{"entity": "researcher", "timestamp": "2026-07-14T03:35:00.723Z", "family": "Schroeder", "given": "Bjoern O", "initials": "BO", "orcid": "0000-0002-6716-8284", "affiliations": ["Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden"], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/c2c57653fc214cbcbb242cbbc524d517.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/c2c57653fc214cbcbb242cbbc524d517"}}, "publications": [{"entity": "publication", "iuid": "fd3d1863ce1e404cbd824f5ec6d4f971", "links": {"self": {"href": "https://publications.scilifelab.se/publication/fd3d1863ce1e404cbd824f5ec6d4f971.json"}, "display": {"href": "https://publications.scilifelab.se/publication/fd3d1863ce1e404cbd824f5ec6d4f971"}}, "title": "The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids.", "authors": [{"family": "Holmberg", "given": "Sandra M", "initials": "SM", "orcid": "0000-0002-6290-2590", "researcher": {"href": "https://publications.scilifelab.se/researcher/7815cc43d5ee43b1b83aea417aaa7734.json"}}, {"family": "Feeney", "given": "Rachel H", "initials": "RH", "orcid": "0000-0002-7686-6279", "researcher": {"href": "https://publications.scilifelab.se/researcher/a1e816ac8a604325b1a878b4a33dbc44.json"}}, {"family": "Prasoodanan P K", "given": "Vishnu", "initials": "V"}, {"family": "Pu\u00e9rtolas-Balint", "given": "Fabiola", "initials": "F", "orcid": "0000-0003-4898-5673", "researcher": {"href": "https://publications.scilifelab.se/researcher/52b9ecd971f64eb89d05334fe9e975bb.json"}}, {"family": "Singh", "given": "Dhirendra K", "initials": "DK"}, {"family": "Wongkuna", "given": "Supapit", "initials": "S", "orcid": "0000-0003-3766-5391", "researcher": {"href": "https://publications.scilifelab.se/researcher/6f1a42a392e642dbaaee6d5dbf6b1ef5.json"}}, {"family": "Zandbergen", "given": "Lotte", "initials": "L"}, {"family": "Hauner", "given": "Hans", "initials": "H"}, {"family": "Brandl", "given": "Beate", "initials": "B"}, {"family": "Nieminen", "given": "Anni I", "initials": "AI", "orcid": "0000-0001-8999-6040", "researcher": {"href": "https://publications.scilifelab.se/researcher/eddac59bcacb4eff9a44249cf2305779.json"}}, {"family": "Skurk", "given": "Thomas", "initials": "T", "orcid": "0000-0002-6875-1658", "researcher": {"href": "https://publications.scilifelab.se/researcher/f312550741dc4fe6b6c3064d2d8b83b7.json"}}, {"family": "Schroeder", "given": "Bjoern O", "initials": "BO", "orcid": "0000-0002-6716-8284", "researcher": {"href": "https://publications.scilifelab.se/researcher/c2c57653fc214cbcbb242cbbc524d517.json"}}], "type": "journal article", "published": "2024-04-25", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "3502", "issn-l": "2041-1723"}, "abstract": "Beneficial gut bacteria are indispensable for developing colonic mucus and fully establishing its protective function against intestinal microorganisms. Low-fiber diet consumption alters the gut bacterial configuration and disturbs this microbe-mucus interaction, but the specific bacteria and microbial metabolites responsible for maintaining mucus function remain poorly understood. By using human-to-mouse microbiota transplantation and ex vivo analysis of colonic mucus function, we here show as a proof-of-concept that individuals who increase their daily dietary fiber intake can improve the capacity of their gut microbiota to prevent diet-mediated mucus defects. Mucus growth, a critical feature of intact colonic mucus, correlated with the abundance of the gut commensal Blautia, and supplementation of Blautia coccoides to mice confirmed its mucus-stimulating capacity. Mechanistically, B. coccoides stimulated mucus growth through the production of the short-chain fatty acids propionate and acetate via activation of the short-chain fatty acid receptor Ffar2, which could serve as a new target to restore mucus growth during mucus-associated lifestyle diseases.", "doi": "10.1038/s41467-024-47594-w", "pmid": "38664378", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11045866"}, {"db": "pii", "key": "10.1038/s41467-024-47594-w"}], "notes": [], "created": "2024-11-25T10:16:38.017Z", "modified": "2024-11-25T10:16:38.245Z"}, {"entity": "publication", "iuid": "aa7cdea45678475ca4310179b0f37df0", "links": {"self": {"href": "https://publications.scilifelab.se/publication/aa7cdea45678475ca4310179b0f37df0.json"}, "display": {"href": "https://publications.scilifelab.se/publication/aa7cdea45678475ca4310179b0f37df0"}}, "title": "A multi-strategy antimicrobial discovery approach reveals new ways to combatChlamydia", "authors": [{"family": "\u00d6lander", "given": "Magnus", "initials": "M"}, {"family": "V\u00e1zquez", "given": "Daniel Rea", "initials": "DR"}, {"family": "Meier", "given": "Karsten", "initials": "K"}, {"family": "Mooij", "given": "Lieke", "initials": "L"}, {"family": "Fredlund", "given": "Johanna", "initials": "J"}, {"family": "Pu\u00e9rtolas-Balint", "given": "Fabiola", "initials": "F", "orcid": "0000-0003-4898-5673", "researcher": {"href": "https://publications.scilifelab.se/researcher/52b9ecd971f64eb89d05334fe9e975bb.json"}}, {"family": "Calpe", "given": "Eduard", "initials": "E"}, {"family": "D\u00edaz", "given": "Mar\u00eda Ray\u00f3n", "initials": "MR"}, {"family": "van der Wal", "given": "Karin", "initials": "K"}, {"family": "Schroeder", "given": "Bjoern O", "initials": "BO", "orcid": "0000-0002-6716-8284", "researcher": {"href": "https://publications.scilifelab.se/researcher/c2c57653fc214cbcbb242cbbc524d517.json"}}, {"family": "Sixt", "given": "Barbara Susanne", "initials": "BS", "orcid": "0000-0002-5607-8902", "researcher": {"href": "https://publications.scilifelab.se/researcher/998ac876b31f45c5b10d36f0d10c7390.json"}}], "type": "posted-content", "published": "2023-11-30", "journal": {"title": "biorxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.11.30.569351", "pmid": null, "labels": {"Chemical Biology Consortium Sweden": "Service"}, "xrefs": [], "notes": [], "created": "2024-01-22T08:01:55.831Z", "modified": "2025-12-18T19:40:37.733Z"}, {"entity": "publication", "iuid": "6e423bae8c7141548aaf0589c8f8adf7", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6e423bae8c7141548aaf0589c8f8adf7.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6e423bae8c7141548aaf0589c8f8adf7"}}, "title": "The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function.", "authors": [{"family": "Volk", "given": "Joana K", "initials": "JK"}, {"family": "Nystr\u00f6m", "given": "Elisabeth E L", "initials": "EEL"}, {"family": "van der Post", "given": "Sjoerd", "initials": "S"}, {"family": "Abad", "given": "Beatriz M", "initials": "BM"}, {"family": "Schroeder", "given": "Bjoern O", "initials": "BO", "orcid": "0000-0002-6716-8284", "researcher": {"href": "https://publications.scilifelab.se/researcher/c2c57653fc214cbcbb242cbbc524d517.json"}}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Svensson", "given": "Frida", "initials": "F"}, {"family": "J\u00e4verfelt", "given": "Sofia", "initials": "S"}, {"family": "Johansson", "given": "Malin E V", "initials": "MEV", "orcid": "0000-0002-4237-6677", "researcher": {"href": "https://publications.scilifelab.se/researcher/520dab35c19049c8b3f1083a92e60d56.json"}}, {"family": "Hansson", "given": "Gunnar C", "initials": "GC", "orcid": "0000-0002-1900-1869", "researcher": {"href": "https://publications.scilifelab.se/researcher/44b3815603154322a6dac16f2fc1c1e9.json"}}, {"family": "Birchenough", "given": "George M H", "initials": "GMH", "orcid": "0000-0003-2283-2353", "researcher": {"href": "https://publications.scilifelab.se/researcher/aecb4d51bffc490d87b0a4fffb7de59a.json"}}], "type": "journal article", "published": "2019-11-04", "journal": {"title": "J. Exp. Med.", "issn": "1540-9538", "volume": "216", "issue": "11", "pages": "2602-2618", "issn-l": "0022-1007"}, "abstract": "The inner mucus layer (IML) is a critical barrier that protects the colonic epithelium from luminal threats and inflammatory bowel disease. Innate immune signaling is thought to regulate IML formation via goblet cell Nlrp6 inflammasome activity that controls secretion of the mucus structural component Muc2. We report that isolated colonic goblet cells express components of several inflammasomes; however, analysis of IML properties in multiple inflammasome-deficient mice, including littermate-controlled Nlrp6 , detect a functional IML barrier in all strains. Analysis of mice lacking inflammasome substrate cytokines identifies a defective IML in -/-Il18 mice, but this phenotype is ultimately traced to a microbiota-driven, Il18-independent effect. Analysis of phenotypic transfer between IML-deficient and IML-intact mice finds that the Bacteroidales family S24-7 (Muribaculaceae) and genus -/-Adlercrutzia consistently positively covary with IML barrier function. Together, our results demonstrate that baseline IML formation and function is independent of inflammasome activity and highlights the role of the microbiota in determining IML barrier function.", "doi": "10.1084/jem.20190679", "pmid": "31420376", "labels": {"Integrated Microscopy Technologies Gothenburg": "Service"}, "xrefs": [{"db": "pii", "key": "jem.20190679"}, {"db": "pmc", "key": "PMC6829596"}], "notes": [], "created": "2020-01-23T16:14:20.940Z", "modified": "2021-06-16T16:20:41.684Z"}]}