Publications 2018

664 publications

Cryo-EM structure of the yeast respiratory supercomplex
Rathore S, Berndtsson J, Marin-Buera L, ..., Brzezinski P, Ott M
Nat Struct Mol Biol - (-) - [2018-12-31; online 2018-12-31]
Cryo-EM [Collaborative]
B cell alterations during BAFF inhibition with belimumab in SLE.
Ramsköld D, Parodis I, Lakshmikanth T, ..., Gunnarsson I, Malmström V
pii: S2352-3964(18)30612-1
EBioMedicine - (-) - [2018-12-25; online 2018-12-25]
Mass Cytometry [Service]
Deep Learning in Image Cytometry: A Review
Gupta A, Harrison PJ, Wieslander H, ..., Sintorn IM, Wählby C
Cytometry - (-) - [2018-12-19; online 2018-12-19]
BioImage Informatics [Collaborative]
Carbon’s Three-Center, Four-Electron Tetrel Bond, Treated Experimentally
Karim A, Schulz N, Andersson H, ..., Keller S, Erdélyi M
J. Am. Chem. Soc. - (-) - [2018-12-07; online 2018-12-07]
Swedish NMR Centre (SNC) [Service]
Cotranslational Folding of a Pentarepeat β-Helix Protein.
Notari L, Martínez-Carranza M, Farías-Rico JA, Stenmark P, von Heijne G
pii: S0022-2836(18)30737-X PDB: 6FLS
J. Mol. Biol. 430 (24) 5196-5206 [2018-12-07; online 2018-10-27]
Protein Science Facility (PSF) [Service]
Porous Cellulose Nanofiber-Based Microcapsules for Biomolecular Sensing
Paulraj T, Wennmalm S, Riazanova AV, ..., Crespo GA, Svagan AJ
ACS Appl. Mater. Interfaces 10 (48) 41146-41154 [2018-12-05; online 2018-11-09]
Advanced Light Microscopy (ALM) [Collaborative]
Crystal Structures and Cytotoxicity of ent-Kaurane-Type Diterpenoids from Two Aspilia Species
Yaouba S, Valkonen A, Coghi P, ..., Erdélyi M, Yenesew A
Molecules 23 (12) 3199 [2018-12-04; online 2018-12-04]
Swedish NMR Centre (SNC) [Service]
Sharing of photobionts in sympatric populations of Thamnolia and Cetraria lichens: evidence from high-throughput sequencing
Onuț-Brännström I, Benjamin M, Scofield DG, ..., Lindström ES, Johannesson H
ENA: ERR2307093 ENA: ERR2307094 ENA: ERR2307095 ENA: ERR2307096 ENA: ERR2307097 ENA: ERR2307098 GENBANK: MG372066
Sci Rep 8 (1) - [2018-12-00; online 2018-03-13]
Bioinformatics Compute and Storage [Service] NGI Uppsala (Uppsala Genome Center) [Service] National Genomics Infrastructure [Service]
Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins
Spåhr H, Chia T, Lingford JP, ..., Filipovska A, Rackham O
Nat Commun 9 (1) - [2018-12-00; online 2018-06-07]
Protein Science Facility (PSF) [Service]
Humanizing Miniature Hearts through 4-Flow Cannulation Perfusion Decellularization and Recellularization
Nguyen DT, O’Hara M, Graneli C, ..., Althage M, Heydarkhan-Hagvall S
Sci Rep 8 (1) - [2018-12-00; online 2018-05-10]
Centre for Cellular Imaging [Service]
Abundant fish protein inhibits α-synuclein amyloid formation
Werner T, Kumar R, Horvath I, Scheers N, Wittung-Stafshede P
Sci Rep 8 (1) - [2018-12-00; online 2018-04-03]
Centre for Cellular Imaging [Service]
Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia
Shiozawa Y, Malcovati L, Gallì A, ..., Ogawa S, Cazzola M
EBI: EGAS00001002346
Nat Commun 9 (1) - [2018-12-00; online 2018-09-07]
Clinical Genomics Uppsala [Service]
Soft-tissue evidence for homeothermy and crypsis in a Jurassic ichthyosaur
Lindgren J, Sjövall P, Thiel V, ..., Ojika M, Schweitzer MH
Nature 564 (7736) 359-365 [2018-12-00; online 2018-12-05]
Gothenburg Imaging Mass Spectrometry [Collaborative]
The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization
Lindström L, Li T, Malycheva D, ..., Rosselló CA, Alvarado-Kristensson M
Commun Biol 1 (1) - [2018-12-00; online 2018-05-03]
Centre for Cellular Imaging [Service]
Structure of a functional obligate complex III2IV2 respiratory supercomplex from Mycobacterium smegmatis
Wiseman B, Nitharwal RG, Fedotovskaya O, ..., Brzezinski P, Högbom M
Nat Struct Mol Biol 25 (12) 1128-1136 [2018-12-00; online 2018-12-05]
Cryo-EM [Service]
The shape of the ribosome exit tunnel affects cotranslational protein folding
Kudva R, Tian P, Pardo-Avila F, ..., Bernstein HD, von Heijne G
Elife 7 (-) - [2018-11-26; online 2018-11-26]
Cryo-EM [Service]
New tools for automated high-resolution cryo-EM structure determination in RELION-3
Zivanov J, Nakane T, Forsberg BO, ..., Lindahl E, Scheres SH
Elife 7 (-) - [2018-11-09; online 2018-11-09]
Cryo-EM [Technology development]
Metal-free ribonucleotide reduction powered by a DOPA radical in Mycoplasma pathogens
Srinivas V, Lebrette H, Lundin D, ..., Sjöberg BM, Högbom M
Nature 563 (7731) 416-420 [2018-11-00; online 2018-10-31]
Proteogenomics [Collaborative]
LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease.
Karlsson T, Kvarnbrink S, Holmlund C, ..., Johansson M, Hedman H
pii: S0169-5002(18)30576-2
Lung Cancer 125 (-) 174-184 [2018-11-00; online 2018-09-24]
Clinical Genomics Uppsala [Collaborative]
Glycomics@ExPASy: Bridging the Gap.
Mariethoz J, Alocci D, Gastaldello A, ..., Packer NH, Lisacek F
pii: RA118.000799 pmc: PMC6210229
Mol. Cell Proteomics 17 (11) 2164-2176 [2018-11-00; online 2018-08-10]
Glycoproteomics [Collaborative]
Copper Chaperone Atox1 Interacts with Cell Cycle Proteins.
Matson Dzebo M, Blockhuys S, Valenzuela S, ..., Esbjörner EK, Wittung-Stafshede P
pii: S2001-0370(18)30138-7 pmc: PMC6231052
Computational and Structural Biotechnology Journal 16 (-) 443-449 [2018-10-31; online 2018-10-31]
Glycoproteomics [Service]
Amplification of the Melanocortin-1 Receptor in Nephrotic Syndrome Identifies a Target for Podocyte Cytoskeleton Stabilization.
Bergwall L, Wallentin H, Elvin J, ..., Nyström J, Buvall L
pii: 10.1038/s41598-018-34004-7 pmc: PMC6200758
Sci Rep 8 (1) 15731 [2018-10-24; online 2018-10-24]
Glycoproteomics [Collaborative]
XLSY: Extra-Large NMR Spectroscopy
Pustovalova Y, Mayzel M, Orekhov VY
Angew. Chem. Int. Ed. 57 (43) 14043-14045 [2018-10-22; online 2018-10-01]
Swedish NMR Centre (SNC) [Technology development]
Halogen Bond Asymmetry in Solution
Lindblad S, Mehmeti K, Veiga AX, ..., Gräfenstein J, Erdélyi M
J. Am. Chem. Soc. 140 (41) 13503-13513 [2018-10-17; online 2018-09-20]
Swedish NMR Centre (SNC) [Service]
BabA-mediated adherence of pediatric ulcerogenic H. pylori strains to gastric mucins at neutral and acidic pH.
Quintana-Hayashi MP, Rocha R, Padra M, ..., Oleastro M, Lindén SK
Virulence 9 (1) 1699-1717 [2018-10-10; online 2018-10-10]
Glycoproteomics [Service]
Chorea, psychosis, acanthocytosis, and prolonged survival associated with
Paucar M, Pajak A, Freyer C, ..., Wredenberg A, Svenningsson P
pii: WNL.0000000000006320 pmc: PMC6177277
Neurology 91 (15) 710-712 [2018-10-09; online 2018-09-14]
Bioinformatics Compute and Storage [Service] Clinical Genomics Stockholm [Service]
An orthotopic glioblastoma animal model suitable for high-throughput screenings
Pudelko L, Edwards S, Balan M, ..., Helleday T, Bräutigam L
Neuro Oncol 20 (11) 1475-1484 [2018-10-09; online 2018-05-10]
Advanced Light Microscopy (ALM) [Collaborative]
Enhanced validation of antibodies for research applications.
Edfors F, Hober A, Linderbäck K, ..., Forsström B, Uhlen M
pii: 10.1038/s41467-018-06642-y pmc: PMC6175901 ProteomeXchange: PXD005914 ProteomeXchange: PXD010178 Panorama Public Datasets: https://panoramaweb.org/western_blot.url BioProject: https://www.ncbi.nlm.nih.gov/bioproject/PRJNA183192 BioProject: PRJNA183192
Nat Commun 9 (1) 4130 [2018-10-08; online 2018-10-08]
Bioinformatics Compute and Storage [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
Evangelou E, Warren HR, Mosen-Ansorena D, ..., Caulfield MJ, Million Veteran Program
pii: 10.1038/s41588-018-0205-x
Nat. Genet. 50 (10) 1412-1425 [2018-10-00; online 2018-09-17]
Bioinformatics Compute and Storage [Service]
Using Scipion for stream image processing at Cryo-EM facilities
Gómez-Blanco J, de la Rosa-Trevín JM, Marabini R, ..., Conesa P, Carazo JM
Journal of Structural Biology - (-) - [2018-10-00; online 2018-10-00]
Cryo-EM [Technology development]
Associations of Circulating Protein Levels With Lipid Fractions in the General Population
Figarska SM, Gustafsson S, Sundström J, ..., Lind L, Ingelsson E
Arterioscler Thromb Vasc Biol 38 (10) 2505-2518 [2018-10-00; online 2018-10-00]
Clinical Biomarkers [Service]
Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality
Fernandez C, Rysä J, Almgren P, ..., Ruskoaho H, Melander O
J Intern Med 284 (4) 377-387 [2018-10-00; online 2018-07-02]
Clinical Biomarkers [Service]
The Xerobranching Response Represses Lateral Root Formation When Roots Are Not in Contact with Water
Orman-Ligeza B, Morris EC, Parizot B, ..., Beeckman T, Draye X
Current Biology 28 (19) 3165-3173.e5 [2018-10-00; online 2018-10-00]
Swedish Metabolomics Centre (SMC) [Service]
NMR Determination of the Binding Constant of Ionic Species: A Caveat
Schulz N, Schindler S, Huber SM, Erdelyi M
J. Org. Chem. 83 (18) 10881-10886 [2018-09-21; online 2018-08-15]
Swedish NMR Centre (SNC) [Service]
System-wide Identification and prioritization of Enzyme Substrates by Thermal Analysis (SIESTA)
Saei AA, Beusch C, Sabatier P, ..., Schuler H, Zubarev R
- - (-) - [2018-09-21; online 2018-09-21]
Chemical Proteomics [Collaborative]
ProTargetMiner: A proteome signature library of anticancer molecules for functional discovery
Saei AA, Chernobrovkin A, Sabatier P, ..., Vegvari A, Zubarev R
- - (-) - [2018-09-18; online 2018-09-18]
Chemical Proteomics [Technology development]
Contribution of allelic imbalance to colorectal cancer.
Palin K, Pitkänen E, Turunen M, ..., Taipale J, Aaltonen LA
pii: 10.1038/s41467-018-06132-1 pmc: PMC6131244 European Nucleotide Archive: PRJEB25645 European Genome-phenome Archive: EGAS00001002966 European Genome-phenome Archive: EGAS00001003010 Zenodo: https://doi.org/10.5281/zenodo.1222172
Nat Commun 9 (1) 3664 [2018-09-10; online 2018-09-10]
Bioinformatics Compute and Storage [Service] High-throughput Genome Engineering (HTGE) [Collaborative] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]
Neuroblastoma with flat genomic profile: a question of representativity?
Valind A, Öra I, Mertens F, Gisselsson D
BMJ Case Reports - (-) bcr-2018-225568 [2018-09-08; online 2018-09-08]
Clinical Genomics Lund [Service]
Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs
Fernández-Blanco JA, Fakih D, Arike L, ..., Ermund A, Hansson GC
JCI Insight 3 (17) - [2018-09-06; online 2018-09-06]
Centre for Cellular Imaging [Service]
FADD (Fas-Associated Protein With Death Domain), Caspase-3, and Caspase-8 and Incidence of Ischemic Stroke
Muhammad IF, Borné Y, Melander O, ..., Söderholm M, Engström G
Stroke 49 (9) 2224-2226 [2018-09-00; online 2018-09-00]
Clinical Biomarkers [Service]
Ein Fall von Pankreaskarzinom
Löhr JM, Kordes M, Gustafsson-Liljefors M, ..., Permert J, Jäger D
Forum 33 (4) 232-235 [2018-09-00; online 2018-08-14]
Clinical Genomics Stockholm [Collaborative]
The molecular genetic basis of herbivory between butterflies and their host plants.
Nallu S, Hill JA, Don K, ..., Wheat CW, Kronforst MR
pii: 10.1038/s41559-018-0629-9 pmc: PMC6149523 mid: NIHMS979338 SRA: SRP134094 Transcriptome Shotgun Assembly Sequence Database: GGJX00000000 Transcriptome Shotgun Assembly Sequence Database: GGKA00000000 Transcriptome Shotgun Assembly Sequence Database: GGJQ00000000 Transcriptome Shotgun Assembly Sequence Database: GGJO00000000 Transcriptome Shotgun Assembly Sequence Database: GGJY00000000 Transcriptome Shotgun Assembly Sequence Database: GGJZ00000000 Transcriptome Shotgun Assembly Sequence Database: GGKB00000000 Transcriptome Shotgun Assembly Sequence Database: GGKC00000000
Nat Ecol Evol 2 (9) 1418-1427 [2018-09-00; online 2018-08-03]
Bioinformatics Compute and Storage [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]
Broad spectrum developmental role of Brachypodium AUX1
van der Schuren A, Voiniciuc C, Bragg J, ..., Pauly M, Hardtke CS
New Phytol 219 (4) 1216-1223 [2018-09-00; online 2018-06-27]
Swedish Metabolomics Centre (SMC) [Service]
Autoantibody profiling reveals four protein candidate autoantigens associated with systemic lupus erythematosus.
Frostegård J, Hellström C, Nilsson P, Frostegård AG, Ajeganova S
Lupus 27 (10) 1670-1678 [2018-09-00; online 2018-07-24]
Autoimmunity Profiling [Service]
STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue
Sütt S, Cansby E, Paul A, ..., Enerbäck S, Mahlapuu M
- 238 (3) 187-202 [2018-09-00; online 2018-09-00]
Centre for Cellular Imaging [Service]
Diversity of Interneurons in the Dorsal Striatum Revealed by Single-Cell RNA Sequencing and PatchSeq.
Muñoz-Manchado AB, Bengtsson Gonzales C, Zeisel A, ..., Linnarsson S, Hjerling-Leffler J
pii: S2211-1247(18)31156-2 pmc: PMC6117871
Cell Rep 24 (8) 2179-2190.e7 [2018-08-21; online 2018-08-23]
Eukaryotic Single Cell Genomics (ESCG) [Service]
Pharmacokinetic Properties of the Nephrotoxin Orellanine in Rats.
Najar D, Haraldsson B, Thorsell A, ..., Nyström J, Ebefors K
pii: toxins10080333 pmc: PMC6116018
Toxins (Basel) 10 (8) - [2018-08-17; online 2018-08-17]
Glycoproteomics [Service]
Proteomic Biomarkers for Incident Aortic Stenosis Requiring Valvular Replacement
Ljungberg J, Janiec M, Bergdahl IA, ..., Fall T, Söderberg S
Circulation 138 (6) 590-599 [2018-08-07; online 2018-08-07]
Clinical Biomarkers [Service]
A bacteriophage enzyme induces bacterial metabolic perturbation that confers a novel promiscuous function.
Jerlström Hultqvist J, Warsi O, Söderholm A, ..., Selmer M, Andersson DI
pii: 10.1038/s41559-018-0568-5
Nat Ecol Evol 2 (8) 1321-1330 [2018-08-00; online 2018-05-28]
Glycoproteomics [Collaborative]
Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides.
Saravanan R, Holdbrook DA, Petrlova J, ..., Malmsten M, Schmidtchen A
pii: 10.1038/s41467-018-05242-0 pmc: PMC6050251
Nat Commun 9 (1) 2762 [2018-07-17; online 2018-07-17]
Targeted and Structural Proteomics [Service]
Autoantibody profiling in intraocular fluid of patients with uveitis.
Ten Berge JC, Schreurs MW, van Rosmalen J, Rothova A
pii: S0014-4835(18)30007-1
Exp. Eye Res. 176 (-) 141-146 [2018-07-10; online 2018-07-10]
Autoimmunity Profiling [Service]
Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury.
Kapur R, Kim M, Rebetz J, ..., Speck ER, Semple JW
pii: bloodadvances.2018018903 pmc: PMC6039664
Blood Adv 2 (13) 1651-1663 [2018-07-10; online 2018-07-12]
Clinical Genomics Lund [Service]
Metabolic Profiling of Multiorgan Samples: Evaluation of MODY5/RCAD Mutant Mice
Torell F, Bennett K, Cereghini S, ..., Trygg J, Lundstedt T
J. Proteome Res. 17 (7) 2293-2306 [2018-07-06; online 2018-06-06]
Swedish Metabolomics Centre (SMC) [Service]
OLMα2 Cells Bidirectionally Modulate Learning
Siwani S, França ASC, Mikulovic S, ..., Tort ABL, Kullander K
Neuron 99 (2) 404-412.e3 [2018-07-00; online 2018-07-00]
Advanced Light Microscopy (ALM) [Collaborative] Bioinformatics Compute and Storage [Service]
Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity
Nyström EEL, Birchenough GMH, van der Post S, ..., Hansson GC, Johansson MEV
EBioMedicine 33 (-) 134-143 [2018-07-00; online 2018-07-00]
Centre for Cellular Imaging [Service]
appreci8: a pipeline for precise variant calling integrating 8 tools
Sandmann S, Karimi M, de Graaf AO, ..., Jansen JH, Dugas M
- - (-) - [2018-06-26; online 2018-06-26]
Clinical Genomics Uppsala [Service]
Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks
De Vadder F, Grasset E, Mannerås Holm L, ..., Olofsson LE, Bäckhed F
Proc Natl Acad Sci USA 115 (25) 6458-6463 [2018-06-19; online 2018-06-04]
Centre for Cellular Imaging [Service]
Liquid Norbornadiene Photoswitches for Solar Energy Storage
Dreos A, Wang Z, Udmark J, ..., Nielsen MB, Moth-Poulsen K
Adv. Energy Mater. 8 (18) 1703401 [2018-06-00; online 2018-03-25]
Swedish NMR Centre (SNC) [Service]
Electrochemistry in and of the Fly Brain
Majdi S, Larsson A, Hoang Philipsen M, Ewing AG
Electroanalysis 30 (6) 999-1010 [2018-06-00; online 2018-04-14]
Gothenburg Imaging Mass Spectrometry [Collaborative]
Plant Hormonomics: Multiple Phytohormone Profiling by Targeted Metabolomics
Šimura J, Antoniadi I, Široká J, ..., Ljung K, Novák O
Plant Physiol. 177 (2) 476-489 [2018-06-00; online 2018-04-27]
Swedish Metabolomics Centre (SMC) [Service]
The Properties of Amyloid-β Fibrils Are Determined by their Path of Formation
Brännström K, Islam T, Gharibyan AL, ..., Pamrén A, Olofsson A
Journal of Molecular Biology 430 (13) 1940-1949 [2018-06-00; online 2018-06-00]
Cryo-EM [Service]
A mass spectrometry imaging approach for investigating how drug-drug interactions influence drug blood-brain barrier permeability.
Vallianatou T, Strittmatter N, Nilsson A, ..., Goodwin RJA, Andrén PE
pii: S1053-8119(18)30015-6
Neuroimage 172 (-) 808-816 [2018-05-15; online 2018-01-10]
National Resource for Mass Spectrometry Imaging [Service]
BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma.
Sime W, Niu Q, Abassi Y, ..., Fu H, Massoumi R
pii: 10.1038/s41419-018-0500-6 pmc: PMC5913307
Cell Death Dis 9 (5) 458 [2018-05-01; online 2018-05-01]
Targeted and Structural Proteomics [Service]
Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells
Guzzi N, Cieśla M, Ngoc PCT, ..., Hsieh AC, Bellodi C
Cell 173 (5) 1204-1216.e26 [2018-05-00; online 2018-05-00]
Targeted and Structural Proteomics [Service]
Uterine progesterone signaling is a target for metformin therapy in PCOS-like rats
Hu M, Zhang Y, Feng J, ..., Shao LR, Billig H
- 237 (2) 123-137 [2018-05-00; online 2018-05-00]
Centre for Cellular Imaging [Service]
Identification of novel diagnostic biomarkers for deep venous thrombosis
Memon AA, Sundquist K, PirouziFard M, ..., Sundquist J, Zöller B
Br J Haematol 181 (3) 378-385 [2018-05-00; online 2018-04-19]
Clinical Biomarkers [Service]
Kynurenine pathway is altered in patients with SLE and associated with severe fatigue
Åkesson K, Pettersson S, Ståhl S, ..., Svenungsson E, Idborg H
Lupus Sci Med 5 (1) e000254 [2018-05-00; online 2018-05-23]
Swedish NMR Centre (SNC) [Collaborative]
Ethylene signaling induces gelatinous layers with typical features of tension wood in hybrid aspen
Felten J, Vahala J, Love J, ..., Mellerowicz EJ, Sundberg B
New Phytol 218 (3) 999-1014 [2018-05-00; online 2018-03-12]
Cryo-EM [Service]
Ultra-rapid auxin metabolite profiling for high-throughput mutant screening in Arabidopsis
Pěnčík A, Casanova-Sáez R, Pilařová V, ..., Ljung K, Novák O
- 69 (10) 2569-2579 [2018-04-27; online 2018-03-03]
Swedish Metabolomics Centre (SMC) [Service]
Rebooting Human Immunology.
Davis MM, Brodin P
Annu. Rev. Immunol. 36 (-) 843-864 [2018-04-26; online 2018-02-28]
Mass Cytometry [Collaborative]
Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib
Ladds MJGW, Pastor-Fernández A, Popova G, ..., Bhatia R, Laín S
OSF: https://osf.io/sreqf/?view_only=bd0c5cd611be481984ef164d5d15df3d
PLoS ONE 13 (4) e0195956 [2018-04-23; online 2018-04-23]
Drug Discovery and Development (DDD) [Service]
Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers
Trillo-Muyo S, Nilsson HE, Recktenwald CV, ..., Hebert H, Hansson GC
J. Biol. Chem. 293 (15) 5746-5754 [2018-04-13; online 2018-02-13]
Centre for Cellular Imaging [Service]
Active and inactive β1 integrins segregate into distinct nanoclusters in focal adhesions
Spiess M, Hernandez-Varas P, Oddone A, ..., Lakadamyali M, Strömblad S
J. Cell Biol. - (-) jcb.201707075 [2018-04-09; online 2018-04-09]
Advanced Light Microscopy (ALM) [Collaborative]
Allele-selective RUNX1 binding regulates P1 blood group status by transcriptional control of A4GALT.
Westman JS, Stenfelt L, Vidovic K, ..., Kjellström S, Olsson ML
pii: blood-2017-08-803080
Blood 131 (14) 1611-1616 [2018-04-05; online 2018-02-08]
Targeted and Structural Proteomics [Service]
Structure of the chloroplast ribosome with chl-RRF and hibernation-promoting factor
Boerema AP, Aibara S, Paul B, ..., Lindahl E, Amunts A
PDB: 6ERI EMDB: EMD-3941 EMDB: EMD-3942 EMDB: EMD-3943
NPLANTS 4 (4) 212-217 [2018-04-00; online 2018-04-02]
Cryo-EM [Service]
Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes.
Klaesson A, Grannas K, Ebai T, ..., Söderberg O, Landegren U
pii: 10.1038/s41598-018-23582-1 pmc: PMC5876389
Sci Rep 8 (1) 5400 [2018-03-29; online 2018-03-29]
PLA and Single Cell Proteomics [Technology development]
Peptide ion channel toxins from the bootlace worm, the longest animal on Earth.
Jacobsson E, Andersson HS, Strand M, ..., Tytgat J, Göransson U
pii: 10.1038/s41598-018-22305-w pmc: PMC5864730
Sci Rep 8 (1) 4596 [2018-03-22; online 2018-03-22]
National Resource for Mass Spectrometry Imaging [Service]
Molecular mechanism of ATP versus GTP selectivity of adenylate kinase
Rogne P, Rosselin M, Grundström C, ..., Sauer UH, Wolf-Watz M
Proc Natl Acad Sci USA 115 (12) 3012-3017 [2018-03-20; online 2018-03-05]
Swedish NMR Centre (SNC) [Service]
ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease.
Bremer HD, Landegren N, Sjöberg R, ..., Kämpe O, Hansson-Hamlin H
pii: 10.1038/s41598-018-23034-w pmc: PMC5859008
Sci Rep 8 (1) 4852 [2018-03-19; online 2018-03-19]
Autoimmunity Profiling [Service] Bioinformatics Compute and Storage [Service]
Transcriptional stimulation of rate-limiting components of the autophagic pathway improves plant fitness
Minina EA, Moschou PN, Vetukuri RR, ..., Hofius D, Bozhkov PV
- 69 (6) 1415-1432 [2018-03-14; online 2018-01-20]
Swedish Metabolomics Centre (SMC) [Service]
Darkened leaves use different metabolic strategies for senescence and survival
Law SR, Chrobok D, Juvany M, ..., Gardestrom P, Keech O
Plant Physiol. - (-) pp.00062.2018 [2018-03-09; online 2018-03-09]
Swedish Metabolomics Centre (SMC) [Service]
Genome-wide analysis yields new loci associating with aortic valve stenosis.
Helgadottir A, Thorleifsson G, Gretarsdottir S, ..., Holm H, Stefansson K
pii: 10.1038/s41467-018-03252-6 pmc: PMC5840367
Nat Commun 9 (1) 987 [2018-03-07; online 2018-03-07]
NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]
Sexual dimorphism in the width of the mouse synaptonemal complex
Agostinho A, Kouznetsova A, Hernández-Hernández A, ..., Brismar H, Höög C
J Cell Sci 131 (5) jcs212548 [2018-03-01; online 2018-02-02]
Advanced Light Microscopy (ALM) [Collaborative]
Proteomic Profiling for Cardiovascular Biomarker Discovery in Orthostatic Hypotension
Johansson M, Ricci F, Aung N, ..., Melander O, Fedorowski A
Hypertension 71 (3) 465-472 [2018-03-00; online 2018-03-00]
Clinical Biomarkers [Service]
Galectin-3 levels relate in children to total body fat, abdominal fat, body fat distribution, and cardiac size
Dencker M, Arvidsson D, Karlsson MK, ..., Andersen LB, Thorsson O
Eur J Pediatr 177 (3) 461-467 [2018-03-00; online 2018-01-11]
Clinical Biomarkers [Service]
Current applications of antibody microarrays.
Chen Z, Dodig-Crnković T, Schwenk JM, Tao SC
pii: 9184 pmc: PMC5830343
Clin Proteomics 15 (-) 7 [2018-02-28; online 2018-02-28]
Translational Plasma Profiling [Collaborative]
Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.
Stafford WC, Peng X, Olofsson MH, ..., Linder S, Arnér ESJ
pii: 10/428/eaaf7444
Sci Transl Med 10 (428) - [2018-02-14; online 2018-02-16]
Protein Science Facility (PSF) [Service]
Advancing the immunoaffinity platform AFFIRM to targeted measurements of proteins in serum in the pg/ml range.
Säll A, Corbee D, Vikström S, ..., Persson H, Waldemarson S
pii: PONE-D-17-23519 pmc: PMC5810979 PeptideAtlas: PASS00852
PLoS ONE 13 (2) e0189116 [2018-02-13; online 2018-02-13]
Drug Discovery and Development (DDD) [Technology development]
Dispersed Uniform Nanoparticles from a Macroscopic Organosilica Powder
Church TL, Bernin D, Garcia-Bennett AE, Hedin N
Langmuir 34 (6) 2274-2281 [2018-02-13; online 2018-02-05]
Swedish NMR Centre (SNC) [Collaborative]
Proteomic analyses identify prognostic biomarkers for pancreatic ductal adenocarcinoma.
Hu D, Ansari D, Pawłowski K, ..., Marko-Varga G, Andersson R
pii: 23929 pmc: PMC5839402
Oncotarget 9 (11) 9789-9807 [2018-02-09; online 2018-01-03]
Targeted and Structural Proteomics [Service]
Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation.
Agudelo LZ, Ferreira DMS, Cervenka I, ..., Berggren P, Ruas JL
pii: S1550-4131(18)30053-6
Cell Metab. 27 (2) 378-392.e5 [2018-02-06; online 2018-02-08]
Bioinformatics Compute and Storage [Service] Mass Cytometry [Collaborative]
MYCN-amplified neuroblastoma maintains an aggressive and undifferentiated phenotype by deregulation of estrogen and NGF signaling
Dzieran J, Rodriguez Garcia A, Westermark UK, ..., Lehtiö J, Arsenian-Henriksson M
Proc Natl Acad Sci USA 115 (6) E1229-E1238 [2018-02-06; online 2018-01-26]
Proteogenomics [Collaborative]
Graphene Oxide Elicits Membrane Lipid Changes and Neutrophil Extracellular Trap Formation
Mukherjee SP, Lazzaretto B, Hultenby K, ..., Malmberg P, Fadeel B
Chem 4 (2) 334-358 [2018-02-00; online 2018-02-00]
Gothenburg Imaging Mass Spectrometry [Collaborative]
Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold
Carter M, Jemth AS, Carreras-Puigvert J, ..., Helleday T, Stenmark P
Structure 26 (2) 295-303.e6 [2018-02-00; online 2018-02-00]
Protein Science Facility (PSF) [Service]
Establishment of Photosynthesis through Chloroplast Development Is Controlled by Two Distinct Regulatory Phases
Dubreuil C, Jin X, Barajas-López JdD, ..., Small I, Strand Å
Plant Physiol. 176 (2) 1199-1214 [2018-02-00; online 2017-06-16]
Cryo-EM [Service]
Quantitative image analysis of protein expression and colocalisation in skin sections
Zhang H, Ericsson M, Virtanen M, ..., Vahlquist A, Törmä H
Exp Dermatol 27 (2) 196-199 [2018-02-00; online 2018-01-09]
BioImage Informatics [Service]
The Folding Pathway of an Ig Domain is Conserved On and Off the Ribosome
Tian P, Steward A, Kudva R, ..., Clarke J, Best R
- - (-) - [2018-01-24; online 2018-01-24]
Cryo-EM [Service]
Genetical genomics of growth in a chicken model.
Johnsson M, Henriksen R, Höglund A, ..., Jensen P, Wright D
pii: 10.1186/s12864-018-4441-3 pmc: PMC5782384 ArrayExpress: E-MTAB-5572
BMC Genomics 19 (1) 72 [2018-01-23; online 2018-01-23]
Bioinformatics Compute and Storage [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]
Sample handling of gastric tissue and O-glycan alterations in paired gastric cancer and non-tumorigenic tissues.
Adamczyk B, Jin C, Polom K, ..., Roviello F, Karlsson NG
pii: 10.1038/s41598-017-18299-6 pmc: PMC5762837
Sci Rep 8 (1) 242 [2018-01-10; online 2018-01-10]
Glycoproteomics [Technology development]
Differential impact of RB status on E2F1 reprogramming in human cancer.
McNair C, Xu K, Mandigo AC, ..., Brown M, Knudsen KE
pii: 93566 pmc: PMC5749518
J. Clin. Invest. 128 (1) 341-358 [2018-01-02; online 2017-12-04]
Clinical Genomics Stockholm [Service]
Surface treatment of cellulose nanocrystals (CNC): effects on dispersion rheology
Sahlin K, Forsgren L, Moberg T, ..., Rigdahl M, Westman G
Cellulose 25 (1) 331-345 [2018-01-00; online 2017-11-28]
Swedish NMR Centre (SNC) [Collaborative]
Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration
Schroeder BO, Birchenough GMH, Ståhlman M, ..., Hansson GC, Bäckhed F
Cell Host & Microbe 23 (1) 27-40.e7 [2018-01-00; online 2018-01-00]
Centre for Cellular Imaging [Service]
Optimising methods for the recovery and quantification of di- and tripeptides in soil
J�mtg�rd S, Robinson N, Moritz T, Colgrave ML, Schmidt S
Soil Res. - (-) - [2018-00-00; online 2018-00-00]
Swedish Metabolomics Centre (SMC) [Service]
Synthesis of novel 1,2,4-thiadiazinane 1,1-dioxides via three component SuFEx type reaction
Khumalo MF, Akpan ED, Chinthakindi PK, ..., Naicker T, Arvidsson PI
RSC Adv. 8 (65) 37503-37507 [2018-00-00; online 2018-00-00]
Drug Discovery and Development (DDD) [Technology development]
Whole Slide Image Registration for the Study of Tumor Heterogeneity
Solorzano L, Almeida GM, Mesquita B, ..., Oliveira C, Wählby C
- - (-) 95-102 [2018-00-00; online 2018-09-14]
BioImage Informatics [Technology development]