Spatial Mass Spectrometry

Spatial multiomic insights into acute cocaine exposure

Nezhyva M, Shahen-Zoabi S, Kabirova M, ..., Margulis K, Jansson ET

- 3 (10) - [2024-10-01; online 2024-10-10]

The CHCHD2-CHCHD10 protein complex is modulated by mitochondrial dysfunction and alters lipid homeostasis in the mouse brain

Gerlach J, Pireddu P, Zhang X, ..., Svenningsson P, Filograna R

- - (-) - [2024-09-14; online 2024-09-14]

Hydrazide-based reactive matrices for the sensitive detection of aldehydes and ketones by MALDI mass spectrometry imaging.

Lodén H, Schembri LS, Nilsson A, ..., Odell LR, Andrén PE

Chem. Commun. (Camb.) 60 (69) 9238-9241 [2024-08-22; online 2024-08-22]

The involvement of cyclotides in the heavy metal tolerance of Viola spp.

Sychta K, Słomka A, Shariatgorji R, ..., Göransson U, Slazak B

Sci Rep 14 (1) 19306 [2024-08-20; online 2024-08-20]

Hypoxic-Ischemic Insult Alters Polyamine and Neurotransmitter Abundance in the Specific Neonatal Rat Brain Subregions.

Mácha H, Luptáková D, Juránek I, Andrén PE, Havlíček V

ACS Chem Neurosci 15 (15) 2811-2821 [2024-08-07; online 2024-07-26]

Applying Spatial Metabolomics To Investigate Age- and Drug-Induced Neurochemical Changes.

Vallianatou T, Angerer TB, Kaya I, ..., Svenningsson P, Andrén PE

ACS Chem Neurosci 15 (15) 2822-2829 [2024-08-07; online 2024-07-29]

Hydrogen production by a fully de novo enzyme.

Berglund S, Bassy C, Kaya I, ..., Magnuson A, Glover SD

Dalton Trans 53 (31) 12905-12916 [2024-08-06; online 2024-08-06]

Regional Changes in Brain Biomolecular Markers in a Collagen-Induced Arthritis Rat Model.

Millen AME, Maluleke TT, Pienaar L, ..., Andrén PE, Baijnath S

Biology (Basel) 13 (7) - [2024-07-10; online 2024-07-10]

GABA-mediated inhibition of human CD4+ T cell functions is enhanced by insulin but impaired by high glucose levels.

Jin Z, Hammoud H, Bhandage AK, ..., Kamali-Moghaddam M, Birnir B

EBioMedicine 105 (-) 105217 [2024-07-00; online 2024-06-28]

Bioinformatics Support and Infrastructure [Service] Bioinformatics Support, Infrastructure and Training [Service] Spatial Mass Spectrometry [Collaborative]

Playing with Protic Additives to Improve the Outcome of Rhodium‐Catalyzed Hydroarylation of Fullerene C60 with Arylboronic Acids

Ergun Dönmez M, Eriksson M, Hulu G, Nordström M, Grennberg H

Helvetica Chimica Acta 107 (2) - [2024-02-00; online 2024-01-16]

Year 2023

Rapid Metabolic Profiling of 1 μL Crude Cerebrospinal Fluid by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Can Differentiate De Novo Parkinson's Disease.

Vallianatou T, Nilsson A, Bjärterot P, ..., Svenningsson P, Andrén PE

Anal. Chem. 95 (50) 18352-18360 [2023-12-19; online 2023-12-07]

Label-Free Quantitative Thermal Proteome Profiling Reveals Target Transcription Factors with Activities Modulated by MC3R Signaling.

Sandbaumhüter FA, Nezhyva M, Andrén PE, Jansson ET

Anal. Chem. 95 (41) 15400-15408 [2023-10-17; online 2023-10-07]

Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.

He Y, Kaya I, Shariatgorji R, ..., Andren PE, Svenningsson P

Nat Commun 14 (1) 5804 [2023-09-19; online 2023-09-19]

Spatial multimodal analysis of transcriptomes and metabolomes in tissues.

Vicari M, Mirzazadeh R, Nilsson A, ..., Andrén PE, Lundeberg J

Nat. Biotechnol. - (-) - [2023-09-04; online 2023-09-04]

In Situ Sequencing (ISS) [Collaborative] Spatial Mass Spectrometry [Collaborative]

Spatial lipidomics reveals brain region-specific changes of sulfatides in an experimental MPTP Parkinson's disease primate model.

Kaya I, Nilsson A, Luptáková D, ..., Bezard E, Andrén PE

NPJ Parkinsons Dis 9 (1) 118 [2023-07-26; online 2023-07-26]

A Base‐Free, Low Temperature Click and Release Reaction for the In Situ Generation of Diazomethane

Schembri LS, Olaniran E, Söderström M, Skillinghaug B, Odell LR

Adv. Synth. Catal. 365 (11) 1839-1845 [2023-06-13; online 2023-05-23]

RNA interactome capture in Escherichia coli globally identifies RNA-binding proteins.

Stenum TS, Kumar AD, Sandbaumhüter FA, ..., Jansson ET, Holmqvist E

Nucleic Acids Res. 51 (9) 4572-4587 [2023-05-22; online 2023-03-30]

On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging.

Kaya I, Schembri LS, Nilsson A, ..., Odell LR, Andrén PE

J. Am. Soc. Mass Spectrom. 34 (5) 836-846 [2023-05-03; online 2023-04-13]

Hydrogen production by a fully de novo enzyme

Berglund S, Bassy C, Kaya I, ..., Magnuson A, Glover S

- - (-) - [2023-04-17; online 2023-04-17]

Zero-Degree Celsius Capillary Electrophoresis Electrospray Ionization for Hydrogen Exchange Mass Spectrometry.

Aerts JT, Andrén PE, Jansson ET

Anal. Chem. 95 (2) 1149-1158 [2023-01-17; online 2022-12-22]

Enantioselective CE-MS analysis of ketamine metabolites in urine.

Sandbaumhüter FA, Aerts JT, Theurillat R, ..., Thormann W, Jansson ET

Electrophoresis 44 (1-2) 125-134 [2023-01-00; online 2022-12-09]

Year 2022

The Influence of Plant Stress Hormones and Biotic Elicitors on Cyclotide Production in Viola uliginosa Cell Suspension Cultures.

Slazak B, Jędrzejska A, Badyra B, ..., Andrén PE, Göransson U

Plants (Basel) 11 (14) - [2022-07-19; online 2022-07-19]

Basal ganglia neuropeptides show abnormal processing associated with L-DOPA-induced dyskinesia.

Hulme H, Fridjonsdottir E, Vallianatou T, ..., Bezard E, Andrén PE

NPJ Parkinsons Dis 8 (1) 41 [2022-04-13; online 2022-04-13]

Well-Plate μFASP for Proteomic Analysis of Single Pancreatic Islets.

Sandbaumhüter FA, Nezhyva M, Eriksson O, ..., Andrén PE, Jansson ET

J. Proteome Res. 21 (4) 1167-1174 [2022-04-01; online 2022-03-16]

The involvement of cyclotides in mutual interactions of violets and the two-spotted spider mite.

Slazak B, Jędrzejska A, Badyra B, ..., Göransson U, Kiełkiewicz M

Sci Rep 12 (1) 1914 [2022-02-03; online 2022-02-03]

Method To Visualize the Intratumor Distribution and Impact of Gemcitabine in Pancreatic Ductal Adenocarcinoma by Multimodal Imaging.

Strittmatter N, Richards FM, Race AM, ..., Goodwin RJA, Jodrell DI

Anal. Chem. 94 (3) 1795-1803 [2022-01-25; online 2022-01-10]

Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems.

Fridjonsdottir E, Vallianatou T, Mantas I, ..., Svenningsson P, Andrén PE

ACS Chem. Biol. 17 (1) 147-158 [2022-01-21; online 2021-12-21]

Year 2021

Holistic Characterization of a Salmonella Typhimurium Infection Model Using Integrated Molecular Imaging.

Strittmatter N, Kanvatirth P, Inglese P, ..., Goodwin RJA, Mastroeni P

J. Am. Soc. Mass Spectrom. 32 (12) 2791-2802 [2021-12-01; online 2021-11-12]

Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis.

Becker K, Cao S, Nilsson A, ..., Liepinsh E, Hobbie SN

EBioMedicine 73 (-) 103652 [2021-11-00; online 2021-11-02]

Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.

Luptáková D, Vallianatou T, Nilsson A, ..., Loryan I, Andrén PE

Mol. Psychiatry - (-) - [2021-09-03; online 2021-09-03]

Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice.

Becker K, Aranzana-Climent V, Cao S, ..., Hobbie SN, ENABLE consortium

Clin. Microbiol. Infect. 27 (9) 1315-1321 [2021-09-00; online 2020-12-11]

Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide.

Rofo F, Sandbaumhüter FA, Chourlia A, ..., Jansson ET, Hultqvist G

ACS Chem Neurosci 12 (13) 2529-2541 [2021-07-07; online 2021-06-25]

TAAR1-Dependent and -Independent Actions of Tyramine in Interaction With Glutamate Underlie Central Effects of Monoamine Oxidase Inhibition.

Mantas I, Vallianatou T, Yang Y, ..., Andrén PE, Svenningsson P

Biol. Psychiatry 90 (1) 16-27 [2021-07-01; online 2020-12-19]

Spatial visualization of comprehensive brain neurotransmitter systems and neuroactive substances by selective in situ chemical derivatization mass spectrometry imaging.

Shariatgorji R, Nilsson A, Fridjonsdottir E, ..., Odell LR, Andrén PE

Nat Protoc 16 (7) 3298-3321 [2021-07-00; online 2021-06-02]

Cyclotide host-defense tailored for species and environments in violets from the Canary Islands.

Slazak B, Kaltenböck K, Steffen K, ..., Andrén PE, Göransson U

Sci Rep 11 (1) 12452 [2021-06-14; online 2021-06-14]

Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain.

Vallianatou T, Shariatgorji R, Nilsson A, ..., Svenningsson P, Andrén PE

ACS Chem Neurosci 12 (10) 1811-1823 [2021-05-19; online 2021-05-03]

Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA-induced dyskinesia.

Fridjonsdottir E, Shariatgorji R, Nilsson A, ..., Bezard E, Andrén PE

Sci Adv 7 (2) - [2021-01-00; online 2021-01-06]

Year 2020

Bromopyrylium Derivatization Facilitates Identification by Mass Spectrometry Imaging of Monoamine Neurotransmitters and Small Molecule Neuroactive Compounds.

Shariatgorji R, Nilsson A, Strittmatter N, ..., Goodwin RJA, Andrén PE

J. Am. Soc. Mass Spectrom. 31 (12) 2553-2557 [2020-12-02; online 2020-07-21]

Cross-validated Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Quantitation Protocol for a Pharmaceutical Drug and Its Drug-Target Effects in the Brain Using Time-of-Flight and Fourier Transform Ion Cyclotron Resonance Analyzers.

Källback P, Vallianatou T, Nilsson A, ..., Svenningsson P, Andrén PE

Anal. Chem. 92 (21) 14676-14684 [2020-11-03; online 2020-10-21]

µ Opioid Receptor Agonism for L-DOPA-Induced Dyskinesia in Parkinson's Disease.

Bezard E, Li Q, Hulme H, ..., Andren PE, Crossman AR

J. Neurosci. 40 (35) 6812-6819 [2020-08-26; online 2020-07-20]

Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy.

Hulme H, Fridjonsdottir E, Gunnarsdottir H, ..., Svenningsson P, Andrén PE

Neurobiol. Dis. 137 (-) 104738 [2020-04-00; online 2020-01-10]

Deficits in Motor Performance, Neurotransmitters and Synaptic Plasticity in Elderly and Experimental Parkinsonian Mice Lacking GPR37.

Zhang X, Mantas I, Fridjonsdottir E, ..., Chergui K, Svenningsson P

Front Aging Neurosci 12 (-) 84 [2020-03-27; online 2020-03-27]

Non-dopaminergic Alterations in Depression-Like FSL Rats in Experimental Parkinsonism and L-DOPA Responses.

Schintu N, Zhang X, Stroth N, ..., Andrén PE, Svenningsson P

Front Pharmacol 11 (-) 304 [2020-03-20; online 2020-03-20]

Revealing the Regional Localization and Differential Lung Retention of Inhaled Compounds by Mass Spectrometry Imaging.

Hamm GR, Bäckström E, Brülls M, ..., Fridén M, Goodwin RJA

J Aerosol Med Pulm Drug Deliv 33 (1) 43-53 [2020-02-00; online 2019-07-31]

Year 2019

Molecular imaging identifies age-related attenuation of acetylcholine in retrosplenial cortex in response to acetylcholinesterase inhibition.

Vallianatou T, Shariatgorji M, Nilsson A, ..., Svenningsson P, Andrén PE

Neuropsychopharmacology 44 (12) 2091-2098 [2019-11-00; online 2019-04-22]

Detection of a High-Turnover Serotonin Circuit in the Mouse Brain Using Mass Spectrometry Imaging.

Sugiyama E, Guerrini MM, Honda K, ..., Suematsu M, Sugiura Y

iScience 20 (-) 359-372 [2019-10-25; online 2019-09-27]

Comprehensive mapping of neurotransmitter networks by MALDI-MS imaging.

Shariatgorji M, Nilsson A, Fridjonsdottir E, ..., Odell LR, Andrén PE

Nat. Methods 16 (10) 1021-1028 [2019-10-00; online 2019-09-23]

α-synuclein-lipoprotein interactions and elevated ApoE level in cerebrospinal fluid from Parkinson's disease patients.

Paslawski W, Zareba-Paslawska J, Zhang X, ..., Andrén PE, Svenningsson P

Proc. Natl. Acad. Sci. U.S.A. 116 (30) 15226-15235 [2019-07-23; online 2019-07-03]

Year 2018

Uncovering the regional localization of inhaled salmeterol retention in the lung.

Bäckström E, Hamm G, Nilsson A, ..., Goodwin RJA, Fridén M

Drug Deliv 25 (1) 838-845 [2018-11-00; online 2018-03-29]

How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests - Cyclotides as a Comprehensive Plant Host Defense System.

Slazak B, Kapusta M, Strömstedt AA, ..., Kuta E, Göransson U

Front Plant Sci 9 (-) 1296 [2018-09-11; online 2018-09-11]

Quantitation of Endogenous Metabolites in Mouse Tumors Using Mass-Spectrometry Imaging.

Swales JG, Dexter A, Hamm G, ..., Critchlow SE, Goodwin RJA

Anal. Chem. 90 (10) 6051-6058 [2018-05-15; online 2018-04-26]

A mass spectrometry imaging approach for investigating how drug-drug interactions influence drug blood-brain barrier permeability.

Vallianatou T, Strittmatter N, Nilsson A, ..., Goodwin RJA, Andrén PE

Neuroimage 172 (-) 808-816 [2018-05-15; online 2018-01-10]

Editorial and Review: 29th ASMS Sanibel Conference on Mass Spectrometry-Peptidomics: Bridging the Gap between Proteomics and Metabolomics by MS.

Li L, Andrén PE, Sweedler JV

J. Am. Soc. Mass Spectrom. 29 (5) 801-806 [2018-05-00; online 2018-04-07]

Peptide ion channel toxins from the bootlace worm, the longest animal on Earth.

Jacobsson E, Andersson HS, Strand M, ..., Tytgat J, Göransson U

Sci Rep 8 (1) 4596 [2018-03-22; online 2018-03-22]

A Space Efficient Direct Access Data Compression Approach for Mass Spectrometry Imaging.

Källback P, Nilsson A, Shariatgorji M, Andrén PE

Anal. Chem. 90 (6) 3676-3682 [2018-03-20; online 2018-03-08]

Striatal Tyrosine Hydroxylase Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine.

Zhang X, Mantas I, Alvarsson A, ..., Chergui K, Svenningsson P

Front Pharmacol 9 (-) 166 [2018-03-01; online 2018-03-01]

Yale School of Public Health Symposium on tissue imaging mass spectrometry: illuminating phenotypic heterogeneity and drug disposition at the molecular level.

Charkoftaki G, Rattray NJW, Andrén PE, ..., Johnson CH, Vasiliou V

Hum Genomics 12 (1) 10 [2018-02-27; online 2018-02-27]

Brain Tissue Sample Stabilization and Extraction Strategies for Neuropeptidomics.

Fridjonsdottir E, Nilsson A, Wadensten H, Andrén PE

Methods Mol. Biol. 1719 (-) 41-49 [2018-02-25; online 2018-02-25]

Year 2017

Mass Spectrometry Imaging proves differential absorption profiles of well-characterised permeability markers along the crypt-villus axis.

Nilsson A, Peric A, Strimfors M, ..., Andrén PE, Hilgendorf C

Sci Rep 7 (1) 6352 [2017-07-25; online 2017-07-25]

Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection.

Hulme HE, Meikle LM, Wessel H, ..., Burchmore R, Wall DM

Sci Rep 7 (1) 2786 [2017-06-05; online 2017-06-05]

Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB).

De Rosa M, Lu L, Zamaratski E, ..., Mowbray SL, Karlén A

Bioorg. Med. Chem. 25 (3) 897-911 [2017-02-01; online 2016-12-07]

Year 2016

Simultaneous imaging of multiple neurotransmitters and neuroactive substances in the brain by desorption electrospray ionization mass spectrometry.

Shariatgorji M, Strittmatter N, Nilsson A, ..., Goodwin RJ, Andren PE

Neuroimage 136 (-) 129-138 [2016-08-01; online 2016-05-04]

Direct imaging of elemental distributions in tissue sections by laser ablation mass spectrometry.

Shariatgorji M, Nilsson A, Bonta M, ..., Limbeck A, Andrén PE

Methods 104 (-) 86-92 [2016-07-15; online 2016-06-02]

msIQuant--Quantitation Software for Mass Spectrometry Imaging Enabling Fast Access, Visualization, and Analysis of Large Data Sets.

Källback P, Nilsson A, Shariatgorji M, Andrén PE

Anal. Chem. 88 (8) 4346-4353 [2016-04-19; online 2016-04-05]

Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo.

Ashton S, Song YH, Nolan J, ..., Jewsbury PJ, Barry ST

Sci Transl Med 8 (325) 325ra17 [2016-02-10; online 2016-02-13]