{"entity": "researcher", "timestamp": "2026-07-17T15:18:12.667Z", "family": "Pizzolato", "given": "Giulia", "initials": "G", "orcid": "0000-0002-0776-456X", "affiliations": ["Wallenberg Centre for Molecular Medicine (WCMM), Link\u00f6ping University, Link\u00f6ping 58185, Sweden.", "Department of Biomedical and Clinical Sciences (BKV), Link\u00f6ping University, Link\u00f6ping 58185, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/ef73508c139e455d9f5378f6e7c30728.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/ef73508c139e455d9f5378f6e7c30728"}}, "publications": [{"entity": "publication", "iuid": "5a0eec7e1de34b63b052c1ec086abb9e", "links": {"self": {"href": "https://publications.scilifelab.se/publication/5a0eec7e1de34b63b052c1ec086abb9e.json"}, "display": {"href": "https://publications.scilifelab.se/publication/5a0eec7e1de34b63b052c1ec086abb9e"}}, "title": "The oncogenic transcription factor FOXQ1 is a differential regulator of Wnt target genes.", "authors": [{"family": "Pizzolato", "given": "Giulia", "initials": "G", "orcid": "0000-0002-0776-456X", "researcher": {"href": "https://publications.scilifelab.se/researcher/ef73508c139e455d9f5378f6e7c30728.json"}}, {"family": "Moparthi", "given": "Lavanya", "initials": "L", "orcid": "0000-0002-6030-3084", "researcher": {"href": "https://publications.scilifelab.se/researcher/c2207da5d7d34dd2a8def5239eaf351d.json"}}, {"family": "S\u00f6derholm", "given": "Simon", "initials": "S"}, {"family": "Cant\u00f9", "given": "Claudio", "initials": "C"}, {"family": "Koch", "given": "Stefan", "initials": "S", "orcid": "0000-0003-3579-4229", "researcher": {"href": "https://publications.scilifelab.se/researcher/74c70c1aa5624edfb9d9b36ce7bef947.json"}}], "type": "journal article", "published": "2022-10-01", "journal": {"title": "J. Cell. Sci.", "issn": "1477-9137", "volume": "135", "issue": "19", "issn-l": "0021-9533"}, "abstract": "The forkhead box transcription factor FOXQ1 contributes to the pathogenesis of carcinomas. In colorectal cancers, FOXQ1 promotes tumour metastasis by inducing epithelial-to-mesenchymal transition (EMT) of cancer cells. FOXQ1 may exacerbate cancer by activating the oncogenic Wnt/\u03b2-catenin signalling pathway. However, the role of FOXQ1 in the Wnt pathway remains to be resolved. Here, we report that FOXQ1 is an activator of Wnt-induced transcription and regulator of \u03b2-catenin target gene expression. Upon Wnt pathway activation, FOXQ1 synergises with the \u03b2-catenin nuclear complex to boost the expression of major Wnt targets. In parallel, we find that FOXQ1 controls the differential expression of various Wnt target genes in a \u03b2-catenin-independent manner. Using RNA sequencing of colorectal cancer cell lines, we show that Wnt signalling and FOXQ1 converge on a transcriptional programme linked to EMT and cell migration. Additionally, we demonstrate that FOXQ1 occupies Wnt-responsive elements in \u03b2-catenin target gene promoters and recruits a similar set of co-factors to the \u03b2-catenin-associated transcription factor Tcf7l1. Taken together, our results indicate a multifaceted role of FOXQ1 in Wnt/\u03b2-catenin signalling, which may drive the metastasis of colorectal cancers.", "doi": "10.1242/jcs.260082", "pmid": "36124643", "labels": {"Clinical Genomics Link\u00f6ping": "Service", "Clinical Genomics": "Service"}, "xrefs": [{"db": "pii", "key": "277173"}], "notes": [], "created": "2022-12-01T14:08:05.597Z", "modified": "2022-12-01T14:08:05.811Z"}]}