{"entity": "researcher", "timestamp": "2026-08-11T14:14:32.230Z", "family": "Smith", "given": "Jonathon A B", "initials": "JAB", "orcid": "0000-0003-2452-1655", "affiliations": ["Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/bffd42f562b3485fb50090c02aceeaef.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/bffd42f562b3485fb50090c02aceeaef"}}, "publications": [{"entity": "publication", "iuid": "7aa0f32803b94812952a1ad8388a0b27", "links": {"self": {"href": "https://publications.scilifelab.se/publication/7aa0f32803b94812952a1ad8388a0b27.json"}, "display": {"href": "https://publications.scilifelab.se/publication/7aa0f32803b94812952a1ad8388a0b27"}}, "title": "Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes.", "authors": [{"family": "Pillon", "given": "Nicolas J", "initials": "NJ", "orcid": "0000-0003-1107-9490", "researcher": {"href": "https://publications.scilifelab.se/researcher/4b917d3e521149ec9d695c62ac2d1b85.json"}}, {"family": "Smith", "given": "Jonathon A B", "initials": "JAB", "orcid": "0000-0003-2452-1655", "researcher": {"href": "https://publications.scilifelab.se/researcher/bffd42f562b3485fb50090c02aceeaef.json"}}, {"family": "Alm", "given": "Petter S", "initials": "PS"}, {"family": "Chibalin", "given": "Alexander V", "initials": "AV", "orcid": "0000-0002-6339-6271", "researcher": {"href": "https://publications.scilifelab.se/researcher/8ac028a96dd746c5896f7e5536f978c1.json"}}, {"family": "Alhusen", "given": "Julia", "initials": "J"}, {"family": "Arner", "given": "Erik", "initials": "E"}, {"family": "Carninci", "given": "Piero", "initials": "P", "orcid": "0000-0001-7202-7243", "researcher": {"href": "https://publications.scilifelab.se/researcher/b3fce15806ba4fb9bc1fda7e52470fad.json"}}, {"family": "Fritz", "given": "Tomas", "initials": "T"}, {"family": "Otten", "given": "Julia", "initials": "J", "orcid": "0000-0001-9016-1139", "researcher": {"href": "https://publications.scilifelab.se/researcher/0038b9a380164700b77cda3879133a29.json"}}, {"family": "Olsson", "given": "Tommy", "initials": "T"}, {"family": "van Doorslaer de Ten Ryen", "given": "Sophie", "initials": "S", "orcid": "0000-0003-4452-1361", "researcher": {"href": "https://publications.scilifelab.se/researcher/e5612041bba948f18e7b795369b2f4f2.json"}}, {"family": "Deldicque", "given": "Louise", "initials": "L", "orcid": "0000-0003-3393-5278", "researcher": {"href": "https://publications.scilifelab.se/researcher/a2d95c5f9ecc4fa8b8661810177085d1.json"}}, {"family": "Caidahl", "given": "Kenneth", "initials": "K", "orcid": "0000-0002-5079-9696", "researcher": {"href": "https://publications.scilifelab.se/researcher/c54c79603a954f9e81d2b82470e3ec36.json"}}, {"family": "Wallberg-Henriksson", "given": "Harriet", "initials": "H", "orcid": "0000-0001-7681-1537", "researcher": {"href": "https://publications.scilifelab.se/researcher/3b84ac00890a44ddb3b6732687003281.json"}}, {"family": "Krook", "given": "Anna", "initials": "A", "orcid": "0000-0002-0891-0258", "researcher": {"href": "https://publications.scilifelab.se/researcher/f43339bcd571486b845a3b10e241bcc4.json"}}, {"family": "Zierath", "given": "Juleen R", "initials": "JR", "orcid": "0000-0001-6891-7497", "researcher": {"href": "https://publications.scilifelab.se/researcher/f4ef2b94ba2d44dd9b41192567a7af53.json"}}], "type": "journal article", "published": "2022-09-09", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "8", "issue": "36", "pages": "eabo3192", "issn-l": "2375-2548"}, "abstract": "Mechanistic insights into the molecular events by which exercise enhances the skeletal muscle phenotype are lacking, particularly in the context of type 2 diabetes. Here, we unravel a fundamental role for exercise-responsive cytokines (exerkines) on skeletal muscle development and growth in individuals with normal glucose tolerance or type 2 diabetes. Acute exercise triggered an inflammatory response in skeletal muscle, concomitant with an infiltration of immune cells. These exercise effects were potentiated in type 2 diabetes. In response to contraction or hypoxia, cytokines were mainly produced by endothelial cells and macrophages. The chemokine CXCL12 was induced by hypoxia in endothelial cells, as well as by conditioned medium from contracted myotubes in macrophages. We found that CXCL12 was associated with skeletal muscle remodeling after exercise and differentiation of cultured muscle. Collectively, acute aerobic exercise mounts a noncanonical inflammatory response, with an atypical production of exerkines, which is potentiated in type 2 diabetes.", "doi": "10.1126/sciadv.abo3192", "pmid": "36070371", "labels": {"Spatial Proteomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9451165"}], "notes": [], "created": "2023-11-21T15:13:19.754Z", "modified": "2023-11-21T15:13:19.970Z"}, {"entity": "publication", "iuid": "2f54929bed214af5a91abc8de9637883", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2f54929bed214af5a91abc8de9637883.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2f54929bed214af5a91abc8de9637883"}}, "title": "Three weeks of interrupting sitting lowers fasting glucose and glycemic variability, but not glucose tolerance, in free-living women and men with obesity.", "authors": [{"family": "Smith", "given": "Jonathon A B", "initials": "JAB", "orcid": "0000-0003-2452-1655", "researcher": {"href": "https://publications.scilifelab.se/researcher/bffd42f562b3485fb50090c02aceeaef.json"}}, {"family": "Savikj", "given": "Mladen", "initials": "M", "orcid": "0000-0002-9708-0750", "researcher": {"href": "https://publications.scilifelab.se/researcher/f54575f9767948b3a2663012cfed3932.json"}}, {"family": "Sethi", "given": "Parneet", "initials": "P"}, {"family": "Platt", "given": "Simon", "initials": "S"}, {"family": "Gabriel", "given": "Brendan M", "initials": "BM", "orcid": "0000-0001-6878-8779", "researcher": {"href": "https://publications.scilifelab.se/researcher/1fa7198e43f648b5ab2da4d43f71962d.json"}}, {"family": "Hawley", "given": "John A", "initials": "JA"}, {"family": "Dunstan", "given": "David", "initials": "D"}, {"family": "Krook", "given": "Anna", "initials": "A", "orcid": "0000-0002-0891-0258", "researcher": {"href": "https://publications.scilifelab.se/researcher/f43339bcd571486b845a3b10e241bcc4.json"}}, {"family": "Zierath", "given": "Juleen R", "initials": "JR", "orcid": "0000-0001-6891-7497", "researcher": {"href": "https://publications.scilifelab.se/researcher/f4ef2b94ba2d44dd9b41192567a7af53.json"}}, {"family": "N\u00e4slund", "given": "Erik", "initials": "E"}], "type": "journal article", "published": "2021-08-01", "journal": {"title": "Am J Physiol Endocrinol Metab", "issn": "1522-1555", "volume": "321", "issue": "2", "pages": "E203-E216", "issn-l": null}, "abstract": "We aimed to determine whether interrupting prolonged sitting improves glycemic control and the metabolic profile of free-living adults with obesity. Sixteen sedentary individuals {10 women/6 men; median [interquartile range (IQR)] age 50 (44-53) yr, body mass index (BMI) 32 (32-35.8) kg/m2} were fitted with continuous glucose and activity monitors for 4 wk. After a 1-wk baseline period, participants were randomized into habitual lifestyle (Control) or frequent activity breaks from sitting (FABS) intervention groups. Each day, between 0800 and 1800 h, FABS received smartwatch notifications to break sitting with 3 min of low-to-moderate-intensity physical activity every 30 min. Glycemic control was assessed by oral glucose tolerance test (OGTT) and continuous glucose monitoring. Blood samples and vastus lateralis biopsies were taken for assessment of clinical chemistry and the skeletal muscle lipidome, respectively. Compared with baseline, FABS increased median steps by 744 [IQR (483-951)] and walking time by 10.4 [IQR (2.2-24.6)] min/day. Other indices of activity/sedentary behavior were unchanged. Glucose tolerance and average 24-h glucose curves were also unaffected. However, mean (\u00b1SD) fasting glucose levels [-0.34 (\u00b10.37) mmol/L] and daily glucose variation [%CV; -2% (\u00b12.2%)] reduced in FABS, suggesting a modest benefit for glycemic control that was most robust at higher volumes of daily activity. Clinical chemistry and the skeletal muscle lipidome were largely unperturbed, although two long-chain triglycerides increased 1.25-fold in FABS, postintervention. All parameters remained stable in control. Under free-living conditions, FABS lowered fasting glucose and glucose variability. Larger volumes of activity breaks from sitting may be required to promote greater health benefits.NEW & NOTEWORTHY Under free-living conditions, breaking sitting modestly increased activity behavior. Breaking sitting was insufficient to modulate glucose tolerance or the skeletal muscle lipidome. Activity breaks reduced fasting blood glucose levels and daily glucose variation compared with baseline, with a tendency to also decrease fasting LDLc. This intervention may represent the minimal dose for breaking sedentary behavior, with larger volumes of activity possibly required to promote greater health benefits.", "doi": "10.1152/ajpendo.00599.2020", "pmid": "34151582", "labels": {"Swedish Metabolomics Centre": "Service"}, "xrefs": [{"db": "ClinicalTrials.gov", "key": "NCT03083587"}], "notes": [], "created": "2021-12-09T20:05:42.759Z", "modified": "2025-10-17T13:03:15.867Z"}, {"entity": "publication", "iuid": "2fbb3c01bdfc42fcb76d81c03118c91a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2fbb3c01bdfc42fcb76d81c03118c91a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2fbb3c01bdfc42fcb76d81c03118c91a"}}, "title": "Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity.", "authors": [{"family": "Pillon", "given": "Nicolas J", "initials": "NJ", "orcid": "0000-0003-1107-9490", "researcher": {"href": "https://publications.scilifelab.se/researcher/4b917d3e521149ec9d695c62ac2d1b85.json"}}, {"family": "Gabriel", "given": "Brendan M", "initials": "BM", "orcid": "0000-0001-6878-8779", "researcher": {"href": "https://publications.scilifelab.se/researcher/1fa7198e43f648b5ab2da4d43f71962d.json"}}, {"family": "Dollet", "given": "Lucile", "initials": "L"}, {"family": "Smith", "given": "Jonathon A B", "initials": "JAB", "orcid": "0000-0003-2452-1655", "researcher": {"href": "https://publications.scilifelab.se/researcher/bffd42f562b3485fb50090c02aceeaef.json"}}, {"family": "Sard\u00f3n Puig", "given": "Laura", "initials": "L", "orcid": "0000-0002-0481-4023", "researcher": {"href": "https://publications.scilifelab.se/researcher/73c9841603dc43edae07c7e606776225.json"}}, {"family": "Botella", "given": "Javier", "initials": "J", "orcid": "0000-0001-9722-8519", "researcher": {"href": "https://publications.scilifelab.se/researcher/199f6b058cb342b391566273dc4faf78.json"}}, {"family": "Bishop", "given": "David J", "initials": "DJ", "orcid": "0000-0002-6956-9188", "researcher": {"href": "https://publications.scilifelab.se/researcher/ecaa5fe4ab9649c8a90ae1fed84a222e.json"}}, {"family": "Krook", "given": "Anna", "initials": "A", "orcid": "0000-0002-0891-0258", "researcher": {"href": "https://publications.scilifelab.se/researcher/f43339bcd571486b845a3b10e241bcc4.json"}}, {"family": "Zierath", "given": "Juleen R", "initials": "JR", "orcid": "0000-0001-6891-7497", "researcher": {"href": "https://publications.scilifelab.se/researcher/f4ef2b94ba2d44dd9b41192567a7af53.json"}}], "type": "journal article", "published": "2020-01-24", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "11", "issue": "1", "pages": "470"}, "abstract": "The molecular mechanisms underlying the response to exercise and inactivity are not fully understood. We propose an innovative approach to profile the skeletal muscle transcriptome to exercise and inactivity using 66 published datasets. Data collected from human studies of aerobic and resistance exercise, including acute and chronic exercise training, were integrated using meta-analysis methods (www.metamex.eu). Here we use gene ontology and pathway analyses to reveal selective pathways activated by inactivity, aerobic versus resistance and acute versus chronic exercise training. We identify NR4A3 as one of the most exercise- and inactivity-responsive genes, and establish a role for this nuclear receptor in mediating the metabolic responses to exercise-like stimuli in vitro. The meta-analysis (MetaMEx) also highlights the differential response to exercise in individuals with metabolic impairments. MetaMEx provides the most extensive dataset of skeletal muscle transcriptional responses to different modes of exercise and an online interface to readily interrogate the database.", "doi": "10.1038/s41467-019-13869-w", "pmid": "31980607", "labels": {"Bioinformatics Support, Infrastructure and Training": "Service", "Bioinformatics Support and Infrastructure": "Service", "Bioinformatics (NBIS)": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-019-13869-w"}, {"db": "pmc", "key": "PMC6981202"}], "notes": [], "created": "2020-01-07T15:03:10.909Z", "modified": "2021-11-10T12:54:37.387Z"}]}