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Cheng T, Diarbakerli E, Simony A, Østerheden Andersen M, Danielsson A, Kere J, Einarsdottir E, Gerdhem P
Pain Rep 10 (1) e1227 [2025-02-00; online 2024-12-19]
Back pain is common in idiopathic scoliosis. The aim of this study was to study known genetic variants associated with pain in individuals with idiopathic scoliosis. We included 1442 individuals with juvenile or adolescent idiopathic scoliosis from Sweden and Denmark. Single nucleotide variants (SNV) genotyping was performed on 37 SNVs. Pain was assessed using 2 questionnaires. The mean pain domain score on the Scoliosis Research Society 22 revised questionnaire (SRS-22r) ranging between 1 (worst) and 5 (best) was dichotomized into a "back pain group" (score <4) and a "no back pain group" (score ≥4). The EuroQol 5-dimensions (EQ-5D) 3 level pain domain was dichotomized into a "no pain group" and a "pain group." Odds ratios were used to describe the associations. Based on the SRS-22r pain domain scores, 456 individuals (32%) reported back pain. Based on the EQ-5D questionnaire, 813 individuals (56%) reported moderate or extreme pain/discomfort. The odds ratio for the associations between the selected genetic variants and back pain or pain in general as measured with SRS-22r and EQ-5D-3L ranged between 0.88 to 1.17 and 0.86 to 1.16, with P-values ranging between 0.08 to 0.99 and 0.08 to 0.95. This study suggests that known genetic variants associated with pain do not play a significant role in the development of pain in individuals with idiopathic scoliosis.
NGI Uppsala (SNP&SEQ Technology Platform) [Service]
National Genomics Infrastructure [Service]
PubMed 39713503
DOI 10.1097/PR9.0000000000001227
Crossref 10.1097/PR9.0000000000001227
pmc: PMC11661741
pii: PAINREPORTS-D-23-0205