{"entity": "researcher", "timestamp": "2026-06-15T18:01:43.181Z", "family": "Chauhan", "given": "Pallavi", "initials": "P", "orcid": "0000-0002-5160-6673", "affiliations": ["Department of Biology, Lund University, Ecology Building, Lund 22362, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/c2ca3733447d4e38ae5cce50d1b4d165.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/c2ca3733447d4e38ae5cce50d1b4d165"}}, "publications": [{"entity": "publication", "iuid": "a054c0f7162b4df2b065275b4b1037bb", "links": {"self": {"href": "https://publications.scilifelab.se/publication/a054c0f7162b4df2b065275b4b1037bb.json"}, "display": {"href": "https://publications.scilifelab.se/publication/a054c0f7162b4df2b065275b4b1037bb"}}, "title": "Mettl15-Mettl17 modulates the transition from early to late pre-mitoribosome.", "authors": [{"family": "Zgadzay", "given": "Yury", "initials": "Y"}, {"family": "Mirabello", "given": "Claudio", "initials": "C", "orcid": "0000-0001-7868-034X", "researcher": {"href": "https://publications.scilifelab.se/researcher/00052b54a3d24fd4a6e648f987d15e5f.json"}}, {"family": "Wanes", "given": "George", "initials": "G"}, {"family": "P\u00e1nek", "given": "Tom\u00e1\u0161", "initials": "T"}, {"family": "Chauhan", "given": "Prashant", "initials": "P", "orcid": "0000-0002-5160-6673", "researcher": {"href": "https://publications.scilifelab.se/researcher/c2ca3733447d4e38ae5cce50d1b4d165.json"}}, {"family": "Nystedt", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0001-7809-7664", "researcher": {"href": "https://publications.scilifelab.se/researcher/f0af5a168baa4b00a6fab8d3447ebfb4.json"}}, {"family": "Z\u00edkov\u00e1", "given": "Alena", "initials": "A"}, {"family": "Whitford", "given": "Paul C", "initials": "PC"}, {"family": "Gahura", "given": "Ond\u0159ej", "initials": "O"}, {"family": "Amunts", "given": "Alexey", "initials": "A", "orcid": "0000-0002-5302-1740", "researcher": {"href": "https://publications.scilifelab.se/researcher/e7d0bf36ad1a47f5b5b88f78d1e15395.json"}}], "type": "journal article", "published": "2025-08-27", "journal": {"title": "Structure", "issn": "1878-4186", "issn-l": "0969-2126", "volume": null, "issue": null, "pages": null}, "abstract": "The biogenesis of the mitoribosomal small subunit involves a dynamic network of assembly factors. Conserved methyltransferases Mettl15 and Mettl17 act on the solvent-exposed surface of rRNA. Binding of Mettl17 is associated with the early assembly stage, whereas Mettl15 is involved in the late stage. Here, we integrate structural data from Trypanosoma brucei with mammalian homologs and molecular dynamics simulations. We reveal how the interplay of Mettl15 and Mettl17 in intermediate steps links the distinct stages of small subunit assembly. The analysis suggests a model wherein Mettl17 acts as a platform for Mettl15 recruitment. Subsequent release of Mettl17 allows a conformational change of Mettl15 for substrate recognition. Upon methylation, Mettl15 adopts a loosely bound state which leads to its replacement by initiation factors, concluding the assembly. Together, our results indicate that assembly factors Mettl15 and Mettl17 cooperate to regulate the biogenesis process.", "doi": "10.1016/j.str.2025.08.002", "pmid": "40882632", "labels": {"Bioinformatics (NBIS)": "Collaborative", "Bioinformatics Support, Infrastructure and Training": "Collaborative", "Bioinformatics Long-term Support WABI": "Collaborative"}, "xrefs": [{"db": "pii", "key": "S0969-2126(25)00306-5"}], "notes": [], "created": "2025-09-08T06:24:34.626Z", "modified": "2025-11-21T11:42:45.696Z"}, {"entity": "publication", "iuid": "796f460ce9794c089a8bdd175c3a9b65", "links": {"self": {"href": "https://publications.scilifelab.se/publication/796f460ce9794c089a8bdd175c3a9b65.json"}, "display": {"href": "https://publications.scilifelab.se/publication/796f460ce9794c089a8bdd175c3a9b65"}}, "title": "Restricted X chromosome introgression and support for Haldane's rule in hybridizing damselflies.", "authors": [{"family": "Swaegers", "given": "Janne", "initials": "J", "orcid": "0000-0003-1952-3170", "researcher": {"href": "https://publications.scilifelab.se/researcher/0cb5191ea7e94e8696e42fc15e854ce8.json"}}, {"family": "S\u00e1nchez-Guill\u00e9n", "given": "Rosa Ana", "initials": "RA", "orcid": "0000-0001-6024-8321", "researcher": {"href": "https://publications.scilifelab.se/researcher/c03f95fe4ced4dd690950ab8bb656710.json"}}, {"family": "Chauhan", "given": "Pallavi", "initials": "P", "orcid": "0000-0002-5160-6673", "researcher": {"href": "https://publications.scilifelab.se/researcher/c2ca3733447d4e38ae5cce50d1b4d165.json"}}, {"family": "Wellenreuther", "given": "Maren", "initials": "M", "orcid": "0000-0002-2764-8291", "researcher": {"href": "https://publications.scilifelab.se/researcher/82e9b593bf0f4535a7b9231608b1e27d.json"}}, {"family": "Hansson", "given": "Bengt", "initials": "B", "orcid": "0000-0001-6694-8169", "researcher": {"href": "https://publications.scilifelab.se/researcher/01f0144e207c41dcbc4d5aec68690e4b.json"}}], "type": "journal article", "published": "2022-07-27", "journal": {"title": "Proc. Biol. Sci.", "issn": "1471-2954", "issn-l": "0962-8452", "volume": "289", "issue": "1979", "pages": "20220968"}, "abstract": "Contemporary hybrid zones act as natural laboratories for the investigation of species boundaries and may shed light on the little understood roles of sex chromosomes in species divergence. Sex chromosomes are considered to function as a hotspot of genetic divergence between species; indicated by less genomic introgression compared to autosomes during hybridization. Moreover, they are thought to contribute to Haldane's rule, which states that hybrids of the heterogametic sex are more likely to be inviable or sterile. To test these hypotheses, we used contemporary hybrid zones of Ischnura elegans, a damselfly species that has been expanding its range into the northern and western regions of Spain, leading to chronic hybridization with its sister species Ischnura graellsii. We analysed genome-wide SNPs in the Spanish I. elegans and I. graellsii hybrid zone and found (i) that the X chromosome shows less genomic introgression compared to autosomes, and (ii) that males are underrepresented among admixed individuals, as predicted by Haldane's rule. This is the first study in Odonata that suggests a role of the X chromosome in reproductive isolation. Moreover, our data add to the few studies on species with X0 sex determination system and contradict the hypothesis that the absence of a Y chromosome causes exceptions to Haldane's rule.", "doi": "10.1098/rspb.2022.0968", "pmid": "35855603", "labels": {"NGI Short read": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "National Genomics Infrastructure": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9297008"}, {"db": "Dryad", "key": "10.5061/dryad.gqnk98sp8"}], "notes": [], "created": "2022-11-09T15:50:07.860Z", "modified": "2024-01-16T13:48:35.646Z"}]}