{"entity": "researcher", "timestamp": "2026-07-11T23:13:48.809Z", "family": "Draczkowski", "given": "Piotr", "initials": "P", "orcid": "0000-0002-9408-2670", "affiliations": ["National Bioinformatics Infrastructure Sweden, SciLifeLab, Solna, Sweden.", "Department of Synthesis and Chemical Technology of Pharmaceutical Substances, Medical University of Lublin, Lublin, Poland."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/efa7492df2464ccdb31320e4f5bb51e9.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/efa7492df2464ccdb31320e4f5bb51e9"}}, "publications": [{"entity": "publication", "iuid": "ceaf1969c97a4727bf39dfdf61d788be", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ceaf1969c97a4727bf39dfdf61d788be.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ceaf1969c97a4727bf39dfdf61d788be"}}, "title": "MIA40 suppresses cell death induced by apoptosis-inducing factor 1.", "authors": [{"family": "Mussulini", "given": "Ben Hur Marins", "initials": "BHM", "orcid": "0000-0003-4321-5709", "researcher": {"href": "https://publications.scilifelab.se/researcher/a5d73d54bba342edbc4af1606bf7af79.json"}}, {"family": "Maruszczak", "given": "Klaudia K", "initials": "KK", "orcid": "0000-0003-4080-9368", "researcher": {"href": "https://publications.scilifelab.se/researcher/456fceca130940b8a46137d5d2756043.json"}}, {"family": "Draczkowski", "given": "Piotr", "initials": "P", "orcid": "0000-0002-9408-2670", "researcher": {"href": "https://publications.scilifelab.se/researcher/efa7492df2464ccdb31320e4f5bb51e9.json"}}, {"family": "Borrero-Landazabal", "given": "Mayra A", "initials": "MA", "orcid": "0000-0003-3464-4042", "researcher": {"href": "https://publications.scilifelab.se/researcher/0a6bac5b1045422abddc2b136642cf4a.json"}}, {"family": "Ayyamperumal", "given": "Selvaraj", "initials": "S", "orcid": "0000-0003-2634-391X", "researcher": {"href": "https://publications.scilifelab.se/researcher/fe24ea5ef2494e60b633aea581c0bc89.json"}}, {"family": "Wnorowski", "given": "Artur", "initials": "A"}, {"family": "Wasilewski", "given": "Michal", "initials": "M", "orcid": "0000-0002-4890-5103", "researcher": {"href": "https://publications.scilifelab.se/researcher/772c69846aff4fd081a53a7f704eaff2.json"}}, {"family": "Chacinska", "given": "Agnieszka", "initials": "A", "orcid": "0000-0002-2832-2568", "researcher": {"href": "https://publications.scilifelab.se/researcher/0f6574d6e83b4e65a2721be9527de5ff.json"}}], "type": "journal article", "published": "2025-04-00", "journal": {"title": "EMBO Rep.", "issn": "1469-3178", "volume": "26", "issue": "7", "pages": "1835-1862", "issn-l": "1469-221X"}, "abstract": "Mitochondria harbor respiratory complexes that perform oxidative phosphorylation. Complex I is the first enzyme of the respiratory chain that oxidizes NADH. A dysfunction in complex I can result in higher cellular levels of NADH, which in turn strengthens the interaction between apoptosis-inducing factor 1 (AIFM1) and Mitochondrial intermembrane space import and assembly protein 40 (MIA40) in the mitochondrial intermembrane space. We investigated whether MIA40 modulates the activity of AIFM1 upon increased NADH/NAD+ balance. We found that in model cells characterized by an increase in NADH the AIFM1-MIA40 interaction is strengthened and these cells demonstrate resistance to AIFM1-induced cell death. Either silencing of MIA40, rescue of complex I, or depletion of NADH through the expression of yeast NADH-ubiquinone oxidoreductase-2 sensitized NDUFA13-KO cells to AIFM1-induced cell death. These findings indicate that the complex of MIA40 and AIFM1 suppresses AIFM1-induced cell death in a NADH-dependent manner. This study identifies an effector complex involved in regulating the programmed cell death that accommodates the metabolic changes in the cell and provides a molecular explanation for AIFM1-mediated chemoresistance of cancer cells.", "doi": "10.1038/s44319-025-00406-8", "pmid": "40055465", "labels": {"Cryo-EM": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC11976965"}, {"db": "pii", "key": "10.1038/s44319-025-00406-8"}], "notes": [], "created": "2025-11-25T08:59:24.731Z", "modified": "2025-11-25T08:59:25.528Z"}]}