{"entity": "researcher", "timestamp": "2026-07-13T09:54:14.578Z", "family": "Schiopu", "given": "Alexandru", "initials": "A", "orcid": "0000-0002-7587-5050", "affiliations": [], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/c7d2edf9030a445583f692dc4d884b7f.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/c7d2edf9030a445583f692dc4d884b7f"}}, "publications": [{"entity": "publication", "iuid": "ee2e0ed6e5fc4e969acfc7bd207dfefe", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ee2e0ed6e5fc4e969acfc7bd207dfefe.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ee2e0ed6e5fc4e969acfc7bd207dfefe"}}, "title": "Progenitor exhausted PD-1+ T cells are cellular targets of immune checkpoint inhibition in atherosclerosis.", "authors": [{"family": "Mulholland", "given": "Megan", "initials": "M", "orcid": "0000-0002-3352-0403", "researcher": {"href": "https://publications.scilifelab.se/researcher/332a484487504958849ef563550cd8a0.json"}}, {"family": "Chalou", "given": "Anthi", "initials": "A", "orcid": "0009-0008-4969-3262", "researcher": {"href": "https://publications.scilifelab.se/researcher/5294de2282b44506977b10f1f8da6f47.json"}}, {"family": "Andersson", "given": "Samuel H A", "initials": "SHA", "orcid": "0009-0009-7497-9403", "researcher": {"href": "https://publications.scilifelab.se/researcher/863588877fc848ca96ba6b2e66c9086a.json"}}, {"family": "Depuydt", "given": "Marie A C", "initials": "MAC", "orcid": "0000-0002-7174-1952", "researcher": {"href": "https://publications.scilifelab.se/researcher/1725c990029e403fb7b0c228b112f418.json"}}, {"family": "Yu", "given": "Yinda", "initials": "Y"}, {"family": "Lin", "given": "Shiying", "initials": "S"}, {"family": "Tallb\u00e4ck", "given": "Klara", "initials": "K", "orcid": "0009-0009-4506-6330", "researcher": {"href": "https://publications.scilifelab.se/researcher/1210f8d35a2d480d839300492143a8bc.json"}}, {"family": "Ericsson", "given": "Astrid", "initials": "A"}, {"family": "Jakobsson", "given": "Gabriel", "initials": "G", "orcid": "0000-0001-5071-9505", "researcher": {"href": "https://publications.scilifelab.se/researcher/99f0995b89884f6eb8d33e0e51c33800.json"}}, {"family": "de Mol", "given": "Jill", "initials": "J", "orcid": "0000-0003-3541-9912", "researcher": {"href": "https://publications.scilifelab.se/researcher/7c34c673397547b4bcecf3994d44882a.json"}}, {"family": "Kryvokhyzha", "given": "Dmytro", "initials": "D"}, {"family": "Lichtman", "given": "Andrew H", "initials": "AH", "orcid": "0000-0002-3546-058X", "researcher": {"href": "https://publications.scilifelab.se/researcher/c22011616511413b8c9f22be31a1f951.json"}}, {"family": "Foks", "given": "Amanda C", "initials": "AC", "orcid": "0000-0002-9747-3458", "researcher": {"href": "https://publications.scilifelab.se/researcher/d6713b7fbb8942bea6789bc4e07d575c.json"}}, {"family": "Schiopu", "given": "Alexandru", "initials": "A", "orcid": "0000-0002-7587-5050", "researcher": {"href": "https://publications.scilifelab.se/researcher/c7d2edf9030a445583f692dc4d884b7f.json"}}, {"family": "Bj\u00f6rkbacka", "given": "Harry", "initials": "H", "orcid": "0000-0003-3918-0857", "researcher": {"href": "https://publications.scilifelab.se/researcher/9f4c07bc840f491d843f67a9932d5f3a.json"}}, {"family": "Sl\u00fctter", "given": "Bram", "initials": "B", "orcid": "0000-0003-3996-0503", "researcher": {"href": "https://publications.scilifelab.se/researcher/aa4acafdcb714986a064c0c0369bd4f8.json"}}, {"family": "Gister\u00e5", "given": "Anton", "initials": "A", "orcid": "0000-0002-4614-8030", "researcher": {"href": "https://publications.scilifelab.se/researcher/3e2beec3559745a6ba1859252df4a547.json"}}, {"family": "Engelbertsen", "given": "Daniel", "initials": "D", "orcid": "0000-0002-0289-5210", "researcher": {"href": "https://publications.scilifelab.se/researcher/fc4f0e42f9444337adb276360c27c5cc.json"}}], "type": "journal article", "published": "2025-10-00", "journal": {"title": "Nat Cardiovasc Res", "issn": "2731-0590", "volume": "4", "issue": "10", "pages": "1311-1328", "issn-l": null}, "abstract": "Immune checkpoint inhibitors (ICIs), targeting checkpoint receptors such as programmed cell death protein 1 (PD-1), are associated with increased risk of cardiovascular events, but the underlying mechanisms remain poorly understood. Here we show that PD-1+ T cells from murine atherosclerotic aortas mainly display a progenitor exhausted phenotype (PD-1intSlamf6+Tim3-), produce IFN\u03b3 in vivo, exhibit signs of recent proliferation and maintain polyfunctionality. PD-1 blockade induced marked changes in plaque immune phenotype, with increased PD-1high T cell accumulation, IFN\u03b3 production, formation of lymphocyte foci and neutrophil recruitment. Depletion of PD-1high T cells prior to PD-1 blockade did not impede T cell recruitment, suggesting a role for progenitor exhausted PD-1int T cells in ICI-driven T cell plaque accumulation. Human circulating PD-1+ T cells produced IFN\u03b3 and were associated with subclinical coronary atherosclerosis. Our studies highlight IFN\u03b3-producing PD-1+ T cells as a potential key immune cell population mediating increased cardiovascular risk in patients with cancer receiving ICI.", "doi": "10.1038/s44161-025-00713-2", "pmid": "41057609", "labels": {"Clinical Genomics Lund": "Service", "Clinical Genomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12520982"}, {"db": "pii", "key": "10.1038/s44161-025-00713-2"}], "notes": [], "created": "2025-11-06T09:28:37.756Z", "modified": "2025-11-06T09:28:38.934Z"}, {"entity": "publication", "iuid": "fbe87ad7cdb14ba598144e9efea8ef01", "links": {"self": {"href": "https://publications.scilifelab.se/publication/fbe87ad7cdb14ba598144e9efea8ef01.json"}, "display": {"href": "https://publications.scilifelab.se/publication/fbe87ad7cdb14ba598144e9efea8ef01"}}, "title": "Plasma proteomic and metabolomic profiling of coronary and carotid atherosclerosis in the SCAPIS study-differences and similarities.", "authors": [{"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications.scilifelab.se/researcher/4ed3f066719f43b291743a8bdaf3d2a0.json"}}, {"family": "Gummesson", "given": "Anders", "initials": "A"}, {"family": "Hammar", "given": "Ulf", "initials": "U"}, {"family": "Ahlstr\u00f6m", "given": "H\u00e5kan", "initials": "H"}, {"family": "Anger\u00e5s", "given": "Oskar", "initials": "O", "orcid": "0000-0002-3474-2438", "researcher": {"href": "https://publications.scilifelab.se/researcher/ffefb8f0aa0b4622b2eb80551a9389c5.json"}}, {"family": "Blomberg", "given": "Anders", "initials": "A"}, {"family": "Brandberg", "given": "John", "initials": "J"}, {"family": "Caidahl", "given": "Kenneth", "initials": "K"}, {"family": "Chorell", "given": "Elin", "initials": "E", "orcid": "0000-0002-8057-1684", "researcher": {"href": "https://publications.scilifelab.se/researcher/e3f7dfbecd6d4f80a9015080ec717ccc.json"}}, {"family": "Engvall", "given": "Jan Edvin", "initials": "JE"}, {"family": "Eriksson", "given": "Per", "initials": "P"}, {"family": "Erlinge", "given": "David", "initials": "D"}, {"family": "Gigante", "given": "Bruna", "initials": "B", "orcid": "0000-0003-4508-7990", "researcher": {"href": "https://publications.scilifelab.se/researcher/3ac1bdc52e3241ea9eb5645f603229a3.json"}}, {"family": "Hjelmgren", "given": "Ola", "initials": "O"}, {"family": "Hultdin", "given": "Johan", "initials": "J"}, {"family": "Jernberg", "given": "Tomas", "initials": "T", "orcid": "0000-0003-1695-379X", "researcher": {"href": "https://publications.scilifelab.se/researcher/cbe08775f7a047ffa46bf6e065c776c9.json"}}, {"family": "Kihlberg", "given": "Johan", "initials": "J"}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications.scilifelab.se/researcher/4c517dacca7c4ec58a3e03b59ffb4044.json"}}, {"family": "Magnusson", "given": "Martin", "initials": "M"}, {"family": "Nystr\u00f6m", "given": "Fredrik Hans", "initials": "FH"}, {"family": "Pirazzi", "given": "Carlo", "initials": "C"}, {"family": "Schiopu", "given": "Alexandru", "initials": "A", "orcid": "0000-0002-7587-5050", "researcher": {"href": "https://publications.scilifelab.se/researcher/c7d2edf9030a445583f692dc4d884b7f.json"}}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications.scilifelab.se/researcher/91a40d3c138d43f2b0d38f66be4b71c7.json"}}, {"family": "S\u00f6derberg", "given": "Stefan", "initials": "S"}, {"family": "\u00d6stgren", "given": "Carl Johan", "initials": "CJ"}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications.scilifelab.se/researcher/b40c03613a3a46368ed855fc95b79e31.json"}}], "type": "journal article", "published": "2025-09-29", "journal": {"title": "Cardiovasc. Res.", "issn": "1755-3245", "volume": "121", "issue": "11", "pages": "1649-1652", "issn-l": "0008-6363"}, "abstract": null, "doi": "10.1093/cvr/cvaf076", "pmid": "40327543", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12477672"}, {"db": "pii", "key": "8125826"}], "notes": [], "created": "2025-11-25T19:22:38.477Z", "modified": "2025-11-25T19:23:39.737Z"}, {"entity": "publication", "iuid": "14fae7f53f414c66aa6903c0f026d037", "links": {"self": {"href": "https://publications.scilifelab.se/publication/14fae7f53f414c66aa6903c0f026d037.json"}, "display": {"href": "https://publications.scilifelab.se/publication/14fae7f53f414c66aa6903c0f026d037"}}, "title": "Circulating soluble LOX-1 and patient prognosis after an acute coronary syndrome.", "authors": [{"family": "Schiopu", "given": "Alexandru", "initials": "A", "orcid": "0000-0002-7587-5050", "researcher": {"href": "https://publications.scilifelab.se/researcher/c7d2edf9030a445583f692dc4d884b7f.json"}}, {"family": "Svedlund", "given": "Sara", "initials": "S"}, {"family": "Narasimhan", "given": "Gayathri", "initials": "G"}, {"family": "Juin Loong", "given": "Bi", "initials": "B"}, {"family": "Yndigegn", "given": "Troels", "initials": "T", "orcid": "0000-0002-8960-2125", "researcher": {"href": "https://publications.scilifelab.se/researcher/2c5f5069c767413eaa653581f7f0bfe9.json"}}, {"family": "Varma", "given": "Vijayalakshmi", "initials": "V"}, {"family": "Ongstad", "given": "Emily L", "initials": "EL"}, {"family": "Goncalves", "given": "Isabel", "initials": "I"}, {"family": "Coll\u00e9n", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Jan", "initials": "J"}, {"family": "Gan", "given": "Li-Ming", "initials": "LM"}], "type": "journal article", "published": "2025-09-16", "journal": {"title": "Heart", "issn": "1468-201X", "issn-l": "1355-6037"}, "abstract": "The lectin-like oxidised low-density lipoprotein receptor-1 (LOX-1) mediates atherosclerotic plaque inflammation and vulnerability. On activation, LOX-1 sheds its extracellular domain into the circulation as soluble LOX-1 (sLOX-1). sLOX-1 is markedly elevated in patients with acute coronary syndrome (ACS).\n\nWe prospectively assessed the associations between plasma sLOX-1 and the development of heart failure (HF), major adverse cardiovascular events (MACE) and coronary and left ventricular (LV) dysfunction in two cohorts of patients with ACS. The first cohort comprised 524 patients recruited during the acute index event at the coronary care unit of Sk\u00e5ne University Hospital, Malm\u00f6, Sweden. The second cohort included 363 patients with ACS treated with acute percutaneous intervention at Sahlgrenska University Hospital, Gothenburg, Sweden. Additionally, we examined the anti-inflammatory effects of LOX-1 blockade in vitro using human umbilical vein endothelial cells (HUVECs).\n\nIn the first cohort, acute-phase sLOX-1 was associated with incident HF and MACE independently of cardiovascular risk factors, revascularisation and medication (HR per 1-SD sLOX-1 increase: 1.57 (95% CI: 1.10 to 2.23; p=0.012) for HF and 1.36 (1.08 to 1.71; p=0.009) for MACE). Elevated sLOX-1 was also associated with lower LV ejection fraction and accelerated remodelling, as measured by echocardiography at 1-year post-ACS. In the second cohort, sLOX-1 was negatively associated with left anterior descending coronary artery flow reserve and LV systolic function, and positively correlated with soluble markers of systemic inflammation and cardiac overload at 4 and 16 weeks post-ACS. In vitro, antibody-mediated LOX-1 blockade prevented oxidised low-density lipoprotein-induced HUVEC activation.\n\nElevated plasma sLOX-1 at baseline and during follow-up is associated with incident HF and MACE, as well as cardiac and coronary dysfunction in patients with ACS. As plasma sLOX-1 levels may reflect the intensity of LOX-1 expression on vascular and immune cells, these findings support LOX-1 as a potentially important therapeutic target to improve prognosis in patients with ACS.", "doi": "10.1136/heartjnl-2025-326315", "pmid": "40957671", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pii", "key": "heartjnl-2025-326315"}], "notes": [], "created": "2025-11-25T19:20:38.823Z", "modified": "2025-11-25T19:20:38.894Z"}, {"entity": "publication", "iuid": "73591eb545e74c9498be82b00256074b", "links": {"self": {"href": "https://publications.scilifelab.se/publication/73591eb545e74c9498be82b00256074b.json"}, "display": {"href": "https://publications.scilifelab.se/publication/73591eb545e74c9498be82b00256074b"}}, "title": "Elevated IL-27 in patients with acute coronary syndrome is associated with adverse ventricular remodeling and increased risk of recurrent myocardial infarction and cardiovascular death.", "authors": [{"family": "Grufman", "given": "Helena", "initials": "H"}, {"family": "Yndigegn", "given": "Troels", "initials": "T"}, {"family": "Gon\u00e7alves", "given": "Isabel", "initials": "I"}, {"family": "Nilsson", "given": "Jan", "initials": "J"}, {"family": "Schiopu", "given": "Alexandru", "initials": "A", "orcid": "0000-0002-7587-5050", "researcher": {"href": "https://publications.scilifelab.se/researcher/c7d2edf9030a445583f692dc4d884b7f.json"}}], "type": "clinical trial", "published": "2019-10-00", "journal": {"title": "Cytokine", "issn": "1096-0023", "issn-l": "1043-4666", "volume": "122", "issue": null, "pages": "154208"}, "abstract": "IL-27 is an immunoregulatory cytokine belonging to the IL-6/IL-12 family that was found to be elevated in acute coronary syndrome (ACS) patients. We investigated whether IL-27 is related to post-ischemic cardiac remodeling and long-term prognosis in this patient group.\n\nWe included 524 ACS patients, defined as acute myocardial infarction (AMI) or unstable angina (UA). A subgroup of 107 patients donated blood samples 6 weeks after the index event, and underwent a follow-up echocardiographical examination at 1 year. We measured plasma levels of IL-27, high sensitivity troponin T (hsTNT), C-reactive protein (hsCRP) and cystatin C at baseline and in the 6-week samples. The median follow-up period of the cohort was 2.2 years.\n\nThe incidence of the combined end-point of AMI and cardiovascular death was higher in patients with plasma IL-27 within the top two tertiles both at baseline and after 6 weeks. After correction for cardiovascular risk factors, medication, hsTNT, hsCRP, and eGFR, patients with baseline IL-27 levels within the highest tertile had a significantly elevated risk for the combined end-point compared with the lowest tertile (hazard ratio 2.70, 95% CI 1.06-6.90, p = .038). Additionally, higher baseline IL-27 levels were associated with deleterious left ventricular remodeling and deterioration of systolic and diastolic function during the first year of follow-up.\n\nElevated IL-27 at the time of an ACS is independently related to impaired cardiac function and worse long-term prognosis. Our data warrants further mechanistic studies to elucidate the involvement of IL-27 in cardiac repair and remodeling after ACS.", "doi": "10.1016/j.cyto.2017.11.002", "pmid": "29428559", "labels": {"Clinical Biomarkers": "Service", "PLA and Single Cell Proteomics": "Service", "Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pii", "key": "S1043-4666(17)30344-7"}], "notes": [], "created": "2020-01-23T16:03:59.926Z", "modified": "2023-04-14T13:55:55.654Z"}]}