{"entity": "researcher", "timestamp": "2026-08-14T12:12:03.010Z", "family": "Arcoverde Cerveira", "given": "Rodrigo", "initials": "R", "orcid": "0000-0002-1145-2534", "affiliations": ["Division of Immunology and Allergy, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/df30915fb0e849609871f5237a33ff2b.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/df30915fb0e849609871f5237a33ff2b"}}, "publications": [{"entity": "publication", "iuid": "99f60b817821490f9e17cd2af2cecd6a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/99f60b817821490f9e17cd2af2cecd6a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/99f60b817821490f9e17cd2af2cecd6a"}}, "title": "Scifer: An R/Bioconductor package for large-scale integration of Sanger sequencing and flow cytometry data of index-sorted single cells", "authors": [{"family": "Arcoverde Cerveira", "given": "Rodrigo", "initials": "R", "orcid": "0000-0002-1145-2534", "researcher": {"href": "https://publications.scilifelab.se/researcher/df30915fb0e849609871f5237a33ff2b.json"}}, {"family": "Lenart", "given": "Klara", "initials": "K", "orcid": "0000-0002-4984-2618", "researcher": {"href": "https://publications.scilifelab.se/researcher/b2e93a7400934289947153f095273178.json"}}, {"family": "Martin", "given": "Marcel", "initials": "M"}, {"family": "Hinchcliff", "given": "Matthew James", "initials": "MJ"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Ye", "given": "Kewei", "initials": "K"}, {"family": "Assis Geraldo", "given": "Juliana", "initials": "J"}, {"family": "Kreslavsky", "given": "Taras", "initials": "T", "orcid": "0000-0002-6672-1914", "researcher": {"href": "https://publications.scilifelab.se/researcher/94bb90e31ed1447a9835a1adae1c8daa.json"}}, {"family": "Ols", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-9784-7176", "researcher": {"href": "https://publications.scilifelab.se/researcher/e1343e56a87f49c4abc7beb6f36b87c1.json"}}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications.scilifelab.se/researcher/737245a5bc2144bd90be71487cbb3192.json"}}], "type": "journal-article", "published": "2024-12-00", "journal": {"title": "Immunoinformatics (Amst)", "issn": "2667-1190", "volume": "16", "pages": "100046", "issn-l": null}, "abstract": null, "doi": "10.1016/j.immuno.2024.100046", "pmid": null, "labels": {"Bioinformatics Support, Infrastructure and Training": "Collaborative", "Bioinformatics Long-term Support WABI": "Collaborative", "Bioinformatics Support for Computational Resources": "Service", "Bioinformatics (NBIS)": "Collaborative"}, "xrefs": [], "notes": [], "created": "2024-11-12T13:52:10.971Z", "modified": "2025-04-07T07:28:33.218Z"}, {"entity": "publication", "iuid": "af902f42fab44b62a2b01a329fd1e915", "links": {"self": {"href": "https://publications.scilifelab.se/publication/af902f42fab44b62a2b01a329fd1e915.json"}, "display": {"href": "https://publications.scilifelab.se/publication/af902f42fab44b62a2b01a329fd1e915"}}, "title": "Three immunizations with Novavax's protein vaccines increase antibody breadth and provide durable protection from SARS-CoV-2.", "authors": [{"family": "Lenart", "given": "Klara", "initials": "K", "orcid": "0000-0002-4984-2618", "researcher": {"href": "https://publications.scilifelab.se/researcher/b2e93a7400934289947153f095273178.json"}}, {"family": "Arcoverde Cerveira", "given": "Rodrigo", "initials": "R", "orcid": "0000-0002-1145-2534", "researcher": {"href": "https://publications.scilifelab.se/researcher/df30915fb0e849609871f5237a33ff2b.json"}}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Ols", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-9784-7176", "researcher": {"href": "https://publications.scilifelab.se/researcher/e1343e56a87f49c4abc7beb6f36b87c1.json"}}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ", "orcid": "0000-0002-0227-5636", "researcher": {"href": "https://publications.scilifelab.se/researcher/6105f3617cdf4241bf335299ac957ee5.json"}}, {"family": "Kim", "given": "Changil", "initials": "C", "orcid": "0000-0003-4977-4384", "researcher": {"href": "https://publications.scilifelab.se/researcher/f2212e39632b4184b3dfa8f985b87221.json"}}, {"family": "Cagigi", "given": "Alberto", "initials": "A"}, {"family": "Gagne", "given": "Matthew", "initials": "M", "orcid": "0000-0001-5526-6162", "researcher": {"href": "https://publications.scilifelab.se/researcher/ca410207419743c4a8a5b609d5941459.json"}}, {"family": "Davis", "given": "Brandon", "initials": "B"}, {"family": "Germosen", "given": "Daritza", "initials": "D"}, {"family": "Roy", "given": "Vicky", "initials": "V", "orcid": "0000-0002-5064-1098", "researcher": {"href": "https://publications.scilifelab.se/researcher/d7215b0bed734c9b88fe892cf3cd94ea.json"}}, {"family": "Alter", "given": "Galit", "initials": "G"}, {"family": "Letscher", "given": "H\u00e9l\u00e8ne", "initials": "H"}, {"family": "Van Wassenhove", "given": "J\u00e9r\u00f4me", "initials": "J", "orcid": "0000-0001-7298-465X", "researcher": {"href": "https://publications.scilifelab.se/researcher/059f7210f3ba486984768bf32f7dbc41.json"}}, {"family": "Gros", "given": "Wesley", "initials": "W"}, {"family": "Gallou\u00ebt", "given": "Anne-Sophie", "initials": "AS"}, {"family": "Le Grand", "given": "Roger", "initials": "R", "orcid": "0000-0002-4928-4484", "researcher": {"href": "https://publications.scilifelab.se/researcher/e0b9f73082164b0092d9483ff474fc1c.json"}}, {"family": "Kleanthous", "given": "Harry", "initials": "H", "orcid": "0000-0001-7115-235X", "researcher": {"href": "https://publications.scilifelab.se/researcher/f590083a978347d5b2c329d4400dabd6.json"}}, {"family": "Guebre-Xabier", "given": "Mimi", "initials": "M"}, {"family": "Murrell", "given": "Ben", "initials": "B", "orcid": "0000-0002-0393-4445", "researcher": {"href": "https://publications.scilifelab.se/researcher/8a899203048943489bf7b6310a32b19f.json"}}, {"family": "Patel", "given": "Nita", "initials": "N"}, {"family": "Glenn", "given": "Gregory", "initials": "G"}, {"family": "Smith", "given": "Gale", "initials": "G", "orcid": "0000-0002-6482-6026", "researcher": {"href": "https://publications.scilifelab.se/researcher/1b50ad721d0a45b2957eb38a7afd803c.json"}}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications.scilifelab.se/researcher/737245a5bc2144bd90be71487cbb3192.json"}}], "type": "journal article", "published": "2024-01-20", "journal": {"title": "NPJ Vaccines", "issn": "2059-0105", "issn-l": null, "volume": "9", "issue": "1", "pages": "17"}, "abstract": "The immune responses to Novavax's licensed NVX-CoV2373 nanoparticle Spike protein vaccine against SARS-CoV-2 remain incompletely understood. Here, we show in rhesus macaques that immunization with Matrix-MTM adjuvanted vaccines predominantly elicits immune events in local tissues with little spillover to the periphery. A third dose of an updated vaccine based on the Gamma (P.1) variant 7 months after two immunizations with licensed NVX-CoV2373 resulted in significant enhancement of anti-spike antibody titers and antibody breadth including neutralization of forward drift Omicron variants. The third immunization expanded the Spike-specific memory B cell pool, induced significant somatic hypermutation, and increased serum antibody avidity, indicating considerable affinity maturation. Seven months after immunization, vaccinated animals controlled infection by either WA-1 or P.1 strain, mediated by rapid anamnestic antibody and T cell responses in the lungs. In conclusion, a third immunization with an adjuvanted, low-dose recombinant protein vaccine significantly improved the quality of B cell responses, enhanced antibody breadth, and provided durable protection against SARS-CoV-2 challenge.", "doi": "10.1038/s41541-024-00806-2", "pmid": "38245545", "labels": {"Affinity Proteomics Stockholm": "Service", "Bioinformatics Support for Computational Resources": "Service", "Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10799869"}, {"db": "pii", "key": "10.1038/s41541-024-00806-2"}], "notes": [], "created": "2024-10-08T15:06:47.828Z", "modified": "2025-02-28T14:15:13.257Z"}, {"entity": "publication", "iuid": "1e042f602f324b7eb585860df4f9dcc5", "links": {"self": {"href": "https://publications.scilifelab.se/publication/1e042f602f324b7eb585860df4f9dcc5.json"}, "display": {"href": "https://publications.scilifelab.se/publication/1e042f602f324b7eb585860df4f9dcc5"}}, "title": "Unmodified rabies mRNA vaccine elicits high cross-neutralizing antibody titers and diverse B cell memory responses.", "authors": [{"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Cagigi", "given": "Alberto", "initials": "A"}, {"family": "Arcoverde Cerveira", "given": "Rodrigo", "initials": "R", "orcid": "0000-0002-1145-2534", "researcher": {"href": "https://publications.scilifelab.se/researcher/df30915fb0e849609871f5237a33ff2b.json"}}, {"family": "Ols", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-9784-7176", "researcher": {"href": "https://publications.scilifelab.se/researcher/e1343e56a87f49c4abc7beb6f36b87c1.json"}}, {"family": "Kern", "given": "Theresa", "initials": "T", "orcid": "0009-0000-0151-5442", "researcher": {"href": "https://publications.scilifelab.se/researcher/da58a11a6fcc47babadfd35a7fdae808.json"}}, {"family": "Lin", "given": "Ang", "initials": "A"}, {"family": "Eriksson", "given": "Bengt", "initials": "B"}, {"family": "Dodds", "given": "Michael G", "initials": "MG"}, {"family": "Jasny", "given": "Edith", "initials": "E"}, {"family": "Schwendt", "given": "Kim", "initials": "K"}, {"family": "Freuling", "given": "Conrad", "initials": "C"}, {"family": "M\u00fcller", "given": "Thomas", "initials": "T"}, {"family": "Corcoran", "given": "Martin", "initials": "M"}, {"family": "Karlsson Hedestam", "given": "Gunilla B", "initials": "GB"}, {"family": "Petsch", "given": "Benjamin", "initials": "B"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications.scilifelab.se/researcher/737245a5bc2144bd90be71487cbb3192.json"}}], "type": "journal article", "published": "2023-06-22", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "3713", "issn-l": "2041-1723"}, "abstract": "Licensed rabies virus vaccines based on whole inactivated virus are effective in humans. However, there is a lack of detailed investigations of the elicited immune response, and whether responses can be improved using novel vaccine platforms. Here we show that two doses of a lipid nanoparticle-formulated unmodified mRNA vaccine encoding the rabies virus glycoprotein (RABV-G) induces higher levels of RABV-G specific plasmablasts and T cells in blood, and plasma cells in the bone marrow compared to two doses of Rabipur in non-human primates. The mRNA vaccine also generates higher RABV-G binding and neutralizing antibody titers than Rabipur, while the degree of somatic hypermutation and clonal diversity of the response are similar for the two vaccines. The higher overall antibody titers induced by the mRNA vaccine translates into improved cross-neutralization of related lyssavirus strains, suggesting that this platform has potential for the development of a broadly protective vaccine against these viruses.", "doi": "10.1038/s41467-023-39421-5", "pmid": "37349310", "labels": {"Bioinformatics Support, Infrastructure and Training": "Service", "Bioinformatics Support for Computational Resources": "Service", "Bioinformatics (NBIS)": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10287699"}, {"db": "pii", "key": "10.1038/s41467-023-39421-5"}], "notes": [], "created": "2023-12-01T12:29:38.796Z", "modified": "2024-01-16T13:48:33.121Z"}, {"entity": "publication", "iuid": "579194408fda4d8c9e4324e8a98dd4e1", "links": {"self": {"href": "https://publications.scilifelab.se/publication/579194408fda4d8c9e4324e8a98dd4e1.json"}, "display": {"href": "https://publications.scilifelab.se/publication/579194408fda4d8c9e4324e8a98dd4e1"}}, "title": "Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19.", "authors": [{"family": "Yu", "given": "Meng", "initials": "M", "orcid": "0000-0002-9798-6624", "researcher": {"href": "https://publications.scilifelab.se/researcher/0e0d4b3b53994166af0f2f7fd0679c6b.json"}}, {"family": "Charles", "given": "Afandi", "initials": "A", "orcid": "0000-0003-0022-3303", "researcher": {"href": "https://publications.scilifelab.se/researcher/29721279f6fb4c50a2f96d86a0ce9686.json"}}, {"family": "Cagigi", "given": "Alberto", "initials": "A"}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications.scilifelab.se/researcher/38fe3a44fdb547b885cce5b6f490b2bc.json"}}, {"family": "\u00d6sterberg", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "Azizmohammadi", "given": "Lida", "initials": "L"}, {"family": "\u00c5hlberg", "given": "Eric", "initials": "E"}, {"family": "Falck-Jones", "given": "Ryan", "initials": "R", "orcid": "0000-0002-0985-8658", "researcher": {"href": "https://publications.scilifelab.se/researcher/addfd2bdc37b4f7cb7bf4cb65183b153.json"}}, {"family": "Svensson", "given": "Julia", "initials": "J"}, {"family": "Nie", "given": "Mu", "initials": "M"}, {"family": "Warnqvist", "given": "Anna", "initials": "A"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Lenart", "given": "Klara", "initials": "K", "orcid": "0000-0002-4984-2618", "researcher": {"href": "https://publications.scilifelab.se/researcher/b2e93a7400934289947153f095273178.json"}}, {"family": "Arcoverde Cerveira", "given": "Rodrigo", "initials": "R", "orcid": "0000-0002-1145-2534", "researcher": {"href": "https://publications.scilifelab.se/researcher/df30915fb0e849609871f5237a33ff2b.json"}}, {"family": "Ols", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-9784-7176", "researcher": {"href": "https://publications.scilifelab.se/researcher/e1343e56a87f49c4abc7beb6f36b87c1.json"}}, {"family": "Lindgren", "given": "Gustaf", "initials": "G"}, {"family": "Lin", "given": "Ang", "initials": "A"}, {"family": "Maecker", "given": "Holden", "initials": "H", "orcid": "0000-0003-0795-9946", "researcher": {"href": "https://publications.scilifelab.se/researcher/e3bcc923a42f4137a30d6ba7cb850d7f.json"}}, {"family": "Bell", "given": "Max", "initials": "M", "orcid": "0000-0001-7464-0324", "researcher": {"href": "https://publications.scilifelab.se/researcher/4bf2fb404fae432aa21aa9eb34098efc.json"}}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Albert", "given": "Jan", "initials": "J", "orcid": "0000-0001-9020-0521", "researcher": {"href": "https://publications.scilifelab.se/researcher/d23f55d392eb411d90a53c2fb22aced3.json"}}, {"family": "Sundling", "given": "Christopher", "initials": "C", "orcid": "0000-0002-6138-690X", "researcher": {"href": "https://publications.scilifelab.se/researcher/89c1e689a46b4b14adb0dc99e1c0a58c.json"}}, {"family": "Czarnewski", "given": "Paulo", "initials": "P"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications.scilifelab.se/researcher/95c1b345ae434fb383b7fe6a1d053c80.json"}}, {"family": "F\u00e4rnert", "given": "Anna", "initials": "A"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications.scilifelab.se/researcher/737245a5bc2144bd90be71487cbb3192.json"}}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A", "orcid": "0000-0001-6966-7039", "researcher": {"href": "https://publications.scilifelab.se/researcher/b874ce1e1fd4455e9d681c3d3db74ed0.json"}}], "type": "journal article", "published": "2023-04-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "14", "issue": "1", "pages": "2164"}, "abstract": "Effective humoral immune responses require well-orchestrated B and T follicular helper (Tfh) cell interactions. Whether these interactions are impaired and associated with COVID-19 disease severity is unclear. Here, longitudinal blood samples across COVID-19 disease severity are analysed. We find that during acute infection SARS-CoV-2-specific circulating Tfh (cTfh) cells expand with disease severity. SARS-CoV-2-specific cTfh cell frequencies correlate with plasmablast frequencies and SARS-CoV-2 antibody titers, avidity and neutralization. Furthermore, cTfh cells but not other memory CD4 T cells, from severe patients better induce plasmablast differentiation and antibody production compared to cTfh cells from mild patients. However, virus-specific cTfh cell development is delayed in patients that display or later develop severe disease compared to those with mild disease, which correlates with delayed induction of high-avidity neutralizing antibodies. Our study suggests that impaired generation of functional virus-specific cTfh cells delays high-quality antibody production at an early stage, potentially enabling progression to severe disease.", "doi": "10.1038/s41467-023-37835-9", "pmid": "37061513", "labels": {"Bioinformatics Long-term Support WABI": "Collaborative", "Bioinformatics Support, Infrastructure and Training": "Collaborative", "Bioinformatics (NBIS)": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC10105364"}, {"db": "pii", "key": "10.1038/s41467-023-37835-9"}], "notes": [], "created": "2023-04-21T13:16:11.901Z", "modified": "2023-11-16T14:36:19.050Z"}]}