Wrighton S

The hinge-engineered IgG1-IgG3 hybrid subclass IgGh47 potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodies.

Izadi A, Karami Y, Bratanis E, ..., Malmström L, Nordenfelt P

Nat Commun 15 (1) 3600 [2024-04-27; online 2024-04-27]

Drug Discovery and Development (DDD) [Service]

Subclass-switched anti-spike IgG3 oligoclonal cocktails strongly enhance Fc-mediated opsonization.

Izadi A, Hailu A, Godzwon M, ..., Bahnan W, Nordenfelt P

Proc. Natl. Acad. Sci. U.S.A. 120 (15) e2217590120 [2023-04-11; online 2023-04-03]

Drug Discovery and Development (DDD) [Service]

A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein mediates immune function.

Bahnan W, Happonen L, Khakzad H, ..., Malmström J, Nordenfelt P

EMBO Mol Med 15 (2) e16208 [2023-02-08; online 2022-12-12]

Structural Proteomics [Collaborative]