{"entity": "researcher", "timestamp": "2026-10-05T21:26:19.429Z", "family": "Krivanek", "given": "Jan", "initials": "J", "orcid": "0000-0002-7590-187X", "affiliations": [], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/e716ca0e1b464dd9850687d8f5aa6758.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/e716ca0e1b464dd9850687d8f5aa6758"}}, "publications": [{"entity": "publication", "iuid": "7c8ceca997cd49d6927b755e583e0da4", "links": {"self": {"href": "https://publications.scilifelab.se/publication/7c8ceca997cd49d6927b755e583e0da4.json"}, "display": {"href": "https://publications.scilifelab.se/publication/7c8ceca997cd49d6927b755e583e0da4"}}, "title": "Schwann cell precursors represent a neural crest-like state with biased multipotency.", "authors": [{"family": "Kastriti", "given": "Maria Eleni", "initials": "ME", "orcid": "0000-0002-0563-7399", "researcher": {"href": "https://publications.scilifelab.se/researcher/9e0722d8c5484a13bb37c3a3b084ff8c.json"}}, {"family": "Faure", "given": "Louis", "initials": "L", "orcid": "0000-0003-4621-586X", "researcher": {"href": "https://publications.scilifelab.se/researcher/bbf218e53c854d69a1b474a61480c33f.json"}}, {"family": "Von Ahsen", "given": "Dorothea", "initials": "D"}, {"family": "Bouderlique", "given": "Thibault Gerald", "initials": "TG"}, {"family": "Bostr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0001-5252-4023", "researcher": {"href": "https://publications.scilifelab.se/researcher/2af59464d2c74c27af7a43fb5d1a670e.json"}}, {"family": "Solovieva", "given": "Tatiana", "initials": "T", "orcid": "0000-0001-6194-2550", "researcher": {"href": "https://publications.scilifelab.se/researcher/1c88055db071476db108cbc014226964.json"}}, {"family": "Jackson", "given": "Cameron", "initials": "C"}, {"family": "Bronner", "given": "Marianne", "initials": "M", "orcid": "0000-0003-4274-1862", "researcher": {"href": "https://publications.scilifelab.se/researcher/56516b93bfb047aeab63c9d2fee21d4a.json"}}, {"family": "Meijer", "given": "Dies", "initials": "D", "orcid": "0000-0002-8461-6341", "researcher": {"href": "https://publications.scilifelab.se/researcher/ae5c7bfbb900485fb51238882500ab76.json"}}, {"family": "Hadjab", "given": "Saida", "initials": "S"}, {"family": "Lallemend", "given": "Francois", "initials": "F"}, {"family": "Erickson", "given": "Alek", "initials": "A"}, {"family": "Kaucka", "given": "Marketa", "initials": "M", "orcid": "0000-0002-8781-9769", "researcher": {"href": "https://publications.scilifelab.se/researcher/933187e42ddc4ab6a29c46d5cca411e6.json"}}, {"family": "Dyachuk", "given": "Viacheslav", "initials": "V"}, {"family": "Perlmann", "given": "Thomas", "initials": "T"}, {"family": "Lahti", "given": "Laura", "initials": "L"}, {"family": "Krivanek", "given": "Jan", "initials": "J", "orcid": "0000-0002-7590-187X", "researcher": {"href": "https://publications.scilifelab.se/researcher/e716ca0e1b464dd9850687d8f5aa6758.json"}}, {"family": "Brunet", "given": "Jean-Francois", "initials": "JF"}, {"family": "Fried", "given": "Kaj", "initials": "K"}, {"family": "Adameyko", "given": "Igor", "initials": "I", "orcid": "0000-0001-5471-0356", "researcher": {"href": "https://publications.scilifelab.se/researcher/346f484a56cb4ad5b866b194ccd44e4f.json"}}], "type": "journal article", "published": "2022-09-01", "journal": {"title": "EMBO J.", "issn": "1460-2075", "volume": "41", "issue": "17", "pages": "e108780", "issn-l": "0261-4189"}, "abstract": "Schwann cell precursors (SCPs) are nerve-associated progenitors that can generate myelinating and non-myelinating Schwann cells but also are multipotent like the neural crest cells from which they originate. SCPs are omnipresent along outgrowing peripheral nerves throughout the body of vertebrate embryos. By using single-cell transcriptomics to generate a gene expression atlas of the entire neural crest lineage, we show that early SCPs and late migratory crest cells have similar transcriptional profiles characterised by a multipotent \"hub\" state containing cells biased towards traditional neural crest fates. SCPs keep diverging from the neural crest after being primed towards terminal Schwann cells and other fates, with different subtypes residing in distinct anatomical locations. Functional experiments using CRISPR-Cas9 loss-of-function further show that knockout of the common \"hub\" gene Sox8 causes defects in neural crest-derived cells along peripheral nerves by facilitating differentiation of SCPs towards sympathoadrenal fates. Finally, specific tumour populations found in melanoma, neurofibroma and neuroblastoma map to different stages of SCP/Schwann cell development. Overall, SCPs resemble migrating neural crest cells that maintain multipotency and become transcriptionally primed towards distinct lineages.", "doi": "10.15252/embj.2021108780", "pmid": "35815410", "labels": {"NGI Single cell": "Service", "NGI Stockholm (Genomics Production)": "Service", "National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Applications)": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9434083"}], "notes": [], "created": "2024-10-14T11:53:36.186Z", "modified": "2024-10-14T11:53:37.393Z"}, {"entity": "publication", "iuid": "a3077264f8cc4b788b7506ddb9b5546f", "links": {"self": {"href": "https://publications.scilifelab.se/publication/a3077264f8cc4b788b7506ddb9b5546f.json"}, "display": {"href": "https://publications.scilifelab.se/publication/a3077264f8cc4b788b7506ddb9b5546f"}}, "title": "Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth.", "authors": [{"family": "Krivanek", "given": "Jan", "initials": "J", "orcid": "0000-0002-7590-187X", "researcher": {"href": "https://publications.scilifelab.se/researcher/e716ca0e1b464dd9850687d8f5aa6758.json"}}, {"family": "Soldatov", "given": "Ruslan A", "initials": "RA"}, {"family": "Kastriti", "given": "Maria Eleni", "initials": "ME"}, {"family": "Chontorotzea", "given": "Tatiana", "initials": "T"}, {"family": "Herdina", "given": "Anna Nele", "initials": "AN"}, {"family": "Petersen", "given": "Julian", "initials": "J", "orcid": "0000-0002-7444-0610", "researcher": {"href": "https://publications.scilifelab.se/researcher/74d20bbfd5a540a58aac82ada8d80b0d.json"}}, {"family": "Szarowska", "given": "Bara", "initials": "B"}, {"family": "Landova", "given": "Marie", "initials": "M"}, {"family": "Matejova", "given": "Veronika Kovar", "initials": "VK"}, {"family": "Holla", "given": "Lydie Izakovicova", "initials": "LI", "orcid": "0000-0002-7610-8929", "researcher": {"href": "https://publications.scilifelab.se/researcher/2c239a2405d04c14ad3d1a08759d1457.json"}}, {"family": "Kuchler", "given": "Ulrike", "initials": "U"}, {"family": "Zdrilic", "given": "Ivana Vidovic", "initials": "IV"}, {"family": "Vijaykumar", "given": "Anushree", "initials": "A", "orcid": "0000-0002-9311-8715", "researcher": {"href": "https://publications.scilifelab.se/researcher/2e151e4b5e2d49ab925969f0b425ed58.json"}}, {"family": "Balic", "given": "Anamaria", "initials": "A", "orcid": "0000-0001-6796-1197", "researcher": {"href": "https://publications.scilifelab.se/researcher/53dc6465cd6b44c38e2e29aeb3f077a7.json"}}, {"family": "Marangoni", "given": "Pauline", "initials": "P"}, {"family": "Klein", "given": "Ophir D", "initials": "OD", "orcid": "0000-0002-6254-7082", "researcher": {"href": "https://publications.scilifelab.se/researcher/aab94ed0b4f549ef941147b2ffbe27c9.json"}}, {"family": "Neves", "given": "Vitor C M", "initials": "VCM"}, {"family": "Yianni", "given": "Val", "initials": "V", "orcid": "0000-0001-9857-7577", "researcher": {"href": "https://publications.scilifelab.se/researcher/aa7601d7378f41319dfb7cc9210ccfea.json"}}, {"family": "Sharpe", "given": "Paul T", "initials": "PT", "orcid": "0000-0003-2116-9561", "researcher": {"href": "https://publications.scilifelab.se/researcher/d32e7381201b4d9e932b44da8f37e3b1.json"}}, {"family": "Harkany", "given": "Tibor", "initials": "T"}, {"family": "Metscher", "given": "Brian D", "initials": "BD", "orcid": "0000-0002-6514-4406", "researcher": {"href": "https://publications.scilifelab.se/researcher/5ab0055dc0374b4bb88f9bfbb2e0313a.json"}}, {"family": "Baj\u00e9noff", "given": "Marc", "initials": "M"}, {"family": "Mina", "given": "Mina", "initials": "M"}, {"family": "Fried", "given": "Kaj", "initials": "K"}, {"family": "Kharchenko", "given": "Peter V", "initials": "PV", "orcid": "0000-0002-6036-5875", "researcher": {"href": "https://publications.scilifelab.se/researcher/a67002dec1264bf2865da0017405ee9b.json"}}, {"family": "Adameyko", "given": "Igor", "initials": "I", "orcid": "0000-0001-5471-0356", "researcher": {"href": "https://publications.scilifelab.se/researcher/346f484a56cb4ad5b866b194ccd44e4f.json"}}], "type": "journal article", "published": "2020-09-23", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "11", "issue": "1", "pages": "4816", "issn-l": "2041-1723"}, "abstract": "Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of cell dynamics enabling unarrested growth. This model relies on spatially-restricted stem, progenitor and differentiated populations in the epithelial and mesenchymal compartments underlying the coordinated expansion of two major branches of pulpal cells and diverse epithelial subtypes. Further comparisons of human and mouse teeth yield both parallelisms and differences in tissue heterogeneity and highlight the specifics behind growing and non-growing modes. Despite being similar at a coarse level, mouse and human teeth reveal molecular differences and species-specific cell subtypes suggesting possible evolutionary divergence. Overall, here we provide an atlas of human and mouse teeth with a focus on growth and differentiation.", "doi": "10.1038/s41467-020-18512-7", "pmid": "32968047", "labels": {"Eukaryotic Single Cell Genomics (ESCG)": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-020-18512-7"}, {"db": "pmc", "key": "PMC7511944"}], "notes": [], "created": "2021-12-10T20:15:06.566Z", "modified": "2022-01-03T10:04:22.911Z"}]}