GBA1 T369M and Parkinson's disease - Further evidence of a lack of association in the Swedish population.

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Brolin KA, Bäckström D, Wallenius J, Gan-Or Z, Puschmann A, Hansson O, Swanberg M

Parkinsonism Relat Disord 130 (-) 107191 [2025-01-00; online 2024-10-31]

Variants in GBA1 are important genetic risk factors in Parkinson's disease (PD). GBA1 T369M has been linked to an ∼80 % increased PD risk but the reports are conflicting and the relevance of GBA1 variants in different populations varies. A lack of association between T369M and PD in the Swedish population was recently reported but needs further validation. We therefore investigated T369M in 1,808 PD patients and 2,183 controls and our results support that T369M is not a risk factor for PD in the Swedish population.

Clinical Genomics Lund [Service]

PubMed 39514913

DOI 10.1016/j.parkreldis.2024.107191

Crossref 10.1016/j.parkreldis.2024.107191

pii: S1353-8020(24)01203-3