{"entity": "researcher", "timestamp": "2026-03-12T19:18:34.615Z", "family": "Forsthuber", "given": "Agnes", "initials": "A", "orcid": "0000-0001-6396-0090", "affiliations": ["Skin and Endothelium Research Division, Department of Dermatology, Medical University of Vienna, Vienna, Austria."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/dd76e819ba654fc5b30475456f4bb147.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/dd76e819ba654fc5b30475456f4bb147"}}, "publications": [{"entity": "publication", "iuid": "60264368eb424544b7cc9bf7716494ab", "links": {"self": {"href": "https://publications.scilifelab.se/publication/60264368eb424544b7cc9bf7716494ab.json"}, "display": {"href": "https://publications.scilifelab.se/publication/60264368eb424544b7cc9bf7716494ab"}}, "title": "Cancer-associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy.", "authors": [{"family": "Forsthuber", "given": "Agnes", "initials": "A", "orcid": "0000-0001-6396-0090", "researcher": {"href": "https://publications.scilifelab.se/researcher/dd76e819ba654fc5b30475456f4bb147.json"}}, {"family": "Aschenbrenner", "given": "Bertram", "initials": "B", "orcid": "0000-0003-1177-7109", "researcher": {"href": "https://publications.scilifelab.se/researcher/c8091adf276f4ca5af2e9c295a93b964.json"}}, {"family": "Korosec", "given": "Ana", "initials": "A"}, {"family": "Jacob", "given": "Tina", "initials": "T"}, {"family": "Annusver", "given": "Karl", "initials": "K", "orcid": "0000-0002-9515-7216", "researcher": {"href": "https://publications.scilifelab.se/researcher/941902f72c214c868d0136cf433442a7.json"}}, {"family": "Krajic", "given": "Natalia", "initials": "N", "orcid": "0000-0002-9255-5251", "researcher": {"href": "https://publications.scilifelab.se/researcher/ec8d05c1d9ae4e0698967d93b23d4dc5.json"}}, {"family": "Kholodniuk", "given": "Daria", "initials": "D"}, {"family": "Frech", "given": "Sophie", "initials": "S", "orcid": "0000-0002-6190-8595", "researcher": {"href": "https://publications.scilifelab.se/researcher/aa8e8d558e7c46f1b27722302e4050bb.json"}}, {"family": "Zhu", "given": "Shaohua", "initials": "S"}, {"family": "Purkhauser", "given": "Kim", "initials": "K", "orcid": "0000-0003-1732-9673", "researcher": {"href": "https://publications.scilifelab.se/researcher/6e2a51d5352b4558a358fddca6eada62.json"}}, {"family": "Lipp", "given": "Katharina", "initials": "K"}, {"family": "Werner", "given": "Franziska", "initials": "F"}, {"family": "Nguyen", "given": "Vy", "initials": "V"}, {"family": "Griss", "given": "Johannes", "initials": "J", "orcid": "0000-0003-2206-9511", "researcher": {"href": "https://publications.scilifelab.se/researcher/db31a8cdd1ea4a7d81a7d6d3a52f1f8b.json"}}, {"family": "Bauer", "given": "Wolfgang", "initials": "W", "orcid": "0000-0002-0155-1176", "researcher": {"href": "https://publications.scilifelab.se/researcher/00fbdb6833e342acb2f68abf2d7c41b6.json"}}, {"family": "Soler Cardona", "given": "Ana", "initials": "A"}, {"family": "Weber", "given": "Benedikt", "initials": "B", "orcid": "0000-0002-7217-4590", "researcher": {"href": "https://publications.scilifelab.se/researcher/d5b34f118cbb43cfb16a8b0c3038d83b.json"}}, {"family": "Weninger", "given": "Wolfgang", "initials": "W"}, {"family": "Gesslbauer", "given": "Bernhard", "initials": "B"}, {"family": "Staud", "given": "Clement", "initials": "C"}, {"family": "Nedomansky", "given": "Jakob", "initials": "J"}, {"family": "Radtke", "given": "Christine", "initials": "C"}, {"family": "Wagner", "given": "Stephan N", "initials": "SN", "orcid": "0000-0003-4941-7029", "researcher": {"href": "https://publications.scilifelab.se/researcher/9c147211ed64433282e4feee5240852b.json"}}, {"family": "Petzelbauer", "given": "Peter", "initials": "P", "orcid": "0000-0001-7080-5259", "researcher": {"href": "https://publications.scilifelab.se/researcher/a741b6b9df654451ae52e193c19ce837.json"}}, {"family": "Kasper", "given": "Maria", "initials": "M", "orcid": "0000-0002-6117-2717", "researcher": {"href": "https://publications.scilifelab.se/researcher/b036a8a125ca4f0896f2e832e1248dc0.json"}}, {"family": "Lichtenberger", "given": "Beate M", "initials": "BM", "orcid": "0000-0001-6882-0257", "researcher": {"href": "https://publications.scilifelab.se/researcher/92555bb2628c4b29b72398c9608dc721.json"}}], "type": "journal article", "published": "2024-11-08", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "9678", "issn-l": "2041-1723"}, "abstract": "Cancer-associated fibroblasts (CAFs) play a key role in cancer progression and treatment outcome. This study dissects the intra-tumoral diversity of CAFs in basal cell carcinoma, squamous cell carcinoma, and melanoma using molecular and spatial single-cell analysis. We identify three distinct CAF subtypes: myofibroblast-like RGS5+ CAFs, matrix CAFs (mCAFs), and immunomodulatory CAFs (iCAFs). Large-cohort tissue analysis reveals significant shifts in CAF subtype patterns with increasing malignancy. Two CAF subtypes exhibit immunomodulatory properties via different mechanisms. mCAFs sythesize extracellular matrix and may restrict T cell invasion in low-grade tumors via ensheathing tumor nests, while iCAFs are enriched in late-stage tumors, and express high levels of cytokines and chemokines to aid immune cell recruitment and activation. This is supported by the induction of an iCAF-like phenotype with immunomodulatory functions in primary healthy fibroblasts exposed to skin cancer cell secretomes. Thus, targeting CAF variants holds promise to enhance immunotherapy efficacy in skin cancers.", "doi": "10.1038/s41467-024-53908-9", "pmid": "39516494", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11549091"}, {"db": "pii", "key": "10.1038/s41467-024-53908-9"}], "notes": [], "created": "2024-11-25T10:18:25.172Z", "modified": "2024-11-25T10:18:25.564Z"}]}