{"entity": "researcher", "timestamp": "2026-06-08T04:55:17.367Z", "family": "Albrectsen", "given": "Benedicte R", "initials": "BR", "orcid": "0000-0002-9337-4540", "affiliations": ["Department of Plant Physiology, Ume\u00e5 University (Ume\u00e5 Plant Science Centre), 90187, Ume\u00e5, Sweden. benedicte.albrectsen@umu.se."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/cf822eff202b4547849f8a8a9d4efc02.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/cf822eff202b4547849f8a8a9d4efc02"}}, "publications": [{"entity": "publication", "iuid": "f95bdf8e170c4590b325788476b5774a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f95bdf8e170c4590b325788476b5774a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f95bdf8e170c4590b325788476b5774a"}}, "title": "PECTIN ACETYLESTERASE9 Affects the Transcriptome and Metabolome and Delays Aphid Feeding.", "authors": [{"family": "Kloth", "given": "Karen J", "initials": "KJ", "orcid": "0000-0002-0379-5473", "researcher": {"href": "https://publications.scilifelab.se/researcher/54e0bb41dc5b44f38cf4a88dcc7ff14b.json"}}, {"family": "Abreu", "given": "Ilka N", "initials": "IN", "orcid": "0000-0003-4728-0161", "researcher": {"href": "https://publications.scilifelab.se/researcher/1cb725d57dfe40588d386dafe2c58479.json"}}, {"family": "Delhomme", "given": "Nicolas", "initials": "N", "orcid": "0000-0002-3053-0796", "researcher": {"href": "https://publications.scilifelab.se/researcher/107fbbd40f1444fb838ad4c0365738fa.json"}}, {"family": "Pet\u0159\u00edk", "given": "Ivan", "initials": "I"}, {"family": "Villard", "given": "Clo\u00e9", "initials": "C"}, {"family": "Str\u00f6m", "given": "Cecilia", "initials": "C"}, {"family": "Amini", "given": "Fariba", "initials": "F"}, {"family": "Nov\u00e1k", "given": "Ond\u0159ej", "initials": "O"}, {"family": "Moritz", "given": "Thomas", "initials": "T", "orcid": "0000-0002-4258-3190", "researcher": {"href": "https://publications.scilifelab.se/researcher/95ad5b7fe48f42eda1328f54a385e097.json"}}, {"family": "Albrectsen", "given": "Benedicte R", "initials": "BR", "orcid": "0000-0002-9337-4540", "researcher": {"href": "https://publications.scilifelab.se/researcher/cf822eff202b4547849f8a8a9d4efc02.json"}}], "type": "journal article", "published": "2019-12-00", "journal": {"volume": "181", "issn": "1532-2548", "issue": "4", "pages": "1704-1720", "title": "Plant Physiol.", "issn-l": "0032-0889"}, "abstract": "The plant cell wall plays an important role in damage-associated molecular pattern-induced resistance to pathogens and herbivorous insects. Our current understanding of cell wall-mediated resistance is largely based on the degree of pectin methylesterification. However, little is known about the role of pectin acetylesterification in plant immunity. This study describes how one pectin-modifying enzyme, PECTIN ACETYLESTERASE 9 (PAE9), affects the Arabidopsis (Arabidopsis thaliana) transcriptome, secondary metabolome, and aphid performance. Electro-penetration graphs showed that Myzus persicae aphids established phloem feeding earlier on pae9 mutants. Whole-genome transcriptome analysis revealed a set of 56 differentially expressed genes (DEGs) between uninfested pae9-2 mutants and wild-type plants. The majority of the DEGs were enriched for biotic stress responses and down-regulated in the pae9-2 mutant, including PAD3 and IGMT2, involved in camalexin and indole glucosinolate biosynthesis, respectively. Relative quantification of more than 100 secondary metabolites revealed decreased levels of several compounds, including camalexin and oxylipins, in two independent pae9 mutants. In addition, absolute quantification of phytohormones showed that jasmonic acid (JA), jasmonoyl-Ile, salicylic acid, abscisic acid, and indole-3-acetic acid were compromised due to PAE9 loss of function. After aphid infestation, however, pae9 mutants increased their levels of camalexin, glucosinolates, and JA, and no long-term effects were observed on aphid fitness. Overall, these data show that PAE9 is required for constitutive up-regulation of defense-related compounds, but that it is not required for aphid-induced defenses. The signatures of phenolic antioxidants, phytoprostanes, and oxidative stress-related transcripts indicate that the processes underlying PAE9 activity involve oxidation-reduction reactions.", "doi": "10.1104/pp.19.00635", "pmid": "31551361", "labels": {"National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Applications)": "Service", "NGI Stockholm (Genomics Production)": "Service", "Bioinformatics Support for Computational Resources": "Service", "Swedish Metabolomics Centre": "Service"}, "xrefs": [{"db": "pii", "key": "pp.19.00635"}, {"db": "pmc", "key": "PMC6878011"}], "notes": [], "created": "2020-01-07T15:46:12.838Z", "modified": "2025-10-17T13:03:17.046Z"}, {"entity": "publication", "iuid": "c03e5bb7fa3a4716ba7efa89ba684c00", "links": {"self": {"href": "https://publications.scilifelab.se/publication/c03e5bb7fa3a4716ba7efa89ba684c00.json"}, "display": {"href": "https://publications.scilifelab.se/publication/c03e5bb7fa3a4716ba7efa89ba684c00"}}, "title": "Leaf metabolic signatures induced by real and simulated herbivory in black mustard (Brassica nigra).", "authors": [{"family": "Papazian", "given": "Stefano", "initials": "S", "orcid": "0000-0003-2538-8702", "researcher": {"href": "https://publications.scilifelab.se/researcher/5de990c59ec4460e92c414dbc0ed0b16.json"}}, {"family": "Girdwood", "given": "Tristan", "initials": "T"}, {"family": "Wessels", "given": "Bernard A", "initials": "BA", "orcid": "0000-0003-0717-1630", "researcher": {"href": "https://publications.scilifelab.se/researcher/6c8a7ef9a3e64345b2be703fb991cf41.json"}}, {"family": "Poelman", "given": "Erik H", "initials": "EH", "orcid": "0000-0003-3285-613X", "researcher": {"href": "https://publications.scilifelab.se/researcher/0bc115c757fb423aa0e0a0d5c720577e.json"}}, {"family": "Dicke", "given": "Marcel", "initials": "M", "orcid": "0000-0001-8565-8896", "researcher": {"href": "https://publications.scilifelab.se/researcher/824294e73c4d43948aa11139277ad550.json"}}, {"family": "Moritz", "given": "Thomas", "initials": "T", "orcid": "0000-0002-4258-3190", "researcher": {"href": "https://publications.scilifelab.se/researcher/95ad5b7fe48f42eda1328f54a385e097.json"}}, {"family": "Albrectsen", "given": "Benedicte R", "initials": "BR", "orcid": "0000-0002-9337-4540", "researcher": {"href": "https://publications.scilifelab.se/researcher/cf822eff202b4547849f8a8a9d4efc02.json"}}], "type": "journal article", "published": "2019-09-28", "journal": {"volume": "15", "issn": "1573-3890", "issue": "10", "pages": "130", "title": "Metabolomics", "issn-l": "1573-3882"}, "abstract": "The oxylipin methyl jasmonate (MeJA) is a plant hormone active in response signalling and defence against herbivores. Although MeJA is applied experimentally to mimic herbivory and induce plant defences, its downstream effects on the plant metabolome are largely uncharacterized, especially in the context of primary growth and tissue-specificity of the response.\n\nWe investigated the effects of MeJA-simulated and real caterpillar herbivory on the foliar metabolome of the wild plant Brassica nigra and monitored the herbivore-induced responses in relation to leaf ontogeny.\n\nAs single or multiple herbivory treatments, MeJA- and mock-sprayed plants were consecutively exposed to caterpillars or left untreated. Gas chromatography (GC) and liquid chromatography (LC) time-of-flight mass-spectrometry (TOF-MS) were combined to analyse foliar compounds, including central primary and specialized defensive plant metabolites.\n\nPlant responses were stronger in young leaves, which simultaneously induced higher chlorophyll levels. Both MeJA and caterpillar herbivory induced similar, but not identical, accumulation of tricarboxylic acids (TCAs), glucosinolates (GSLs) and phenylpropanoids (PPs), but only caterpillar feeding led to depletion of amino acids. MeJA followed by caterpillars caused higher induction of defence compounds, including a three-fold increase in the major defence compound allyl-GSL (sinigrin). When feeding on MeJA-treated plants, caterpillars gained less weight indicative of the reduced host-plant quality and enhanced resistance.\n\nThe metabolomics approach showed that plant responses induced by herbivory extend beyond the regulation of defence metabolism and are tightly modulated throughout leaf development. This leads to a new understanding of the plant metabolic potential that can be exploited for future plant protection strategies.", "doi": "10.1007/s11306-019-1592-4", "pmid": "31563978", "labels": {"Bioinformatics Support for Computational Resources": "Service", "Swedish Metabolomics Centre": "Service"}, "xrefs": [{"db": "pii", "key": "10.1007/s11306-019-1592-4"}, {"db": "pmc", "key": "PMC6765471"}], "notes": [], "created": "2020-01-07T15:47:26.746Z", "modified": "2025-10-17T13:03:17.353Z"}]}