Hansson GC

The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins.

Gallego P, Garcia-Bonete MJ, Trillo-Muyo S, ..., Johansson MEV, Hansson GC

Nat Commun 14 (1) 1969 [2023-04-08; online 2023-04-08]

Cryo-EM [Service]

Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport.

Dolan B, Ermund A, Martinez-Abad B, Johansson MEV, Hansson GC

Sci Signal 15 (752) eabl5848 [2022-09-20; online 2022-09-20]

Integrated Microscopy Technologies Gothenburg [Service]

Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota.

Luis AS, Baslé A, Byrne DP, ..., Martens EC, Cartmell A

Nat. Chem. Biol. 18 (8) 841-849 [2022-08-00; online 2022-06-16]

Glycoproteomics and MS Proteomics [Collaborative]

A single sulfatase is required to access colonic mucin by a gut bacterium.

Luis AS, Jin C, Pereira GV, ..., Cartmell A, Martens EC

Nature 598 (7880) 332-337 [2021-10-00; online 2021-10-06]

Glycoproteomics and MS Proteomics [Collaborative]

Association between Brachyspira and irritable bowel syndrome with diarrhoea.

Jabbar KS, Dolan B, Eklund L, ..., Simren M, Hansson GC

Gut 70 (6) 1117-1129 [2021-06-00; online 2020-11-11]

Integrated Microscopy Technologies Gothenburg [Service]

An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function.

Nyström EEL, Martinez-Abad B, Arike L, ..., Hansson GC, Johansson MEV

Science 372 (6539) - [2021-04-16; online 2021-04-17]

Integrated Microscopy Technologies Gothenburg [Service]

Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis.

van der Post S, Jabbar KS, Birchenough G, ..., Johansson MEV, Hansson GC

Gut 68 (12) 2142-2151 [2019-12-00; online 2019-03-26]

Integrated Microscopy Technologies Gothenburg [Service]

Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2-processing properties.

Nyström EEL, Arike L, Ehrencrona E, Hansson GC, Johansson MEV

J. Biol. Chem. 294 (45) 17075-17089 [2019-11-08; online 2019-09-29]

Integrated Microscopy Technologies Gothenburg [Service]

The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function.

Volk JK, Nyström EEL, van der Post S, ..., Hansson GC, Birchenough GMH

J. Exp. Med. 216 (11) 2602-2618 [2019-11-04; online 2019-08-16]

Integrated Microscopy Technologies Gothenburg [Service]

The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane.

Schneider H, Berger E, Dolan B, ..., Pelaseyed T, Hansson GC

Biochem. J. 476 (16) 2281-2295 [2019-08-22; online 2019-08-22]

Integrated Microscopy Technologies Gothenburg [Service]

Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs.

Fernández-Blanco JA, Fakih D, Arike L, ..., Ermund A, Hansson GC

JCI Insight 3 (17) - [2018-09-06; online 2018-09-06]

Integrated Microscopy Technologies Gothenburg [Service]

Postnatal development of the small intestinal mucosa drives age-dependent, regio-selective susceptibility to Escherichia coli K1 infection.

Birchenough GM, Dalgakiran F, Witcomb LA, ..., Hansson GC, Taylor PW

Sci Rep 7 (1) 83 [2017-03-06; online 2017-03-06]

Integrated Microscopy Technologies Gothenburg [Service]