Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation.

Zhang Q, Bastard P, Bolze A, Jouanguy E, Zhang SY, COVID Human Genetic Effort , Cobat A, Notarangelo LD, Su HC, Abel L, Casanova JL

Med 1 (1) 14-20 [2020-12-18; online 2020-12-29]

The risk of life-threatening COVID-19 pneumonia increases sharply after 65 years of age, but other epidemiological risk factors, genetic or otherwise, are modest. Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type I IFNs account for at least 10% of critical cases.

Cellular Immunomonitoring [Collaborative]

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PubMed 33363283

DOI 10.1016/j.medj.2020.12.001

Crossref 10.1016/j.medj.2020.12.001

pii: S2666-6340(20)30029-5
pmc: PMC7748410