{"entity": "researcher", "timestamp": "2026-08-09T07:47:59.345Z", "family": "Atanassov", "given": "Ilian", "initials": "I", "orcid": "0000-0001-8259-2545", "affiliations": ["Proteomics Core Facility, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/f8d22eab41e44364be8966abaf693de1.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/f8d22eab41e44364be8966abaf693de1"}}, "publications": [{"entity": "publication", "iuid": "675f9e483128451bae7b9c4ff4df7de5", "links": {"self": {"href": "https://publications.scilifelab.se/publication/675f9e483128451bae7b9c4ff4df7de5.json"}, "display": {"href": "https://publications.scilifelab.se/publication/675f9e483128451bae7b9c4ff4df7de5"}}, "title": "Proteolytic cleavage activates the mitochondrial isoform of TOP3A.", "authors": [{"family": "Erdinc", "given": "Direnis", "initials": "D", "orcid": "0000-0002-5830-9911", "researcher": {"href": "https://publications.scilifelab.se/researcher/84ac70e933964561a3de794818f19bb1.json"}}, {"family": "Albus", "given": "Christin A", "initials": "CA", "orcid": "0000-0002-6259-7151", "researcher": {"href": "https://publications.scilifelab.se/researcher/ec36c816e9fe4800aeb343752a8dea67.json"}}, {"family": "Rodr\u00edguez-Luis", "given": "Alejandro", "initials": "A", "orcid": "0000-0003-3989-1317", "researcher": {"href": "https://publications.scilifelab.se/researcher/b6d5387162594c99b66912602952861e.json"}}, {"family": "Menger", "given": "Katja E", "initials": "KE", "orcid": "0000-0002-6972-7326", "researcher": {"href": "https://publications.scilifelab.se/researcher/591cc4b1736f480a8fa737d3125be624.json"}}, {"family": "Thorsell", "given": "Annika", "initials": "A"}, {"family": "Atanassov", "given": "Ilian", "initials": "I", "orcid": "0000-0001-8259-2545", "researcher": {"href": "https://publications.scilifelab.se/researcher/f8d22eab41e44364be8966abaf693de1.json"}}, {"family": "Rov\u0161nik", "given": "Ur\u0161ka", "initials": "U", "orcid": "0000-0001-5889-6899", "researcher": {"href": "https://publications.scilifelab.se/researcher/199ce7dade164889902f7ae01e4b4577.json"}}, {"family": "Falkenberg", "given": "Maria", "initials": "M", "orcid": "0000-0001-8713-173X", "researcher": {"href": "https://publications.scilifelab.se/researcher/562109b99a5c4eb3bd8b92f30014828b.json"}}, {"family": "Gustafsson", "given": "Claes M", "initials": "CM", "orcid": "0000-0003-3531-8468", "researcher": {"href": "https://publications.scilifelab.se/researcher/2851656430d147dab7a8a32e50fee7b7.json"}}, {"family": "Nicholls", "given": "Thomas J J", "initials": "TJJ", "orcid": "0000-0002-3034-4109", "researcher": {"href": "https://publications.scilifelab.se/researcher/46e55e31c134464c8d8f71cc553ef198.json"}}], "type": "journal article", "published": "2025-10-28", "journal": {"title": "Nucleic Acids Res.", "issn": "1362-4962", "volume": "53", "issue": "20", "issn-l": "0305-1048"}, "abstract": "The TOP3A gene encodes two isoforms, one targeted to the nucleus and one to mitochondria. Nuclear TOP3A functions as part of the BTRR complex to resolve double Holliday junctions during homologous recombination, while the mitochondrial isoform separates hemicatenated daughter mitochondrial DNA (mtDNA) molecules following DNA replication. Here, we show that the mitochondrial isoform of TOP3A undergoes proteolytic cleavage by the mitochondrial processing peptidase, removing ~90 amino acids from the C-terminus. This cleavage enhances the enzyme's biochemical properties, increasing single-stranded DNA binding and decatenation activity. Notably, all BTRR complex subunits, except TOP3A, are absent from mitochondria, suggesting that proteolytic processing enables TOP3A to function autonomously in mtDNA maintenance. We propose that this cleavage represents a post-import maturation step that tailors TOP3A to its mitochondrial context by uncoupling it from nuclear protein interactions and enhancing its catalytic efficiency.", "doi": "10.1093/nar/gkaf1140", "pmid": "41189053", "labels": {"Glycoproteomics and MS Proteomics": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC12585908"}, {"db": "pii", "key": "8313834"}], "notes": [], "created": "2025-11-20T18:16:59.783Z", "modified": "2025-11-24T15:41:51.127Z"}, {"entity": "publication", "iuid": "9f05d86339b84c169856faace9e38db9", "links": {"self": {"href": "https://publications.scilifelab.se/publication/9f05d86339b84c169856faace9e38db9.json"}, "display": {"href": "https://publications.scilifelab.se/publication/9f05d86339b84c169856faace9e38db9"}}, "title": "The mitochondrial methylation potential gates mitoribosome assembly.", "authors": [{"family": "Glasgow", "given": "Ruth I C", "initials": "RIC"}, {"family": "Singh", "given": "Vivek", "initials": "V", "orcid": "0000-0003-4656-3362", "researcher": {"href": "https://publications.scilifelab.se/researcher/0576b8ffc93d42f6b47d9d0d7d01bbd0.json"}}, {"family": "Pe\u00f1a-P\u00e9rez", "given": "Luc\u00eda", "initials": "L", "orcid": "0000-0002-5044-7754", "researcher": {"href": "https://publications.scilifelab.se/researcher/111f8a8c4c6d4d2ea60e5fc76831b7fa.json"}}, {"family": "Wilhalm", "given": "Alissa", "initials": "A"}, {"family": "Moedas", "given": "Marco F", "initials": "MF"}, {"family": "Moore", "given": "David", "initials": "D"}, {"family": "Rosenberger", "given": "Florian A", "initials": "FA", "orcid": "0000-0003-4604-6170", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e9cd9d0742d40e3b5dc1abfde64d5c4.json"}}, {"family": "Li", "given": "Xinping", "initials": "X"}, {"family": "Atanassov", "given": "Ilian", "initials": "I", "orcid": "0000-0001-8259-2545", "researcher": {"href": "https://publications.scilifelab.se/researcher/f8d22eab41e44364be8966abaf693de1.json"}}, {"family": "Saba", "given": "Mira", "initials": "M"}, {"family": "Cipullo", "given": "Miriam", "initials": "M"}, {"family": "Rorbach", "given": "Joanna", "initials": "J", "orcid": "0000-0002-2891-2840", "researcher": {"href": "https://publications.scilifelab.se/researcher/a069374613a7403b818ce7ca400f3627.json"}}, {"family": "Wedell", "given": "Anna", "initials": "A"}, {"family": "Freyer", "given": "Christoph", "initials": "C", "orcid": "0000-0003-0418-1673", "researcher": {"href": "https://publications.scilifelab.se/researcher/888298d25fb94acca7639063d3592373.json"}}, {"family": "Amunts", "given": "Alexey", "initials": "A", "orcid": "0000-0002-5302-1740", "researcher": {"href": "https://publications.scilifelab.se/researcher/e7d0bf36ad1a47f5b5b88f78d1e15395.json"}}, {"family": "Wredenberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-2500-6121", "researcher": {"href": "https://publications.scilifelab.se/researcher/3ea9ee7305424cdb8c238ef569e5be03.json"}}], "type": "journal article", "published": "2025-06-25", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "16", "issue": "1", "pages": "5388"}, "abstract": "S-adenosylmethionine (SAM) is the principal methyl donor in cells and is essential for mitochondrial gene expression, influencing RNA modifications, translation, and ribosome biogenesis. Using direct long-read RNA sequencing in mouse tissues and embryonic fibroblasts, we show that processing of the mitochondrial ribosomal gene cluster fails in the absence of mitochondrial SAM, leading to an accumulation of unprocessed precursors. Proteomic analysis of ribosome fractions revealed these precursors associated with processing and assembly factors, indicating stalled biogenesis. Structural analysis by cryo-electron microscopy demonstrated that SAM-dependent methylation is required for peptidyl transferase centre formation during mitoribosome assembly. Our findings identify a critical role for SAM in coordinating mitoribosomal RNA processing and large subunit maturation, linking cellular methylation potential to mitochondrial translation capacity.", "doi": "10.1038/s41467-025-60977-x", "pmid": "40562754", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (Uppsala Genome Center)": "Service", "NGI Long read": "Service", "Bioinformatics Support for Computational Resources": "Service", "NGI Stockholm (Genomics Applications)": null}, "xrefs": [{"db": "pmc", "key": "PMC12198368"}, {"db": "pii", "key": "10.1038/s41467-025-60977-x"}], "notes": [], "created": "2025-08-19T13:45:26.954Z", "modified": "2025-12-08T12:41:21.324Z"}, {"entity": "publication", "iuid": "2a1aa60f79b748bab652fae28b784691", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2a1aa60f79b748bab652fae28b784691.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2a1aa60f79b748bab652fae28b784691"}}, "title": "Mechanism of mitoribosomal small subunit biogenesis and preinitiation.", "authors": [{"family": "Itoh", "given": "Yuzuru", "initials": "Y", "orcid": "0000-0001-7802-5572", "researcher": {"href": "https://publications.scilifelab.se/researcher/12516bf2aeb44f9ba7e380b7be1bf582.json"}}, {"family": "Khawaja", "given": "Anas", "initials": "A"}, {"family": "Laptev", "given": "Ivan", "initials": "I", "orcid": "0000-0002-1893-2055", "researcher": {"href": "https://publications.scilifelab.se/researcher/6316213061d54141a39ba6fdbd47d535.json"}}, {"family": "Cipullo", "given": "Miriam", "initials": "M"}, {"family": "Atanassov", "given": "Ilian", "initials": "I", "orcid": "0000-0001-8259-2545", "researcher": {"href": "https://publications.scilifelab.se/researcher/f8d22eab41e44364be8966abaf693de1.json"}}, {"family": "Sergiev", "given": "Petr", "initials": "P", "orcid": "0000-0001-8866-1863", "researcher": {"href": "https://publications.scilifelab.se/researcher/99b196a60aa2470caf698cb35fba2ebd.json"}}, {"family": "Rorbach", "given": "Joanna", "initials": "J", "orcid": "0000-0002-2891-2840", "researcher": {"href": "https://publications.scilifelab.se/researcher/a069374613a7403b818ce7ca400f3627.json"}}, {"family": "Amunts", "given": "Alexey", "initials": "A", "orcid": "0000-0002-5302-1740", "researcher": {"href": "https://publications.scilifelab.se/researcher/e7d0bf36ad1a47f5b5b88f78d1e15395.json"}}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "606", "issue": "7914", "pages": "603-608", "issn-l": "0028-0836"}, "abstract": "Mitoribosomes are essential for the synthesis and maintenance of bioenergetic proteins. Here we use cryo-electron microscopy to determine a series of the small mitoribosomal subunit (SSU) intermediates in complex with auxiliary factors, revealing a sequential assembly mechanism. The methyltransferase TFB1M binds to partially unfolded rRNA h45 that is promoted by RBFA, while the mRNA channel is blocked. This enables binding of METTL15 that promotes further rRNA maturation and a large conformational change of RBFA. The new conformation allows initiation factor mtIF3 to already occupy the subunit interface during the assembly. Finally, the mitochondria-specific ribosomal protein mS37 (ref. 1) outcompetes RBFA to complete the assembly with the SSU-mS37-mtIF3 complex2 that proceeds towards mtIF2 binding and translation initiation. Our results explain how the action of step-specific factors modulate the dynamic assembly of the SSU, and adaptation of a unique protein, mS37, links the assembly to initiation to establish the catalytic human mitoribosome.", "doi": "10.1038/s41586-022-04795-x", "pmid": "35676484", "labels": {"Global Proteomics and Proteogenomics": "Service", "Cryo-EM": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9200640"}, {"db": "pii", "key": "10.1038/s41586-022-04795-x"}], "notes": [], "created": "2022-11-24T11:48:58.764Z", "modified": "2022-12-02T09:59:24.357Z"}, {"entity": "publication", "iuid": "2fa2f808b1704aa48c255a9d72580b1f", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2fa2f808b1704aa48c255a9d72580b1f.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2fa2f808b1704aa48c255a9d72580b1f"}}, "title": "The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication.", "authors": [{"family": "Jiang", "given": "Min", "initials": "M", "orcid": "0000-0002-7005-937X", "researcher": {"href": "https://publications.scilifelab.se/researcher/862b43b10af944108db18b48d57ba4a1.json"}}, {"family": "Xie", "given": "Xie", "initials": "X", "orcid": "0000-0002-8021-9875", "researcher": {"href": "https://publications.scilifelab.se/researcher/c0feb563228e42579c5aee512d250e5d.json"}}, {"family": "Zhu", "given": "Xuefeng", "initials": "X", "orcid": "0000-0002-4759-4446", "researcher": {"href": "https://publications.scilifelab.se/researcher/eebd5f32ac0c48869c90ba2d2ba94fa9.json"}}, {"family": "Jiang", "given": "Shan", "initials": "S", "orcid": "0000-0003-2020-6447", "researcher": {"href": "https://publications.scilifelab.se/researcher/6bd8b6e66470485f9978b3db1bb3b765.json"}}, {"family": "Milenkovic", "given": "Dusanka", "initials": "D", "orcid": "0000-0003-0151-8760", "researcher": {"href": "https://publications.scilifelab.se/researcher/7667a08efad244b88892a772f51ccf50.json"}}, {"family": "Misic", "given": "Jelena", "initials": "J", "orcid": "0000-0002-1562-0582", "researcher": {"href": "https://publications.scilifelab.se/researcher/ed5101973de04ee896ee41a2657612c4.json"}}, {"family": "Shi", "given": "Yonghong", "initials": "Y"}, {"family": "Tandukar", "given": "Nirwan", "initials": "N", "orcid": "0000-0001-7769-5304", "researcher": {"href": "https://publications.scilifelab.se/researcher/6fc8863a94e6450c9218b97453380785.json"}}, {"family": "Li", "given": "Xinping", "initials": "X", "orcid": "0000-0002-7427-0017", "researcher": {"href": "https://publications.scilifelab.se/researcher/836410d8d48f47fbb5bfd46deac8f6e8.json"}}, {"family": "Atanassov", "given": "Ilian", "initials": "I", "orcid": "0000-0001-8259-2545", "researcher": {"href": "https://publications.scilifelab.se/researcher/f8d22eab41e44364be8966abaf693de1.json"}}, {"family": "Jenninger", "given": "Louise", "initials": "L"}, {"family": "Hoberg", "given": "Emily", "initials": "E"}, {"family": "Albarran-Gutierrez", "given": "Sara", "initials": "S", "orcid": "0000-0003-1403-3922", "researcher": {"href": "https://publications.scilifelab.se/researcher/9231ff3b6f994dfaa9bc8f2a52746d78.json"}}, {"family": "Szilagyi", "given": "Zsolt", "initials": "Z"}, {"family": "Macao", "given": "Bertil", "initials": "B"}, {"family": "Siira", "given": "Stefan J", "initials": "SJ", "orcid": "0000-0002-8391-0143", "researcher": {"href": "https://publications.scilifelab.se/researcher/4739679420014daca252a8a6ea68597e.json"}}, {"family": "Carelli", "given": "Valerio", "initials": "V", "orcid": "0000-0003-4923-6404", "researcher": {"href": "https://publications.scilifelab.se/researcher/55d1ecff8faa4f4e90e515a6472f7701.json"}}, {"family": "Griffith", "given": "Jack D", "initials": "JD"}, {"family": "Gustafsson", "given": "Claes M", "initials": "CM"}, {"family": "Nicholls", "given": "Thomas J", "initials": "TJ", "orcid": "0000-0002-3034-4109", "researcher": {"href": "https://publications.scilifelab.se/researcher/46e55e31c134464c8d8f71cc553ef198.json"}}, {"family": "Filipovska", "given": "Aleksandra", "initials": "A", "orcid": "0000-0002-6998-8403", "researcher": {"href": "https://publications.scilifelab.se/researcher/c5130ef46efb4fcd8d3b7bbd5c1e7708.json"}}, {"family": "Larsson", "given": "Nils-G\u00f6ran", "initials": "NG", "orcid": "0000-0001-5100-996X", "researcher": {"href": "https://publications.scilifelab.se/researcher/1dc68aa2893a4ab8845fc32d8d6bc59a.json"}}, {"family": "Falkenberg", "given": "Maria", "initials": "M", "orcid": "0000-0001-8713-173X", "researcher": {"href": "https://publications.scilifelab.se/researcher/562109b99a5c4eb3bd8b92f30014828b.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "7", "issue": "27", "issn-l": "2375-2548"}, "abstract": "We report a role for the mitochondrial single-stranded DNA binding protein (mtSSB) in regulating mitochondrial DNA (mtDNA) replication initiation in mammalian mitochondria. Transcription from the light-strand promoter (LSP) is required both for gene expression and for generating the RNA primers needed for initiation of mtDNA synthesis. In the absence of mtSSB, transcription from LSP is strongly up-regulated, but no replication primers are formed. Using deep sequencing in a mouse knockout model and biochemical reconstitution experiments with pure proteins, we find that mtSSB is necessary to restrict transcription initiation to optimize RNA primer formation at both origins of mtDNA replication. Last, we show that human pathological versions of mtSSB causing severe mitochondrial disease cannot efficiently support primer formation and initiation of mtDNA replication.", "doi": "10.1126/sciadv.abf8631", "pmid": "34215584", "labels": {"Integrated Microscopy Technologies Gothenburg": "Service"}, "xrefs": [{"db": "pii", "key": "7/27/eabf8631"}], "notes": [], "created": "2023-02-16T08:17:57.108Z", "modified": "2023-02-16T08:17:57.519Z"}, {"entity": "publication", "iuid": "131283b276484c18b504aa4dc0115f19", "links": {"self": {"href": "https://publications.scilifelab.se/publication/131283b276484c18b504aa4dc0115f19.json"}, "display": {"href": "https://publications.scilifelab.se/publication/131283b276484c18b504aa4dc0115f19"}}, "title": "The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters.", "authors": [{"family": "Schober", "given": "Florian A", "initials": "FA", "orcid": "0000-0003-4604-6170", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e9cd9d0742d40e3b5dc1abfde64d5c4.json"}}, {"family": "Moore", "given": "David", "initials": "D"}, {"family": "Atanassov", "given": "Ilian", "initials": "I", "orcid": "0000-0001-8259-2545", "researcher": {"href": "https://publications.scilifelab.se/researcher/f8d22eab41e44364be8966abaf693de1.json"}}, {"family": "Moedas", "given": "Marco F", "initials": "MF", "orcid": "0000-0001-5461-0320", "researcher": {"href": "https://publications.scilifelab.se/researcher/7a9cd9caaa014f4280544a243520e18c.json"}}, {"family": "Clemente", "given": "Paula", "initials": "P"}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1", "orcid": "0000-0002-1287-0906", "researcher": {"href": "https://publications.scilifelab.se/researcher/74be6e7c877e4f0da6c7ed3747f3ef9d.json"}}, {"family": "Fissi", "given": "Najla El", "initials": "NE", "orcid": "0000-0002-6631-4630", "researcher": {"href": "https://publications.scilifelab.se/researcher/dec87cba920947028856aadb5892f7a6.json"}}, {"family": "Filograna", "given": "Roberta", "initials": "R"}, {"family": "Bucher", "given": "Anna-Lena", "initials": "AL", "orcid": "0000-0002-9391-4850", "researcher": {"href": "https://publications.scilifelab.se/researcher/7ec4467fb36b44f0a0b1dfa056ec964d.json"}}, {"family": "Hinze", "given": "Yvonne", "initials": "Y", "orcid": "0000-0002-2966-9862", "researcher": {"href": "https://publications.scilifelab.se/researcher/a922a71f2fde43908945980353ed595a.json"}}, {"family": "The", "given": "Matthew", "initials": "M", "orcid": "0000-0002-5401-5553", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e90cde879dc41eaade439bcf951a646.json"}}, {"family": "Hedman", "given": "Erik", "initials": "E", "orcid": "0000-0003-4017-9749", "researcher": {"href": "https://publications.scilifelab.se/researcher/ffc752d50a6649248c6809ea5aec803d.json"}}, {"family": "Chernogubova", "given": "Ekaterina", "initials": "E"}, {"family": "Begzati", "given": "Arjana", "initials": "A", "orcid": "0000-0002-8770-8022", "researcher": {"href": "https://publications.scilifelab.se/researcher/a15af0dbd68445538bd92c89f6d901df.json"}}, {"family": "Wibom", "given": "Rolf", "initials": "R", "orcid": "0000-0001-6721-4642", "researcher": {"href": "https://publications.scilifelab.se/researcher/c7d5fc666ef84a8784d8b28ecf233146.json"}}, {"family": "Jain", "given": "Mohit", "initials": "M"}, {"family": "Nilsson", "given": "Roland", "initials": "R", "orcid": "0000-0002-6020-7498", "researcher": {"href": "https://publications.scilifelab.se/researcher/0667c6d082934d818445fe0187dbb23e.json"}}, {"family": "K\u00e4ll", "given": "Lukas", "initials": "L", "orcid": "0000-0001-5689-9797", "researcher": {"href": "https://publications.scilifelab.se/researcher/9c9f4444f83e43d79c4772a430ca3969.json"}}, {"family": "Wedell", "given": "Anna", "initials": "A"}, {"family": "Freyer", "given": "Christoph", "initials": "C", "orcid": "0000-0003-0418-1673", "researcher": {"href": "https://publications.scilifelab.se/researcher/888298d25fb94acca7639063d3592373.json"}}, {"family": "Wredenberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-2500-6121", "researcher": {"href": "https://publications.scilifelab.se/researcher/3ea9ee7305424cdb8c238ef569e5be03.json"}}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "7", "issue": "8", "issn-l": "2375-2548"}, "abstract": "Induction of the one-carbon cycle is an early hallmark of mitochondrial dysfunction and cancer metabolism. Vital intermediary steps are localized to mitochondria, but it remains unclear how one-carbon availability connects to mitochondrial function. Here, we show that the one-carbon metabolite and methyl group donor S-adenosylmethionine (SAM) is pivotal for energy metabolism. A gradual decline in mitochondrial SAM (mitoSAM) causes hierarchical defects in fly and mouse, comprising loss of mitoSAM-dependent metabolites and impaired assembly of the oxidative phosphorylation system. Complex I stability and iron-sulfur cluster biosynthesis are directly controlled by mitoSAM levels, while other protein targets are predominantly methylated outside of the organelle before import. The mitoSAM pool follows its cytosolic production, establishing mitochondria as responsive receivers of one-carbon units. Thus, we demonstrate that cellular methylation potential is required for energy metabolism, with direct relevance for pathophysiology, aging, and cancer.", "doi": "10.1126/sciadv.abf0717", "pmid": "33608280", "labels": {"NGI Stockholm (Genomics Applications)": "Service", "NGI Stockholm (Genomics Production)": "Service", "National Genomics Infrastructure": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "7/8/eabf0717"}, {"db": "pmc", "key": "PMC7895438"}], "notes": [], "created": "2021-12-06T13:45:25.780Z", "modified": "2024-01-16T13:48:40.799Z"}]}