{"entity": "researcher", "timestamp": "2026-03-05T08:15:58.010Z", "family": "Vapalahti", "given": "Olli", "initials": "O", "orcid": "0000-0003-2270-6824", "affiliations": [], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/ddd242b27ab54495aa9e135590938eaf.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/ddd242b27ab54495aa9e135590938eaf"}}, "publications": [{"entity": "publication", "iuid": "b5c8c85e130e40d7984d2c097b23a4ea", "links": {"self": {"href": "https://publications.scilifelab.se/publication/b5c8c85e130e40d7984d2c097b23a4ea.json"}, "display": {"href": "https://publications.scilifelab.se/publication/b5c8c85e130e40d7984d2c097b23a4ea"}}, "title": "Intranasal trimeric sherpabody inhibits SARS-CoV-2 including recent immunoevasive Omicron subvariants.", "authors": [{"family": "M\u00e4kel\u00e4", "given": "Anna R", "initials": "AR"}, {"family": "U\u011furlu", "given": "Hasan", "initials": "H", "orcid": "0000-0002-3849-7847", "researcher": {"href": "https://publications.scilifelab.se/researcher/aa26094fded848c685b7ad9d2355b4dc.json"}}, {"family": "Hannula", "given": "Liina", "initials": "L"}, {"family": "Kant", "given": "Ravi", "initials": "R", "orcid": "0000-0003-3878-9775", "researcher": {"href": "https://publications.scilifelab.se/researcher/5ee44aebd7174ab9bb5fc741c0a13e2b.json"}}, {"family": "Salminen", "given": "Petja", "initials": "P"}, {"family": "Fagerlund", "given": "Riku", "initials": "R"}, {"family": "M\u00e4ki", "given": "Sanna", "initials": "S"}, {"family": "Haveri", "given": "Anu", "initials": "A", "orcid": "0000-0003-4620-7536", "researcher": {"href": "https://publications.scilifelab.se/researcher/981b0b4c9c9e47138958c7d8753d3340.json"}}, {"family": "Strandin", "given": "Tomas", "initials": "T"}, {"family": "Kareinen", "given": "Lauri", "initials": "L"}, {"family": "Hepojoki", "given": "Jussi", "initials": "J", "orcid": "0000-0001-5699-214X", "researcher": {"href": "https://publications.scilifelab.se/researcher/90f4bea163f34c08ade5950650ef9566.json"}}, {"family": "Kuivanen", "given": "Suvi", "initials": "S"}, {"family": "Levanov", "given": "Lev", "initials": "L"}, {"family": "Pasternack", "given": "Arja", "initials": "A", "orcid": "0000-0002-6088-4245", "researcher": {"href": "https://publications.scilifelab.se/researcher/1e8c1a42861e49a99be70101486ed3b1.json"}}, {"family": "Naves", "given": "Rauno A", "initials": "RA"}, {"family": "Ritvos", "given": "Olli", "initials": "O"}, {"family": "\u00d6sterlund", "given": "Pamela", "initials": "P", "orcid": "0000-0002-2229-6661", "researcher": {"href": "https://publications.scilifelab.se/researcher/f4657c21b1c1489eb139604a276b8738.json"}}, {"family": "Sironen", "given": "Tarja", "initials": "T", "orcid": "0000-0002-2344-2755", "researcher": {"href": "https://publications.scilifelab.se/researcher/8060fb77390f429e862149edf1435b5c.json"}}, {"family": "Vapalahti", "given": "Olli", "initials": "O", "orcid": "0000-0003-2270-6824", "researcher": {"href": "https://publications.scilifelab.se/researcher/ddd242b27ab54495aa9e135590938eaf.json"}}, {"family": "Kipar", "given": "Anja", "initials": "A", "orcid": "0000-0001-7289-3459", "researcher": {"href": "https://publications.scilifelab.se/researcher/0b82e8542b104dd79e189137733305e1.json"}}, {"family": "Huiskonen", "given": "Juha T", "initials": "JT", "orcid": "0000-0002-0348-7323", "researcher": {"href": "https://publications.scilifelab.se/researcher/c858a2e60971462f9e53653320c9eb0f.json"}}, {"family": "Rissanen", "given": "Ilona", "initials": "I", "orcid": "0000-0003-4937-1825", "researcher": {"href": "https://publications.scilifelab.se/researcher/20befd1e39cc4530b46c4f961c9a435c.json"}}, {"family": "Saksela", "given": "Kalle", "initials": "K", "orcid": "0000-0003-0827-122X", "researcher": {"href": "https://publications.scilifelab.se/researcher/5615e2d363d84510bd0e70b80f886f5f.json"}}], "type": "journal article", "published": "2023-03-24", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "1637", "issn-l": "2041-1723"}, "abstract": "The emergence of increasingly immunoevasive SARS-CoV-2 variants emphasizes the need for prophylactic strategies to complement vaccination in fighting the COVID-19 pandemic. Intranasal administration of neutralizing antibodies has shown encouraging protective potential but there remains a need for SARS-CoV-2 blocking agents that are less vulnerable to mutational viral variation and more economical to produce in large scale. Here we describe TriSb92, a highly manufacturable and stable trimeric antibody-mimetic sherpabody targeted against a conserved region of the viral spike glycoprotein. TriSb92 potently neutralizes SARS-CoV-2, including the latest Omicron variants like BF.7, XBB, and BQ.1.1. In female Balb/c mice intranasal administration of just 5 or 50 micrograms of TriSb92 as early as 8 h before but also 4 h after SARS-CoV-2 challenge can protect from infection. Cryo-EM and biochemical studies reveal triggering of a conformational shift in the spike trimer as the inhibitory mechanism of TriSb92. The potency and robust biochemical properties of TriSb92 together with its resistance against viral sequence evolution suggest that TriSb92 could be useful as a nasal spray for protecting susceptible individuals from SARS-CoV-2 infection.", "doi": "10.1038/s41467-023-37290-6", "pmid": "36964125", "labels": {"Cryo-EM": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10037368"}, {"db": "pii", "key": "10.1038/s41467-023-37290-6"}], "notes": [], "created": "2023-06-08T20:24:47.138Z", "modified": "2023-11-26T14:06:35.516Z"}, {"entity": "publication", "iuid": "1350e5c702b3487dba34a7e5cf586808", "links": {"self": {"href": "https://publications.scilifelab.se/publication/1350e5c702b3487dba34a7e5cf586808.json"}, "display": {"href": "https://publications.scilifelab.se/publication/1350e5c702b3487dba34a7e5cf586808"}}, "title": "Nanobody engineering for SARS-CoV-2 neutralization and detection", "authors": [{"family": "Hannula", "given": "Liina", "initials": "L", "orcid": "0000-0001-7586-7539", "researcher": {"href": "https://publications.scilifelab.se/researcher/0c5c0e90fd5e4247bbd03f2beac0d955.json"}}, {"family": "Kuivanen", "given": "Suvi", "initials": "S", "orcid": "0000-0002-2347-5397", "researcher": {"href": "https://publications.scilifelab.se/researcher/ff9ce113016a4ea7a81cebd045ae7547.json"}}, {"family": "Lasham", "given": "Jonathan", "initials": "J", "orcid": "0000-0001-6393-9654", "researcher": {"href": "https://publications.scilifelab.se/researcher/47da5df97f3f4bea8eab630eb26b36d4.json"}}, {"family": "Kant", "given": "Ravi", "initials": "R", "orcid": "0000-0003-3878-9775", "researcher": {"href": "https://publications.scilifelab.se/researcher/5ee44aebd7174ab9bb5fc741c0a13e2b.json"}}, {"family": "Kareinen", "given": "Lauri", "initials": "L", "orcid": "0000-0003-2525-7817", "researcher": {"href": "https://publications.scilifelab.se/researcher/57a587b74c2d43e18ea4d580125bb049.json"}}, {"family": "Bogacheva", "given": "Mariia", "initials": "M", "orcid": "0000-0001-6608-1120", "researcher": {"href": "https://publications.scilifelab.se/researcher/4fbc1f8cb4af43baac9dbc587b34950a.json"}}, {"family": "Strandin", "given": "Tomas", "initials": "T", "orcid": "0000-0002-2454-7479", "researcher": {"href": "https://publications.scilifelab.se/researcher/fcfa4fe443d04b258f6b45ec84297565.json"}}, {"family": "Sironen", "given": "Tarja", "initials": "T", "orcid": "0000-0002-2344-2755", "researcher": {"href": "https://publications.scilifelab.se/researcher/8060fb77390f429e862149edf1435b5c.json"}}, {"family": "Sharma", "given": "Vivek", "initials": "V", "orcid": "0000-0002-8838-3151", "researcher": {"href": "https://publications.scilifelab.se/researcher/5a6299ddcafc4274940548261eddd42e.json"}}, {"family": "Saviranta", "given": "Petri", "initials": "P", "orcid": "0000-0002-3289-0621", "researcher": {"href": "https://publications.scilifelab.se/researcher/4b23027247eb47f7a62dd0e6eb460b33.json"}}, {"family": "Kipar", "given": "Anja", "initials": "A"}, {"family": "Vapalahti", "given": "Olli", "initials": "O", "orcid": "0000-0003-2270-6824", "researcher": {"href": "https://publications.scilifelab.se/researcher/ddd242b27ab54495aa9e135590938eaf.json"}}, {"family": "Huiskonen", "given": "Juha T", "initials": "JT", "orcid": "0000-0002-0348-7323", "researcher": {"href": "https://publications.scilifelab.se/researcher/c858a2e60971462f9e53653320c9eb0f.json"}}, {"family": "Rissanen", "given": "Ilona", "initials": "I", "orcid": "0000-0003-4937-1825", "researcher": {"href": "https://publications.scilifelab.se/researcher/20befd1e39cc4530b46c4f961c9a435c.json"}}], "type": "posted-content", "published": "2022-09-14", "journal": {"title": "biorxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2022.09.14.507920", "pmid": null, "labels": {"Cryo-EM": "Service"}, "xrefs": [], "notes": [], "created": "2023-11-26T14:09:02.711Z", "modified": "2025-12-18T19:59:56.976Z"}, {"entity": "publication", "iuid": "9ca42c9a52d44cd99374572d2643ad5a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/9ca42c9a52d44cd99374572d2643ad5a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/9ca42c9a52d44cd99374572d2643ad5a"}}, "title": "Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19.", "authors": [{"family": "Rodriguez", "given": "Lucie", "initials": "L"}, {"family": "Pekkarinen", "given": "Pirkka T", "initials": "PT"}, {"family": "Lakshmikanth", "given": "Tadepally", "initials": "T", "orcid": "0000-0001-7256-5770", "researcher": {"href": "https://publications.scilifelab.se/researcher/92e81aa6b0cf4ff0a18b14098bf0fcc1.json"}}, {"family": "Tan", "given": "Ziyang", "initials": "Z"}, {"family": "Consiglio", "given": "Camila Rosat", "initials": "CR"}, {"family": "Pou", "given": "Christian", "initials": "C"}, {"family": "Chen", "given": "Yang", "initials": "Y"}, {"family": "Mugabo", "given": "Constantin Habimana", "initials": "CH"}, {"family": "Nguyen", "given": "Ngoc Anh", "initials": "NA", "orcid": "0000-0003-3367-8048", "researcher": {"href": "https://publications.scilifelab.se/researcher/ba8cb2f13825449f9892570cc2793964.json"}}, {"family": "Nowlan", "given": "Kirsten", "initials": "K"}, {"family": "Strandin", "given": "Tomas", "initials": "T"}, {"family": "Levanov", "given": "Lev", "initials": "L"}, {"family": "Mikes", "given": "Jaromir", "initials": "J", "orcid": "0000-0002-9941-7855", "researcher": {"href": "https://publications.scilifelab.se/researcher/21c127bffa7c4a01af7fad8ba6bac90b.json"}}, {"family": "Wang", "given": "Jun", "initials": "J"}, {"family": "Kantele", "given": "Anu", "initials": "A"}, {"family": "Hepojoki", "given": "Jussi", "initials": "J", "orcid": "0000-0001-5699-214X", "researcher": {"href": "https://publications.scilifelab.se/researcher/90f4bea163f34c08ade5950650ef9566.json"}}, {"family": "Vapalahti", "given": "Olli", "initials": "O", "orcid": "0000-0003-2270-6824", "researcher": {"href": "https://publications.scilifelab.se/researcher/ddd242b27ab54495aa9e135590938eaf.json"}}, {"family": "Heinonen", "given": "Santtu", "initials": "S"}, {"family": "Kek\u00e4l\u00e4inen", "given": "Eliisa", "initials": "E"}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications.scilifelab.se/researcher/40097353cdb24e52bf2330eb687042bf.json"}}], "type": "journal article", "published": "2020-08-25", "journal": {"title": "Cell Reports Medicine", "issn": "2666-3791", "issn-l": "2666-3791", "volume": "1", "issue": "5", "pages": "100078"}, "abstract": "Severe disease of SARS-CoV-2 is characterized by vigorous inflammatory responses in the lung, often with a sudden onset after 5-7 days of stable disease. Efforts to modulate this hyperinflammation and the associated acute respiratory distress syndrome rely on the unraveling of the immune cell interactions and cytokines that drive such responses. Given that every patient is captured at different stages of infection, longitudinal monitoring of the immune response is critical and systems-level analyses are required to capture cellular interactions. Here, we report on a systems-level blood immunomonitoring study of 37 adult patients diagnosed with COVID-19 and followed with up to 14 blood samples from acute to recovery phases of the disease. We describe an IFN\u03b3-eosinophil axis activated before lung hyperinflammation and changes in cell-cell co-regulation during different stages of the disease. We also map an immune trajectory during recovery that is shared among patients with severe COVID-19.", "doi": "10.1016/j.xcrm.2020.100078", "pmid": "32838342", "labels": {"Affinity Proteomics Stockholm": "Service", "Cellular Immunomonitoring": "Technology development", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "S2666-3791(20)30099-9"}, {"db": "pii", "key": "100078"}, {"db": "pmc", "key": "PMC7405891"}], "notes": [], "created": "2020-08-10T15:24:35.789Z", "modified": "2024-01-16T13:48:41.879Z"}]}