{"entity": "researcher", "timestamp": "2026-08-17T01:48:21.211Z", "family": "van Zanten", "given": "Martijn", "initials": "M", "orcid": "0000-0002-2810-7374", "affiliations": ["Molecular Plant Physiology, Institute of Environmental Biology, Utrecht University, 3584 CH Utrecht, The Netherlands; m.vanzanten@uu.nl."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/d89e1170c6534bf884a3e61d2afa4de3.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/d89e1170c6534bf884a3e61d2afa4de3"}}, "publications": [{"entity": "publication", "iuid": "80c909d7dec54c0387f5bd88df21a144", "links": {"self": {"href": "https://publications.scilifelab.se/publication/80c909d7dec54c0387f5bd88df21a144.json"}, "display": {"href": "https://publications.scilifelab.se/publication/80c909d7dec54c0387f5bd88df21a144"}}, "title": "The chemical compound 'Heatin' stimulates hypocotyl elongation and interferes with the Arabidopsis NIT1-subfamily of nitrilases.", "authors": [{"family": "van der Woude", "given": "Lennard", "initials": "L"}, {"family": "Piotrowski", "given": "Markus", "initials": "M"}, {"family": "Klaasse", "given": "Gruson", "initials": "G"}, {"family": "Paulus", "given": "Judith K", "initials": "JK"}, {"family": "Krahn", "given": "Daniel", "initials": "D"}, {"family": "Ninck", "given": "Sabrina", "initials": "S"}, {"family": "Kaschani", "given": "Farnusch", "initials": "F"}, {"family": "Kaiser", "given": "Markus", "initials": "M"}, {"family": "Nov\u00e1k", "given": "Ond\u0159ej", "initials": "O"}, {"family": "Ljung", "given": "Karin", "initials": "K"}, {"family": "Bulder", "given": "Suzanne", "initials": "S"}, {"family": "van Verk", "given": "Marcel", "initials": "M"}, {"family": "Snoek", "given": "Basten L", "initials": "BL"}, {"family": "Fiers", "given": "Martijn", "initials": "M"}, {"family": "Martin", "given": "Nathaniel I", "initials": "NI"}, {"family": "van der Hoorn", "given": "Renier A L", "initials": "RAL"}, {"family": "Robert", "given": "St\u00e9phanie", "initials": "S"}, {"family": "Smeekens", "given": "Sjef", "initials": "S"}, {"family": "van Zanten", "given": "Martijn", "initials": "M", "orcid": "0000-0002-2810-7374", "researcher": {"href": "https://publications.scilifelab.se/researcher/d89e1170c6534bf884a3e61d2afa4de3.json"}}], "type": "journal article", "published": "2021-06-00", "journal": {"title": "Plant J.", "issn": "1365-313X", "issn-l": "0960-7412", "volume": "106", "issue": "6", "pages": "1523-1540"}, "abstract": "Temperature passively affects biological processes involved in plant growth. Therefore, it is challenging to study the dedicated temperature signalling pathways that orchestrate thermomorphogenesis, a suite of elongation growth-based adaptations that enhance leaf-cooling capacity. We screened a chemical library for compounds that restored hypocotyl elongation in the pif4-2-deficient mutant background at warm temperature conditions in Arabidopsis thaliana to identify modulators of thermomorphogenesis. The small aromatic compound 'Heatin', containing 1-iminomethyl-2-naphthol as a pharmacophore, was selected as an enhancer of elongation growth. We show that ARABIDOPSIS ALDEHYDE OXIDASES redundantly contribute to Heatin-mediated hypocotyl elongation. Following a chemical proteomics approach, the members of the NITRILASE1-subfamily of auxin biosynthesis enzymes were identified among the molecular targets of Heatin. Our data reveal that nitrilases are involved in promotion of hypocotyl elongation in response to high temperature and Heatin-mediated hypocotyl elongation requires the NITRILASE1-subfamily members, NIT1 and NIT2. Heatin inhibits NIT1-subfamily enzymatic activity in vitro and the application of Heatin accordingly results in the accumulation of NIT1-subfamily substrate indole-3-acetonitrile in vivo. However, levels of the NIT1-subfamily product, bioactive auxin (indole-3-acetic acid), were also significantly increased. It is likely that the stimulation of hypocotyl elongation by Heatin might be independent of its observed interaction with NITRILASE1-subfamily members. However, nitrilases may contribute to the Heatin response by stimulating indole-3-acetic acid biosynthesis in an indirect way. Heatin and its functional analogues present novel chemical entities for studying auxin biology.", "doi": "10.1111/tpj.15250", "pmid": "33768644", "labels": {"Swedish Metabolomics Centre": "Service", "Chemical Biology Consortium Sweden": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC8360157"}], "notes": [], "created": "2021-11-22T15:17:07.290Z", "modified": "2025-10-17T13:04:28.101Z"}, {"entity": "publication", "iuid": "f480233670f141638fceaf3eb9cc9899", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f480233670f141638fceaf3eb9cc9899.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f480233670f141638fceaf3eb9cc9899"}}, "title": "HISTONE DEACETYLASE 9 stimulates auxin-dependent thermomorphogenesis in Arabidopsis thaliana by mediating H2A.Z depletion.", "authors": [{"family": "van der Woude", "given": "Lennard C", "initials": "LC"}, {"family": "Perrella", "given": "Giorgio", "initials": "G"}, {"family": "Snoek", "given": "Basten L", "initials": "BL"}, {"family": "van Hoogdalem", "given": "Mark", "initials": "M"}, {"family": "Nov\u00e1k", "given": "Ond\u0159ej", "initials": "O"}, {"family": "van Verk", "given": "Marcel C", "initials": "MC"}, {"family": "van Kooten", "given": "Heleen N", "initials": "HN"}, {"family": "Zorn", "given": "Lennert E", "initials": "LE"}, {"family": "Tonckens", "given": "Rolf", "initials": "R"}, {"family": "Dongus", "given": "Joram A", "initials": "JA", "orcid": "0000-0002-8553-6802", "researcher": {"href": "https://publications.scilifelab.se/researcher/bbeee215a1b74a16b6763411de5695ef.json"}}, {"family": "Praat", "given": "Myrthe", "initials": "M"}, {"family": "Stouten", "given": "Evelien A", "initials": "EA"}, {"family": "Proveniers", "given": "Marcel C G", "initials": "MCG"}, {"family": "Vellutini", "given": "Elisa", "initials": "E"}, {"family": "Patitaki", "given": "Eirini", "initials": "E"}, {"family": "Shapulatov", "given": "Umidjon", "initials": "U"}, {"family": "Kohlen", "given": "Wouter", "initials": "W", "orcid": "0000-0001-9057-2392", "researcher": {"href": "https://publications.scilifelab.se/researcher/b5fe9d3b2df9467395a6eedc8cc7083b.json"}}, {"family": "Balasubramanian", "given": "Sureshkumar", "initials": "S", "orcid": "0000-0002-1057-2606", "researcher": {"href": "https://publications.scilifelab.se/researcher/0e28bd6f3ffd446aae39f89fc316e7ec.json"}}, {"family": "Ljung", "given": "Karin", "initials": "K", "orcid": "0000-0003-2901-189X", "researcher": {"href": "https://publications.scilifelab.se/researcher/f91b1e1f90c24559b915ebcd265804a4.json"}}, {"family": "van der Krol", "given": "Alexander R", "initials": "AR"}, {"family": "Smeekens", "given": "Sjef", "initials": "S", "orcid": "0000-0001-6631-9426", "researcher": {"href": "https://publications.scilifelab.se/researcher/a617c3b604424e049ec8084a30dc73de.json"}}, {"family": "Kaiserli", "given": "Eirini", "initials": "E", "orcid": "0000-0003-1517-4591", "researcher": {"href": "https://publications.scilifelab.se/researcher/8747fd0d93e441e98e9fb289920bc523.json"}}, {"family": "van Zanten", "given": "Martijn", "initials": "M", "orcid": "0000-0002-2810-7374", "researcher": {"href": "https://publications.scilifelab.se/researcher/d89e1170c6534bf884a3e61d2afa4de3.json"}}], "type": "journal article", "published": "2019-12-10", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "116", "issue": "50", "pages": "25343-25354", "issn-l": "0027-8424"}, "abstract": "Many plant species respond to unfavorable high ambient temperatures by adjusting their vegetative body plan to facilitate cooling. This process is known as thermomorphogenesis and is induced by the phytohormone auxin. Here, we demonstrate that the chromatin-modifying enzyme HISTONE DEACETYLASE 9 (HDA9) mediates thermomorphogenesis but does not interfere with hypocotyl elongation during shade avoidance. HDA9 is stabilized in response to high temperature and mediates histone deacetylation at the YUCCA8 locus, a rate-limiting enzyme in auxin biosynthesis, at warm temperatures. We show that HDA9 permits net eviction of the H2A.Z histone variant from nucleosomes associated with YUCCA8, allowing binding and transcriptional activation by PHYTOCHROME INTERACTING FACTOR 4, followed by auxin accumulation and thermomorphogenesis.", "doi": "10.1073/pnas.1911694116", "pmid": "31767749", "labels": {"Swedish Metabolomics Centre": "Service"}, "xrefs": [{"db": "pii", "key": "1911694116"}, {"db": "pmc", "key": "PMC6911240"}], "notes": [], "created": "2020-01-07T15:50:34.394Z", "modified": "2025-10-17T13:03:17.004Z"}]}