JSON
Spang A, Saw JH, Jørgensen SL, Zaremba-Niedzwiedzka K, Martijn J, Lind AE, van Eijk R, Schleper C, Guy L, Ettema TJ
Nature 521 (7551) 173-179 [2015-05-14; online 2015-05-07]
The origin of the eukaryotic cell remains one of the most contentious puzzles in modern biology. Recent studies have provided support for the emergence of the eukaryotic host cell from within the archaeal domain of life, but the identity and nature of the putative archaeal ancestor remain a subject of debate. Here we describe the discovery of 'Lokiarchaeota', a novel candidate archaeal phylum, which forms a monophyletic group with eukaryotes in phylogenomic analyses, and whose genomes encode an expanded repertoire of eukaryotic signature proteins that are suggestive of sophisticated membrane remodelling capabilities. Our results provide strong support for hypotheses in which the eukaryotic host evolved from a bona fide archaeon, and demonstrate that many components that underpin eukaryote-specific features were already present in that ancestor. This provided the host with a rich genomic 'starter-kit' to support the increase in the cellular and genomic complexity that is characteristic of eukaryotes.
NGI Uppsala (SNP&SEQ Technology Platform)
National Genomics Infrastructure
PubMed 25945739
DOI 10.1038/nature14447
Crossref 10.1038/nature14447
pii: nature14447
pmc: PMC4444528
mid: EMS63446
GENBANK: JYIM00000000
GENBANK: KP869578
GENBANK: KP869579
GENBANK: KP869580
GENBANK: KP869581
GENBANK: KP869582
GENBANK: KP869583
GENBANK: KP869584
GENBANK: KP869585
GENBANK: KP869586
GENBANK: KP869587
GENBANK: KP869588
GENBANK: KP869589
GENBANK: KP869590
GENBANK: KP869591
GENBANK: KP869592
GENBANK: KP869593
GENBANK: KP869594
GENBANK: KP869595
GENBANK: KP869596
GENBANK: KP869597
GENBANK: KP869598
GENBANK: KP869599
GENBANK: KP869600
GENBANK: KP869601
GENBANK: KP869602
GENBANK: KP869603
GENBANK: KP869604
GENBANK: KP869605
GENBANK: KP869606
GENBANK: KP869607
GENBANK: KP869608
GENBANK: KP869609
GENBANK: KP869610
GENBANK: KP869611
GENBANK: KP869612
GENBANK: KP869613
GENBANK: KP869614
GENBANK: KP869615
GENBANK: KP869616
GENBANK: KP869617
GENBANK: KP869618
GENBANK: KP869619
GENBANK: KP869620
GENBANK: KP869621
GENBANK: KP869622
GENBANK: KP869623
GENBANK: KP869624
GENBANK: KP869625
GENBANK: KP869626
GENBANK: KP869627
GENBANK: KP869628
GENBANK: KP869629
GENBANK: KP869630
GENBANK: KP869631
GENBANK: KP869632
GENBANK: KP869633
GENBANK: KP869634
GENBANK: KP869635
GENBANK: KP869636
GENBANK: KP869637
GENBANK: KP869638
GENBANK: KP869639
GENBANK: KP869640
GENBANK: KP869641
GENBANK: KP869642
GENBANK: KP869643
GENBANK: KP869644
GENBANK: KP869645
GENBANK: KP869646
GENBANK: KP869647
GENBANK: KP869648
GENBANK: KP869649
GENBANK: KP869650
GENBANK: KP869651
GENBANK: KP869652
GENBANK: KP869653
GENBANK: KP869654
GENBANK: KP869655
GENBANK: KP869656
GENBANK: KP869657
GENBANK: KP869658
GENBANK: KP869659
GENBANK: KP869660
GENBANK: KP869661
GENBANK: KP869662
GENBANK: KP869663
GENBANK: KP869664
GENBANK: KP869665
GENBANK: KP869666
GENBANK: KP869667
GENBANK: KP869668
GENBANK: KP869669
GENBANK: KP869670
GENBANK: KP869671
GENBANK: KP869672
GENBANK: KP869673
GENBANK: KP869674
GENBANK: KP869675
GENBANK: KP869676
GENBANK: KP869677
GENBANK: KP869678
GENBANK: KP869679
GENBANK: KP869680
GENBANK: KP869681
GENBANK: KP869682
GENBANK: KP869683
GENBANK: KP869684
GENBANK: KP869685
GENBANK: KP869686
GENBANK: KP869687
GENBANK: KP869688
GENBANK: KP869689
GENBANK: KP869690
GENBANK: KP869691
GENBANK: KP869692
GENBANK: KP869693
GENBANK: KP869694
GENBANK: KP869695
GENBANK: KP869696
GENBANK: KP869697
GENBANK: KP869698
GENBANK: KP869699
GENBANK: KP869700
GENBANK: KP869701
GENBANK: KP869702
GENBANK: KP869703
GENBANK: KP869704
GENBANK: KP869705
GENBANK: KP869706
GENBANK: KP869707
GENBANK: KP869708
GENBANK: KP869709
GENBANK: KP869710
GENBANK: KP869711
GENBANK: KP869712
GENBANK: KP869713
GENBANK: KP869714
GENBANK: KP869715
GENBANK: KP869716
GENBANK: KP869717
GENBANK: KP869718
GENBANK: KP869719
GENBANK: KP869720
GENBANK: KP869721
GENBANK: KP869722
GENBANK: KP869723
GENBANK: KP869724
GENBANK: LAZR00000000
SRA: SRP045692