{"entity": "researcher", "timestamp": "2026-07-22T16:27:00.785Z", "family": "de Miranda", "given": "Joachim R", "initials": "JR", "orcid": "0000-0002-0335-0386", "affiliations": [], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/d0bd25adff9b48e694c30279d0db901b.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/d0bd25adff9b48e694c30279d0db901b"}}, "publications": [{"entity": "publication", "iuid": "8429a7b57d90423694dc843eeb6ad606", "links": {"self": {"href": "https://publications.scilifelab.se/publication/8429a7b57d90423694dc843eeb6ad606.json"}, "display": {"href": "https://publications.scilifelab.se/publication/8429a7b57d90423694dc843eeb6ad606"}}, "title": "Cold case: The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970's Egypt.", "authors": [{"family": "de Miranda", "given": "Joachim R", "initials": "JR", "orcid": "0000-0002-0335-0386", "researcher": {"href": "https://publications.scilifelab.se/researcher/d0bd25adff9b48e694c30279d0db901b.json"}}, {"family": "Brettell", "given": "Laura E", "initials": "LE"}, {"family": "Chejanovsky", "given": "Nor", "initials": "N"}, {"family": "Childers", "given": "Anna K", "initials": "AK"}, {"family": "Dalmon", "given": "Anne", "initials": "A"}, {"family": "Deboutte", "given": "Ward", "initials": "W"}, {"family": "de Graaf", "given": "Dirk C", "initials": "DC"}, {"family": "Doublet", "given": "Vincent", "initials": "V"}, {"family": "Gebremedhn", "given": "Haftom", "initials": "H"}, {"family": "Genersch", "given": "Elke", "initials": "E"}, {"family": "Gisder", "given": "Sebastian", "initials": "S"}, {"family": "Granberg", "given": "Fredrik", "initials": "F"}, {"family": "Haddad", "given": "Nizar J", "initials": "NJ"}, {"family": "Kaden", "given": "Rene", "initials": "R"}, {"family": "Manley", "given": "Robyn", "initials": "R"}, {"family": "Matthijnssens", "given": "Jelle", "initials": "J"}, {"family": "Meeus", "given": "Ivan", "initials": "I"}, {"family": "Migdadi", "given": "Hussein", "initials": "H"}, {"family": "Milbrath", "given": "Meghan O", "initials": "MO"}, {"family": "Mondet", "given": "Fanny", "initials": "F"}, {"family": "Remnant", "given": "Emily J", "initials": "EJ"}, {"family": "Roberts", "given": "John M K", "initials": "JMK"}, {"family": "Ryabov", "given": "Eugene V", "initials": "EV"}, {"family": "Sela", "given": "Noa", "initials": "N"}, {"family": "Smagghe", "given": "Guy", "initials": "G"}, {"family": "Somanathan", "given": "Hema", "initials": "H"}, {"family": "Wilfert", "given": "Lena", "initials": "L"}, {"family": "Wright", "given": "Owen N", "initials": "ON"}, {"family": "Martin", "given": "Stephen J", "initials": "SJ"}, {"family": "Ball", "given": "Brenda V", "initials": "BV"}], "type": "journal article", "published": "2022-01-15", "journal": {"title": "Virol J", "issn": "1743-422X", "issn-l": "1743-422X", "volume": "19", "issue": "1", "pages": "12"}, "abstract": "In 1977, a sample of diseased adult honeybees (Apis mellifera) from Egypt was found to contain large amounts of a previously unknown virus, Egypt bee virus, which was subsequently shown to be serologically related to deformed wing virus (DWV). By sequencing the original isolate, we demonstrate that Egypt bee virus is in fact a fourth unique, major variant of DWV (DWV-D): more closely related to DWV-C than to either DWV-A or DWV-B. DWV-A and DWV-B are the most common DWV variants worldwide due to their close relationship and transmission by Varroa destructor. However, we could not find any trace of DWV-D in several hundred RNA sequencing libraries from a worldwide selection of honeybee, varroa and bumblebee samples. This means that DWV-D has either become extinct, been replaced by other DWV variants better adapted to varroa-mediated transmission, or persists only in a narrow geographic or host range, isolated from common bee and beekeeping trade routes.", "doi": "10.1186/s12985-022-01740-2", "pmid": "35033134", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (Uppsala Genome Center)": "Service", "NGI Long read": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "10.1186/s12985-022-01740-2"}, {"db": "pmc", "key": "PMC8760790"}], "notes": [], "created": "2022-01-26T17:11:25.823Z", "modified": "2024-01-16T13:48:37.713Z"}, {"entity": "publication", "iuid": "f5c4593d66bd47b7b8c4b6ec46b98e11", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f5c4593d66bd47b7b8c4b6ec46b98e11.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f5c4593d66bd47b7b8c4b6ec46b98e11"}}, "title": "The honeybee (Apis mellifera) developmental state shapes the genetic composition of the deformed wing virus-A quasispecies during serial transmission.", "authors": [{"family": "Ya\u00f1ez", "given": "Orlando", "initials": "O", "orcid": "0000-0001-8493-2726", "researcher": {"href": "https://publications.scilifelab.se/researcher/e202e4f4253b4e6f91d6f3bfcf8247cb.json"}}, {"family": "Ch\u00e1vez-Galarza", "given": "Julio", "initials": "J"}, {"family": "Tellgren-Roth", "given": "Christian", "initials": "C", "orcid": "0000-0003-0502-3693", "researcher": {"href": "https://publications.scilifelab.se/researcher/982873aade554b38b26b877298db5115.json"}}, {"family": "Pinto", "given": "M Alice", "initials": "MA", "orcid": "0000-0001-9663-8399", "researcher": {"href": "https://publications.scilifelab.se/researcher/62c4785cb6714a09be0ec688ed4fce92.json"}}, {"family": "Neumann", "given": "Peter", "initials": "P"}, {"family": "de Miranda", "given": "Joachim R", "initials": "JR", "orcid": "0000-0002-0335-0386", "researcher": {"href": "https://publications.scilifelab.se/researcher/d0bd25adff9b48e694c30279d0db901b.json"}}], "type": "journal article", "published": "2020-04-06", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "10", "issue": "1", "pages": "5956", "issn-l": "2045-2322"}, "abstract": "The main biological threat to the western honeybee (Apis mellifera) is the parasitic mite Varroa destructor, largely because it vectors lethal epidemics of honeybee viruses that, in the absence of this mite, are relatively innocuous. The severe pathology is a direct consequence of excessive virus titres caused by this novel transmission route. However, little is known about how the virus adapts genetically during transmission and whether this influences the pathology. Here, we show that upon injection into honeybee pupae, the deformed wing virus type-A (DWV-A) quasispecies undergoes a rapid, extensive expansion of its sequence space, followed by strong negative selection towards a uniform, common shape by the time the pupae have completed their development, with no difference between symptomatic and asymptomatic adults in either DWV titre or genetic composition. This suggests that the physiological and molecular environment during pupal development has a strong, conservative influence on shaping the DWV-A quasispecies in emerging adults. There was furthermore no evidence of any progressive adaptation of the DWV-A quasispecies to serial intra-abdominal injection, simulating mite transmission, despite the generation of ample variation immediately following each transmission, suggesting that the virus either had already adapted to transmission by injection, or was unaffected by it.", "doi": "10.1038/s41598-020-62673-w", "pmid": "32249797", "labels": {"NGI Uppsala (Uppsala Genome Center)": "Collaborative", "National Genomics Infrastructure": "Collaborative", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s41598-020-62673-w"}, {"db": "pmc", "key": "PMC7136270"}], "notes": [], "created": "2020-09-15T07:19:57.145Z", "modified": "2024-01-16T13:48:42.634Z"}]}