{"entity": "researcher", "timestamp": "2026-08-08T16:07:40.864Z", "family": "Lilja", "given": "Lina", "initials": "L", "orcid": "0000-0003-2908-7456", "affiliations": ["Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.", "Region V\u00e4stra G\u00f6taland, Research and Development Primary Health Care and Kungsh\u00f6jd Pediatric Clinic, Gothenburg, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/dbd8f5f9d6454648b700455cb1d64c91.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/dbd8f5f9d6454648b700455cb1d64c91"}}, "publications": [{"entity": "publication", "iuid": "1883c3293a9942b7bbff3df7e9c1d61b", "links": {"self": {"href": "https://publications.scilifelab.se/publication/1883c3293a9942b7bbff3df7e9c1d61b.json"}, "display": {"href": "https://publications.scilifelab.se/publication/1883c3293a9942b7bbff3df7e9c1d61b"}}, "title": "BMI during childhood and puberty - associations with blood pressure and hypertension.", "authors": [{"family": "Lilja", "given": "Lina", "initials": "L", "orcid": "0000-0003-2908-7456", "researcher": {"href": "https://publications.scilifelab.se/researcher/dbd8f5f9d6454648b700455cb1d64c91.json"}}, {"family": "Bygdell", "given": "Maria", "initials": "M", "orcid": "0000-0002-0737-8642", "researcher": {"href": "https://publications.scilifelab.se/researcher/b54e9b05bcb74e4a91a4e9cfcdf187aa.json"}}, {"family": "Martikainen", "given": "Jari", "initials": "J", "orcid": "0000-0003-0366-1683", "researcher": {"href": "https://publications.scilifelab.se/researcher/dfd56b6dfb74494890131a51097996d8.json"}}, {"family": "Li", "given": "Huiqi", "initials": "H", "orcid": "0000-0002-1127-0829", "researcher": {"href": "https://publications.scilifelab.se/researcher/abcde2f8415b4c17971fcd44c25c3d50.json"}}, {"family": "Schmidt", "given": "Caroline", "initials": "C", "orcid": "0000-0001-8534-3237", "researcher": {"href": "https://publications.scilifelab.se/researcher/a80ef1ead9ec48bbbcdcd9a16724c716.json"}}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0003-4289-5722", "researcher": {"href": "https://publications.scilifelab.se/researcher/fbc3ade3079e4265ad42ed1be485bc24.json"}}, {"family": "Rosengren", "given": "Annika", "initials": "A", "orcid": "0000-0002-5409-6605", "researcher": {"href": "https://publications.scilifelab.se/researcher/59e4c8b35336454ab5f74df9c6b9531b.json"}}, {"family": "Ohlsson", "given": "Claes", "initials": "C", "orcid": "0000-0002-9633-2805", "researcher": {"href": "https://publications.scilifelab.se/researcher/995dac358caa4a169fc889b7a3eef44a.json"}}, {"family": "Kindblom", "given": "Jenny M", "initials": "JM", "orcid": "0000-0001-8437-0639", "researcher": {"href": "https://publications.scilifelab.se/researcher/5d338479632e48c0ba14bf948e4cc34f.json"}}], "type": "journal article", "published": "2025-06-25", "journal": {"title": "Eur J Prev Cardiol", "issn": "2047-4881", "issn-l": "2047-4873"}, "abstract": "The present study aimed to evaluate the association between BMI during childhood and puberty and blood pressure and hypertension in midlife, and to explore midlife BMI as a potential mediator of these associations.\n\nWe linked the BMI Epidemiology Study Gothenburg (BEST) with developmental BMI, with the Swedish CArdioPulmonary bioImage Study (SCAPIS) with blood pressure and hypertension in midlife (n= 2394). The associations between childhood BMI (7-8 years) and pubertal BMI change (young adult BMI minus childhood BMI), and blood pressure and hypertension in midlife, were evaluated using linear or logistic regression models. Mediation analysis was conducted to evaluate the indirect effect, via midlife BMI, and the direct effect on blood pressure and hypertension. The analyses were adjusted for birth year and smoking.\n\nThe pubertal BMI change was positively associated with systolic and diastolic blood pressure and hypertension in midlife, independent of childhood BMI, in both men and women (p<0.01). For men but not for women, childhood BMI was positively associated with systolic and diastolic blood pressure in midlife, independent of the pubertal BMI change (p<0.01). No significant independent association was observed for childhood BMI with hypertension. Mediation analyses for the association between the pubertal BMI change and blood pressure and hypertension in midlife indicate that these associations were largely mediated by BMI in midlife.\n\nThese findings indicate that high blood pressure may originate in early life. A life-course approach for targeted prevention, starting already during the developmental years, could reduce the risk of high blood pressure.", "doi": "10.1093/eurjpc/zwaf376", "pmid": "40561523", "labels": {"Clinical Genomics": "Collaborative", "Clinical Genomics Gothenburg": "Collaborative"}, "xrefs": [{"db": "pii", "key": "8173940"}], "notes": [], "created": "2025-07-08T13:55:21.859Z", "modified": "2025-11-04T11:36:37.987Z"}, {"entity": "publication", "iuid": "c4457596e25f4294b7de86e18511da65", "links": {"self": {"href": "https://publications.scilifelab.se/publication/c4457596e25f4294b7de86e18511da65.json"}, "display": {"href": "https://publications.scilifelab.se/publication/c4457596e25f4294b7de86e18511da65"}}, "title": "Overweight in childhood and young adulthood increases the risk for adult thromboembolic events.", "authors": [{"family": "Lilja", "given": "Lina", "initials": "L", "orcid": "0000-0003-2908-7456", "researcher": {"href": "https://publications.scilifelab.se/researcher/dbd8f5f9d6454648b700455cb1d64c91.json"}}, {"family": "Bygdell", "given": "Maria", "initials": "M"}, {"family": "Martikainen", "given": "Jari", "initials": "J"}, {"family": "Rosengren", "given": "Annika", "initials": "A", "orcid": "0000-0002-5409-6605", "researcher": {"href": "https://publications.scilifelab.se/researcher/59e4c8b35336454ab5f74df9c6b9531b.json"}}, {"family": "Kindblom", "given": "Jenny M", "initials": "JM"}, {"family": "Ohlsson", "given": "Claes", "initials": "C", "orcid": "0000-0002-9633-2805", "researcher": {"href": "https://publications.scilifelab.se/researcher/995dac358caa4a169fc889b7a3eef44a.json"}}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "J. Intern. Med.", "issn": "1365-2796", "issn-l": "0954-6820", "volume": "293", "issue": "5", "pages": "615-623"}, "abstract": "Approximately one third of thromboembolic (TE) events are related to obesity, but to which extent elevated body mass index (BMI) during the distinct periods of childhood and puberty contributes is not known. We aimed to evaluate the impact of high BMI during childhood and puberty for the risk of adult venous and arterial thromboembolic events (VTE, ATE, respectively) in men.\r\n\r\nWe included 37,672 men from the BMI Epidemiology Study (BEST) Gothenburg with data on weight and height in childhood, young adult age, and on pubertal BMI change. Information on outcomes (VTE [n = 1683], ATE [n = 144], or any first TE event [VTE or ATE; n = 1780]) was retrieved from Swedish national registers. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated by Cox regressions.\r\n\r\nBoth BMI at 8 years of age and the pubertal BMI change were associated with VTE, independently of each other (BMI at 8: HR 1.06 per standard deviation [SD] increase, 95% CI, 1.01;1.11; pubertal BMI change: HR 1.11 per SD increase, 95% CI, 1.06;1.16). Individuals with normal weight during childhood followed by young adult overweight (HR 1.40, 95% CI, 1.15;1.72), and individuals with overweight at both childhood and young adult age (HR 1.48, 95% CI, 1.14;1.92), had a significantly increased risk of VTE in adult life, compared with the normal weight reference group. Individuals with overweight in childhood and in young adult age had increased risk of ATE and TE.\r\n\r\nYoung adult overweight was a strong determinant, and childhood overweight a moderate determinant, of the risk of VTE in adult men.", "doi": "10.1111/joim.13617", "pmid": "36860115", "labels": {"Clinical Genomics Gothenburg": "Collaborative", "Clinical Genomics": "Collaborative"}, "xrefs": [], "notes": [], "created": "2023-06-16T15:03:24.996Z", "modified": "2023-11-30T22:36:52.306Z"}]}