{"entity": "researcher", "timestamp": "2026-08-14T13:08:45.688Z", "family": "Ohlsson", "given": "Bodil", "initials": "B", "orcid": "0000-0002-9142-5244", "affiliations": [], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/d61d0a97d7df49e5856419fc06769c23.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/d61d0a97d7df49e5856419fc06769c23"}}, "publications": [{"entity": "publication", "iuid": "11b1c52028724a8ab4327a6302a5187b", "links": {"self": {"href": "https://publications.scilifelab.se/publication/11b1c52028724a8ab4327a6302a5187b.json"}, "display": {"href": "https://publications.scilifelab.se/publication/11b1c52028724a8ab4327a6302a5187b"}}, "title": "The Metabolomic Profile of Microscopic Colitis Is Affected by Smoking but Not Histopathological Diagnosis, Clinical Course, Symptoms, or Treatment.", "authors": [{"family": "Str\u00f6m", "given": "Axel", "initials": "A"}, {"family": "Stenlund", "given": "Hans", "initials": "H", "orcid": "0000-0001-9943-296X", "researcher": {"href": "https://publications.scilifelab.se/researcher/5259d6369f564651ace11d8bff689535.json"}}, {"family": "Ohlsson", "given": "Bodil", "initials": "B", "orcid": "0000-0002-9142-5244", "researcher": {"href": "https://publications.scilifelab.se/researcher/d61d0a97d7df49e5856419fc06769c23.json"}}], "type": "journal article", "published": "2024-05-27", "journal": {"title": "Metabolites", "issn": "2218-1989", "volume": "14", "issue": "6", "issn-l": null}, "abstract": "Microscopic colitis (MC) is classified as collagenous colitis (CC) and lymphocytic colitis (LC). Genetic associations between CC and human leucocyte antigens (HLAs) have been found, with smoking being a predisposing external factor. Smoking has a great impact on metabolomics. The aim of this explorative study was to analyze global metabolomics in MC and to examine whether the metabolomic profile differed regarding the type and course of MC, the presence of IBS-like symptoms, treatment, and smoking habits. Of the 240 identified women with MC aged \u226473 years, 131 completed the study questionnaire; the Rome III questionnaire; and the Visual Analog Scale for Irritable Bowel Syndrome (VAS-IBS). Blood samples were analyzed by ultra-high-performance liquid chromatograph mass spectrometry (UHLC-MS/UHPLC-MSMS). The women, 63.1 (58.7-67.2) years old, were categorized based on CC (n = 76) and LC (n = 55); one episode or refractory MC; IBS-like symptoms or not; use of corticosteroids or not; and smoking habits. The only metabolomic differences found in the univariate model after adjustment for false discovery rate (FDR) were between smokers and non-smokers. Serotonin was markedly increased in smokers (p < 0.001). No clear patterns appeared when conducting a principal component analysis (PCA). No differences in the metabolomic profile were found depending on the type or clinical course of the disease, neither in the whole MC group nor in the subgroup analysis of CC.", "doi": "10.3390/metabo14060303", "pmid": "38921438", "labels": {"Swedish Metabolomics Centre": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC11205623"}, {"db": "pii", "key": "metabo14060303"}], "notes": [], "created": "2024-11-26T10:26:44.671Z", "modified": "2025-10-17T13:03:13.199Z"}, {"entity": "publication", "iuid": "94f890155ce140bcbb88b88e967915d8", "links": {"self": {"href": "https://publications.scilifelab.se/publication/94f890155ce140bcbb88b88e967915d8.json"}, "display": {"href": "https://publications.scilifelab.se/publication/94f890155ce140bcbb88b88e967915d8"}}, "title": "An Okinawan-Based Nordic Diet Leads to Profound Effects on Gut Microbiota and Plasma Metabolites Linked to Glucose and Lipid Metabolism.", "authors": [{"family": "Manoharan", "given": "Lokeshwaran", "initials": "L", "orcid": "0000-0001-9751-5745", "researcher": {"href": "https://publications.scilifelab.se/researcher/000321fd81b9457db66140246bbd9066.json"}}, {"family": "Roth", "given": "Bodil", "initials": "B"}, {"family": "Bang", "given": "Corinna", "initials": "C"}, {"family": "Stenlund", "given": "Hans", "initials": "H", "orcid": "0000-0001-9943-296X", "researcher": {"href": "https://publications.scilifelab.se/researcher/5259d6369f564651ace11d8bff689535.json"}}, {"family": "Ohlsson", "given": "Bodil", "initials": "B", "orcid": "0000-0002-9142-5244", "researcher": {"href": "https://publications.scilifelab.se/researcher/d61d0a97d7df49e5856419fc06769c23.json"}}], "type": "journal article", "published": "2023-07-24", "journal": {"title": "Nutrients", "issn": "2072-6643", "issn-l": "2072-6643", "volume": "15", "issue": "14", "pages": null}, "abstract": "Dietary interventions modify gut microbiota and clinical outcomes. Weight reduction and improved glucose and lipid homeostasis were observed after adopting an Okinawan-based Nordic diet (O-BN) in individuals with type 2 diabetes. The aim of the present study was to explore changes in metabolomics and gut microbiota during O-BN and correlate changes with clinical outcomes. A total of 30 patients (17 women), aged 57.5 \u00b1 8.2 years, diabetes duration 10.4 \u00b1 7.6 years, 90% over-weight, were included. Participants were provided an O-BN for 12 weeks. Before and after intervention, and 16 weeks afterwards, anthropometry and clinical data were estimated and questionnaires were collected, as well as samples of blood and stool. Plasma metabolomics were determined by gas- (GC-MS) or liquid- (LC-MS) chromatography-based mass spectrometry and fecal microbiota determination was based on 16S rRNA amplicons from regions V1-V2. During the intervention, weight (6.8%), waist circumference (6.1%), and levels of glucose, HbA1c, insulin, triglycerides, and cholesterol were decreased. Of 602 metabolites, 323 were changed for any or both periods; 199 (101 lipids) metabolites were decreased while 58 (43 lipids) metabolites were increased during the intervention. Changes in glucose homeostasis were linked to changes in, e.g., 1,5-anhydroglucitol, thyroxine, and chiro-inositol. Changes of microbe beta diversity correlated positively with food components and negatively with IL-18 (p = 0.045). Abundance differences at phylum and genus levels were found. Abundances of Actinobacteria, Bacteroidetes, Firmicutes, and Verrucomicrobia correlated with anthropometry, HbA1c, lipids, inflammation, and food. Changes in metabolites and microbiota were reversed after the intervention. The O-BN-induced changes in metabolomics and gut microbiota correspond to clinical outcomes of reduced weight and inflammation and improved glucose and lipid metabolism.", "doi": "10.3390/nu15143273", "pmid": "37513690", "labels": {"Bioinformatics Support and Infrastructure": "Collaborative", "Bioinformatics Support, Infrastructure and Training": "Collaborative", "Bioinformatics Support for Computational Resources": "Service", "Bioinformatics (NBIS)": "Collaborative", "Swedish Metabolomics Centre": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC10384944"}, {"db": "pii", "key": "nu15143273"}], "notes": [], "created": "2023-08-16T13:15:19.078Z", "modified": "2025-10-17T13:03:13.641Z"}, {"entity": "publication", "iuid": "651395720d3344fa8938a31e17c0c548", "links": {"self": {"href": "https://publications.scilifelab.se/publication/651395720d3344fa8938a31e17c0c548.json"}, "display": {"href": "https://publications.scilifelab.se/publication/651395720d3344fa8938a31e17c0c548"}}, "title": "A starch- and sucrose-reduced dietary intervention in irritable bowel syndrome patients produced a shift in gut microbiota composition along with changes in phylum, genus, and amplicon sequence variant abundances, without affecting the micro-RNA levels.", "authors": [{"family": "Nilholm", "given": "Clara", "initials": "C"}, {"family": "Manoharan", "given": "Lokeshwaran", "initials": "L"}, {"family": "Roth", "given": "Bodil", "initials": "B"}, {"family": "D'Amato", "given": "Mauro", "initials": "M"}, {"family": "Ohlsson", "given": "Bodil", "initials": "B", "orcid": "0000-0002-9142-5244", "researcher": {"href": "https://publications.scilifelab.se/researcher/d61d0a97d7df49e5856419fc06769c23.json"}}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "United European Gastroenterol J", "issn": "2050-6414", "volume": "10", "issue": "4", "pages": "363-375", "issn-l": null}, "abstract": "A randomized clinical trial with a starch- and sucrose-reduced diet (SSRD) in irritable bowel syndrome (IBS) patients has shown clear improvement of participants' symptoms. The present study aimed to explore the effects of the SSRD on the gut microbiota and circulating micro-RNA in relation to nutrient intake and gastrointestinal symptoms.\n\nIBS patients were randomized to a 4-week SSRD intervention (n = 80) or control group (n = 25); habitual diet). At baseline and 4 weeks, blood and fecal samples, 4 day-dietary records, and symptom questionnaires were collected, that is, Rome IV questionnaires, IBS-symptom severity score (IBS-SSS) and visual analog scale for IBS (VAS-IBS). Micro-RNA was analyzed in blood and microbiota in faeces by 16S rRNA from regions V1-V2.\n\nThe alpha diversity was unaffected, whereas beta diversity was decreased (p < 0.001) along with increased abundance of Proteobacteria (p = 0.0036) and decreased abundance of Bacteroidetes phyla (p < 0.001) in the intervention group at 4 weeks. Few changes were noted in the controls. The shift in beta diversity and phyla abundance correlated with decreased intakes of carbohydrates, disaccharides, and starch and increased fat and protein intakes. Proteobacteria abundance also correlated positively (R2 = 0.07, p = 0.0016), and Bacteroidetes negatively (R2 = 0.07, p = 0.0017), with reduced total IBS-SSS. Specific genera, for example, Eubacterium eligens, Lachnospiraceae UCG-001, Victivallis, and Lachnospira increased significantly in the intervention group (p < 0.001 for all), whereas Marvinbryantia, DTU089 (Ruminoccocaceae family), Enterorhabdus, and Olsenella decreased, together with changes in amplicon sequence variant (ASV) levels. Modest changes of genus and ASV abundance were observed in the control group. No changes were observed in micro-RNA expression in either group.\n\nThe SSRD induced a shift in beta diversity along with several bacteria at different levels, associated with changes in nutrient intakes and reduced gastrointestinal symptoms. No corresponding changes were observed in the control group. Neither the nutrient intake nor the microbiota changes affected micro-RNA expression. The study was registered at ClinicalTrials.gov data base (NCT03306381).", "doi": "10.1002/ueg2.12227", "pmid": "35484927", "labels": {"Bioinformatics Support, Infrastructure and Training": "Collaborative", "Bioinformatics Support and Infrastructure": "Collaborative", "Bioinformatics Support for Computational Resources": "Service", "Bioinformatics (NBIS)": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC9103372"}, {"db": "ClinicalTrials.gov", "key": "NCT03306381"}], "notes": [], "created": "2022-05-09T09:39:01.304Z", "modified": "2024-01-16T13:48:36.858Z"}, {"entity": "publication", "iuid": "2b6b696e268f4304a2c4a384d2d48739", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2b6b696e268f4304a2c4a384d2d48739.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2b6b696e268f4304a2c4a384d2d48739"}}, "title": "Metabolic Profiling of Plasma in Patients with Irritable Bowel Syndrome after a 4-Week Starch- and Sucrose-Reduced Diet.", "authors": [{"family": "Stenlund", "given": "Hans", "initials": "H", "orcid": "0000-0001-9943-296X", "researcher": {"href": "https://publications.scilifelab.se/researcher/5259d6369f564651ace11d8bff689535.json"}}, {"family": "Nilholm", "given": "Clara", "initials": "C", "orcid": "0000-0002-5647-2643", "researcher": {"href": "https://publications.scilifelab.se/researcher/8c696d2e6335440fbda3d3f3eedb8ace.json"}}, {"family": "Chorell", "given": "Elin", "initials": "E"}, {"family": "Roth", "given": "Bodil", "initials": "B"}, {"family": "D'Amato", "given": "Mauro", "initials": "M"}, {"family": "Ohlsson", "given": "Bodil", "initials": "B", "orcid": "0000-0002-9142-5244", "researcher": {"href": "https://publications.scilifelab.se/researcher/d61d0a97d7df49e5856419fc06769c23.json"}}], "type": "journal article", "published": "2021-07-04", "journal": {"title": "Metabolites", "issn": "2218-1989", "volume": "11", "issue": "7", "issn-l": null}, "abstract": "A 4-week dietary intervention with a starch- and sucrose-restricted diet (SSRD) was conducted in patients with irritable bowel syndrome (IBS) to examine the metabolic profile in relation to nutrient intake and gastrointestinal symptoms. IBS patients were randomized to SSRD intervention (n = 69) or control continuing with their ordinary food habits (n = 22). Food intake was registered and the questionnaires IBS-symptoms severity scale (IBS-SSS) and visual analog scale for IBS (VAS-IBS) were completed. Metabolomics untargeted analysis was performed by gas chromatography mass spectrometry (GC-MS) and liquid chromatography mass spectrometry (LC-MS) in positive and negative ionization modes. SSRD led to marked changes in circulating metabolite concentrations at the group level, most prominent for reduced starch intake and increased polyunsaturated fat, with small changes in the control group. On an individual level, the correlations were weak. The marked reduction in gastrointestinal symptoms did not correlate with the metabolic changes. SSRD was observed by clear metabolic effects mainly related to linoleic acid metabolism, fatty acid biosynthesis, and beta-oxidation.", "doi": "10.3390/metabo11070440", "pmid": "34357334", "labels": {"Swedish Metabolomics Centre": "Collaborative"}, "xrefs": [{"db": "pii", "key": "metabo11070440"}, {"db": "pmc", "key": "PMC8306703"}], "notes": [], "created": "2021-12-09T20:06:53.596Z", "modified": "2025-10-17T13:03:15.908Z"}, {"entity": "publication", "iuid": "6e1ba26375134b1492a6f8415718252f", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6e1ba26375134b1492a6f8415718252f.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6e1ba26375134b1492a6f8415718252f"}}, "title": "AXIN1 in Plasma or Serum Is a Potential New Biomarker for Endometriosis.", "authors": [{"family": "Ek", "given": "Malin", "initials": "M"}, {"family": "Roth", "given": "Bodil", "initials": "B"}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G"}, {"family": "Ohlsson", "given": "Bodil", "initials": "B", "orcid": "0000-0002-9142-5244", "researcher": {"href": "https://publications.scilifelab.se/researcher/d61d0a97d7df49e5856419fc06769c23.json"}}], "type": "journal article", "published": "2019-01-07", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "issn-l": null, "volume": "20", "issue": "1", "pages": "189"}, "abstract": "Although endometriosis is considered an inflammatory disease, no reliable diagnostic biomarkers exist for use in clinical practice. The aim was to investigate the inflammatory profile in endometriosis using an exploratory approach of inflammation-related proteins. Patients with laparoscopy-verified endometriosis (N = 172), women with microscopic colitis (N = 50), healthy controls (N = 31), and age-matched controls from the general population (N = 100) were enrolled and questionnaires regarding socioeconomic factors, lifestyle habits, and medical history were completed. Sera from patients and healthy controls were analyzed for 92 inflammatory biomarkers using Proximity Extension Assay technology (PEA). Plasma AXIN1 levels were analyzed in patients with endometriosis and controls from the general population by ELISA. General linear model adjusted for age, Mann\u207bWhitney U-test, and principal component analysis (PCA) were used for statistical calculations. Serum levels of AXIN1 and ST1A1 were increased in endometriosis compared with MC (p < 0.001) and healthy controls (p = 0.001), whereas CXCL9 levels were decreased. Plasma levels of AXIN1 were elevated in endometriosis compared with age-matched controls from the general population (30.0 (17.0\u207b38.0) pg/mL vs. 19.5 (15.0\u207b28.0) pg/mL, p < 0.001). PCA analysis identified four clusters of proteins, where one cluster differed between endometriosis and controls, with strong correlations for AXIN1 and ST1A1. Plasma/serum AXIN1 is an interesting biomarker to be further evaluated in endometriosis.", "doi": "10.3390/ijms20010189", "pmid": "30621017", "labels": {"Clinical Biomarkers": "Service", "PLA and Single Cell Proteomics": "Service", "Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pii", "key": "ijms20010189"}, {"db": "pmc", "key": "PMC6337238"}], "notes": [], "created": "2020-01-23T16:05:01.112Z", "modified": "2023-04-14T13:55:59.915Z"}]}