investigated the presence of STAG2 mutations through sequence analysis of all 33 coding exons in 37 primary NB tumors. As no STAG2 mutation was detected in this study, we conclude that inactivating mutation of STAG2 is not likely causative to neuroblastoma aneuploidy.

NGI Stockholm (Genomics Applications)

NGI Stockholm (Genomics Production)

National Genomics Infrastructure

PubMed 24088605

DOI 10.1186/1471-2350-14-102

Crossref 10.1186/1471-2350-14-102

pii: 1471-2350-14-102
pmc: PMC3853135