Backlund M

Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.

Huseby DL, Cao S, Zamaratski E, ..., Hughes D, Karlén A

Proc. Natl. Acad. Sci. U.S.A. 121 (15) e2317274121 [2024-04-09; online 2024-04-05]

Drug Discovery and Development (DDD) [Collaborative]

Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors.

Brem J, Panduwawala T, Hansen JU, ..., Walsh TR, Schofield CJ

Nat Chem 14 (1) 15-24 [2022-01-00; online 2021-12-13]

Drug Discovery and Development (DDD) [Service]

A Series of Analogues to the AT 2R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode.

Isaksson R, Lindman J, Wannberg J, ..., Gising J, Larhed M

ChemistryOpen 8 (1) 114-125 [2019-01-00; online 2019-01-24]

Drug Discovery and Development (DDD) [Collaborative]