{"entity": "researcher", "timestamp": "2026-04-19T02:16:05.751Z", "family": "Mart\u00ed-Rodrigo", "given": "Pablo", "initials": "P", "orcid": "0000-0002-1049-0918", "affiliations": ["Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/e63e9b1775f046ed8c8feb106f8cebca.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/e63e9b1775f046ed8c8feb106f8cebca"}}, "publications": [{"entity": "publication", "iuid": "b2805e31dce94755af4fde64db297814", "links": {"self": {"href": "https://publications.scilifelab.se/publication/b2805e31dce94755af4fde64db297814.json"}, "display": {"href": "https://publications.scilifelab.se/publication/b2805e31dce94755af4fde64db297814"}}, "title": "Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells", "authors": [{"family": "H\u00fchn", "given": "Daniela", "initials": "D"}, {"family": "Mart\u00ed\u2010Rodrigo", "given": "Pablo", "initials": "P", "orcid": "0000-0002-1049-0918", "researcher": {"href": "https://publications.scilifelab.se/researcher/e63e9b1775f046ed8c8feb106f8cebca.json"}}, {"family": "Mouron", "given": "Silvana", "initials": "S"}, {"family": "Hansel", "given": "Catherine", "initials": "C"}, {"family": "Tschapalda", "given": "Kirsten", "initials": "K"}, {"family": "Porebski", "given": "Bartlomiej", "initials": "B"}, {"family": "H\u00e4ggblad", "given": "Maria", "initials": "M"}, {"family": "Lidemalm", "given": "Louise", "initials": "L"}, {"family": "Quintela\u2010Fandino", "given": "Miguel", "initials": "M"}, {"family": "Carreras\u2010Puigvert", "given": "Jordi", "initials": "J"}, {"family": "Fernandez\u2010Capetillo", "given": "Oscar", "initials": "O", "orcid": "0000-0002-2690-6885", "researcher": {"href": "https://publications.scilifelab.se/researcher/7134c59abca24f96903fc50914311b40.json"}}], "type": "journal-article", "published": "2022-01-00", "journal": {"title": "Mol Oncol", "issn": "1574-7891", "issn-l": null, "volume": "16", "issue": "1", "pages": "148-165"}, "abstract": null, "doi": "10.1002/1878-0261.13083", "pmid": null, "labels": {"Chemical Biology Consortium Sweden": "Service"}, "xrefs": [], "notes": [], "created": "2019-11-28T13:54:09.398Z", "modified": "2025-10-17T13:04:27.970Z"}, {"entity": "publication", "iuid": "99bbc9211a014ec2a9ee1106611e757c", "links": {"self": {"href": "https://publications.scilifelab.se/publication/99bbc9211a014ec2a9ee1106611e757c.json"}, "display": {"href": "https://publications.scilifelab.se/publication/99bbc9211a014ec2a9ee1106611e757c"}}, "title": "Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells.", "authors": [{"family": "H\u00fchn", "given": "Daniela", "initials": "D"}, {"family": "Mart\u00ed-Rodrigo", "given": "Pablo", "initials": "P", "orcid": "0000-0002-1049-0918", "researcher": {"href": "https://publications.scilifelab.se/researcher/e63e9b1775f046ed8c8feb106f8cebca.json"}}, {"family": "Mouron", "given": "Silvana", "initials": "S"}, {"family": "Hansel", "given": "Catherine", "initials": "C"}, {"family": "Tschapalda", "given": "Kirsten", "initials": "K"}, {"family": "Porebski", "given": "Bartlomiej", "initials": "B"}, {"family": "H\u00e4ggblad", "given": "Maria", "initials": "M"}, {"family": "Lidemalm", "given": "Louise", "initials": "L"}, {"family": "Quintela-Fandino", "given": "Miguel", "initials": "M"}, {"family": "Carreras-Puigvert", "given": "Jordi", "initials": "J"}, {"family": "Fernandez-Capetillo", "given": "Oscar", "initials": "O", "orcid": "0000-0002-2690-6885", "researcher": {"href": "https://publications.scilifelab.se/researcher/7134c59abca24f96903fc50914311b40.json"}}], "type": "journal article", "published": "2021-08-15", "journal": {"title": "Mol Oncol", "issn": "1878-0261", "issn-l": "1574-7891", "volume": null, "issue": null, "pages": null}, "abstract": "Among others, expression levels of programmed cell death 1 ligand 1 (PD-L1) have been explored as biomarkers of the response to immune checkpoint inhibitors in cancer therapy. Here, we present the results of a chemical screen that interrogated how medically approved drugs influence PD-L1 expression. As expected, corticosteroids and inhibitors of Janus kinases were among the top PD-L1 downregulators. In addition, we identified that PD-L1 expression is induced by antiestrogenic compounds. Transcriptomic analyses indicate that chronic estrogen receptor alpha (ER\u03b1) inhibition triggers a broad immunosuppressive program in ER-positive breast cancer cells, which is subsequent to their growth arrest and involves the activation of multiple immune checkpoints together with the silencing of the antigen-presenting machinery. Accordingly, estrogen-deprived MCF7 cells are resistant to T-cell-mediated cell killing, in a manner that is independent of PD-L1, but which is reverted by estradiol. Our study reveals that while antiestrogen therapies efficiently limit the growth of ER-positive breast cancer cells, they concomitantly trigger a transcriptional program that favors their immune evasion.", "doi": "10.1002/1878-0261.13083", "pmid": "34392603", "labels": {"Chemical Biology Consortium Sweden": "Service"}, "xrefs": [], "notes": [], "created": "2021-11-18T11:57:22.385Z", "modified": "2025-10-17T13:04:28.053Z"}]}