{"entity": "researcher", "timestamp": "2026-08-07T19:23:40.641Z", "family": "Berger", "given": "Evelin", "initials": "E", "orcid": "0000-0002-6223-8845", "affiliations": ["Proteomics Core Facility, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden"], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/fd3899fb5760421086c90269e85f1e6f.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/fd3899fb5760421086c90269e85f1e6f"}}, "publications": [{"entity": "publication", "iuid": "e67223704342411d9a074d5a878fdc42", "links": {"self": {"href": "https://publications.scilifelab.se/publication/e67223704342411d9a074d5a878fdc42.json"}, "display": {"href": "https://publications.scilifelab.se/publication/e67223704342411d9a074d5a878fdc42"}}, "title": "Stem Cell-Associated Proteins and Extracellular Matrix Composition of the Human Atrioventricular Junction.", "authors": [{"family": "Thorsell", "given": "Annika", "initials": "A"}, {"family": "Sj\u00f6lin", "given": "Linn\u00e9a", "initials": "L"}, {"family": "Berger", "given": "Evelin", "initials": "E", "orcid": "0000-0002-6223-8845", "researcher": {"href": "https://publications.scilifelab.se/researcher/fd3899fb5760421086c90269e85f1e6f.json"}}, {"family": "Jeppsson", "given": "Anders", "initials": "A"}, {"family": "Oldfors", "given": "Anders", "initials": "A"}, {"family": "Rotter Sopasakis", "given": "Victoria", "initials": "V"}, {"family": "Vukusic", "given": "Kristina", "initials": "K", "orcid": "0000-0002-4243-0565", "researcher": {"href": "https://publications.scilifelab.se/researcher/342e325123674e74963ae7c4dd307874.json"}}], "type": "journal article", "published": "2024-12-11", "journal": {"title": "Cells", "issn": "2073-4409", "volume": "13", "issue": "24", "issn-l": "2073-4409"}, "abstract": "The human heart regenerates slowly through life, but how new cells are generated is mostly unknown. The atrioventricular junction (AVj) has been indicated as a potential stem cell niche region. Little is known about the protein composition of the human AVj. To map the extracellular matrix (ECM) and expression of stem cell-related biomarkers, this study compares protein and gene expression patterns in AVj and Left Ventricular (LV) tissues. Biopsies were collected from 15 human hearts. Global quantitative proteomics and mRNA sequencing were used to identify differentially expressed proteins and altered genes. Of the total 4904 identified proteins, 1138 were differently expressed between the AVj and LV. While the top proteins in LV were involved in cardiac motor function and energy regulation, the AVj displayed proteins associated with early cardiomyocyte development, differentiation, proliferation, migration, and hypoxia. Furthermore, several developmental signalling pathways, including TGF-\u03b2, TNF, WNT, Notch, and FGF, were represented. RNA-seq data verified that the expressed genes were involved with differentiation, cell growth, proliferation, or ECM organization. Immunohistochemistry confirmed the expression of the stem cell-related biomarkers NPPA and POSTN in the AVj, further strengthening the hypothesis of the AVj as a specialized microenvironment conducive to stem cell niche activity.", "doi": "10.3390/cells13242048", "pmid": "39768140", "labels": {"Glycoproteomics and MS Proteomics": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC11674807"}, {"db": "pii", "key": "cells13242048"}], "notes": [], "created": "2025-02-11T14:16:08.712Z", "modified": "2025-10-22T19:23:46.155Z"}, {"entity": "publication", "iuid": "4ca1b8e485c54e0fa7d4971db645a74a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/4ca1b8e485c54e0fa7d4971db645a74a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/4ca1b8e485c54e0fa7d4971db645a74a"}}, "title": "Comparative Analysis of Plasma Protein Dynamics in Women with ST-Elevation Myocardial Infarction and Takotsubo Syndrome.", "authors": [{"family": "Hussain", "given": "Shafaat", "initials": "S", "orcid": "0000-0001-8008-7262", "researcher": {"href": "https://publications.scilifelab.se/researcher/b00b8b211148477eb60a17245e39ebd4.json"}}, {"family": "Jha", "given": "Sandeep", "initials": "S", "orcid": "0000-0001-7118-6293", "researcher": {"href": "https://publications.scilifelab.se/researcher/6e21caba76ab421cafd9ef2f434e476d.json"}}, {"family": "Berger", "given": "Evelin", "initials": "E", "orcid": "0000-0002-6223-8845", "researcher": {"href": "https://publications.scilifelab.se/researcher/fd3899fb5760421086c90269e85f1e6f.json"}}, {"family": "Molander", "given": "Linnea", "initials": "L"}, {"family": "Sevastianova", "given": "Valentyna", "initials": "V", "orcid": "0000-0003-1216-4216", "researcher": {"href": "https://publications.scilifelab.se/researcher/12195bc549cc462fac9fa77f5d21648e.json"}}, {"family": "Sheybani", "given": "Zahra", "initials": "Z"}, {"family": "Espinosa", "given": "Aaron Shekka", "initials": "AS", "orcid": "0000-0003-4336-5045", "researcher": {"href": "https://publications.scilifelab.se/researcher/d9657c297d4745af968b59ed86ebb059.json"}}, {"family": "Elmahdy", "given": "Ahmed", "initials": "A"}, {"family": "Al-Awar", "given": "Amin", "initials": "A", "orcid": "0000-0002-3199-2634", "researcher": {"href": "https://publications.scilifelab.se/researcher/6ab322a6f4ba42a7ae89ff230c8f07f0.json"}}, {"family": "Kakaei", "given": "Yalda", "initials": "Y"}, {"family": "Kalani", "given": "Mana", "initials": "M", "orcid": "0009-0004-5180-3951", "researcher": {"href": "https://publications.scilifelab.se/researcher/09911121aa0e4e379082ba9e4e007e15.json"}}, {"family": "Zulfaj", "given": "Ermir", "initials": "E"}, {"family": "Nejat", "given": "Amirali", "initials": "A"}, {"family": "Jha", "given": "Abhishek", "initials": "A"}, {"family": "Pylova", "given": "Tetiana", "initials": "T", "orcid": "0000-0002-6041-8690", "researcher": {"href": "https://publications.scilifelab.se/researcher/c56493bb42d44d3aa6dfa4038b582215.json"}}, {"family": "Krasnikova", "given": "Maryna", "initials": "M"}, {"family": "Andersson", "given": "Erik Axel", "initials": "EA"}, {"family": "Omerovic", "given": "Elmir", "initials": "E", "orcid": "0000-0002-3875-8621", "researcher": {"href": "https://publications.scilifelab.se/researcher/e7bb56a96cea489f9a2f46251dff02bb.json"}}, {"family": "Redfors", "given": "Bj\u00f6rn", "initials": "B"}], "type": "journal article", "published": "2024-10-24", "journal": {"title": "Cells", "issn": "2073-4409", "volume": "13", "issue": "21", "pages": "1764", "issn-l": "2073-4409"}, "abstract": "ST-elevation myocardial infarction (STEMI) and Takotsubo syndrome (TS) are two distinct cardiac conditions that both result in sudden loss of cardiac dysfunction and that are difficult to distinguish clinically. This study compared plasma protein changes in 24 women with STEMI and 12 women with TS in the acute phase (days 0-3 post symptom onset) and the stabilization phase (days 7, 14, and 30) to examine the molecular differences between these conditions.\n\nPlasma proteins from STEMI and TS patients were extracted during the acute and stabilization phases and analyzed via quantitative proteomics. Differential expression and functional significance were assessed. Data are accessible on ProteomeXchange, ID PXD051367.\n\nDuring the acute phase, STEMI patients showed higher levels of myocardial inflammation and tissue damage proteins compared to TS patients, along with reduced tissue repair and anti-inflammatory proteins. In the stabilization phase, STEMI patients exhibited ongoing inflammation and disrupted lipid metabolism. Notably, ADIPOQ was consistently downregulated in STEMI patients in both phases. When comparing the acute to the stabilization phase, STEMI patients showed increased inflammatory proteins and decreased structural proteins. Conversely, TS patients showed increased proteins involved in inflammation and the regulatory response to counter excessive inflammation. Consistent protein changes between the acute and stabilization phases in both conditions, such as SAA2, CRP, SAA1, LBP, FGL1, AGT, MAN1A1, APOA4, COMP, and PCOLCE, suggest shared underlying pathophysiological mechanisms.\n\nThis study presents protein changes in women with STEMI or TS and identifies ADIPOQ, SAA2, CRP, SAA1, LBP, FGL1, AGT, MAN1A1, APOA4, COMP, and PCOLCE as candidates for further exploration in both therapeutic and diagnostic contexts.", "doi": "10.3390/cells13211764", "pmid": "39513871", "labels": {"Clinical Genomics Gothenburg": "Service", "Glycoproteomics and MS Proteomics": "Collaborative", "Clinical Genomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11545104"}, {"db": "pii", "key": "cells13211764"}], "notes": [], "created": "2024-11-01T08:24:17.171Z", "modified": "2024-11-27T15:30:46.301Z"}]}