{"entity": "researcher", "timestamp": "2026-08-11T14:35:54.507Z", "family": "Fontanet", "given": "Paula", "initials": "P", "orcid": "0000-0002-5324-6077", "affiliations": ["Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/dfe102480cb7458a941fc70fe7f5cb9b.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/dfe102480cb7458a941fc70fe7f5cb9b"}}, "publications": [{"entity": "publication", "iuid": "3e65ed75308b49efab3cff693834b734", "links": {"self": {"href": "https://publications.scilifelab.se/publication/3e65ed75308b49efab3cff693834b734.json"}, "display": {"href": "https://publications.scilifelab.se/publication/3e65ed75308b49efab3cff693834b734"}}, "title": "Single-cell RNA-sequencing analysis of the developing mouse inner ear identifies molecular logic of auditory neuron diversification.", "authors": [{"family": "Petitpr\u00e9", "given": "Charles", "initials": "C"}, {"family": "Faure", "given": "Louis", "initials": "L", "orcid": "0000-0003-4621-586X", "researcher": {"href": "https://publications.scilifelab.se/researcher/bbf218e53c854d69a1b474a61480c33f.json"}}, {"family": "Uhl", "given": "Phoebe", "initials": "P", "orcid": "0000-0002-5521-7261", "researcher": {"href": "https://publications.scilifelab.se/researcher/ed69ade5f1bc491385c66f6e9df66adf.json"}}, {"family": "Fontanet", "given": "Paula", "initials": "P", "orcid": "0000-0002-5324-6077", "researcher": {"href": "https://publications.scilifelab.se/researcher/dfe102480cb7458a941fc70fe7f5cb9b.json"}}, {"family": "Filova", "given": "Iva", "initials": "I"}, {"family": "Pavlinkova", "given": "Gabriela", "initials": "G"}, {"family": "Adameyko", "given": "Igor", "initials": "I", "orcid": "0000-0001-5471-0356", "researcher": {"href": "https://publications.scilifelab.se/researcher/346f484a56cb4ad5b866b194ccd44e4f.json"}}, {"family": "Hadjab", "given": "Saida", "initials": "S", "orcid": "0000-0001-7953-8396", "researcher": {"href": "https://publications.scilifelab.se/researcher/ed79ab77088f43859e11b75dcae33d73.json"}}, {"family": "Lallemend", "given": "Francois", "initials": "F", "orcid": "0000-0001-5484-0011", "researcher": {"href": "https://publications.scilifelab.se/researcher/9a9494a8ea444facbf3b564670930ab5.json"}}], "type": "journal article", "published": "2022-07-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "13", "issue": "1", "pages": "3878"}, "abstract": "Different types of spiral ganglion neurons (SGNs) are essential for auditory perception by transmitting complex auditory information from hair cells (HCs) to the brain. Here, we use deep, single cell transcriptomics to study the molecular mechanisms that govern their identity and organization in mice. We identify a core set of temporally patterned genes and gene regulatory networks that may contribute to the diversification of SGNs through sequential binary decisions and demonstrate a role for NEUROD1 in driving specification of a Ic-SGN phenotype. We also find that each trajectory of the decision tree is defined by initial co-expression of alternative subtype molecular controls followed by gradual shifts toward cell fate resolution. Finally, analysis of both developing SGN and HC types reveals cell-cell signaling potentially playing a role in the differentiation of SGNs. Our results indicate that SGN identities are drafted prior to birth and reveal molecular principles that shape their differentiation and will facilitate studies of their development, physiology, and dysfunction.", "doi": "10.1038/s41467-022-31580-1", "pmid": "35790771", "labels": {"National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Production)": "Service", "NGI Short read": "Service", "Eukaryotic Single Cell Genomics (ESCG)": "Service", "NGI Stockholm (Genomics Applications)": "Service", "NGI Single cell": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9256748"}, {"db": "pii", "key": "10.1038/s41467-022-31580-1"}], "notes": [], "created": "2022-08-19T08:38:31.468Z", "modified": "2023-10-16T11:38:03.441Z"}, {"entity": "publication", "iuid": "a4bbbc6af47c4ff399e4ce88b4e2f840", "links": {"self": {"href": "https://publications.scilifelab.se/publication/a4bbbc6af47c4ff399e4ce88b4e2f840.json"}, "display": {"href": "https://publications.scilifelab.se/publication/a4bbbc6af47c4ff399e4ce88b4e2f840"}}, "title": "Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice.", "authors": [{"family": "Wu", "given": "Haohao", "initials": "H", "orcid": "0000-0002-5511-7084", "researcher": {"href": "https://publications.scilifelab.se/researcher/8bc2f62b53ce4aabb4db2508e7901228.json"}}, {"family": "Petitpr\u00e9", "given": "Charles", "initials": "C"}, {"family": "Fontanet", "given": "Paula", "initials": "P", "orcid": "0000-0002-5324-6077", "researcher": {"href": "https://publications.scilifelab.se/researcher/dfe102480cb7458a941fc70fe7f5cb9b.json"}}, {"family": "Sharma", "given": "Anil", "initials": "A", "orcid": "0000-0002-7442-8494", "researcher": {"href": "https://publications.scilifelab.se/researcher/53eab132449648df8998ae6de526c99f.json"}}, {"family": "Bellardita", "given": "Carmelo", "initials": "C"}, {"family": "Quadros", "given": "Rolen M", "initials": "RM"}, {"family": "Jannig", "given": "Paulo R", "initials": "PR"}, {"family": "Wang", "given": "Yiqiao", "initials": "Y"}, {"family": "Heimel", "given": "J Alexander", "initials": "JA", "orcid": "0000-0002-5291-4184", "researcher": {"href": "https://publications.scilifelab.se/researcher/1bc34eb2a27f43c680a9198426041468.json"}}, {"family": "Cheung", "given": "Kylie K Y", "initials": "KKY"}, {"family": "Wanderoy", "given": "Simone", "initials": "S"}, {"family": "Xuan", "given": "Yang", "initials": "Y"}, {"family": "Meletis", "given": "Konstantinos", "initials": "K", "orcid": "0000-0001-5665-4781", "researcher": {"href": "https://publications.scilifelab.se/researcher/56822ffe0341444297c820580f52dfd0.json"}}, {"family": "Ruas", "given": "Jorge", "initials": "J", "orcid": "0000-0002-1110-2606", "researcher": {"href": "https://publications.scilifelab.se/researcher/b91c3fde15f7415aa1f6c9263ff913ff.json"}}, {"family": "Gurumurthy", "given": "Channabasavaiah B", "initials": "CB", "orcid": "0000-0002-8022-4033", "researcher": {"href": "https://publications.scilifelab.se/researcher/3f30aa6db34f4d34b3bdb24ecb2069b4.json"}}, {"family": "Kiehn", "given": "Ole", "initials": "O"}, {"family": "Hadjab", "given": "Saida", "initials": "S", "orcid": "0000-0001-7953-8396", "researcher": {"href": "https://publications.scilifelab.se/researcher/ed79ab77088f43859e11b75dcae33d73.json"}}, {"family": "Lallemend", "given": "Fran\u00e7ois", "initials": "F", "orcid": "0000-0001-5484-0011", "researcher": {"href": "https://publications.scilifelab.se/researcher/9a9494a8ea444facbf3b564670930ab5.json"}}], "type": "journal article", "published": "2021-02-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "1026", "issn-l": "2041-1723"}, "abstract": "Proprioceptive neurons (PNs) are essential for the proper execution of all our movements by providing muscle sensory feedback to the central motor network. Here, using deep single cell RNAseq of adult PNs coupled with virus and genetic tracings, we molecularly identify three main types of PNs (Ia, Ib and II) and find that they segregate into eight distinct subgroups. Our data unveil a highly sophisticated organization of PNs into discrete sensory input channels with distinct spatial distribution, innervation patterns and molecular profiles. Altogether, these features contribute to finely regulate proprioception during complex motor behavior. Moreover, while Ib- and II-PN subtypes are specified around birth, Ia-PN subtypes diversify later in life along with increased motor activity. We also show Ia-PNs plasticity following exercise training, suggesting Ia-PNs are important players in adaptive proprioceptive function in adult mice.", "doi": "10.1038/s41467-021-21173-9", "pmid": "33589589", "labels": {"NGI Stockholm (Genomics Production)": null, "NGI Stockholm (Genomics Applications)": null, "National Genomics Infrastructure": null, "Eukaryotic Single Cell Genomics (ESCG)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-21173-9"}, {"db": "pmc", "key": "PMC7884389"}], "notes": [], "created": "2021-06-09T12:14:37.963Z", "modified": "2024-01-16T13:48:40.686Z"}, {"entity": "publication", "iuid": "6f59a84f1afe4e30bd4fb89e91d3311d", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6f59a84f1afe4e30bd4fb89e91d3311d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6f59a84f1afe4e30bd4fb89e91d3311d"}}, "title": "Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates.", "authors": [{"family": "Faure", "given": "Louis", "initials": "L", "orcid": "0000-0003-4621-586X", "researcher": {"href": "https://publications.scilifelab.se/researcher/bbf218e53c854d69a1b474a61480c33f.json"}}, {"family": "Wang", "given": "Yiqiao", "initials": "Y"}, {"family": "Kastriti", "given": "Maria Eleni", "initials": "ME", "orcid": "0000-0002-0563-7399", "researcher": {"href": "https://publications.scilifelab.se/researcher/9e0722d8c5484a13bb37c3a3b084ff8c.json"}}, {"family": "Fontanet", "given": "Paula", "initials": "P", "orcid": "0000-0002-5324-6077", "researcher": {"href": "https://publications.scilifelab.se/researcher/dfe102480cb7458a941fc70fe7f5cb9b.json"}}, {"family": "Cheung", "given": "Kylie K Y", "initials": "KKY"}, {"family": "Petitpr\u00e9", "given": "Charles", "initials": "C"}, {"family": "Wu", "given": "Haohao", "initials": "H"}, {"family": "Sun", "given": "Lynn Linyu", "initials": "LL"}, {"family": "Runge", "given": "Karen", "initials": "K"}, {"family": "Croci", "given": "Laura", "initials": "L", "orcid": "0000-0002-7826-428X", "researcher": {"href": "https://publications.scilifelab.se/researcher/5e08f8646894441297506e2a3eb5fb57.json"}}, {"family": "Landy", "given": "Mark A", "initials": "MA", "orcid": "0000-0002-2789-0774", "researcher": {"href": "https://publications.scilifelab.se/researcher/5334230675f543fc8b870741f103854d.json"}}, {"family": "Lai", "given": "Helen C", "initials": "HC", "orcid": "0000-0003-4334-0243", "researcher": {"href": "https://publications.scilifelab.se/researcher/de71bea36e954743b1e576c7e681f9eb.json"}}, {"family": "Consalez", "given": "Gian Giacomo", "initials": "GG"}, {"family": "de Chevigny", "given": "Antoine", "initials": "A", "orcid": "0000-0002-7413-0591", "researcher": {"href": "https://publications.scilifelab.se/researcher/0a2d23fc97564742905b48e36f4bc585.json"}}, {"family": "Lallemend", "given": "Fran\u00e7ois", "initials": "F"}, {"family": "Adameyko", "given": "Igor", "initials": "I", "orcid": "0000-0001-5471-0356", "researcher": {"href": "https://publications.scilifelab.se/researcher/346f484a56cb4ad5b866b194ccd44e4f.json"}}, {"family": "Hadjab", "given": "Saida", "initials": "S", "orcid": "0000-0001-7953-8396", "researcher": {"href": "https://publications.scilifelab.se/researcher/ed79ab77088f43859e11b75dcae33d73.json"}}], "type": "journal article", "published": "2020-08-21", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "11", "issue": "1", "pages": "4175", "issn-l": "2041-1723"}, "abstract": "Somatic sensation is defined by the existence of a diversity of primary sensory neurons with unique biological features and response profiles to external and internal stimuli. However, there is no coherent picture about how this diversity of cell states is transcriptionally generated. Here, we use deep single cell analysis to resolve fate splits and molecular biasing processes during sensory neurogenesis in mice. Our results identify a complex series of successive and specific transcriptional changes in post-mitotic neurons that delineate hierarchical regulatory states leading to the generation of the main sensory neuron classes. In addition, our analysis identifies previously undetected early gene modules expressed long before fate determination although being clearly associated with defined sensory subtypes. Overall, the early diversity of sensory neurons is generated through successive bi-potential intermediates in which synchronization of relevant gene modules and concurrent repression of competing fate programs precede cell fate stabilization and final commitment.", "doi": "10.1038/s41467-020-17929-4", "pmid": "32826903", "labels": {"Eukaryotic Single Cell Genomics (ESCG)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-020-17929-4"}, {"db": "pmc", "key": "PMC7442800"}], "notes": [], "created": "2020-10-06T11:10:56.370Z", "modified": "2024-01-16T13:48:41.901Z"}]}