Publications 2018

A major locus controls local adaptation and adaptive life history variation in a perennial plant

Wang J, Ding J, ..., Street NR, Ingvarsson PK

Genome Biol. 19 (1) - [2018-12-00; online 2018-06-04]

Bioinformatics Long-term Support WABI [Collaborative]

Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow

Zhu Y, Orre LM, ..., Branca RMM, Lehtiö J

Nat Commun 9 (1) - [2018-12-00; online 2018-03-02]

Bioinformatics Long-term Support WABI [Collaborative]

Comparative omics and feeding manipulations in chicken indicate a shift of the endocrine role of visceral fat towards reproduction

Bornelöv S, Seroussi E, ..., Andersson L, Friedman-Einat M

BMC Genomics 19 (1) - [2018-12-00; online 2018-04-26]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Somatic mutagenesis in satellite cells associates with human skeletal muscle aging

Franco I, Johansson A, ..., Fischer H, Eriksson M

Nat Commun 9 (1) - [2018-12-00; online 2018-02-23]

Bioinformatics Long-term Support WABI [Collaborative]

Extracellular nanovesicles released from the commensal yeast Malassezia sympodialis are enriched in allergens and interact with cells in human skin

Johansson HJ, Vallhov H, ..., Lehtiö J, Scheynius A

Sci Rep 8 (1) - [2018-12-00; online 2018-06-15]

Cryo-EM [Service]

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds MJGW, van Leeuwen IMM, ..., McCormack E, Laín S

Nat Commun 9 (1) - [2018-12-00; online 2018-03-16]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

Effects of predation stress and food ration on perch gut microbiota

Zha Y, Eiler A, Johansson F, Svanbäck R

Microbiome 6 (1) - [2018-12-00; online 2018-02-06]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

RNA-sequencing reveals long-term effects of silver nanoparticles on human lung cells

Gliga AR, Di Bucchianico S, ..., Fadeel B, Karlsson HL

Sci Rep 8 (1) - [2018-12-00; online 2018-04-27]

Bioinformatics Support and Infrastructure [Collaborative]

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

Page BDG, Valerie NCK, ..., Beato M, Helleday T

Nat Commun 9 (1) - [2018-12-00; online 2018-01-17]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]

Extracellular nanovesicles released from the commensal yeast Malassezia sympodialis are enriched in allergens and interact with cells in human skin

Johansson HJ, Vallhov H, ..., Lehtiö J, Scheynius A

Sci Rep 8 (1) - [2018-12-00; online 2018-06-15]

A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons

Södersten E, Toskas K, ..., Perlmann T, Holmberg J

Nat Commun 9 (1) - [2018-12-00; online 2018-03-26]

Bioinformatics Long-term Support WABI [Collaborative]

Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

Kundu S, Ali MA, ..., Hellström M, Sjöblom T

Genome Med 10 (1) - [2018-12-00; online 2018-01-04]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

Feitosa MF, Kraja AT, ..., Province MA, Levy D

PLoS ONE 13 (6) e0198166 [2018-06-18; online 2018-06-18]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

Haapaniemi E, Botla S, ..., Schmierer B, Taipale J

Nat Med - (-) - [2018-06-11; online 2018-06-11]

Topology of membrane proteins — predictions, limitations and variations

Tsirigos KD, Govindarajan S, ..., Shu N, Elofsson A

Current Opinion in Structural Biology 50 (-) 9-17 [2018-06-00; online 2018-06-00]

Bioinformatics Support and Infrastructure [Collaborative]

Equilibrative nucleoside transporter 1 gene polymorphisms and clinical outcomes following acute coronary syndromes: findings from the PLATelet inhibition and patient Outcomes (PLATO) study.

Parker WAE, Eriksson N, ..., Storey RF, PLATO Investigators

Platelets - (-) 1-10 [2018-05-31; online 2018-05-31]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Common genetic variation in the autoimmune regulator (AIRE) locus is associated with autoimmune Addison's disease in Sweden.

Eriksson D, Bianchi M, ..., Rosengren Pielberg G, Kämpe O

Sci Rep 8 (1) 8395 [2018-05-30; online 2018-05-30]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

Davies G, Lam M, ..., Lencz T, Deary IJ

Nat Commun 9 (1) 2098 [2018-05-29; online 2018-05-29]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia.

Chen X, Gustafsson S, ..., Frostegård J, Magnusson PKE

Hum. Mol. Genet. 27 (10) 1809-1818 [2018-05-15; online 2018-03-17]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants.

Zhou A, Taylor AE, ..., Llewellyn DJ, Hyppönen E

Sci Rep 8 (1) 7526 [2018-05-14; online 2018-05-14]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Sarek: A portable workflow for whole-genome sequencing analysis of germline and somatic variants

Garcia M, Juhos S, ..., Nystedt B, Käller M

- - (-) - [2018-05-09; online 2018-05-09]

Bioinformatics Long-term Support WABI [Technology development]

Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids: Results from the CHARGE Consortium.

de Oliveira Otto MC, Lemaitre RN, ..., Siscovick DS, Mozaffarian D

PLoS ONE 13 (5) e0196951 [2018-05-08; online 2018-05-08]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.

Wray NR, Ripke S, ..., Sullivan PF, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

Nat. Genet. 50 (5) 668-681 [2018-05-00; online 2018-04-26]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Mitochondrial Translation Efficiency Controls Cytoplasmic Protein Homeostasis

Suhm T, Kaimal JM, ..., Andréasson C, Ott M

Cell Metabolism - (-) - [2018-05-00; online 2018-05-00]

Bioinformatics Support and Infrastructure [Collaborative]

Transcription profiling of peripheral B cells in antibody-positive primary Sjögren's syndrome reveals upregulated expression of CX3CR1 and a type I and type II interferon signature

Imgenberg-Kreuz J, Sandling JK, ..., Syvänen AC, Nordmark G

Scand J Immunol 87 (5) e12662 [2018-05-00; online 2018-04-18]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus.

Imgenberg-Kreuz J, Carlsson Almlöf J, ..., Syvänen AC, Sandling JK

Ann. Rheum. Dis. 77 (5) 736-743 [2018-05-00; online 2018-02-01]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Quantification of endogenous and exogenous protein expressions of Na,K-ATPase with super-resolution PALM/STORM imaging

Bernhem K, Blom H, Brismar H

PLoS ONE 13 (4) e0195825 [2018-04-25; online 2018-04-25]

Advanced Light Microscopy (ALM) [Technology development]

Experimental validation of predicted cancer genes using FRET

Guala D, Bernhem K, ..., Brismar H, Sonnhammer ELL

Methods Appl. Fluoresc. 6 (3) 035007 [2018-04-25; online 2018-04-25]

Eleven loci with new reproducible genetic associations with allergic disease risk.

Ferreira MAR, Vonk JM, ..., Koppelman GH, Paternoster L

J. Allergy Clin. Immunol. - (-) - [2018-04-19; online 2018-04-19]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

A GWAS meta-analysis from 5 population-based cohorts implicates ion channel genes in the pathogenesis of irritable bowel syndrome.

Bonfiglio F, Henström M, ..., Zhernakova A, D'Amato M

Neurogastroenterol. Motil. - (-) e13358 [2018-04-19; online 2018-04-19]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Data quality of whole genome bisulfite sequencing on Illumina platforms.

Raine A, Liljedahl U, Nordlund J

PLoS ONE 13 (4) e0195972 [2018-04-18; online 2018-04-18]

NGI Uppsala (SNP&SEQ Technology Platform) [Technology development]

Genetic and Environmental Contributions to the Covariation Between Cardiometabolic Traits.

Chen X, Kuja-Halkola R, ..., Pedersen NL, Magnusson PKE

J Am Heart Assoc 7 (9) - [2018-04-18; online 2018-04-18]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Bioinformatics Support and Infrastructure [Service]

Ezerskyte M, Paredes JA, ..., Scicchitano DA, Dreij K

Proc. Natl. Acad. Sci. U.S.A. - (-) - [2018-04-17; online 2018-04-17]

Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima.

Morgunova E, Yin Y, ..., Nilsson L, Taipale J

Elife 7 (-) - [2018-04-11; online 2018-04-11]

Active and inactive β1 integrins segregate into distinct nanoclusters in focal adhesions

Spiess M, Hernandez-Varas P, ..., Lakadamyali M, Strömblad S

J. Cell Biol. - (-) jcb.201707075 [2018-04-09; online 2018-04-09]

Female-specific Association Between Variants on Chromosome 9 and Self-reported Diagnosis of Irritable Bowel Syndrome.

Bonfiglio F, Zheng T, ..., Zhernakova A, D'Amato M

Gastroenterology - (-) - [2018-04-04; online 2018-04-04]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Structure of the chloroplast ribosome with chl-RRF and hibernation-promoting factor

Boerema AP, Aibara S, ..., Lindahl E, Amunts A

NPLANTS 4 (4) 212-217 [2018-04-00; online 2018-04-02]

Cryo-EM [Service]

Identification of Poly(ADP-Ribose) Polymerase Macrodomain Inhibitors Using an AlphaScreen Protocol

Ekblad T, Verheugd P, ..., Elofsson M, Schüler H

SLAS DISCOVERY: Advancing Life Sciences R&D 23 (4) 353-362 [2018-04-00; online 2018-01-09]

Chemical Biology Consortium Sweden (CBCS) [Service] Protein Science Facility (PSF) [Collaborative]

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Malik R, Chauhan G, ..., MEGASTROKE Consortium , MEGASTROKE Consortium:

Nat. Genet. 50 (4) 524-537 [2018-04-00; online 2018-03-12]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Changes in methylation within the STK32B promoter are associated with an increased risk for generalized anxiety disorder in adolescents.

Ciuculete DM, Boström AE, ..., Mwinyi J, Schiöth HB

J Psychiatr Res 102 (-) 44-51 [2018-03-26; online 2018-03-26]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Protein Expression in Tonsillar and Base of Tongue Cancer and in Relation to Human Papillomavirus (HPV) and Clinical Outcome

Ramqvist T, Näsman A, ..., Dalianis T, Munck-Wikland E

Int J Mol Sci 19 (4) 978 [2018-03-25; online 2018-03-25]

Bioinformatics Support and Infrastructure [Collaborative]

A Meta-Analysis of Genome-Wide Association Studies of Growth Differentiation Factor-15 Concentration in Blood.

Jiang J, Thalamuthu A, ..., Sachdev PS, Mather KA

Front Genet 9 (-) 97 [2018-03-23; online 2018-03-23]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Recurrent, low-frequency coding variants contributing to colorectal cancer in the Swedish population.

Jiao X, Liu W, ..., Dunlop M, Lindblom A

PLoS ONE 13 (3) e0193547 [2018-03-16; online 2018-03-16]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Increased thermal stability of nanocellulose composites by functionalization of the sulfate groups on cellulose nanocrystals with azetidinium ions

Börjesson M, Sahlin K, Bernin D, Westman G

J. Appl. Polym. Sci. 135 (10) 45963 [2018-03-10; online 2017-11-08]

Swedish NMR Centre (SNC) [Service]

Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals.

Coleman JRI, Bryois J, ..., Posthuma D, Breen G

Mol. Psychiatry - (-) - [2018-03-08; online 2018-03-08]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis.

Leonard D, Svenungsson E, ..., Criswell LA, Rönnblom L

Ann. Rheum. Dis. - (-) - [2018-03-07; online 2018-03-07]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

The Immunogenicity of a Proline-Substituted Altered Peptide Ligand toward the Cancer-Associated TEIPP Neoepitope Trh4 Is Unrelated to Complex Stability.

Hafstrand I, Doorduijn EM, ..., van Hall T, Achour A

J. Immunol. - (-) - [2018-03-05; online 2018-03-05]

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.

Sung YJ, Winkler TW, ..., Rao DC, Chasman DI

Am. J. Hum. Genet. 102 (3) 375-400 [2018-03-01; online 2018-02-15]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Genetic variants influencing phenotypic variance heterogeneity.

Ek WE, Rask-Andersen M, ..., Gyllensten U, Johansson Å

Hum. Mol. Genet. 27 (5) 799-810 [2018-03-01; online 2018-01-13]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Sexual dimorphism in the width of the mouse synaptonemal complex

Agostinho A, Kouznetsova A, ..., Brismar H, Höög C

J Cell Sci 131 (5) jcs212548 [2018-03-01; online 2018-02-02]

The fungus that came in from the cold: dry rot’s pre-adapted ability to invade buildings

Balasundaram SV, Hess J, ..., Eastwood DC, Skrede I

ISME J 12 (3) 791-801 [2018-03-00; online 2018-01-05]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Functional metagenomics reveals a novel carbapenem-hydrolyzing mobile beta-lactamase from Indian river sediments contaminated with antibiotic production waste

Marathe NP, Janzon A, ..., Kristiansson E, Larsson DGJ

Environment International 112 (-) 279-286 [2018-03-00; online 2018-03-00]

Cleaner fish escape salmon farms and hybridize with local wrasse populations

Faust E, Halvorsen KT, ..., Knutsen H, André C

R. Soc. open sci. 5 (3) 171752 [2018-03-00; online 2018-03-21]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

The ZBED6–IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals

Younis S, Schönke M, ..., Zierath JR, Andersson L

Proc Natl Acad Sci USA 115 (9) E2048-E2057 [2018-02-27; online 2018-02-12]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

The

Hagberg N, Joelsson M, ..., Bryceson YT, Rönnblom L

Ann. Rheum. Dis. - (-) - [2018-02-23; online 2018-02-23]

Targeted Long-Read Sequencing of a Locus Under Long-Term Balancing Selection in Capsella

Bachmann JA, Tedder A, ..., Steige KA, Slotte T

G3 (Bethesda) - (-) g3.300467.2017 [2018-02-23; online 2018-02-23]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

In Situ Target Engagement Studies in Adherent Cells

Axelsson H, Almqvist H, ..., Lundbäck T, Seashore-Ludlow B

ACS Chem. Biol. - (-) - [2018-02-21; online 2018-02-21]

Chemical Biology Consortium Sweden (CBCS) [Technology development]

Two novel colorectal cancer risk loci in the region on chromosome 9q22.32

Thutkawkorapin J, Mahdessian H, ..., Jiao X, Lindblom A

Oncotarget 9 (13) - [2018-02-16; online 2018-01-30]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.

Stafford WC, Peng X, ..., Linder S, Arnér ESJ

Sci Transl Med 10 (428) - [2018-02-14; online 2018-02-16]

Educated natural killer cells show dynamic movement of the activating receptor NKp46 and confinement of the inhibitory receptor Ly49A

Staaf E, Hedde PN, ..., Gratton E, Johansson S

Sci. Signal. 11 (517) eaai9200 [2018-02-13; online 2018-02-13]

Advanced Light Microscopy (ALM) [Service]

Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation.

Agudelo LZ, Ferreira DMS, ..., Berggren P, Ruas JL

Cell Metab. 27 (2) 378-392.e5 [2018-02-06; online 2018-02-08]

Mass Cytometry [Collaborative]

Ten steps to get started in Genome Assembly and Annotation

Dominguez Del Angel V, Hjerde E, ..., Binzer-Panchal M, Lantz H

F1000Res 7 (-) 148 [2018-02-05; online 2018-02-05]

NGI Uppsala (Uppsala Genome Center) [Collaborative]

Single molecule real-time (SMRT) sequencing comes of age: applications and utilities for medical diagnostics

Ardui S, Ameur A, Vermeesch JR, Hestand MS

Nucleic Acids Res - (-) - [2018-02-01; online 2018-02-01]

NGI Uppsala (Uppsala Genome Center) [Collaborative]

Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration

Pettersson-Klein AT, Izadi M, ..., Griffin PR, Ruas JL

Mol Metab - (-) - [2018-02-00; online 2018-02-00]

Drug Discovery and Development (DDD) [Service]

Copy Number Variation Analysis of 100 Twin Pairs Enriched for Neurodevelopmental Disorders.

Stamouli S, Anderlid BM, ..., Tammimies K, Bölte S

Twin Res Hum Genet 21 (1) 1-11 [2018-02-00; online 2018-01-08]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Life after tree death: Does restored dead wood host different fungal communities to natural woody substrates?

Pasanen H, Junninen K, ..., Stenlid J, Kouki J

Forest Ecology and Management 409 (-) 863-871 [2018-02-00; online 2018-02-00]

Red meat intake in chronic kidney disease patients: Two sides of the coin

Mafra D, Borges NA, ..., Lindholm B, Stenvinkel P

Nutrition 46 (-) 26-32 [2018-02-00; online 2018-02-00]

Swedish Metabolomics Centre (SMC) [Service]

Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold

Carter M, Jemth AS, ..., Helleday T, Stenmark P

Structure 26 (2) 295-303.e6 [2018-02-00; online 2018-02-00]

A DNA methylation biomarker of alcohol consumption.

Liu C, Marioni RE, ..., Ingelsson E, Levy D

Mol. Psychiatry 23 (2) 422-433 [2018-02-00; online 2016-11-15]

Bioinformatics Compute and Storage [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service]

T cells are influenced by a long non-coding RNA in the autoimmune associated PTPN2 locus

Houtman M, Shchetynsky K, ..., Malmström V, Padyukov L

Journal of Autoimmunity - (-) - [2018-02-00; online 2018-02-00]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Archaeal community changes in Lateglacial lake sediments: Evidence from ancient DNA

Ahmed E, Parducci L, ..., Slotte T, Wohlfarth B

Quaternary Science Reviews 181 (-) 19-29 [2018-02-00; online 2018-02-00]

Bioinformatics Long-term Support WABI [Collaborative]

Molecular barcoding of viral vectors enables mapping and optimization of mRNA trans-splicing

Davidsson M, Díaz-Fernández P, ..., Lundberg C, Bjorklund T

RNA - (-) rna.063925.117 [2018-01-31; online 2018-01-31]

A comprehensive model of DNA fragmentation for the preservation of High Molecular Weight DNA

Klingstrom T, Bongcam-Rudloff E, Vinnere Pettersson O

- - (-) - [2018-01-27; online 2018-01-27]

NGI Uppsala (Uppsala Genome Center) [Collaborative]

In Situ Analyses Directly in Diarrheal Stool Reveal Large Variations in Bacterial Load and Active Toxin Expression of Enterotoxigenic Escherichia coli and Vibrio cholerae

Begum YA, Rydberg HA, ..., Qadri F, Sjöling Å

mSphere 3 (1) e00517-17 [2018-01-24; online 2018-01-24]

Genetical genomics of growth in a chicken model.

Johnsson M, Henriksen R, ..., Jensen P, Wright D

BMC Genomics 19 (1) 72 [2018-01-23; online 2018-01-23]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.

Jiang X, O'Reilly PF, ..., Kraft P, Kiel DP

Nat Commun 9 (1) 260 [2018-01-17; online 2018-01-17]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Extensive genomic diversity among Mycobacterium marinum strains revealed by whole genome sequencing

Das S, Pettersson F, ..., Ennis DG, Kirsebom L

- - (-) - [2018-01-17; online 2018-01-17]

Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity

Narwal M, Jemth AS, ..., Helleday T, Stenmark P

Biochemistry - (-) - [2018-01-16; online 2018-01-16]

Complete genomic and transcriptional landscape analysis using third-generation sequencing: a case study of Saccharomyces cerevisiae CEN.PK113-7D

Jenjaroenpun P, Wongsurawat T, ..., Nielsen J, Nookaew I

Nucleic Acids Res - (-) - [2018-01-13; online 2018-01-13]

Rapid hybrid speciation in Darwin’s finches

Lamichhaney S, Han F, ..., Grant BR, Grant PR

Science 359 (6372) 224-228 [2018-01-12; online 2017-11-23]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Identification of shared genetic variants between schizophrenia and lung cancer.

Zuber V, Jönsson EG, ..., Mills IG, Andreassen OA

Sci Rep 8 (1) 674 [2018-01-12; online 2018-01-12]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Population genomics of Mesolithic Scandinavia: Investigating early postglacial migration routes and high-latitude adaptation

Günther T, Malmström H, ..., Götherström A, Jakobsson M

PLoS Biol. 16 (1) e2003703 [2018-01-09; online 2018-01-09]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

A protein interaction network centered on leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) regulates growth factor receptors

Faraz M, Herdenberg C, ..., Henriksson R, Hedman H

J. Biol. Chem. - (-) jbc.M117.807487 [2018-01-09; online 2018-01-09]

Bioinformatics Long-term Support WABI [Service]

Evaluating vacquinol-1 in rats carrying glioblastoma models RG2 and NS1

Ahlstedt J, Förnvik K, ..., Salford LG, Redebrandt HN

Oncotarget - (-) - [2018-01-03; online 2018-01-03]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

Cytokine Autoantibody Screening in the Swedish Addison Registry Identifies Patients With Undiagnosed APS1

Eriksson D, Dalin F, ..., Munoz KD, None

J Clin Endocrinol Metab 103 (1) 179-186 [2018-01-01; online 2017-10-20]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Minimizing inequality in access to precision medicine in breast cancer by real-time population-based molecular analysis in the SCAN-B initiative.

Rydén L, Loman N, ..., Saal LH, Borg Å

Br J Surg 105 (2) e158-e168 [2018-01-00; online 2018-01-18]

Clinical Genomics Lund [Collaborative]

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Turcot V, Lu Y, ..., MAGIC Investigators , Understanding Society Scientific Group

Nat. Genet. 50 (1) 26-41 [2018-01-00; online 2017-12-22]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Epigenetic Changes in the CRH Gene are Related to Severity of Suicide Attempt and a General Psychiatric Risk Score in Adolescents.

Jokinen J, Boström AE, ..., Åsberg M, Schiöth HB

EBioMedicine 27 (-) 123-133 [2018-01-00; online 2017-12-18]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

Genomic consequences of intensive inbreeding in an isolated wolf population

Kardos M, Åkesson M, ..., Wikenros C, Ellegren H

Nat Ecol Evol 2 (1) 124-131 [2018-01-00; online 2017-11-20]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

The SubCons webserver: A user friendly web interface for state-of-the-art subcellular localization prediction.

Salvatore M, Shu N, Elofsson A

Protein Sci. 27 (1) 195-201 [2018-01-00; online 2017-10-24]

Bioinformatics Support and Infrastructure [Collaborative]

Single-molecule DNA sequencing of acute myeloid leukemia and myelodysplastic syndromes with multiple TP53 alterations

Lodé L, Ameur A, ..., Lavabre-Bertrand T, Soussi T

Haematologica 103 (1) e13-e16 [2018-01-00; online 2017-10-27]

Bioinformatics Compute and Storage [Service] NGI Uppsala (Uppsala Genome Center) [Service]