Publications 2017

697 publications

The Interaction Modes of Haloimidazolium Salts in Solution
Schulz N, Sokkar P, Engelage E, ..., Sanchez-Garcia E, Huber SM
Chem. Eur. J. - (-) - [2017-12-28; online 2017-12-28]
Swedish NMR Centre (SNC) [Service]
A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth.
Pinheiro T, Otrocka M, Seashore-Ludlow B, ..., Simon A, Kirkham M
pii: S0006-291X(17)32084-3
Biochem. Biophys. Res. Commun. 494 (3-4) 477-483 [2017-12-16; online 2017-10-21]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
Targeting tumor cells based on Phosphodiesterase 3A expression.
Nazir M, Senkowski W, Nyberg F, ..., Larsson R, Fryknäs M
pii: S0014-4827(17)30580-3
Exp. Cell Res. 361 (2) 308-315 [2017-12-15; online 2017-10-26]
Drug Discovery and Development (DDD) [Service]
NMR study of Rcf2 reveals an unusual dimeric topology in detergent micelles
Zhou S, Pettersson P, Brzezinski P, Ädelroth P, Mäler L
ChemBioChem - (-) - [2017-12-14; online 2017-12-14]
Swedish NMR Centre (SNC) [Service]
Gene expression and risk of leukemic transformation in myelodysplasia
Shiozawa Y, Malcovati L, Gallì A, ..., Cazzola M, Ogawa S
Blood 130 (24) 2642-2653 [2017-12-14; online 2017-11-02]
Clinical Genomics Uppsala [Service]
Genomic and phenotypic characteristics of Swedish C. jejuni water isolates.
Nilsson A, Johansson C, Skarp A, ..., Engstrand L, Rautelin H
pii: PONE-D-17-22124 pmc: PMC5720728
PLoS ONE 12 (12) e0189222 [2017-12-07; online 2017-12-07]
Clinical Genomics Stockholm [Service]
The dynamic dimer structure of the chaperone Trigger Factor
Morgado L, Burmann BM, Sharpe T, Mazur A, Hiller S
Nat Commun 8 (1) - [2017-12-00; online 2017-12-08]
Swedish NMR Centre (SNC) [Service]
Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects.
Eriksson A, Chantzi E, Fryknäs M, ..., Höglund M, Larsson R
pii: S0145-2126(17)30565-9
Leuk Res 63 (-) 41-46 [2017-12-00; online 2017-10-28]
Drug Discovery and Development (DDD) [Service]
Automated Training of Deep Convolutional Neural Networks for Cell Segmentation
Sadanandan SK, Ranefall P, Le Guyader S, Wählby C
Sci Rep 7 (1) - [2017-12-00; online 2017-08-10]
BioImage Informatics [Technology development]
Increasing the permeability of Escherichia coli using MAC13243
Muheim C, Götzke H, Eriksson AU, ..., Nørholm MHH, Daley DO
Sci Rep 7 (1) - [2017-12-00; online 2017-12-15]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus
Matzov D, Aibara S, Basu A, ..., Amunts A, Yonath AE
Nat Commun 8 (1) - [2017-12-00; online 2017-09-28]
Cryo-EM [Service]
Lipid Driven Nanodomains in Giant Lipid Vesicles are Fluid and Disordered
Koukalová A, Amaro M, Aydogan G, ..., Hof M, Šachl R
Sci Rep 7 (1) - [2017-12-00; online 2017-07-14]
Swedish NMR Centre (SNC) [Service]
Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1
Lehmann LC, Hewitt G, Aibara S, ..., Boulton SJ, Deindl S
Molecular Cell 68 (5) 847-859.e7 [2017-12-00; online 2017-12-00]
Cryo-EM [Service] Protein Science Facility (PSF) [Service]
Microbial mineralization of cellulose in frozen soils
Segura JH, Nilsson MB, Haei M, ..., Schleucher J, Öquist MG
Nat Commun 8 (1) - [2017-12-00; online 2017-10-27]
Swedish NMR Centre (SNC) [Collaborative]
A short feature vector for image matching: The Log-Polar Magnitude feature descriptor
Matuszewski DJ, Hast A, Wählby C, Sintorn IM
PLoS ONE 12 (11) e0188496 [2017-11-30; online 2017-11-30]
BioImage Informatics [Technology development]
Isolated myelosarcoma is characterized by recurrent NFE2 mutations and concurrent preleukemic clones in the bone marrow.
Lazarevic V, Orsmark-Pietras C, Lilljebjörn H, ..., Juliusson G, Fioretos T
pii: blood-2017-07-793620
Blood - (-) - [2017-11-30; online 2017-11-30]
Clinical Genomics Lund [Collaborative]
A common peptidolytic mechanism for targeting peptide degradation in mitochondria and chloroplasts.
Kmiec B, Branca RMM, Murcha MW, ..., Glaser E, Teixeira PF
pii: S1674-2052(17)30342-8
Mol Plant - (-) - [2017-11-25; online 2017-11-25]
Clinical Proteomics Mass spectrometry [Service]
Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control
Carroni M, Franke KB, Maurer M, ..., Bukau B, Mogk A
EMDB: EMD-3895 EMDB: EMD-3894 EMDB: EMD-3897
Elife 6 (-) - [2017-11-22; online 2017-11-22]
Cryo-EM [Collaborative]
Normalization of mass spectrometry data (NOMAD).
Murie C, Sandri B, Sandberg AS, ..., Wendt C, Larsson O
pii: S2212-4926(17)30174-4
Adv Biol Regul - (-) - [2017-11-20; online 2017-11-20]
Clinical Proteomics Mass spectrometry [Service] Proteogenomics [Service]
Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema.
Egaña I, Kaito H, Nitzsche A, ..., Hellström M, German Mouse Clinic Consortium
pii: 10.1038/s41598-017-14894-9 pmc: PMC5684320
Sci Rep 7 (1) 15453 [2017-11-13; online 2017-11-13]
Clinical Proteomics Mass spectrometry [Service] Proteogenomics [Collaborative]
Cryo-EM reconstruction of the chlororibosome to 3.2 Å resolution within 24 h
Forsberg BO, Aibara S, Kimanius D, ..., Lindahl E, Amunts A
EMDB: EMD-3806 EMDB: EMD-3807 EMDB: EMD-3808
Int Union Crystallogr J IUCr J Int Union Cryst J IUCrJ 4 (6) - [2017-11-01; online 2017-09-22]
Cryo-EM [Service]
Orellanine specifically targets renal clear cell carcinoma.
Buvall L, Hedman H, Khramova A, ..., Haraldsson B, Nyström J
pii: 19555 pmc: PMC5710908
Oncotarget 8 (53) 91085-91098 [2017-10-31; online 2017-07-25]
Glycoproteomics [Collaborative]
Crystal structures of OrfX2 and P47 from a Botulinum neurotoxin OrfX type gene cluster.
Gustafsson R, Berntsson RP, Martínez-Carranza M, ..., Johnson EA, Stenmark P
FEBS Lett. - (-) - [2017-10-25; online 2017-10-25]
Protein Science Facility (PSF) [Service]
Glycoforest 1.0.
Horlacher O, Jin C, Alocci D, ..., Karlsson NG, Lisacek F
Anal. Chem. 89 (20) 10932-10940 [2017-10-17; online 2017-09-25]
Glycoproteomics [Technology development]
Glioblastoma and glioblastoma stem cells are dependent on functional MTH1
Pudelko L, Rouhi P, Sanjiv K, ..., Helleday T, Bräutigam L
Oncotarget 8 (49) - [2017-10-17; online 2017-07-20]
Advanced Light Microscopy (ALM) [Collaborative]
Targeted proteomic analysis of habitual coffee consumption.
Cornelis MC, Gustafsson S, Ärnlöv J, ..., Lind L, Ingelsson E
J. Intern. Med. - (-) - [2017-10-16; online 2017-10-16]
Clinical Biomarkers [Service]
RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer.
Rao S, Sigl V, Wimmer RA, ..., Dougall W, Penninger JM
pii: gad.304162.117 pmc: PMC5733500
Genes Dev. 31 (20) 2099-2112 [2017-10-15; online 2017-11-08]
Clinical Genomics Uppsala [Collaborative]
Proteolytic signatures define unique thrombin-derived peptides present in human wound fluid in vivo.
Saravanan R, Adav SS, Choong YK, ..., Sze SK, Schmidtchen A
pii: 10.1038/s41598-017-13197-3 pmc: PMC5640616
Sci Rep 7 (1) 13136 [2017-10-13; online 2017-10-13]
Targeted and Structural Proteomics [Service]
Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins
Hellinger R, Thell K, Vasileva M, ..., Becker CW, Gruber CW
Front. Chem. 5 (-) - [2017-10-11; online 2017-10-11]
Swedish NMR Centre (SNC) [Service]
Subphenotypes of inflammatory bowel disease are characterized by specific serum protein profiles
Andersson E, Bergemalm D, Kruse R, ..., Repsilber D, Halfvarson J
PLoS ONE 12 (10) e0186142 [2017-10-05; online 2017-10-05]
Clinical Biomarkers [Service]
GlyTouCan: an accessible glycan structure repository.
Tiemeyer M, Aoki K, Paulson J, ..., Narimatsu H, Aoki-Kinoshita KF
pii: 4079955 pmc: PMC5881658
Glycobiology 27 (10) 915-919 [2017-10-01; online 2017-09-20]
Glycoproteomics [Collaborative]
Comprehensive analysis of NMR data using advanced line shape fitting
Niklasson M, Otten R, Ahlner A, ..., Petzold K, Lundström P
J Biomol NMR 69 (2) 93-99 [2017-10-00; online 2017-10-17]
Swedish NMR Centre (SNC) [Service]
Eosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke.
Sundström J, Söderholm M, Borné Y, ..., Orho-Melander M, Engström G
pii: STROKEAHA.117.018450
Stroke 48 (10) 2686-2692 [2017-10-00; online 2017-09-13]
Clinical Biomarkers [Service]
Tumor SHB gene expression affects disease characteristics in human acute myeloid leukemia.
Jamalpour M, Li X, Cavelier L, ..., Höglund M, Welsh M
Tumour Biol. 39 (10) 1010428317720643 [2017-10-00; online 2017-10-07]
Clinical Genomics Uppsala [Collaborative]
Breast cancer in young women and prognosis: How important are proliferation markers?
Fredholm H, Magnusson K, Lindström LS, ..., Frisell J, Fredriksson I
pii: S0959-8049(17)31177-2
Eur. J. Cancer 84 (-) 278-289 [2017-10-00; online 2017-08-29]
Tissue Profiling [Collaborative]
Tumor Necrosis Factor Receptor 1 and 2 Are Associated With Risk of Intracerebral Hemorrhage.
Svensson EH, Söderholm M, Abul-Kasim K, Engström G
pii: STROKEAHA.117.017849
Stroke 48 (10) 2710-2715 [2017-10-00; online 2017-08-22]
Clinical Biomarkers [Service]
New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia.
Lilljebjörn H, Fioretos T
pii: blood-2017-05-742643
Blood 130 (12) 1395-1401 [2017-09-21; online 2017-08-04]
Clinical Genomics Lund [Collaborative]
Plasma stem cell factor levels are associated with risk of cardiovascular disease and death
Björkbacka H, Yao Mattisson I, Wigren M, ..., Engström G, Nilsson J
J Intern Med - (-) - [2017-09-21; online 2017-09-21]
Clinical Biomarkers [Service]
Structures of the human mitochondrial ribosome in native states of assembly
Brown A, Rathore S, Kimanius D, ..., Amunts A, Ramakrishnan V
Nat Struct Mol Biol - (-) - [2017-09-11; online 2017-09-11]
Cryo-EM [Service]
The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes
Yip BH, Steeples V, Repapi E, ..., Pellagatti A, Boultwood J
- 127 (9) 3557-3557 [2017-09-01; online 2017-09-01]
Clinical Genomics Uppsala [Service]
Metabolic profiles from two different breakfast meals characterized by 1 H NMR-based metabolomics
Rådjursöga M, Karlsson GB, Lindqvist HM, ..., Ellegård L, Winkvist A
Food Chem 231 (-) 267-274 [2017-09-00; online 2017-09-00]
Swedish NMR Centre (SNC) [Service]
Effect of food intake on 92 neurological biomarkers in plasma
Dencker M, Björgell O, Hlebowicz J
Brain Behav 7 (9) e00747 [2017-09-00; online 2017-08-01]
Clinical Biomarkers [Service]
Cartilage oligomeric matrix protein forms protein complexes with synovial lubricin via non-covalent and covalent interactions.
Flowers SA, Kalamajski S, Ali L, ..., Karlsson NG, Jin C
pii: S1063-4584(17)30937-8
Osteoarthr. Cartil. 25 (9) 1496-1504 [2017-09-00; online 2017-04-01]
Glycoproteomics [Collaborative]
Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer.
Asim M, Tarish F, Zecchini HI, ..., Neal D, Helleday T
pii: 10.1038/s41467-017-00393-y pmc: PMC5575038
Nat Commun 8 (1) 374 [2017-08-29; online 2017-08-29]
Advanced FISH Technologies [Collaborative]
Clonal Evolution of Autoreactive Germinal Centers.
Degn SE, van der Poel CE, Firl DJ, ..., Victora GD, Carroll MC
pii: S0092-8674(17)30833-4
Cell 170 (5) 913-926.e19 [2017-08-24; online 2017-08-26]
Autoimmunity and Serology Profiling [Service]
Quantitative proteomic characterization of lung-MSC and bone marrow-MSC using DIA-mass spectrometry.
Rolandsson Enes S, Åhrman E, Palani A, ..., Malmström J, Westergren-Thorsson G
pii: 10.1038/s41598-017-09127-y pmc: PMC5570998
Sci Rep 7 (1) 9316 [2017-08-24; online 2017-08-24]
Targeted and Structural Proteomics [Service]
SF3B1-initiating mutations in MDS-RSs target lymphomyeloid hematopoietic stem cells
Mortera-Blanco T, Dimitriou M, Woll PS, ..., Jacobsen SEW, Hellström-Lindberg E
Blood 130 (7) 881-890 [2017-08-17; online 2017-06-20]
Clinical Genomics Uppsala [Service]
Mucin-Inspired Lubrication on Hydrophobic Surfaces
Käsdorf BT, Weber F, Petrou G, ..., Crouzier T, Lieleg O
Biomacromolecules 18 (8) 2454-2462 [2017-08-14; online 2017-07-03]
Protein Science Facility (PSF) [Service]
Use of Proteomics To Investigate Kidney Function Decline over 5 Years.
Carlsson AC, Ingelsson E, Sundström J, ..., Lind L, Ärnlöv J
pii: CJN.08780816 pmc: PMC5544512
Clin J Am Soc Nephrol 12 (8) 1226-1235 [2017-08-07; online 2017-07-21]
Clinical Biomarkers [Service]
The structure of the tetanus toxin reveals pH‐mediated domain dynamics
Masuyer G, Conrad J, Stenmark P
PDB: 5n0b PDB: 5n0c EMD: EMD‐3588
EMBO Rep. 18 (8) 1306-1317 [2017-08-00; online 2017-06-23]
Cryo-EM [Service]
Objective automated quantification of fluorescence signal in histological sections of rat lens
Talebizadeh N, Hagström NZ, Yu Z, ..., Söderberg P, Wählby C
Cytometry 91 (8) 815-821 [2017-08-00; online 2017-05-11]
BioImage Informatics [Collaborative]
Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase
Deville C, Carroni M, Franke KB, ..., Mogk A, Saibil HR
Sci Adv 3 (8) e1701726 [2017-08-00; online 2017-08-04]
Cryo-EM [Service]
Switchable ionic liquids enable efficient nanofibrillation of wood pulp
Berglund L, Anugwom I, Hedenström M, ..., Mikkola JP, Oksman K
Cellulose 24 (8) 3265-3279 [2017-08-00; online 2017-06-06]
Swedish NMR Centre (SNC) [Collaborative]
Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp. teitensis
Deyou T, Marco M, Heydenreich M, ..., Yenesew A, Erdélyi M
J. Nat. Prod. 80 (7) 2060-2066 [2017-07-28; online 2017-06-30]
Swedish NMR Centre (SNC) [Service]
Solution NMR structure of the TRIM21 B-box2 and identification of residues involved in its interaction with the RING domain
Wallenhammar A, Anandapadamanaban M, Lemak A, ..., Wallner B, Sunnerhagen M
PDB: 5JPX Biological Magnetic Resonance Data Bank: 30075
PLoS ONE 12 (7) e0181551 [2017-07-28; online 2017-07-28]
Swedish NMR Centre (SNC) [Service]
Continuous immunotypes describe human immune variation and predict diverse responses.
Kaczorowski KJ, Shekhar K, Nkulikiyimfura D, ..., Chakraborty AK, Brodin P
pii: 1705065114 pmc: PMC5544312
Proc. Natl. Acad. Sci. U.S.A. 114 (30) E6097-E6106 [2017-07-25; online 2017-07-10]
Mass Cytometry [Collaborative]
Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla.
Furlan A, Dyachuk V, Kastriti ME, ..., Ernfors P, Adameyko I
pii: 357/6346/eaal3753
Science 357 (6346) - [2017-07-07; online 2017-07-08]
Eukaryotic Single Cell Genomics (ESCG) [Service]
Paternal personality and social status influence offspring activity in zebrafish.
Zajitschek S, Herbert-Read JE, Abbasi NM, Zajitschek F, Immler S
pii: 10.1186/s12862-017-1005-0 pmc: PMC5496241
BMC Evol. Biol. 17 (1) 157 [2017-07-03; online 2017-07-03]
Genome Engineering Zebrafish [Service]
Epitope mapping of a new anti-Tn antibody detecting gastric cancer cells.
Persson N, Stuhr-Hansen N, Risinger C, ..., Jansson B, Blixt O
pii: 3611453
Glycobiology 27 (7) 635-645 [2017-07-01; online 2017-04-19]
Targeted and Structural Proteomics [Service]
Stability of Proteins in Dried Blood Spot Biobanks
Björkesten J, Enroth S, Shen Q, ..., Kamali-Moghaddam M, Landegren U
Mol Cell Proteomics 16 (7) 1286-1296 [2017-07-00; online 2017-05-13]
PLA and Single Cell Proteomics [Technology development]
Halogen Bonding: A Powerful Tool for Modulation of Peptide Conformation
Danelius E, Andersson H, Jarvoll P, ..., Gräfenstein J, Erdélyi M
Biochemistry 56 (25) 3265-3272 [2017-06-27; online 2017-06-12]
Swedish NMR Centre (SNC) [Service]
Structural basis for ligand binding to an enzyme by a conformational selection pathway
Kovermann M, Grundström C, Sauer-Eriksson AE, Sauer UH, Wolf-Watz M
Proc Natl Acad Sci USA 114 (24) 6298-6303 [2017-06-13; online 2017-05-30]
Swedish NMR Centre (SNC) [Service]
Effect of food intake on 92 biomarkers for cardiovascular disease
Dencker M, Gårdinger Y, Björgell O, Hlebowicz J
PLoS ONE 12 (6) e0178656 [2017-06-06; online 2017-06-06]
Clinical Biomarkers [Service]
Typing and Characterization of Bacteria Using Bottom-up Tandem Mass Spectrometry Proteomics.
Boulund F, Karlsson R, Gonzales-Siles L, ..., Moore ERB, Kristiansson E
pii: M116.061721 pmc: PMC5461537
Mol. Cell Proteomics 16 (6) 1052-1063 [2017-06-00; online 2017-04-18]
Glycoproteomics [Service]
Downregulation of RWA genes in hybrid aspen affects xylan acetylation and wood saccharification
Pawar PMA, Ratke C, Balasubramanian VK, ..., Jönsson LJ, Mellerowicz EJ
New Phytol 214 (4) 1491-1505 [2017-06-00; online 2017-03-03]
Swedish NMR Centre (SNC) [Collaborative]
Tumoral cubilin is a predictive marker for treatment of renal cancer patients with sunitinib and sorafenib.
Niinivirta M, Enblad G, Edqvist PH, ..., Dragomir A, Ullenhag GJ
pii: 10.1007/s00432-017-2365-y pmc: PMC5427164
J. Cancer Res. Clin. Oncol. 143 (6) 961-970 [2017-06-00; online 2017-03-04]
Tissue Profiling [Collaborative]
Expression of CD226 is associated to but not required for NK cell education.
Wagner AK, Kadri N, Snäll J, ..., Kärre K, Chambers BJ
pii: ncomms15627 pmc: PMC5460037
Nat Commun 8 (-) 15627 [2017-05-31; online 2017-05-31]
Mass Cytometry [Technology development]
Expression proteomics study to determine metallodrug targets and optimal drug combinations.
Lee RFS, Chernobrovkin A, Rutishauser D, ..., Zubarev RA, Dyson PJ
pii: 10.1038/s41598-017-01643-1 pmc: PMC5431558
Sci Rep 7 (1) 1590 [2017-05-08; online 2017-05-08]
Chemical Proteomics [Collaborative]
Impact of cytosine methylation on DNA binding specificities of human transcription factors
Yin Y, Morgunova E, Jolma A, ..., Vinson C, Taipale J
Science 356 (6337) eaaj2239 [2017-05-05; online 2017-05-04]
Protein Science Facility (PSF) [Service]
Regulating plant physiology with organic electronics
Poxson DJ, Karady M, Gabrielsson R, ..., Simon DT, Berggren M
Proc Natl Acad Sci USA 114 (18) 4597-4602 [2017-05-02; online 2017-04-18]
Swedish Metabolomics Centre (SMC) [Service]
Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin.
Jiang Y, Marinescu VD, Xie Y, ..., Nelander S, Uhrbom L
pii: S2211-1247(17)30564-8
Cell Rep 19 (5) 1080-1081 [2017-05-02; online 2017-05-04]
Drug Discovery and Development (DDD) [Service]
Structural Diversity of Human Gastric Mucin Glycans.
Jin C, Kenny DT, Skoog EC, ..., Lindén SK, Karlsson NG
pii: 16/5/743 pmc: PMC5417818
Mol. Cell Proteomics 16 (5) 743-758 [2017-05-00; online 2017-05-04]
Glycoproteomics [Service] PLA and Single Cell Proteomics [Service]
FADD, Caspase-3, and Caspase-8 and Incidence of Coronary Events.
Xue L, Borné Y, Mattisson IY, ..., Nilsson J, Engström G
pii: ATVBAHA.117.308995
Arterioscler. Thromb. Vasc. Biol. 37 (5) 983-989 [2017-05-00; online 2017-03-16]
Clinical Biomarkers [Service]
Brodie vs Hummers graphite oxides for preparation of multi-layered materials
Talyzin AV, Mercier G, Klechikov A, ..., Opitz A, Moons E
Carbon 115 (-) 430-440 [2017-05-00; online 2017-05-00]
Swedish NMR Centre (SNC) [Collaborative]
Genetic Profile of Ductal Adenocarcinoma of the Prostate.
Seipel AH, Whitington T, Delahunt B, ..., Lindberg J, Egevad L
pii: S0046-8177(17)30133-8
Hum. Pathol. - (-) - [2017-04-27; online 2017-04-27]
Clinical Genomics Stockholm [Service]
Correlation of histopathologic characteristics to protein expression and function in malignant melanoma.
Welinder C, Pawłowski K, Szasz AM, ..., Wieslander E, Marko-Varga G
pii: PONE-D-16-43238 pmc: PMC5405986
PLoS ONE 12 (4) e0176167 [2017-04-26; online 2017-04-26]
Targeted and Structural Proteomics [Service]
Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Gad H, Koolmeister T, Jemth AS, ..., Scobie M, Ulrika Warpman Berglund &Thomas Helleday
pii: nature22083
Nature 544 (7651) 508 [2017-04-26; online 2017-04-28]
Drug Discovery and Development (DDD) [Service]
dUTPase inhibition augments replication defects of 5-Fluorouracil.
Hagenkort A, Paulin CBJ, Desroses M, ..., Scobie M, Helleday T
pii: 15785 pmc: PMC5410339
Oncotarget 8 (14) 23713-23726 [2017-04-04; online 2017-04-21]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
Sulfonimidamides in Medicinal and Agricultural Chemistry
Chinthakindi PK, Naicker T, Thota N, ..., Kruger HG, Arvidsson PI
Angew. Chem. Int. Ed. 56 (15) 4100-4109 [2017-04-03; online 2017-02-23]
Drug Discovery and Development (DDD) [Technology development]
Lipid response patterns in acute phase paediatric Plasmodium falciparum malaria
Orikiiriza J, Surowiec I, Lindquist E, ..., Trygg J, Normark J
Metabolomics 13 (4) - [2017-04-00; online 2017-02-23]
Swedish Metabolomics Centre (SMC) [Service]
Combined immunodeficiency and hypoglycemia associated with mutations in hypoxia upregulated 1.
Haapaniemi EM, Fogarty CL, Keskitalo S, ..., Seppänen M, Kere J
pii: S0091-6749(16)31375-6
J. Allergy Clin. Immunol. 139 (4) 1391-1393.e11 [2017-04-00; online 2016-12-04]
Bioinformatics Compute and Storage [Service]
HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures.
Davies H, Glodzik D, Morganella S, ..., Stratton MR, Nik-Zainal S
pii: nm.4292
Nat. Med. 23 (4) 517-525 [2017-04-00; online 2017-03-13]
Clinical Genomics Lund [Collaborative]
Light-sensing via hydrogen peroxide and a peroxiredoxin
Bodvard K, Peeters K, Roger F, ..., Käll M, Molin M
Nat Commun 8 (1) - [2017-04-00; online 2017-03-24]
Centre for Cellular Imaging [Service]
FZD10-Gα13 signalling axis points to a role of FZD10 in CNS angiogenesis.
Hot B, Valnohova J, Arthofer E, ..., Mulder J, Schulte G
pii: S0898-6568(17)30029-3
Cell. Signal. 32 (-) 93-103 [2017-04-00; online 2017-01-24]
Fluorescence Tissue Profiling [Collaborative]
Microbial community assembly and evolution in subseafloor sediment
Starnawski P, Bataillon T, Ettema TJG, ..., Schramm A, Kjeldsen KU
BioProject: PRJNA308429 BioProject: PRJNA305566
Proc Natl Acad Sci USA 114 (11) 2940-2945 [2017-03-14; online 2017-02-27]
Bioinformatics Compute and Storage [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]
Discovery of circulating proteins associated to knee radiographic osteoarthritis.
Lourido L, Ayoglu B, Fernández-Tajes J, ..., Nilsson P, Blanco FJ
pii: 10.1038/s41598-017-00195-8 pmc: PMC5427840
Sci Rep 7 (1) 137 [2017-03-09; online 2017-03-09]
Translational Plasma Profiling [Collaborative]
Life-Saving Degeneracy in the Human Immune System.
Brodin P
pii: S1931-3128(17)30080-X
Cell Host Microbe 21 (3) 309-310 [2017-03-08; online 2017-03-11]
Mass Cytometry [Collaborative]
Development of [(11)C]/[(3)H]THK-5351 - A potential novel carbon-11 tau imaging PET radioligand.
Stepanov V, Svedberg M, Jia Z, ..., Nordberg A, Halldin C
pii: S0969-8051(16)30381-X
Nucl. Med. Biol. 46 (-) 50-53 [2017-03-00; online 2016-12-26]
Fluorescence Tissue Profiling [Collaborative]
Discovery of new biomarkers for atrial fibrillation using a custom-made proteomics chip.
Lind L, Sundström J, Stenemo M, Hagström E, Ärnlöv J
pii: heartjnl-2016-309764
Heart 103 (5) 377-382 [2017-03-00; online 2016-09-10]
Clinical Biomarkers [Service]
Genomic Variation in IbA10G2 and Other Patient-Derived Cryptosporidium hominis Subtypes
Sikora P, Andersson S, Winiecka-Krusnell J, ..., Beser J, Arrighi RBG
J. Clin. Microbiol. 55 (3) 844-858 [2017-03-00; online 2016-12-21]
Clinical Genomics Gothenburg [Collaborative]
Use of a proximity extension assay proteomics chip to discover new biomarkers associated with albuminuria.
Carlsson AC, Sundström J, Carrero JJ, ..., Lind L, Ärnlöv J
pii: 2047487316676134
Eur J Prev Cardiol 24 (4) 340-348 [2017-03-00; online 2016-10-28]
Clinical Biomarkers [Service]
Signs of ongoing inflammation in female patients with chronic widespread pain
Gerdle B, Ghafouri B, Ghafouri N, Bäckryd E, Gordh T
Medicine 96 (9) e6130 [2017-03-00; online 2017-03-00]
Clinical Biomarkers [Service]
Stool frequency is associated with gut microbiota composition.
Hadizadeh F, Walter S, Belheouane M, ..., Franke A, D'Amato M
pii: gutjnl-2016-311935
Gut 66 (3) 559-560 [2017-03-00; online 2016-05-20]
Clinical Genomics Stockholm [Collaborative]
Flavonoids fromErythrina schliebenii
Nyandoro SS, Munissi JJE, Kombo M, ..., Rissanen K, Erdélyi M
J. Nat. Prod. 80 (2) 377-383 [2017-02-24; online 2017-01-23]
Swedish NMR Centre (SNC) [Service]
Three Chalconoids and a Pterocarpene from the Roots of Tephrosia aequilata
Atilaw Y, Duffy S, Heydenreich M, ..., Erdélyi M, Yenesew A
Molecules 22 (2) 318 [2017-02-20; online 2017-02-20]
Swedish NMR Centre (SNC) [Service]
Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor.
Gustafsson R, Jemth A, Gustafsson NMS, ..., Helleday T, Stenmark P
pii: 0008-5472.CAN-16-1476
Cancer Res. 77 (4) 937-948 [2017-02-15; online 2016-12-03]
Drug Discovery and Development (DDD) [Collaborative]
Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes.
Romanov RA, Zeisel A, Bakker J, ..., Horvath TL, Harkany T
pii: nn.4462
Nat. Neurosci. 20 (2) 176-188 [2017-02-00; online 2016-12-20]
Fluorescence Tissue Profiling [Collaborative]
Associations of defect mismatch repair genes with prognosis and heredity in sporadic colorectal cancer.
Ghanipour L, Jirström K, Sundström M, Glimelius B, Birgisson H
pii: S0748-7983(16)30951-9
Eur J Surg Oncol 43 (2) 311-321 [2017-02-00; online 2016-11-12]
Tissue Profiling [Service]
Complement peptide C3a stimulates neural plasticity after experimental brain ischaemia
Stokowska A, Atkins AL, Morán J, ..., Dragunow M, Pekna M
Brain 140 (2) 353-369 [2017-02-00; online 2016-12-12]
Centre for Cellular Imaging [Service]
Opioid precursor protein isoform is targeted to the cell nuclei in the human brain.
Kononenko O, Bazov I, Watanabe H, ..., Yakovleva T, Bakalkin G
pii: S0304-4165(16)30405-6 pmc: PMC5323248 mid: NIHMS847462
Biochim. Biophys. Acta 1861 (2) 246-255 [2017-02-00; online 2016-11-14]
Fluorescence Tissue Profiling [Collaborative]
Endocytic turnover of Rab8 controls cell polarization
Vidal-Quadras M, Holst MR, Francis MK, ..., Martín-Belmonte F, Lundmark R
J Cell Sci - (-) jcs.195420 [2017-01-30; online 2017-01-30]
Centre for Cellular Imaging [Service]
Polyoxygenated Cyclohexenes and Other Constituents of Cleistochlamys kirkii Leaves
Nyandoro SS, Munissi JJE, Gruhonjic A, ..., Rissanen K, Erdélyi M
J. Nat. Prod. 80 (1) 114-125 [2017-01-27; online 2016-12-21]
Swedish NMR Centre (SNC) [Service]
Perivascular PDGFR-β is an independent marker for prognosis in renal cell carcinoma.
Frödin M, Mezheyeuski A, Corvigno S, ..., Johansson M, Östman A
pii: bjc2016407 pmc: PMC5243993
Br. J. Cancer 116 (2) 195-201 [2017-01-17; online 2016-12-09]
Tissue Profiling [Service]
Proteomic analysis of enterotoxigenic Escherichia coli (ETEC) in neutral and alkaline conditions.
Gonzales-Siles L, Karlsson R, Kenny D, Karlsson A, Sjöling Å
pii: 10.1186/s12866-016-0914-1 pmc: PMC5219706
BMC Microbiol. 17 (1) 11 [2017-01-07; online 2017-01-07]
Glycoproteomics [Service]
Proteomic analyses of limbic regions in neonatal male, female and androgen receptor knockout mice.
Zettergren A, Karlsson S, Studer E, ..., Sihlbom C, Westberg L
pii: 10.1186/s12868-016-0332-1 pmc: PMC5217640
BMC Neurosci 18 (1) 9 [2017-01-05; online 2017-01-05]
Glycoproteomics [Service]
A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma.
Gremel G, Djureinovic D, Niinivirta M, ..., Stewart GD, Pontén F
pii: 10.1186/s12885-016-3030-6 pmc: PMC5215231
BMC Cancer 17 (1) 9 [2017-01-04; online 2017-01-04]
Tissue Profiling [Technology development]
Small Molecule Microarray Based Discovery of PARP14 Inhibitors
Peng B, Thorsell AG, Karlberg T, Schüler H, Yao SQ
Angew. Chem. Int. Ed. 56 (1) 248-253 [2017-01-02; online 2016-12-05]
Protein Science Facility (PSF) [Service]
SHADE AVOIDANCE 4 Is Required for Proper Auxin Distribution in the Hypocotyl
Ge Y, Yan F, Zourelidou M, ..., Schwechheimer C, Tao Y
Plant Physiol. 173 (1) 788-800 [2017-01-00; online 2016-11-21]
Swedish Metabolomics Centre (SMC) [Service]
Identification of two distinct mesenchymal stromal cell populations in human malignant glioma.
Svensson A, Ramos-Moreno T, Eberstål S, Scheding S, Bengzon J
pii: 10.1007/s11060-016-2302-y pmc: PMC5306185
J. Neurooncol. 131 (2) 245-254 [2017-01-00; online 2016-10-18]
Clinical Genomics Lund [Service]
Synthesis of phenanthridine spiropyrans and studies of their effects on G-quadruplex DNA
Livendahl M, Jamroskovic J, Hedenström M, ..., Sabouri N, Chorell E
Org. Biomol. Chem. 15 (15) 3265-3275 [2017-00-00; online 2017-00-00]
Swedish NMR Centre (SNC) [Collaborative]
Novel spirocyclic systems via multicomponent aza-Diels–Alder reaction
Llona-Minguez S, Throup A, Steiner E, ..., Jenmalm-Jensen A, Helleday T
Org. Biomol. Chem. 15 (37) 7758-7764 [2017-00-00; online 2017-00-00]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
Decoding Gene Expression in 2D and 3D
Bombrun M, Ranefall P, Lindblad J, ..., Nilsson M, Wählby C
Scandinavian Conference on Image Analysis 2017 - (-) 257-268 [2017-00-00; online 2017-05-19]
BioImage Informatics [Collaborative]
Achieving enhanced ionic mobility in nanoporous silica by controlled surface interactions
Garaga MN, Aguilera L, Yaghini N, ..., Persson M, Martinelli A
Phys. Chem. Chem. Phys. 19 (8) 5727-5736 [2017-00-00; online 2017-00-00]
Swedish NMR Centre (SNC) [Service]
Favored surface-limited oxidation of cellulose with Oxone® in water
Ruan CQ, Strømme M, Mihranyan A, Lindh J
RSC Adv. 7 (64) 40600-40607 [2017-00-00; online 2017-00-00]
Swedish NMR Centre (SNC) [Service]