Publications 2015

432 publications

Exploring water as building bricks in enzyme engineering.
Hendil-Forssell P, Martinelle M, Syrén PO
Chem. Commun. (Camb.) 51 (97) 17221-17224 [2015-12-18; online 2015-10-02]
Protein Science Facility (PSF)
Powerful Populations Respond to Viruses and Vaccines.
Brodin P
pii: S1074-7613(15)00496-3
Immunity 43 (6) 1035-1037 [2015-12-15; online 2015-12-20]
Mass Cytometry [Collaborative]
High levels of WNT-5A in human glioma correlate with increased presence of tumor-associated microglia/monocytes.
Dijksterhuis JP, Arthofer E, Marinescu VD, ..., Mulder J, Schulte G
pii: S0014-4827(15)30133-6
Exp. Cell Res. 339 (2) 280-288 [2015-12-10; online 2015-10-25]
Tissue Profiling [Collaborative]
Multi-level omics analysis in a murine model of dystrophin loss and therapeutic restoration.
Roberts TC, Johansson HJ, McClorey G, ..., El Andaloussi S, Wood MJ
pii: ddv381 pmc: PMC4634378
Hum. Mol. Genet. 24 (23) 6756-6768 [2015-12-01; online 2015-09-20]
Bioinformatics and Expression Analysis (BEA)
Protein profiling reveals consequences of lifestyle choices on predicted biological aging.
Enroth S, Enroth SB, Johansson Å, Gyllensten U
pii: srep17282 pmc: PMC4664859
Sci Rep 5 (-) 17282 [2015-12-01; online 2015-12-01]
Clinical Biomarkers
Associations between circulating proteins and corresponding genes expressed in coronary thrombi in patients with acute myocardial infarction.
Helseth R, Weiss TW, Opstad TB, ..., Arnesen H, Seljeflot S
pii: S0049-3848(15)30137-7
Thromb. Res. 136 (6) 1240-1244 [2015-12-00; online 2015-10-08]
Clinical Biomarkers [Service]
Identification of proteins from human permanent erupted enamel.
Castiblanco GA, Rutishauser D, Ilag LL, ..., Castellanos JE, Mejía W
Eur. J. Oral Sci. 123 (6) 390-395 [2015-12-00; online 2015-10-04]
Advanced Mass Spectrometry Proteomics
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
Gaulton KJ, Ferreira T, Lee Y, ..., Morris AP, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
Nat. Genet. 47 (12) 1415-1425 [2015-12-00; online 2015-11-10]
NGI Uppsala (SNP&SEQ Technology Platform) National Genomics Infrastructure
Emmprin Expression Predicts Response and Survival following Cisplatin Containing Chemotherapy for Bladder Cancer: A Validation Study.
Hemdan T, Malmström PU, Jahnson S, Segersten U
pii: S0022-5347(15)04296-2
J. Urol. 194 (6) 1575-1581 [2015-12-00; online 2015-06-30]
Tissue Profiling
Discovery of New Risk Markers for Ischemic Stroke Using a Novel Targeted Proteomics Chip.
Lind L, Siegbahn A, Lindahl B, ..., Sundström J, Ärnlöv J
pii: STROKEAHA.115.010829
Stroke 46 (12) 3340-3347 [2015-12-00; online 2015-11-07]
Clinical Biomarkers
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.
Paternoster L, Standl M, Waage J, ..., Weidinger S, EArly Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium
Nat. Genet. 47 (12) 1449-1456 [2015-12-00; online 2015-10-21]
Mutation Analysis Facility (MAF)
Immunocapture strategies in translational proteomics.
Fredolini C, Byström S, Pin E, ..., Nilsson P, Schwenk JM
Expert Rev Proteomics 13 (1) 83-98 [2015-11-11; online 2015-11-11]
Plasma Profiling [Technology development]
Meta-analysis identifies seven susceptibility loci involved in the atopic march.
Marenholz I, Esparza-Gordillo J, Rüschendorf F, ..., Henderson AJ, Lee YA
pii: ncomms9804 pmc: PMC4667629
Nat Commun 6 (-) 8804 [2015-11-06; online 2015-11-06]
Mutation Analysis Facility (MAF)
Quantitative proteogenomics of human pathogens using DIA-MS.
Malmström L, Bakochi A, Svensson G, ..., Karlsson C, Malmström J
pii: S1874-3919(15)30129-9
J Proteomics 129 (-) 98-107 [2015-11-03; online 2015-09-19]
Bioinformatics Support and Infrastructure Bioinformatics Support, Infrastructure and Training
Mutation in CEP63 co-segregating with developmental dyslexia in a Swedish family.
Einarsdottir E, Svensson I, Darki F, ..., Kere J, Matsson H
pii: 10.1007/s00439-015-1602-1 pmc: PMC4628622
Hum. Genet. 134 (11-12) 1239-1248 [2015-11-00; online 2015-09-25]
NGI Uppsala (Uppsala Genome Center) National Genomics Infrastructure
Fibroblast Growth Factor 23 and Incidence of Subarachnoid Hemorrhage: Nested Case-Control Study.
Söderholm M, Engström G
pii: STROKEAHA.115.010565
Stroke 46 (11) 3260-3262 [2015-11-00; online 2015-09-22]
Clinical Biomarkers [Service]
Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo.
Caraballo R, Larsson M, Nilsson SK, ..., Enquist P, Elofsson M
pii: S0223-5234(15)30241-5
Eur J Med Chem 103 (-) 191-209 [2015-10-20; online 2015-09-12]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
Mutation in NRAS in familial Noonan syndrome--case report and review of the literature.
Ekvall S, Wilbe M, Dahlgren J, ..., Annerén G, Bondeson ML
pii: 10.1186/s12881-015-0239-1 pmc: PMC4607013
BMC Med. Genet. 16 (-) 95 [2015-10-14; online 2015-10-14]
Clinical Genomics Uppsala
The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation.
Gustafsson Sheppard N, Jarl L, Mahadessian D, ..., Jain M, Nilsson R
pii: srep15029 pmc: PMC4602236
Sci Rep 5 (-) 15029 [2015-10-13; online 2015-10-13]
Cell Profiling
The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes.
Xie Y, Bergström T, Jiang Y, ..., Forsberg-Nilsson K, Uhrbom L
pii: S2352-3964(15)30114-6 pmc: PMC4634360
EBioMedicine 2 (10) 1351-1363 [2015-10-00; online 2015-08-15]
Array and Analysis Facility
Acid-Base Catalyst Discriminates between a Fructose 6-Phosphate Aldolase and a Transaldolase
Stellmacher L, Sandalova T, Leptihn S, ..., Sprenger GA, Samland AK
ChemCatChem 7 (19) 3140-3151 [2015-10-00; online 2015-08-06]
Protein Science Facility (PSF)
Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity.
Ahmad S, Thulasingam M, Palombo I, ..., Haeggström JZ, Rinaldo-Matthis A
pii: S1570-9639(15)00169-7
Biochim. Biophys. Acta 1854 (10 Pt A) 1365-1371 [2015-10-00; online 2015-06-13]
Protein Science Facility (PSF)
A New Method for Detecting Associations with Rare Copy-Number Variants.
Tzeng JY, Magnusson PK, Sullivan PF, Swedish Schizophrenia Consortium , Szatkiewicz JP
pii: PGENETICS-D-15-00206 pmc: PMC4592002
PLoS Genet. 11 (10) e1005403 [2015-10-00; online 2015-10-02]
NGI Uppsala (SNP&SEQ Technology Platform) National Genomics Infrastructure
The use of gene arrays and corresponding connectivity mapping (Cmap) to identify novel anti-ageing ingredients.
Gillbro JM, Merinville E, Olsson M, ..., Visdal-Johnsen L, Mavon A
Int J Cosmet Sci 37 Suppl 1 (-) 9-14 [2015-10-00; online 2015-06-27]
Array and Analysis Facility
Dormant phages of Helicobacter pylori reveal distinct populations in Europe.
Vale FF, Vadivelu J, Oleastro M, ..., Mégraud F, Lehours P
pii: srep14333 pmc: PMC4585682
Sci Rep 5 (-) 14333 [2015-09-21; online 2015-09-21]
Clinical Genomics Stockholm [Collaborative]
Gene expression profiling of pre-eclamptic placentae by RNA sequencing.
Kaartokallio T, Cervera A, Kyllönen A, ..., Laivuori H, FINNPEC Core Investigator Group
pii: srep14107 pmc: PMC4585671
Sci Rep 5 (-) 14107 [2015-09-21; online 2015-09-21]
NGI Stockholm (Genomics Applications) NGI Stockholm (Genomics Production) National Genomics Infrastructure
Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing.
Parry M, Rose-Zerilli MJ, Ljungström V, ..., Oscier D, Strefford JC
pii: 1078-0432.CCR-14-2759 pmc: PMC4490180 mid: EMS62676
Clin. Cancer Res. 21 (18) 4174-4183 [2015-09-15; online 2015-03-18]
Clinical Genomics Uppsala
Surface Chemistry of Nanocellulose Fibers Directs Monocyte/Macrophage Response.
Hua K, Ålander E, Lindström T, ..., Strømme M, Ferraz N
Biomacromolecules 16 (9) 2787-2795 [2015-09-14; online 2015-08-08]
BioMaterial Interactions (BioMat)
Quest for Missing Proteins: Update 2015 on Chromosome-Centric Human Proteome Project.
Horvatovich P, Lundberg EK, Chen YJ, ..., Paik YK, Hancock WS
J. Proteome Res. 14 (9) 3415-3431 [2015-09-04; online 2015-06-16]
Cell Profiling
Half-of-the-Sites Reactivity of the Castor Δ9-18:0-Acyl Carrier Protein Desaturase.
Liu Q, Chai J, Moche M, ..., Lindqvist Y, Shanklin J
pii: pp.15.00622 pmc: PMC4577402
Plant Physiol. 169 (1) 432-441 [2015-09-00; online 2015-08-01]
Protein Science Facility (PSF)
Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome
Gu Urban GJ, Friedman M, Ren P, ..., Landegren U, Kamali-Moghaddam M
Sci Rep 5 (1) - [2015-09-00; online 2015-06-16]
PLA and Single Cell Proteomics [Technology development]
Use of a proximity extension assay proteomics chip to discover new biomarkers for human atherosclerosis.
Lind L, Ärnlöv J, Lindahl B, ..., Sundström J, Ingelsson E
pii: S0021-9150(15)30043-5
Atherosclerosis 242 (1) 205-210 [2015-09-00; online 2015-07-24]
Clinical Biomarkers
Shared immunological targets in the lungs and joints of patients with rheumatoid arthritis: identification and validation.
Ytterberg AJ, Joshua V, Reynisdottir G, ..., Klareskog L, Catrina AI
pii: annrheumdis-2013-204912
Ann. Rheum. Dis. 74 (9) 1772-1777 [2015-09-00; online 2014-05-13]
Advanced Mass Spectrometry Proteomics
Synthesis of enantiopure angiotensin II type 2 receptor [AT2R] antagonist EMA401
Wakchaure PB, Bremberg U, Wannberg J, Larhed M
Tetrahedron 71 (38) 6881-6887 [2015-09-00; online 2015-09-00]
Drug Discovery and Development (DDD)
Structure of the Glycosyltransferase Ktr4p from Saccharomyces cerevisiae.
Possner DD, Claesson M, Guy JE
pii: PONE-D-15-23020 pmc: PMC4546622
PLoS ONE 10 (8) e0136239 [2015-08-21; online 2015-08-21]
Protein Science Facility (PSF)
In Vitro and In Vivo Response to Low-Modulus PMMA-Based Bone Cement.
Carlsson E, Mestres G, Treerattrakoon K, ..., Larsson S, Persson C
Biomed Res Int 2015 (-) 594284 [2015-08-20; online 2015-08-20]
BioMaterial Interactions (BioMat)
Comprehensive genomic profiles of small cell lung cancer.
George J, Lim JS, Jang SJ, ..., Sage J, Thomas RK
Nature 524 (7563) 47-53 [2015-08-06; online 2015-07-15]
Clinical Genomics Uppsala [Collaborative]
Heat differentiated complement factor profiling.
Hamsten C, Skattum L, Truedsson L, ..., Nilsson P, Neiman M
pii: S1874-3919(15)30029-4
J Proteomics 126 (-) 155-162 [2015-08-03; online 2015-06-07]
Plasma Profiling [Technology development]
Predisposition to Childhood Otitis Media and Genetic Polymorphisms within the Toll-Like Receptor 4 (TLR4) Locus.
Hafrén L, Einarsdottir E, Kentala E, ..., Kere J, Mattila PS
pii: PONE-D-15-06828 pmc: PMC4503307
PLoS ONE 10 (7) e0132551 [2015-07-15; online 2015-07-15]
Mutation Analysis Facility (MAF)
Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier.
Reyahi A, Nik AM, Ghiami M, ..., Johansson BR, Carlsson P
pii: S1534-5807(15)00324-X
Dev. Cell 34 (1) 19-32 [2015-07-06; online 2015-06-25]
Tissue Profiling [Collaborative]
HHEX_23 AA Genotype Exacerbates Effect of Diabetes on Dementia and Alzheimer Disease: A Population-Based Longitudinal Study.
Xu WL, Pedersen NL, Keller L, ..., Bäckman L, Fratiglioni L
pii: PMEDICINE-D-14-02434 pmc: PMC4501827
PLoS Med. 12 (7) e1001853 [2015-07-00; online 2015-07-14]
Mutation Analysis Facility (MAF)
CTCF/cohesin-binding sites are frequently mutated in cancer.
Katainen R, Dave K, Pitkänen E, ..., Taipale J, Aaltonen LA
pii: ng.3335
Nat. Genet. 47 (7) 818-821 [2015-07-00; online 2015-06-09]
Karolinska High Throughput Center (KHTC)
Dynamics of Cell Generation and Turnover in the Human Heart.
Bergmann O, Zdunek S, Felker A, ..., Druid H, Frisén J
pii: S0092-8674(15)00576-0
Cell 161 (7) 1566-1575 [2015-06-18; online 2015-06-16]
Advanced Light Microscopy (ALM) [Service]
Proximity-dependent initiation of hybridization chain reaction
Koos B, Cane G, Grannas K, ..., Kamali-Moghaddam M, Söderberg O
Nat Commun 6 (-) 7294 [2015-06-12; online 2015-06-12]
PLA and Single Cell Proteomics [Technology development]
Human adaptation to arsenic-rich environments.
Schlebusch CM, Gattepaille LM, Engström K, ..., Jakobsson M, Broberg K
pii: msv046
Mol. Biol. Evol. 32 (6) 1544-1555 [2015-06-00; online 2015-03-06]
NGI Uppsala (SNP&SEQ Technology Platform) National Genomics Infrastructure
Zebrafish: A possible tool to evaluate bioactive ions.
Montazerolghaem M, Nyström L, Engqvist H, Karlsson Ott M
pii: S1742-7061(15)00110-5
Acta Biomater 19 (-) 10-14 [2015-06-00; online 2015-03-17]
Genome Engineering Zebrafish
Differential Gene Regulation in Fibroblasts in Co-culture with Keratinocytes and Head and Neck SCC Cells.
Hakelius M, Saiepour D, Göransson H, ..., Gerdin B, Nowinski D
pii: 35/6/3253
Anticancer Res. 35 (6) 3253-3265 [2015-06-00; online 2015-05-31]
Array and Analysis Facility
Loss of ASRGL1 expression is an independent biomarker for disease-specific survival in endometrioid endometrial carcinoma.
Edqvist PH, Huvila J, Forsström B, ..., Pontén F, Auranen A
pii: S0090-8258(15)00783-0
Gynecol. Oncol. 137 (3) 529-537 [2015-06-00; online 2015-04-07]
Tissue Profiling [Collaborative]
Phylogeny, evolution and classification of gall wasps: the plot thickens.
Ronquist F, Nieves-Aldrey JL, Buffington ML, ..., Liljeblad J, Nylander JA
pii: PONE-D-14-21986 pmc: PMC4439057
PLoS ONE 10 (5) e0123301 [2015-05-20; online 2015-05-20]
Bioinformatics Support and Infrastructure Bioinformatics Support, Infrastructure and Training
CGGBP1 mitigates cytosine methylation at repetitive DNA sequences.
Agarwal P, Collier P, Fritz MH, ..., Westermark B, Singh U
pii: 10.1186/s12864-015-1593-2 pmc: PMC4432828
BMC Genomics 16 (-) 390 [2015-05-16; online 2015-05-16]
NGI Uppsala (Uppsala Genome Center) National Genomics Infrastructure
Complex archaea that bridge the gap between prokaryotes and eukaryotes.
Spang A, Saw JH, Jørgensen SL, ..., Guy L, Ettema TJ
pii: nature14447 pmc: PMC4444528 mid: EMS63446 GENBANK: JYIM00000000 GENBANK: KP869578 GENBANK: KP869579 GENBANK: KP869580 GENBANK: KP869581 GENBANK: KP869582 GENBANK: KP869583 GENBANK: KP869584 GENBANK: KP869585 GENBANK: KP869586 GENBANK: KP869587 GENBANK: KP869588 GENBANK: KP869589 GENBANK: KP869590 GENBANK: KP869591 GENBANK: KP869592 GENBANK: KP869593 GENBANK: KP869594 GENBANK: KP869595 GENBANK: KP869596 GENBANK: KP869597 GENBANK: KP869598 GENBANK: KP869599 GENBANK: KP869600 GENBANK: KP869601 GENBANK: KP869602 GENBANK: KP869603 GENBANK: KP869604 GENBANK: KP869605 GENBANK: KP869606 GENBANK: KP869607 GENBANK: KP869608 GENBANK: KP869609 GENBANK: KP869610 GENBANK: KP869611 GENBANK: KP869612 GENBANK: KP869613 GENBANK: KP869614 GENBANK: KP869615 GENBANK: KP869616 GENBANK: KP869617 GENBANK: KP869618 GENBANK: KP869619 GENBANK: KP869620 GENBANK: KP869621 GENBANK: KP869622 GENBANK: KP869623 GENBANK: KP869624 GENBANK: KP869625 GENBANK: KP869626 GENBANK: KP869627 GENBANK: KP869628 GENBANK: KP869629 GENBANK: KP869630 GENBANK: KP869631 GENBANK: KP869632 GENBANK: KP869633 GENBANK: KP869634 GENBANK: KP869635 GENBANK: KP869636 GENBANK: KP869637 GENBANK: KP869638 GENBANK: KP869639 GENBANK: KP869640 GENBANK: KP869641 GENBANK: KP869642 GENBANK: KP869643 GENBANK: KP869644 GENBANK: KP869645 GENBANK: KP869646 GENBANK: KP869647 GENBANK: KP869648 GENBANK: KP869649 GENBANK: KP869650 GENBANK: KP869651 GENBANK: KP869652 GENBANK: KP869653 GENBANK: KP869654 GENBANK: KP869655 GENBANK: KP869656 GENBANK: KP869657 GENBANK: KP869658 GENBANK: KP869659 GENBANK: KP869660 GENBANK: KP869661 GENBANK: KP869662 GENBANK: KP869663 GENBANK: KP869664 GENBANK: KP869665 GENBANK: KP869666 GENBANK: KP869667 GENBANK: KP869668 GENBANK: KP869669 GENBANK: KP869670 GENBANK: KP869671 GENBANK: KP869672 GENBANK: KP869673 GENBANK: KP869674 GENBANK: KP869675 GENBANK: KP869676 GENBANK: KP869677 GENBANK: KP869678 GENBANK: KP869679 GENBANK: KP869680 GENBANK: KP869681 GENBANK: KP869682 GENBANK: KP869683 GENBANK: KP869684 GENBANK: KP869685 GENBANK: KP869686 GENBANK: KP869687 GENBANK: KP869688 GENBANK: KP869689 GENBANK: KP869690 GENBANK: KP869691 GENBANK: KP869692 GENBANK: KP869693 GENBANK: KP869694 GENBANK: KP869695 GENBANK: KP869696 GENBANK: KP869697 GENBANK: KP869698 GENBANK: KP869699 GENBANK: KP869700 GENBANK: KP869701 GENBANK: KP869702 GENBANK: KP869703 GENBANK: KP869704 GENBANK: KP869705 GENBANK: KP869706 GENBANK: KP869707 GENBANK: KP869708 GENBANK: KP869709 GENBANK: KP869710 GENBANK: KP869711 GENBANK: KP869712 GENBANK: KP869713 GENBANK: KP869714 GENBANK: KP869715 GENBANK: KP869716 GENBANK: KP869717 GENBANK: KP869718 GENBANK: KP869719 GENBANK: KP869720 GENBANK: KP869721 GENBANK: KP869722 GENBANK: KP869723 GENBANK: KP869724 GENBANK: LAZR00000000 SRA: SRP045692
Nature 521 (7551) 173-179 [2015-05-14; online 2015-05-07]
NGI Uppsala (SNP&SEQ Technology Platform) National Genomics Infrastructure
NOTA: a potent metallo-β-lactamase inhibitor
Somboro AM, Tiwari D, Bester LA, ..., Naicker T, Essack SY
J. Antimicrob. Chemother. 70 (5) 1594-1596 [2015-05-00; online 2015-01-06]
Drug Discovery and Development (DDD) [Collaborative]
Tracking the origin of metastatic prostate cancer.
Lindberg J, Kristiansen A, Wiklund P, Grönberg H, Egevad L
pii: S0302-2838(14)00892-6
Eur. Urol. 67 (5) 819-822 [2015-05-00; online 2014-09-24]
NGI Stockholm (Genomics Applications) NGI Stockholm (Genomics Production) National Genomics Infrastructure
Diagnostic urinary proteome profile for immunoglobulin a nephropathy.
Samavat S, Kalantari S, Nafar M, ..., Parvin M, Zubarev RA
pii: 1848/776
Iran J Kidney Dis 9 (3) 239-248 [2015-05-00; online 2015-05-10]
Advanced Mass Spectrometry Proteomics
The role of genetic factors for hearing deterioration across 20 years: a twin study.
Bogo R, Farah A, Johnson AC, ..., Svartengren M, Skjönsberg Å
pii: glu245
J. Gerontol. A Biol. Sci. Med. Sci. 70 (5) 647-653 [2015-05-00; online 2015-02-11]
Mutation Analysis Facility (MAF)
Circulating carnosine dipeptidase 1 associates with weight loss and poor prognosis in gastrointestinal cancer.
Arner P, Henjes F, Schwenk JM, ..., Nilsson P, Rydén M
pii: PONE-D-14-54419 pmc: PMC4405487
PLoS ONE 10 (4) e0123566 [2015-04-21; online 2015-04-21]
Plasma Profiling
Adiposity as a cause of cardiovascular disease: a Mendelian randomization study.
Hägg S, Fall T, Ploner A, ..., Ingelsson E, European Network for Genetic and Genomic Epidemiology Consortium
pii: dyv094 pmc: PMC4553708
Int J Epidemiol 44 (2) 578-586 [2015-04-00; online 2015-05-27]
NGI Uppsala (SNP&SEQ Technology Platform) National Genomics Infrastructure
XRMA and ToF-SIMS Analysis of Normal and Hypomineralized Enamel
Melin L, Lundgren J, Malmberg P, ..., Taube F, Cornell DH
Microsc Microanal 21 (2) 407-421 [2015-04-00; online 2015-02-12]
Gothenburg Imaging Mass Spectrometry [Collaborative]
Duffy antigen receptor genetic variant and the association with Interleukin 8 levels.
Moreno Velásquez I, Kumar J, Björkbacka H, ..., de Faire U, Gigante B
pii: S1043-4666(14)00652-8
Cytokine 72 (2) 178-184 [2015-04-00; online 2015-01-31]
NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]
Fluctuating expression of microRNAs in adenovirus infected cells.
Zhao H, Chen M, Tellgren-Roth C, Pettersson U
pii: S0042-6822(15)00056-2
Virology 478 (-) 99-111 [2015-04-00; online 2015-03-07]
NGI Uppsala (Uppsala Genome Center) National Genomics Infrastructure
Methylation levels of SLC23A2 and NCOR2 genes correlate with spinal muscular atrophy severity.
Zheleznyakova GY, Nilsson EK, Kiselev AV, ..., Baranov VS, Schiöth HB
pii: PONE-D-14-49427 pmc: PMC4378931
PLoS ONE 10 (3) e0121964 [2015-03-30; online 2015-03-30]
NGI Uppsala (Uppsala Genome Center) National Genomics Infrastructure
Low Elastin Content of Carotid Plaques Is Associated with Increased Risk of Ipsilateral Stroke
Asciutto G, Dias NV, Edsfeldt A, ..., Nilsson J, Gonçalves I
PLoS ONE 10 (3) e0121086 [2015-03-24; online 2015-03-24]
Clinical Biomarkers [Service]
Complete genome sequence of Borrelia afzelii K78 and comparative genome analysis.
Schüler W, Bunikis I, Weber-Lehman J, ..., Bergström S, Lundberg U
pii: PONE-D-14-47099 pmc: PMC4370689
PLoS ONE 10 (3) e0120548 [2015-03-23; online 2015-03-23]
NGI Uppsala (Uppsala Genome Center) National Genomics Infrastructure
SLC10A4 is a vesicular amine-associated transporter modulating dopamine homeostasis.
Larhammar M, Patra K, Blunder M, ..., Wallén-Mackenzie Å, Kullander K
pii: S0006-3223(14)00550-2
Biol. Psychiatry 77 (6) 526-536 [2015-03-15; online 2014-09-02]
Advanced Light Microscopy (ALM) [Collaborative]
New genetic loci link adipose and insulin biology to body fat distribution.
Shungin D, Winkler TW, Croteau-Chonka DC, ..., Lindgren CM, Mohlke KL
Nature 518 (7538) 187-196 [2015-02-12; online 2015-02-13]
NGI Uppsala (SNP&SEQ Technology Platform) National Genomics Infrastructure
The GH receptor exon 3 deleted/full-length polymorphism is associated with central adiposity in the general population.
Glad CA, Carlsson LM, Melander O, ..., Svensson PA, Johannsson G
pii: EJE-14-0723
Eur. J. Endocrinol. 172 (2) 123-128 [2015-02-00; online 2014-11-14]
Mutation Analysis Facility (MAF)
Novel high-throughput screening method for identification of fungal dimorphism blockers.
Stylianou M, Uvell H, Lopes JP, ..., Elofsson M, Urban CF
pii: 1087057114552954
J Biomol Screen 20 (2) 285-291 [2015-02-00; online 2014-10-05]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
Associations between the 17q21 region and allergic rhinitis in 5 birth cohorts.
Fuertes E, Söderhäll C, Acevedo N, ..., Carlsten C, Melén E
pii: S0091-6749(14)01188-9
J. Allergy Clin. Immunol. 135 (2) 573-576 [2015-02-00; online 2014-09-30]
Mutation Analysis Facility (MAF)
Prognostic impact of COX-2 in non-small cell lung cancer: a comprehensive compartment-specific evaluation of tumor and stromal cell expression.
Mattsson JS, Bergman B, Grinberg M, ..., Micke P, Gulyas M
pii: S0304-3835(14)00631-4
Cancer Lett. 356 (2 Pt B) 837-845 [2015-01-28; online 2014-10-31]
Tissue Profiling [Collaborative]
Variation in the human immune system is largely driven by non-heritable influences.
Brodin P, Jojic V, Gao T, ..., Maecker HT, Davis MM
pii: S0092-8674(14)01590-6 pmc: PMC4302727 mid: NIHMS651809
Cell 160 (1-2) 37-47 [2015-01-15; online 2015-01-17]
Mass Cytometry [Collaborative]
Defects of CRB2 cause steroid-resistant nephrotic syndrome.
Ebarasi L, Ashraf S, Bierzynska A, ..., Hildebrandt F, Majumdar A
pii: S0002-9297(14)00480-7 pmc: PMC4289689
Am. J. Hum. Genet. 96 (1) 153-161 [2015-01-08; online 2015-01-06]
Genome Engineering Zebrafish
A genetic study on C5-TRAF1 and progression of joint damage in rheumatoid arthritis.
van Steenbergen HW, Rodríguez-Rodríguez L, Berglin E, ..., Rantapää-Dahlqvist S, van der Helm-van Mil AH
pii: s13075-014-0514-0 pmc: PMC4318544
Arthritis Res. Ther. 17 (-) 1 [2015-01-08; online 2015-01-08]
NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]
The higher frequency of IgA deficiency among Swedish twins is not explained by HLA haplotypes.
Frankowiack M, Kovanen RM, Repasky GA, ..., Pedersen NL, Hammarström L
pii: gene201478
Genes Immun. 16 (3) 199-205 [2015-01-08; online 2015-01-08]
NGI Uppsala (SNP&SEQ Technology Platform) National Genomics Infrastructure
A secretagogin locus of the mammalian hypothalamus controls stress hormone release.
Romanov RA, Alpár A, Zhang MD, ..., Hökfelt T, Harkany T
pii: embj.201488977 pmc: PMC4291479
EMBO J. 34 (1) 36-54 [2015-01-02; online 2014-11-29]
Fluorescence Tissue Profiling
Scavenging effect of Trolox released from brushite cements.
Mestres G, Santos CF, Engman L, Persson C, Ott MK
pii: S1742-7061(14)00390-0
Acta Biomater 11 (-) 459-466 [2015-01-00; online 2014-09-18]
BioMaterial Interactions (BioMat)
The Biobanking Analysis Resource Catalogue (BARCdb): a new research tool for the analysis of biobank samples.
Galli J, Oelrich J, Taussig MJ, ..., Ortega-Paino E, Landegren U
pii: gku1008 pmc: PMC4383877
Nucleic Acids Res. 43 (Database issue) D1158-D1162 [2015-01-00; online 2014-10-23]
PLA and Single Cell Proteomics
The effect of N-methylation of amino acids (Ac-X-OMe) on solubility and conformation: a DFT study
Md. Abdur Rauf S, Arvidsson PI, Albericio F, ..., Kruger HG, Honarparvar B
Org. Biomol. Chem. 13 (39) 9993-10006 [2015-00-00; online 2015-00-00]
Drug Discovery and Development (DDD) [Collaborative]