Malmström L

Dissecting the properties of circulating IgG against streptococcal pathogens through a combined systems antigenomics-serology workflow

Gomez Toledo A, Chowdhury S, Hjortswang E, ..., Rasmussen M, Malmström J

Nat Commun 16 (1) - [2025-02-24; online 2025-02-24]

Structural Proteomics [Collaborative]

Streptolysin O accelerates the conversion of plasminogen to plasmin

Tang D, Khakzad H, Hjortswang E, ..., Happonen L, Malmström J

Nat Commun 15 (1) 10212 [2024-11-25; online 2024-11-25]

Structural Proteomics [Technology development]

Multimodal Mass Spectrometry Identifies a Conserved Protective Epitope in S. pyogenes Streptolysin O

Tang D, Gueto-Tettay C, Hjortswang E, ..., Malmström L, Malmström J

Anal. Chem. 96 (22) 9060-9068 [2024-06-04; online 2024-05-03]

Structural Proteomics [Technology development]

The hinge-engineered IgG1-IgG3 hybrid subclass IgGh47 potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodies.

Izadi A, Karami Y, Bratanis E, ..., Malmström L, Nordenfelt P

Nat Commun 15 (1) 3600 [2024-04-27; online 2024-04-27]

Drug Discovery and Development (DDD) [Service]

Proteogenomics decodes the evolution of human ipsilateral breast cancer.

De Marchi T, Pyl PT, Sjöström M, ..., Malmstöm J, Niméus E

Commun Biol 6 (1) 139 [2023-02-02; online 2023-02-02]

Bioinformatics (NBIS) [Collaborative] Bioinformatics Long-term Support WABI [Collaborative] Bioinformatics Support for Computational Resources [Service] Bioinformatics Support, Infrastructure and Training [Collaborative]

Multienzyme deep learning models improve peptide de novo sequencing by mass spectrometry proteomics.

Gueto-Tettay C, Tang D, Happonen L, ..., Malmström J, Malmström L

PLoS Comput. Biol. 19 (1) e1010457 [2023-01-00; online 2023-01-20]

Structural Proteomics [Technology development]

The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms.

Hasan M, Khakzad H, Happonen L, ..., Malmström A, Tykesson E

Chem. Sci. 12 (5) 1869-1885 [2021-02-07; online 2020-12-08]

Structural Proteomics [Collaborative]

Structural determination of Streptococcus pyogenes M1 protein interactions with human immunoglobulin G using integrative structural biology.

Khakzad H, Happonen L, Karami Y, ..., Malmström J, Malmström L

PLoS Comput. Biol. 17 (1) e1008169 [2021-01-00; online 2021-01-07]

Structural Proteomics [Collaborative]