{"entity": "publication", "iuid": "96eafa28ec7c4b058885ebcf5b82c2d1", "timestamp": "2026-07-15T23:02:15.218Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/96eafa28ec7c4b058885ebcf5b82c2d1.json"}, "display": {"href": "https://publications.scilifelab.se/publication/96eafa28ec7c4b058885ebcf5b82c2d1"}}, "title": "Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction.", "authors": [{"family": "Llona-Minguez", "given": "Sabin", "initials": "S"}, {"family": "Throup", "given": "Adam", "initials": "A"}, {"family": "Steiner", "given": "Emilie", "initials": "E"}, {"family": "Lightowler", "given": "Molly", "initials": "M"}, {"family": "Van der Haegen", "given": "Sandra", "initials": "S"}, {"family": "Homan", "given": "Evert", "initials": "E"}, {"family": "Eriksson", "given": "Lars", "initials": "L"}, {"family": "Stenmark", "given": "P\u00e5l", "initials": "P", "orcid": "0000-0003-4777-3417", "researcher": {"href": "https://publications.scilifelab.se/researcher/d97eba9f5edf4d76a5259c4baa8366c5.json"}}, {"family": "Jenmalm-Jensen", "given": "Annika", "initials": "A"}, {"family": "Helleday", "given": "Thomas", "initials": "T", "orcid": "0000-0002-7384-092X", "researcher": {"href": "https://publications.scilifelab.se/researcher/3d7256c271ea4adea404d4ff355f804e.json"}}], "type": "journal article", "published": "2017-09-26", "journal": {"volume": "15", "issn": "1477-0539", "issue": "37", "pages": "7758-7764", "title": "Org. Biomol. Chem.", "issn-l": "1477-0520"}, "abstract": "Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels-Alder reaction. Using previously unexplored cyclic ketones, heterocyclic amines and cyclopentadiene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between \"drug-like\" molecules and natural products.", "doi": "10.1039/c7ob02069d", "pmid": "28891572", "labels": {"Chemical Biology Consortium Sweden": "Collaborative"}, "xrefs": [], "notes": [], "created": "2020-01-13T12:56:59.001Z", "modified": "2025-10-17T13:04:29.155Z"}