{"entity": "researcher", "timestamp": "2026-08-10T14:35:04.697Z", "family": "Pettersson-Kymmer", "given": "Ulrika", "initials": "U", "orcid": "0000-0002-0557-9803", "affiliations": ["Clinical Pharmacology, Department of Integrative Medical Biology, Ume\u00e5 University, SE-90197 Ume\u00e5, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/f3362b7a2ee34c8f9a52261eeb74d636.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/f3362b7a2ee34c8f9a52261eeb74d636"}}, "publications": [{"entity": "publication", "iuid": "34ad4b4804274e6685480880f7336643", "links": {"self": {"href": "https://publications.scilifelab.se/publication/34ad4b4804274e6685480880f7336643.json"}, "display": {"href": "https://publications.scilifelab.se/publication/34ad4b4804274e6685480880f7336643"}}, "title": "Low Circulating Valine Associate With High Risk of Hip Fractures.", "authors": [{"family": "Grahnemo", "given": "Louise", "initials": "L", "orcid": "0000-0001-5276-6612", "researcher": {"href": "https://publications.scilifelab.se/researcher/bb1ac8fe74954a5db43e8e6538cf8235.json"}}, {"family": "Eriksson", "given": "Anna L", "initials": "AL", "orcid": "0000-0001-5455-2810", "researcher": {"href": "https://publications.scilifelab.se/researcher/538ab065918b4201a2689efc50d2ed2f.json"}}, {"family": "Nethander", "given": "Maria", "initials": "M", "orcid": "0000-0003-3688-906X", "researcher": {"href": "https://publications.scilifelab.se/researcher/53d61951f51c4d40bef24672866382cb.json"}}, {"family": "Johansson", "given": "Robert", "initials": "R"}, {"family": "Lorentzon", "given": "Mattias", "initials": "M", "orcid": "0000-0003-0749-1431", "researcher": {"href": "https://publications.scilifelab.se/researcher/237bc87456e3454082a93f0490c4d4c4.json"}}, {"family": "Mellstr\u00f6m", "given": "Dan", "initials": "D"}, {"family": "Pettersson-Kymmer", "given": "Ulrika", "initials": "U", "orcid": "0000-0002-0557-9803", "researcher": {"href": "https://publications.scilifelab.se/researcher/f3362b7a2ee34c8f9a52261eeb74d636.json"}}, {"family": "Ohlsson", "given": "Claes", "initials": "C", "orcid": "0000-0002-9633-2805", "researcher": {"href": "https://publications.scilifelab.se/researcher/995dac358caa4a169fc889b7a3eef44a.json"}}], "type": "meta-analysis", "published": "2023-10-18", "journal": {"title": "J. Clin. Endocrinol. Metab.", "issn": "1945-7197", "issn-l": "0021-972X", "volume": "108", "issue": "11", "pages": "e1384-e1393"}, "abstract": "Hip fractures constitute a major health concern. An adequate supply of amino acids is crucial to ensure optimal acquisition and remodeling of bone. Circulating amino acid levels have been proposed as markers of bone mineral density, but data on their ability to predict incident fractures are scarce.\r\n\r\nTo investigate the associations between circulating amino acids and incident fractures.\r\n\r\nWe used UK Biobank (n = 111 257; 901 hip fracture cases) as a discovery cohort and the Ume\u00e5 Fracture and Osteoporosis (UFO) hip fracture study (hip fracture cases n = 2225; controls n = 2225) for replication. Associations with bone microstructure parameters were tested in a subsample of Osteoporotic Fractures in Men Sweden (n = 449).\r\n\r\nCirculating valine was robustly associated with hip fractures in the UK Biobank (HR per SD increase 0.79, 95% CI 0.73-0.84), and this finding was replicated in the UFO study (combined meta-analysis including 3126 incident hip fracture cases, odds ratio per SD increase 0.84, 95% CI 0.80-0.88). Detailed bone microstructure analyses showed that high circulating valine was associated with high cortical bone area and trabecular thickness.\r\n\r\nLow circulating valine is a robust predictor of incident hip fractures. We propose that circulating valine may add information for hip fracture prediction. Future studies are warranted to determine whether low valine is causally associated with hip fractures.", "doi": "10.1210/clinem/dgad268", "pmid": "37178220", "labels": {"Clinical Genomics Gothenburg": "Collaborative", "Clinical Genomics": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC10583993"}, {"db": "pii", "key": "7161698"}], "notes": [], "created": "2023-11-30T22:32:36.701Z", "modified": "2023-11-30T22:34:37.285Z"}]}