{"entity": "researcher", "timestamp": "2026-07-19T19:14:13.749Z", "family": "Schmitt", "given": "Vivian", "initials": "V", "orcid": "0000-0001-9260-4853", "affiliations": ["Department of Biology, Lund University, Lund, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/e0a5170d13f44da38cd57fa9d14708c6.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/e0a5170d13f44da38cd57fa9d14708c6"}}, "publications": [{"entity": "publication", "iuid": "f7afab38bd424c0185c3ffb34ba09d6b", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f7afab38bd424c0185c3ffb34ba09d6b.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f7afab38bd424c0185c3ffb34ba09d6b"}}, "title": "An mTRAN-mRNA interaction mediates mitochondrial translation initiation in plants.", "authors": [{"family": "Tran", "given": "Huy Cuong", "initials": "HC", "orcid": "0000-0002-7670-2215", "researcher": {"href": "https://publications.scilifelab.se/researcher/ddf057352ae445079a2e9dc51b6326a7.json"}}, {"family": "Schmitt", "given": "Vivian", "initials": "V", "orcid": "0000-0001-9260-4853", "researcher": {"href": "https://publications.scilifelab.se/researcher/e0a5170d13f44da38cd57fa9d14708c6.json"}}, {"family": "Lama", "given": "Sbatie", "initials": "S", "orcid": "0000-0003-0093-8915", "researcher": {"href": "https://publications.scilifelab.se/researcher/7a6c32adfeea44ee97d6cdc08a90e6f7.json"}}, {"family": "Wang", "given": "Chuande", "initials": "C", "orcid": "0000-0002-3102-0931", "researcher": {"href": "https://publications.scilifelab.se/researcher/6858cc1751ec4393befbeea617c876f7.json"}}, {"family": "Launay-Avon", "given": "Alexandra", "initials": "A", "orcid": "0000-0002-1993-313X", "researcher": {"href": "https://publications.scilifelab.se/researcher/483c9872afad41b6a916315884a1a7f1.json"}}, {"family": "Bernfur", "given": "Katja", "initials": "K", "orcid": "0000-0002-7927-9563", "researcher": {"href": "https://publications.scilifelab.se/researcher/4600cd5ea61b41e4ab9b85af90fb41b4.json"}}, {"family": "Sultan", "given": "Kristin", "initials": "K", "orcid": "0009-0002-5619-517X", "researcher": {"href": "https://publications.scilifelab.se/researcher/7288f4347b8440479e0f908b705f9df5.json"}}, {"family": "Khan", "given": "Kasim", "initials": "K", "orcid": "0000-0001-7336-2764", "researcher": {"href": "https://publications.scilifelab.se/researcher/76561aa1400a457aa3aff29a105097f8.json"}}, {"family": "Brunaud", "given": "V\u00e9ronique", "initials": "V", "orcid": "0000-0002-6246-3161", "researcher": {"href": "https://publications.scilifelab.se/researcher/43f86a5a57ed40d09104ceb7563edc70.json"}}, {"family": "Liehrmann", "given": "Arnaud", "initials": "A", "orcid": "0000-0002-4936-1056", "researcher": {"href": "https://publications.scilifelab.se/researcher/17e728328c294053bafd99c21f861cbf.json"}}, {"family": "Castandet", "given": "Beno\u00eet", "initials": "B", "orcid": "0000-0003-1948-8651", "researcher": {"href": "https://publications.scilifelab.se/researcher/eb78c62ee96e4a288be84f2cfb43e900.json"}}, {"family": "Levander", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-0710-9792", "researcher": {"href": "https://publications.scilifelab.se/researcher/1b7add45d810457eb84a72aebbc7b82c.json"}}, {"family": "Rasmusson", "given": "Allan G", "initials": "AG", "orcid": "0000-0003-0734-5020", "researcher": {"href": "https://publications.scilifelab.se/researcher/9980e74c1d904c8f924e7e4298738c20.json"}}, {"family": "Mireau", "given": "Hakim", "initials": "H", "orcid": "0000-0002-2299-5139", "researcher": {"href": "https://publications.scilifelab.se/researcher/6af69c819fa94de6a4795daf00bf9e57.json"}}, {"family": "Delannoy", "given": "Etienne", "initials": "E", "orcid": "0000-0002-0866-2063", "researcher": {"href": "https://publications.scilifelab.se/researcher/e9e67345f58e4739bd96805f89617b89.json"}}, {"family": "Van Aken", "given": "Olivier", "initials": "O", "orcid": "0000-0003-4024-968X", "researcher": {"href": "https://publications.scilifelab.se/researcher/4f8174aa4d9e4031822ea281b6f0f9dd.json"}}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Science", "issn": "1095-9203", "volume": "381", "issue": "6661", "pages": "eadg0995", "issn-l": "0036-8075"}, "abstract": "Plant mitochondria represent the largest group of respiring organelles on the planet. Plant mitochondrial messenger RNAs (mRNAs) lack Shine-Dalgarno-like ribosome-binding sites, so it is unknown how plant mitoribosomes recognize mRNA. We show that \"mitochondrial translation factors\" mTRAN1 and mTRAN2 are land plant-specific proteins, required for normal mitochondrial respiration chain biogenesis. Our studies suggest that mTRANs are noncanonical pentatricopeptide repeat (PPR)-like RNA binding proteins of the mitoribosomal \"small\" subunit. We identified conserved Adenosine (A)/Uridine (U)-rich motifs in the 5' regions of plant mitochondrial mRNAs. mTRAN1 binds this motif, suggesting that it is a mitoribosome homing factor to identify mRNAs. We demonstrate that mTRANs are likely required for translation of all plant mitochondrial mRNAs. Plant mitochondrial translation initiation thus appears to use a protein-mRNA interaction that is divergent from bacteria or mammalian mitochondria.", "doi": "10.1126/science.adg0995", "pmid": "37651534", "labels": {"Bioinformatics Support and Infrastructure": "Collaborative", "Bioinformatics Support, Infrastructure and Training": "Collaborative", "Bioinformatics (NBIS)": "Collaborative"}, "xrefs": [], "notes": [], "created": "2023-09-27T06:59:56.729Z", "modified": "2023-09-27T06:59:57.550Z"}]}