{"entity": "publication", "iuid": "d76d3e51f0094752b0b8b525a73f55a8", "timestamp": "2026-07-22T13:40:55.772Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d76d3e51f0094752b0b8b525a73f55a8.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d76d3e51f0094752b0b8b525a73f55a8"}}, "title": "The genomics of major psychiatric disorders in a large pedigree from Northern Sweden.", "authors": [{"family": "Szatkiewicz", "given": "Jin", "initials": "J"}, {"family": "Crowley", "given": "James J", "initials": "JJ"}, {"family": "Adolfsson", "given": "Annelie Nordin", "initials": "AN"}, {"family": "\u00c5berg", "given": "Karolina A", "initials": "KA"}, {"family": "Alaerts", "given": "Maaike", "initials": "M"}, {"family": "Genovese", "given": "Giulio", "initials": "G"}, {"family": "McCarroll", "given": "Steven", "initials": "S"}, {"family": "Del-Favero", "given": "Jurgen", "initials": "J"}, {"family": "Adolfsson", "given": "Rolf", "initials": "R"}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF", "orcid": "0000-0002-6619-873X", "researcher": {"href": "https://publications.scilifelab.se/researcher/4d95de0b5ab14586980a6a13c8299346.json"}}], "type": "journal article", "published": "2019-02-04", "journal": {"volume": "9", "issn": "2158-3188", "issue": "1", "pages": "60", "title": "Transl Psychiatry", "issn-l": "2158-3188"}, "abstract": "We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls.", "doi": "10.1038/s41398-019-0414-9", "pmid": "30718465", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s41398-019-0414-9"}, {"db": "pmc", "key": "PMC6362018"}], "notes": [], "created": "2019-04-23T09:58:54.570Z", "modified": "2024-01-16T13:48:44.705Z"}