Comprehensive analysis of copy number variation in monozygotic twins discordant for bipolar disorder or schizophrenia.

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Bloom RJ, Kähler AK, Collins AL, Chen G, Cannon TD, Hultman C, Sullivan PF

Schizophr. Res. 146 (1-3) 289-290 [2013-05-00; online 2013-03-20]

Copy number variation plays a clear role in the etiology of many psychiatric disorders, particularly schizophrenia. We performed array-CGH to look for copy number variants between five pairs of monozygotic twins discordant for bipolar disorder or schizophrenia. Our study found no differences in copy number variants between the sets of twins. Although alluring, realistic accounting for heterogeneity and chimerism highlights the technological limitations in studying monozygotic twins discordant for psychiatric disorders.

Mutation Analysis Facility (MAF)

PubMed 23507357

DOI 10.1016/j.schres.2013.02.021

Crossref 10.1016/j.schres.2013.02.021

pii: S0920-9964(13)00113-8
pmc: PMC3650833
mid: NIHMS450150