{"entity": "researcher", "timestamp": "2026-07-13T09:58:32.925Z", "family": "Henriksson", "given": "Marie Arsenian", "initials": "MA", "orcid": "0000-0001-6376-7792", "affiliations": ["Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/e78a2e958a7b4eaaa9aecad01f0e7c57.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/e78a2e958a7b4eaaa9aecad01f0e7c57"}}, "publications": [{"entity": "publication", "iuid": "6364cb53a18c436d8ce6315496b97353", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6364cb53a18c436d8ce6315496b97353.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6364cb53a18c436d8ce6315496b97353"}}, "title": "Combined targeting of PRDX6 and GSTP1 as a potential differentiation strategy for neuroblastoma treatment.", "authors": [{"family": "Lia\u00f1o-Pons", "given": "Judit", "initials": "J", "orcid": "0000-0001-8097-4750", "researcher": {"href": "https://publications.scilifelab.se/researcher/8285ad3848b94349b5d603d817f82db6.json"}}, {"family": "Garde-Lapido", "given": "Elisa", "initials": "E", "orcid": "0009-0001-5321-1253", "researcher": {"href": "https://publications.scilifelab.se/researcher/eb52703f9d1944e5bc91922727deb49c.json"}}, {"family": "Fahrig", "given": "Fenja L", "initials": "FL", "orcid": "0009-0008-9040-5752", "researcher": {"href": "https://publications.scilifelab.se/researcher/1de91297944a444a9d866dd451806130.json"}}, {"family": "J\u00e4ckering", "given": "Merle", "initials": "M", "orcid": "0009-0003-9519-2120", "researcher": {"href": "https://publications.scilifelab.se/researcher/5c3ca09ca6cd42aba02538439b46b63c.json"}}, {"family": "Yuan", "given": "Ye", "initials": "Y"}, {"family": "Andersson", "given": "Stina", "initials": "S", "orcid": "0000-0003-3226-4740", "researcher": {"href": "https://publications.scilifelab.se/researcher/13415a4a70654146ac1c56e009ee31c4.json"}}, {"family": "Schort", "given": "Lea", "initials": "L"}, {"family": "Esteve", "given": "Maria", "initials": "M", "orcid": "0000-0003-2299-9153", "researcher": {"href": "https://publications.scilifelab.se/researcher/9ea254453baa4725a3fd36a5491a57cb.json"}}, {"family": "Mohlin", "given": "Sofie", "initials": "S", "orcid": "0000-0002-2458-3963", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e095a99e2c84d52b13973c9d46d128a.json"}}, {"family": "Bedoya-Reina", "given": "Oscar C", "initials": "OC", "orcid": "0009-0001-1703-2258", "researcher": {"href": "https://publications.scilifelab.se/researcher/94abfc2a001941cb8c33b64271618be9.json"}}, {"family": "Arsenian-Henriksson", "given": "Marie", "initials": "M", "orcid": "0000-0001-6376-7792", "researcher": {"href": "https://publications.scilifelab.se/researcher/e78a2e958a7b4eaaa9aecad01f0e7c57.json"}}], "type": "journal article", "published": "2025-06-24", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "122", "issue": "25", "pages": "e2427211122", "issn-l": "0027-8424"}, "abstract": "Neuroblastoma (NB) is a heterogeneous childhood cancer, characterized by the amplification of the MYCN oncogene in 40% of the high-risk cases. Our previous work demonstrated that MYCN drives metabolic reprogramming in NB, including upregulation of antioxidant enzymes. Here, we identify peroxiredoxin 6 (PRDX6) as a promising therapeutic target in NB. Pharmacological inhibition of PRDX6 reduces MYCN levels, induces apoptosis, and promotes neuronal differentiation accompanied by lipid droplet accumulation, essential for the phenotypic reprogramming. Moreover, combined inhibition of PRDX6 and glutathione S-transferase Pi 1 (GSTP1), a key antioxidant enzyme needed for PRDX6 activation, demonstrated synergistic effects both in vitro and in vivo. This strategy results in neuronal maturation as well as activity and initiates downstream pathways distinct from the ones triggered by retinoic acid, the differentiation-inducing agent currently used in clinical practice for NB. Notably, both PRDX6 and GSTP1 are highly expressed in the developing murine adrenal gland, as well as in high-risk, MYCN-amplified NB, correlating with an undifferentiated state and poor prognosis. Together, our results provide insights into the potential of PRDX6 and GSTP1 as therapeutic targets for differentiation induction for children with NB.", "doi": "10.1073/pnas.2427211122", "pmid": "40531876", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12207458"}], "notes": [], "created": "2025-11-28T10:48:18.601Z", "modified": "2025-11-28T10:48:18.946Z"}, {"entity": "publication", "iuid": "2327ce3d72bd48d988b4642d35ae1d05", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2327ce3d72bd48d988b4642d35ae1d05.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2327ce3d72bd48d988b4642d35ae1d05"}}, "title": "MOXD1 is a lineage-specific gene and a tumor suppressor in neuroblastoma.", "authors": [{"family": "Fredlund", "given": "Elina", "initials": "E", "orcid": "0009-0006-1986-1267", "researcher": {"href": "https://publications.scilifelab.se/researcher/49c035ee375d466e8cb10b230ca51395.json"}}, {"family": "Andersson", "given": "Stina", "initials": "S", "orcid": "0000-0003-3226-4740", "researcher": {"href": "https://publications.scilifelab.se/researcher/13415a4a70654146ac1c56e009ee31c4.json"}}, {"family": "Hilgert", "given": "Elien", "initials": "E", "orcid": "0000-0002-4715-6972", "researcher": {"href": "https://publications.scilifelab.se/researcher/a09fe68866854929a507cc66f721392b.json"}}, {"family": "Monferrer", "given": "Ezequiel", "initials": "E"}, {"family": "\u00c1lvarez-Hern\u00e1n", "given": "Guadalupe", "initials": "G", "orcid": "0000-0001-5725-6515", "researcher": {"href": "https://publications.scilifelab.se/researcher/e5c136f13154416b8aa895db485856de.json"}}, {"family": "Karakaya", "given": "Sinan", "initials": "S"}, {"family": "Loontiens", "given": "Siebe", "initials": "S", "orcid": "0000-0002-4602-4580", "researcher": {"href": "https://publications.scilifelab.se/researcher/9e652c656ace4c8f947a2d84b4bfa8b5.json"}}, {"family": "Bek", "given": "Jan Willem", "initials": "JW", "orcid": "0000-0003-1337-1970", "researcher": {"href": "https://publications.scilifelab.se/researcher/908c4fb4652842f8b8ea436a2265eaf4.json"}}, {"family": "Gregor", "given": "Tomas", "initials": "T", "orcid": "0000-0002-7974-1316", "researcher": {"href": "https://publications.scilifelab.se/researcher/3c2c049df61f4fe3a4a2918e99158dd2.json"}}, {"family": "Lecomte", "given": "Estelle", "initials": "E"}, {"family": "Magnusson", "given": "Emma", "initials": "E"}, {"family": "Miltenyte", "given": "Enrika", "initials": "E"}, {"family": "Cabirol", "given": "Marie", "initials": "M"}, {"family": "Kyknas", "given": "Michail", "initials": "M", "orcid": "0009-0004-0813-2670", "researcher": {"href": "https://publications.scilifelab.se/researcher/c67634dfede84d038c0d0dc8535eba15.json"}}, {"family": "Engstr\u00f6m", "given": "Niklas", "initials": "N", "orcid": "0000-0003-2399-985X", "researcher": {"href": "https://publications.scilifelab.se/researcher/7a002fa86f9c46fea630c84b02419d6a.json"}}, {"family": "Henriksson", "given": "Marie Arsenian", "initials": "MA", "orcid": "0000-0001-6376-7792", "researcher": {"href": "https://publications.scilifelab.se/researcher/e78a2e958a7b4eaaa9aecad01f0e7c57.json"}}, {"family": "Hammarlund", "given": "Emma", "initials": "E", "orcid": "0000-0001-7625-4793", "researcher": {"href": "https://publications.scilifelab.se/researcher/f2b34455bcd94586a8be8a7adeefe7cc.json"}}, {"family": "Rosenblum", "given": "Jared S", "initials": "JS", "orcid": "0000-0001-5941-9082", "researcher": {"href": "https://publications.scilifelab.se/researcher/49b3dd45a5cd494191b4d24e6edb721f.json"}}, {"family": "Noguera", "given": "Rosa", "initials": "R", "orcid": "0000-0003-4546-7459", "researcher": {"href": "https://publications.scilifelab.se/researcher/91dc687d57f947ba9dde1d129e6c8222.json"}}, {"family": "Speleman", "given": "Frank", "initials": "F"}, {"family": "van Nes", "given": "Johan", "initials": "J"}, {"family": "Mohlin", "given": "Sofie", "initials": "S", "orcid": "0000-0002-2458-3963", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e095a99e2c84d52b13973c9d46d128a.json"}}], "type": "journal article", "published": "2024-06-21", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "10", "issue": "25", "pages": "eado1583", "issn-l": "2375-2548"}, "abstract": "Neuroblastoma is a childhood developmental cancer; however, its embryonic origins remain poorly understood. Moreover, in-depth studies of early tumor-driving events are limited because of the lack of appropriate models. Herein, we analyzed RNA sequencing data obtained from human neuroblastoma samples and found that loss of expression of trunk neural crest-enriched gene MOXD1 associates with advanced disease and worse outcome. Further, by using single-cell RNA sequencing data of human neuroblastoma cells and fetal adrenal glands and creating in vivo models of zebrafish, chick, and mouse, we show that MOXD1 is a determinate of tumor development. In addition, we found that MOXD1 expression is highly conserved and restricted to mesenchymal neuroblastoma cells and Schwann cell precursors during healthy development. Our findings identify MOXD1 as a lineage-restricted tumor-suppressor gene in neuroblastoma, potentiating further stratification of these tumors and development of novel therapeutic interventions.", "doi": "10.1126/sciadv.ado1583", "pmid": "38905335", "labels": {"Clinical Genomics Lund": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11192077"}], "notes": [], "created": "2024-11-17T16:35:21.203Z", "modified": "2025-11-10T13:57:53.132Z"}, {"entity": "publication", "iuid": "d101ccc4ae954ebeb335218ebbaf0967", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d101ccc4ae954ebeb335218ebbaf0967.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d101ccc4ae954ebeb335218ebbaf0967"}}, "title": "MOXD1 is a gate-keeper of organ homeostasis and functions as a tumor-suppressor in neuroblastoma", "authors": [{"family": "Fredlund", "given": "Elina", "initials": "E", "orcid": "0009-0006-1986-1267", "researcher": {"href": "https://publications.scilifelab.se/researcher/49c035ee375d466e8cb10b230ca51395.json"}}, {"family": "Andersson", "given": "Stina", "initials": "S"}, {"family": "Hilgert", "given": "Elien", "initials": "E", "orcid": "0000-0002-4715-6972", "researcher": {"href": "https://publications.scilifelab.se/researcher/a09fe68866854929a507cc66f721392b.json"}}, {"family": "\u00c1lvarez-Hern\u00e1n", "given": "Guadalupe", "initials": "G", "orcid": "0000-0001-5725-6515", "researcher": {"href": "https://publications.scilifelab.se/researcher/e5c136f13154416b8aa895db485856de.json"}}, {"family": "Monferrer", "given": "Ezequiel", "initials": "E"}, {"family": "Karakaya", "given": "Sinan", "initials": "S"}, {"family": "Gregor", "given": "Tomas", "initials": "T", "orcid": "0000-0002-7974-1316", "researcher": {"href": "https://publications.scilifelab.se/researcher/3c2c049df61f4fe3a4a2918e99158dd2.json"}}, {"family": "Loontiens", "given": "Siebe", "initials": "S", "orcid": "0000-0002-4602-4580", "researcher": {"href": "https://publications.scilifelab.se/researcher/9e652c656ace4c8f947a2d84b4bfa8b5.json"}}, {"family": "Bek", "given": "Jan Willem", "initials": "JW", "orcid": "0000-0003-1337-1970", "researcher": {"href": "https://publications.scilifelab.se/researcher/908c4fb4652842f8b8ea436a2265eaf4.json"}}, {"family": "Lecomte", "given": "Estelle", "initials": "E"}, {"family": "Magnusson", "given": "Emma", "initials": "E"}, {"family": "Miltenyte", "given": "Enrika", "initials": "E"}, {"family": "Cabirol", "given": "Marie", "initials": "M"}, {"family": "Kyknas", "given": "Michail", "initials": "M", "orcid": "0009-0004-0813-2670", "researcher": {"href": "https://publications.scilifelab.se/researcher/c67634dfede84d038c0d0dc8535eba15.json"}}, {"family": "Engstr\u00f6m", "given": "Niklas", "initials": "N", "orcid": "0000-0003-2399-985X", "researcher": {"href": "https://publications.scilifelab.se/researcher/7a002fa86f9c46fea630c84b02419d6a.json"}}, {"family": "Henriksson", "given": "Marie Arsenian", "initials": "MA", "orcid": "0000-0001-6376-7792", "researcher": {"href": "https://publications.scilifelab.se/researcher/e78a2e958a7b4eaaa9aecad01f0e7c57.json"}}, {"family": "Hammarlund", "given": "Emma", "initials": "E", "orcid": "0000-0001-7625-4793", "researcher": {"href": "https://publications.scilifelab.se/researcher/f2b34455bcd94586a8be8a7adeefe7cc.json"}}, {"family": "Noguera", "given": "Rosa", "initials": "R", "orcid": "0000-0003-4546-7459", "researcher": {"href": "https://publications.scilifelab.se/researcher/91dc687d57f947ba9dde1d129e6c8222.json"}}, {"family": "Speleman", "given": "Frank", "initials": "F"}, {"family": "van Nes", "given": "Johan", "initials": "J"}, {"family": "Mohlin", "given": "Sofie", "initials": "S", "orcid": "0000-0002-2458-3963", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e095a99e2c84d52b13973c9d46d128a.json"}}], "type": "posted-content", "published": "2023-01-19", "journal": {"title": "biorxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.01.17.524367", "pmid": null, "labels": {"Clinical Genomics Lund": "Service", "Clinical Genomics": "Service"}, "xrefs": [], "notes": [], "created": "2023-11-21T18:41:01.829Z", "modified": "2025-12-18T19:56:22.668Z"}, {"entity": "publication", "iuid": "565d8f3b4cd9490199a4fb8c85baf591", "links": {"self": {"href": "https://publications.scilifelab.se/publication/565d8f3b4cd9490199a4fb8c85baf591.json"}, "display": {"href": "https://publications.scilifelab.se/publication/565d8f3b4cd9490199a4fb8c85baf591"}}, "title": "Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome.", "authors": [{"family": "Li", "given": "Shuijie", "initials": "S"}, {"family": "Li", "given": "Wenyu", "initials": "W"}, {"family": "Yuan", "given": "Juan", "initials": "J"}, {"family": "Bullova", "given": "Petra", "initials": "P", "orcid": "0000-0002-5411-2185", "researcher": {"href": "https://publications.scilifelab.se/researcher/2c9fa1a447d749f09e98b2d7b39ce499.json"}}, {"family": "Wu", "given": "Jieyu", "initials": "J", "orcid": "0000-0002-7063-6990", "researcher": {"href": "https://publications.scilifelab.se/researcher/7289b6f5c3a34230bab08796a50c4832.json"}}, {"family": "Zhang", "given": "Xuepei", "initials": "X"}, {"family": "Liu", "given": "Yong", "initials": "Y", "orcid": "0000-0002-0574-2877", "researcher": {"href": "https://publications.scilifelab.se/researcher/5d854de5bb2847b599ebb9ab5b473552.json"}}, {"family": "Plescher", "given": "Monika", "initials": "M"}, {"family": "Rodriguez", "given": "Javier", "initials": "J"}, {"family": "Bedoya-Reina", "given": "Oscar C", "initials": "OC"}, {"family": "Jannig", "given": "Paulo R", "initials": "PR"}, {"family": "Valente-Silva", "given": "Paula", "initials": "P"}, {"family": "Yu", "given": "Meng", "initials": "M"}, {"family": "Henriksson", "given": "Marie Arsenian", "initials": "MA", "orcid": "0000-0001-6376-7792", "researcher": {"href": "https://publications.scilifelab.se/researcher/e78a2e958a7b4eaaa9aecad01f0e7c57.json"}}, {"family": "Zubarev", "given": "Roman A", "initials": "RA"}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A"}, {"family": "Suzuki", "given": "Carolyn K", "initials": "CK", "orcid": "0000-0003-2187-7568", "researcher": {"href": "https://publications.scilifelab.se/researcher/86f57ca06463441eb8387e22ad9e7a15.json"}}, {"family": "Ruas", "given": "Jorge L", "initials": "JL", "orcid": "0000-0002-1110-2606", "researcher": {"href": "https://publications.scilifelab.se/researcher/b91c3fde15f7415aa1f6c9263ff913ff.json"}}, {"family": "Holmberg", "given": "Johan", "initials": "J"}, {"family": "Larsson", "given": "Catharina", "initials": "C"}, {"family": "Christofer Juhlin", "given": "C", "initials": "C", "orcid": "0000-0002-5945-9081", "researcher": {"href": "https://publications.scilifelab.se/researcher/bb660e24421749d4acaaf6e9a90042f8.json"}}, {"family": "von Kriegsheim", "given": "Alex", "initials": "A", "orcid": "0000-0002-4952-8573", "researcher": {"href": "https://publications.scilifelab.se/researcher/2fa9e20e6f4042dfb87d38e7f35b6e58.json"}}, {"family": "Cao", "given": "Yihai", "initials": "Y", "orcid": "0000-0003-1308-0065", "researcher": {"href": "https://publications.scilifelab.se/researcher/4bf6e84ee15648159f9f849ac85bd4b7.json"}}, {"family": "Schlisio", "given": "Susanne", "initials": "S", "orcid": "0000-0002-2605-3771", "researcher": {"href": "https://publications.scilifelab.se/researcher/fa8c1128e0d54cfe80758282ef94809b.json"}}], "type": "journal article", "published": "2022-06-00", "journal": {"title": "Nat Metab", "issn": "2522-5812", "volume": "4", "issue": "6", "pages": "739-758", "issn-l": "2522-5812"}, "abstract": "Mitochondria are the main consumers of oxygen within the cell. How mitochondria sense oxygen levels remains unknown. Here we show an oxygen-sensitive regulation of TFAM, an activator of mitochondrial transcription and replication, whose alteration is linked to tumours arising in the von Hippel-Lindau syndrome. TFAM is hydroxylated by EGLN3 and subsequently bound by the von Hippel-Lindau tumour-suppressor protein, which stabilizes TFAM by preventing mitochondrial proteolysis. Cells lacking wild-type VHL or in which EGLN3 is inactivated have reduced mitochondrial mass. Tumorigenic VHL variants leading to different clinical manifestations fail to bind hydroxylated TFAM. In contrast, cells harbouring the Chuvash polycythaemia VHLR200W mutation, involved in hypoxia-sensing disorders without tumour development, are capable of binding hydroxylated TFAM. Accordingly, VHL-related tumours, such as pheochromocytoma and renal cell carcinoma cells, display low mitochondrial content, suggesting that impaired mitochondrial biogenesis is linked to VHL tumorigenesis. Finally, inhibiting proteolysis by targeting LONP1 increases mitochondrial content in VHL-deficient cells and sensitizes therapy-resistant tumours to sorafenib treatment. Our results offer pharmacological avenues to sensitize therapy-resistant VHL tumours by focusing on the mitochondria.", "doi": "10.1038/s42255-022-00593-x", "pmid": "35760869", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "mid", "key": "EMS145242"}, {"db": "pmc", "key": "PMC9236906"}, {"db": "pii", "key": "10.1038/s42255-022-00593-x"}], "notes": [], "created": "2023-11-27T21:50:23.129Z", "modified": "2024-01-16T13:48:36.287Z"}]}