{"entity": "researcher", "timestamp": "2026-03-16T18:26:38.604Z", "family": "Kallazhi", "given": "Aswathy", "initials": "A", "orcid": "0009-0003-4585-2792", "affiliations": ["Science for Life Laboratory and Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Svante Arrhenius v\u00e4g 20C, Stockholm, 10691, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/df59bcc8d7524fdfaad0b6b43abe4e86.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/df59bcc8d7524fdfaad0b6b43abe4e86"}}, "publications": [{"entity": "publication", "iuid": "7d95af839fa143759ce68c732ed930c2", "links": {"self": {"href": "https://publications.scilifelab.se/publication/7d95af839fa143759ce68c732ed930c2.json"}, "display": {"href": "https://publications.scilifelab.se/publication/7d95af839fa143759ce68c732ed930c2"}}, "title": "The heat shock protein LarA activates the Lon protease in response to proteotoxic stress.", "authors": [{"family": "Omnus", "given": "Deike J", "initials": "DJ", "orcid": "0000-0002-4091-4291", "researcher": {"href": "https://publications.scilifelab.se/researcher/4012e43cedf04b19be7a7edfa227aa8f.json"}}, {"family": "Fink", "given": "Matthias J", "initials": "MJ", "orcid": "0000-0002-4620-2009", "researcher": {"href": "https://publications.scilifelab.se/researcher/16ee1108730641498bcf0d38b116cb18.json"}}, {"family": "Kallazhi", "given": "Aswathy", "initials": "A", "orcid": "0009-0003-4585-2792", "researcher": {"href": "https://publications.scilifelab.se/researcher/df59bcc8d7524fdfaad0b6b43abe4e86.json"}}, {"family": "Xandri Zaragoza", "given": "Maria", "initials": "M"}, {"family": "Leppert", "given": "Axel", "initials": "A", "orcid": "0000-0001-6223-3350", "researcher": {"href": "https://publications.scilifelab.se/researcher/e89c2b7f8a294cfdae4848e96be7520b.json"}}, {"family": "Landreh", "given": "Michael", "initials": "M", "orcid": "0000-0002-7958-4074", "researcher": {"href": "https://publications.scilifelab.se/researcher/87494f4204c04be9bce5e9ddcdc92d8a.json"}}, {"family": "Jonas", "given": "Kristina", "initials": "K", "orcid": "0000-0002-1469-4424", "researcher": {"href": "https://publications.scilifelab.se/researcher/3351b638c7904141b4ae20dd41929e26.json"}}], "type": "journal article", "published": "2023-11-22", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "7636", "issn-l": "2041-1723"}, "abstract": "The Lon protease is a highly conserved protein degradation machine that has critical regulatory and protein quality control functions in cells from the three domains of life. Here, we report the discovery of a \u03b1-proteobacterial heat shock protein, LarA, that functions as a dedicated Lon regulator. We show that LarA accumulates at the onset of proteotoxic stress and allosterically activates Lon-catalysed degradation of a large group of substrates through a five amino acid sequence at its C-terminus. Further, we find that high levels of LarA cause growth inhibition in a Lon-dependent manner and that Lon-mediated degradation of LarA itself ensures low LarA levels in the absence of stress. We suggest that the temporal LarA-dependent activation of Lon helps to meet an increased proteolysis demand in response to protein unfolding stress. Our study defines a regulatory interaction of a conserved protease with a heat shock protein, serving as a paradigm of how protease activity can be tuned under changing environmental conditions.", "doi": "10.1038/s41467-023-43385-x", "pmid": "37993443", "labels": {"Global Proteomics and Proteogenomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10665427"}, {"db": "pii", "key": "10.1038/s41467-023-43385-x"}], "notes": [], "created": "2023-11-29T12:37:38.523Z", "modified": "2023-11-29T12:37:38.620Z"}]}