Targeting SOX9 for degradation to inhibit chemoresistance, metastatic spread, and recurrence.

Suryo Rahmanto A, Swartling FJ, Sangfelt O

Mol Cell Oncol 4 (1) e1252871 [2016-11-08; online 2016-11-08]

Cancer cells with stem-like properties are believed to contribute to treatment resistance, dissemination, and recurrence. SOX9 controls stem cell plasticity and its deregulation may provide a basis for tumor progression. Here, we summarize our findings of targeted SOX9 destruction by SCF(FBW7) (Skp1/Cul1/F-box) in medulloblastoma and its potential for therapeutic intervention.

Bioinformatics Compute and Storage [Service]

NGI Uppsala (Uppsala Genome Center) [Service]

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PubMed 28197531

DOI 10.1080/23723556.2016.1252871

Crossref 10.1080/23723556.2016.1252871

1252871

pmc PMC5286959