{"entity": "researcher", "timestamp": "2026-11-09T05:08:11.718Z", "family": "Edholm", "given": "Adam", "initials": "A", "orcid": "0009-0000-5363-8313", "affiliations": ["Department of Medical Sciences, Uppsala University , Uppsala, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/cabd97c68bc44b61ac34896b1b3562f3.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/cabd97c68bc44b61ac34896b1b3562f3"}}, "publications": [{"entity": "publication", "iuid": "c0dc106bf5f34eb8bef8ff0bf5354ae6", "links": {"self": {"href": "https://publications.scilifelab.se/publication/c0dc106bf5f34eb8bef8ff0bf5354ae6.json"}, "display": {"href": "https://publications.scilifelab.se/publication/c0dc106bf5f34eb8bef8ff0bf5354ae6"}}, "title": "18F-CETO in adrenocortical carcinoma: first clinical-translational study of an adrenocortical-targeting PET tracer.", "authors": [{"family": "Edholm", "given": "Adam", "initials": "A", "orcid": "0009-0000-5363-8313", "researcher": {"href": "https://publications.scilifelab.se/researcher/cabd97c68bc44b61ac34896b1b3562f3.json"}}, {"family": "Zhang", "given": "Liang", "initials": "L", "orcid": "0000-0001-8448-6754", "researcher": {"href": "https://publications.scilifelab.se/researcher/3870b8b522f345dba7c6d908e1511299.json"}}, {"family": "MacFarlane", "given": "James", "initials": "J"}, {"family": "\u00c5kerstr\u00f6m", "given": "Tobias", "initials": "T"}, {"family": "Senanayake", "given": "Russell", "initials": "R"}, {"family": "Welin", "given": "Staffan", "initials": "S"}, {"family": "Hegedus", "given": "Agnes", "initials": "A"}, {"family": "Cheow", "given": "Heok K", "initials": "HK"}, {"family": "Lase", "given": "Ieva", "initials": "I"}, {"family": "St\u00e5lberg", "given": "Peter", "initials": "P"}, {"family": "Monazzam", "given": "Azita", "initials": "A", "orcid": "0000-0002-5332-5816", "researcher": {"href": "https://publications.scilifelab.se/researcher/8368f5967e7b49d996abe1f58efbf56d.json"}}, {"family": "Gillett", "given": "Daniel", "initials": "D"}, {"family": "Aloj", "given": "Luigi", "initials": "L"}, {"family": "Hellman", "given": "Per", "initials": "P"}, {"family": "Wargelius", "given": "Hanna", "initials": "H"}, {"family": "Tadross", "given": "John A", "initials": "JA"}, {"family": "Antoni", "given": "Gunnar", "initials": "G"}, {"family": "Aigbirhio", "given": "Franklin", "initials": "F"}, {"family": "Skogseid", "given": "Britt", "initials": "B"}, {"family": "Gurnell", "given": "Mark", "initials": "M"}, {"family": "Backman", "given": "Samuel", "initials": "S", "orcid": "0009-0002-5704-8817", "researcher": {"href": "https://publications.scilifelab.se/researcher/88cf7b79be704fe4b4f71ba8db3005a4.json"}}, {"family": "Sundin", "given": "Anders", "initials": "A"}, {"family": "Casey", "given": "Ruth T", "initials": "RT", "orcid": "0009-0006-9938-8819", "researcher": {"href": "https://publications.scilifelab.se/researcher/8b5e112ba3f74219b067c6358dfcb5d7.json"}}, {"family": "Crona", "given": "Joakim", "initials": "J", "orcid": "0000-0003-0677-4894", "researcher": {"href": "https://publications.scilifelab.se/researcher/2c601868a0c14b13a01b2868a4fb690e.json"}}], "type": "journal article", "published": "2026-10-01", "journal": {"title": "Endocr. Relat. Cancer", "issn": "1479-6821", "volume": "33", "issue": "10", "issn-l": "1351-0088"}, "abstract": "The adrenocortical-specific PET tracer [11C]metomidate (11C-MTO) shows high diagnostic accuracy in adrenocortical carcinoma (ACC), but complex radiochemistry and short half-life limit clinical implementation. The novel tracer para-chloro-2-[18F]fluoroethyletomidate (18F-CETO) may enable broader use. In this bicentric study, 20 ACC patients underwent PET/CT with 18F-CETO and [18F]fluoro-2-deoxy-D-glucose (18F-FDG), with 235 lesions identified. 18F-CETO detected more lesions than 18F-FDG at initial staging in 5/13 patients, whereas fewer lesions were detected at re-staging in 5/7 patients (P = 0.002). A further 70 patients with 18F-CETO or 11C-MTO-PET/CT and an anatomical imaging reference were used to explore the utility of adrenocortical imaging. Three adrenocortical imaging phenotypes were defined: homogeneous-high (n = 71), homogeneous-low (n = 11), and heterogeneous (n = 8), which showed differences in overall survival in exploratory analyses. Tumors were characterized by RNA sequencing and immunohistochemistry showing correlation between tracer-uptake to CYP11B1 expression and adrenocortical differentiation. These findings suggest a potential role for 18F-CETO in ACC phenotyping and initial staging.", "doi": "10.1530/ERC-26-0314", "pmid": "42775908", "labels": {"National Genomics Infrastructure": "Service", "NGI Short read": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC13663316"}, {"db": "pii", "key": "78256"}], "notes": [], "created": "2026-11-06T09:12:27.735Z", "modified": "2026-11-06T09:12:28.039Z"}]}